{"id":"https://openalex.org/W2162630407","doi":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","title":"Understanding Psychological Stress, Its Biological Processes, and Impact on Primary Headache","display_name":"Understanding Psychological Stress, Its Biological Processes, and Impact on Primary Headache","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W2162630407","doi":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","mag":"2162630407","pmid":"https://pubmed.ncbi.nlm.nih.gov/17040334"},"language":"en","primary_location":{"id":"doi:10.1111/j.1526-4610.2006.00580.x","doi":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110305376","display_name":"Justin M. Nash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Nash","raw_affiliation_strings":["Center for Behavioral and Preventive Medicine, Brown Medical School, The Miriam Hospital, Providence, RI 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Behavioral and Preventive Medicine, Brown Medical School, The Miriam Hospital, Providence, RI 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081869794","display_name":"Ronald W. Thebarge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald W. Thebarge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.4805,"has_fulltext":false,"cited_by_count":187,"citation_normalized_percentile":{"value":0.81192335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"46","issue":"9","first_page":"1377","last_page":"1386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14085","display_name":"Student Stress and Coping","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-headache","display_name":"primary headache","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8679999709129333},{"id":"https://openalex.org/keywords/headache-exacerbation","display_name":"headache exacerbation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/headache-related-disability","display_name":"headache-related disability","score":0.9779999852180481},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9710000157356262},{"id":"https://openalex.org/keywords/stress-reduction","display_name":"stress reduction","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.802952229976654},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.5618539452552795},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5287342071533203},{"id":"https://openalex.org/C3017995614","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Primary headache","level":3,"score":0.48269057273864746},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4822962284088135},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47604846954345703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4662569761276245},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.43905365467071533},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.36187928915023804},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.3291916251182556},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.31757238507270813},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21736493706703186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12822234630584717},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018781","descriptor_name":"Tension-Type Headache","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018781","descriptor_name":"Tension-Type Headache","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018781","descriptor_name":"Tension-Type Headache","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1526-4610.2006.00580.x","doi":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2006.00580.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},{"id":"pmid:17040334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17040334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1955956111","https://openalex.org/W1966859908","https://openalex.org/W1971904249","https://openalex.org/W1971940798","https://openalex.org/W1980612932","https://openalex.org/W1982499392","https://openalex.org/W1984654153","https://openalex.org/W1987586940","https://openalex.org/W1989495089","https://openalex.org/W1999283019","https://openalex.org/W2002079836","https://openalex.org/W2002142158","https://openalex.org/W2004725284","https://openalex.org/W2004725892","https://openalex.org/W2006145844","https://openalex.org/W2014208168","https://openalex.org/W2022761808","https://openalex.org/W2022883873","https://openalex.org/W2024650277","https://openalex.org/W2025743795","https://openalex.org/W2026990722","https://openalex.org/W2027871132","https://openalex.org/W2036485904","https://openalex.org/W2043433825","https://openalex.org/W2050141372","https://openalex.org/W2057460915","https://openalex.org/W2066561718","https://openalex.org/W2067334138","https://openalex.org/W2067827902","https://openalex.org/W2071533953","https://openalex.org/W2071648203","https://openalex.org/W2074192427","https://openalex.org/W2074548534","https://openalex.org/W2077048201","https://openalex.org/W2085581945","https://openalex.org/W2090232207","https://openalex.org/W2094875685","https://openalex.org/W2098335992","https://openalex.org/W2099748730","https://openalex.org/W2115979058","https://openalex.org/W2120279490","https://openalex.org/W2143377484","https://openalex.org/W2145964611","https://openalex.org/W2150540543","https://openalex.org/W2151186028","https://openalex.org/W2156538250","https://openalex.org/W2167251010","https://openalex.org/W2246500122","https://openalex.org/W2319298661","https://openalex.org/W2334787351","https://openalex.org/W6690748539"],"related_works":["https://openalex.org/W2165819577","https://openalex.org/W2404553049","https://openalex.org/W1990834536","https://openalex.org/W2773713955","https://openalex.org/W4407526802","https://openalex.org/W1528943641","https://openalex.org/W4416921736","https://openalex.org/W6892463717","https://openalex.org/W3130777885","https://openalex.org/W1979415737"],"abstract_inverted_index":{"Psychological":[0],"stress":[1,28,50,71,111,119,174,185,190,218,238],"is":[2,30,114,120],"generally":[3],"acknowledged":[4],"to":[5,10,24,41,54,64,86,122,207],"be":[6,80],"a":[7,81,99,160,209],"central":[8,139],"contributor":[9],"primary":[11,124],"headache.":[12],"Stress":[13,77,141],"results":[14],"from":[15],"any":[16],"challenge":[17],"or":[18,22],"threat,":[19],"either":[20],"real":[21],"perceived,":[23],"normal":[25],"functioning.":[26,45],"The":[27],"response":[29,51],"the":[31,38,49,92,95,136,153,170,182,187,194,214,217,223,227,234],"body's":[32],"activation":[33,47],"of":[34,48,94,150,184,189,197,213,216,237],"physiological":[35],"systems,":[36],"namely":[37],"hypothalamic-pituitary-adrenal":[39],"axis,":[40],"protect":[42],"and":[43,56,72,102,105,131,138,148,167,186,201,219,222,239,248],"restore":[44],"Chronic":[46],"can":[52,60,78,142,157,205,231],"lead":[53],"wear":[55],"tear":[57],"that":[58,70,84,162,173,225,242],"eventually":[59],"predispose":[61],"an":[62,164],"individual":[63,107],"disease.":[65],"There":[66],"are":[67,74,179],"multiple":[68],"ways":[69],"headache":[73,87,96,108,113,125,154,198,220,244],"closely":[75],"related.":[76],"(a)":[79],"predisposing":[82],"factor":[83],"contributes":[85],"disorder":[88,97,199,245],"onset,":[89,246],"(b)":[90],"accelerate":[91],"progression":[93],"into":[98],"chronic":[100],"condition,":[101],"(c)":[103],"precipitate":[104],"exacerbate":[106],"episodes.":[109],"How":[110],"impacts":[112],"not":[115],"often":[116],"understood.":[117],"However,":[118],"assumed":[121],"affect":[123],"by":[126],"directly":[127],"impacting":[128],"pain":[129],"production":[130],"modulation":[132],"processes":[133],"at":[134,193],"both":[135],"peripheral":[137],"levels.":[140],"also":[143,232],"independently":[144],"worsen":[145],"headache-related":[146],"disability":[147],"quality":[149],"life.":[151],"Finally,":[152],"experience":[155],"itself":[156],"serve":[158],"as":[159],"stressor":[161],"compromises":[163],"individual's":[165],"health":[166],"well-being.":[168],"With":[169],"prominent":[171],"role":[172],"plays":[175],"in":[176],"headache,":[177],"there":[178],"implications":[180],"for":[181],"evaluation":[183],"use":[188],"reduction":[191],"strategies":[192],"various":[195],"stages":[196],"onset":[200],"progression.":[202],"Future":[203],"directions":[204],"help":[206],"develop":[208],"better":[210],"empirical":[211],"understanding":[212],"pattern":[215],"connections":[221],"mechanisms":[224],"explain":[226],"connections.":[228],"Further":[229],"research":[230],"examine":[233],"interactive":[235],"effects":[236],"other":[240],"factors":[241],"impact":[243],"course,":[247],"adjustment.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}