{"id":"https://openalex.org/W2162553503","doi":null,"title":"Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.","display_name":"Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.","publication_year":2002,"publication_date":"2002-09-15","ids":{"openalex":"https://openalex.org/W2162553503","mag":"2162553503","pmid":"https://pubmed.ncbi.nlm.nih.gov/12235001"},"language":"en","primary_location":{"id":"pmid:12235001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12235001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024420635","display_name":"Hong Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Sheng","raw_affiliation_strings":["Comprehensive Cancer Center, Department of Dermatology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Department of Dermatology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068773843","display_name":"Sara Goich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Goich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Aiqin Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aiqin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035488582","display_name":"Marina A. Grachtchouk","orcid":"https://orcid.org/0000-0003-4677-2834","observed_orcids":["https://orcid.org/0000-0003-4677-2834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Grachtchouk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081903152","display_name":"Lori Lowe","orcid":"https://orcid.org/0000-0002-2359-8426","observed_orcids":["https://orcid.org/0000-0002-2359-8426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori Lowe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110762405","display_name":"Rong Mo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Mo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108088809","display_name":"Kui Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kui Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017065880","display_name":"Fr\u00e9d\u00e9ric J. de Sauvage","orcid":"https://orcid.org/0000-0002-5275-2584","observed_orcids":["https://orcid.org/0000-0002-5275-2584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic J de Sauvage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060872339","display_name":"Hiroshi Sasaki","orcid":"https://orcid.org/0000-0001-8752-6846","observed_orcids":["https://orcid.org/0000-0001-8752-6846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919331","display_name":"Chi\u2010chung Hui","orcid":"https://orcid.org/0000-0001-7047-6694","observed_orcids":["https://orcid.org/0000-0001-7047-6694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi-chung Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063308144","display_name":"Andrzej Antoni Dlugosz","orcid":"https://orcid.org/0000-0002-9791-3257","observed_orcids":["https://orcid.org/0000-0002-9791-3257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej A Dlugosz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6268,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.81714859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"18","first_page":"5308","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gli2","display_name":"GLI2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/skin-tumors","display_name":"skin tumors","score":0.703000009059906},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/trichoblastoma","display_name":"trichoblastoma","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cylindroma","display_name":"cylindroma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/basaloid-follicular-hamartoma","display_name":"basaloid follicular hamartoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/keratin-5-promoter","display_name":"keratin 5 promoter","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-phenotype","display_name":"tumor phenotype","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oncogenicity","display_name":"oncogenicity","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C120407494","wikidata":"https://www.wikidata.org/wiki/Q14886491","display_name":"GLI2","level":4,"score":0.9523102045059204},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.8198429346084595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7017613649368286},{"id":"https://openalex.org/C97182474","wikidata":"https://www.wikidata.org/wiki/Q14886904","display_name":"GLI3","level":5,"score":0.5527863502502441},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5377732515335083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5347532033920288},{"id":"https://openalex.org/C2991961867","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair cycle","level":3,"score":0.5243085622787476},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.49310752749443054},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4813559651374817},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.47953224182128906},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4567173719406128},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4463717043399811},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.43464478850364685},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4309832751750946},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4210726320743561},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39386963844299316},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3874039947986603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3522492051124573},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.26330333948135376},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25358039140701294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20969527959823608}],"mesh":[{"descriptor_ui":"D000075746","descriptor_name":"Zinc Finger Protein Gli2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12235001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12235001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.317.9524","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.317.9524","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/62/18/5308.full.pdf","raw_type":"text"},{"id":"mag:2162553503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12235001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6659183058","display_name":"Molecular Basis of Epithelial Skin Cancer","funder_award_id":"R01CA087837","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862605","display_name":"University of Michigan Rogel Cancer Center Support Grant 2023-2028","funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000863960","display_name":"Training Grant in Cell and Molecular Dermatology","funder_award_id":"T32AR007197","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W47953737","https://openalex.org/W123775848","https://openalex.org/W1494381630","https://openalex.org/W1517007299","https://openalex.org/W1569152804","https://openalex.org/W1594815607","https://openalex.org/W1607562326","https://openalex.org/W1674361195","https://openalex.org/W1676048097","https://openalex.org/W1901208108","https://openalex.org/W1944404325","https://openalex.org/W1950508909","https://openalex.org/W1954982245","https://openalex.org/W1969869774","https://openalex.org/W1976583497","https://openalex.org/W1977688398","https://openalex.org/W1980332250","https://openalex.org/W1980591242","https://openalex.org/W1981708895","https://openalex.org/W1995392458","https://openalex.org/W1996550171","https://openalex.org/W1999375026","https://openalex.org/W2001155940","https://openalex.org/W2005022274","https://openalex.org/W2008567133","https://openalex.org/W2009482935","https://openalex.org/W2011437456","https://openalex.org/W2011533200","https://openalex.org/W2012199249","https://openalex.org/W2014418134","https://openalex.org/W2019150363","https://openalex.org/W2021354108","https://openalex.org/W2028898761","https://openalex.org/W2032668283","https://openalex.org/W2035524441","https://openalex.org/W2037571907","https://openalex.org/W2037917041","https://openalex.org/W2044616474","https://openalex.org/W2050469657","https://openalex.org/W2053718752","https://openalex.org/W2054400088","https://openalex.org/W2057380783","https://openalex.org/W2066281055","https://openalex.org/W2076585109","https://openalex.org/W2080628861","https://openalex.org/W2088862548","https://openalex.org/W2090542192","https://openalex.org/W2096148741","https://openalex.org/W2099118069","https://openalex.org/W2102752088","https://openalex.org/W2108272515","https://openalex.org/W2108707301","https://openalex.org/W2114702304","https://openalex.org/W2127001212","https://openalex.org/W2133290375","https://openalex.org/W2134386050","https://openalex.org/W2137598946","https://openalex.org/W2138979073","https://openalex.org/W2139168265","https://openalex.org/W2140619393","https://openalex.org/W2160899662","https://openalex.org/W2167578565","https://openalex.org/W2334149595","https://openalex.org/W2397256054"],"related_works":["https://openalex.org/W2021354108","https://openalex.org/W1969050050","https://openalex.org/W7099453198","https://openalex.org/W814878073","https://openalex.org/W2084940761","https://openalex.org/W2044348636","https://openalex.org/W3169719484","https://openalex.org/W2151907359","https://openalex.org/W1676048097","https://openalex.org/W1994029119"],"abstract_inverted_index":{"Development":[0],"of":[1,23,30,46,53,75,94,103,136,155,163,202,215,236],"basal":[2],"cell":[3,183],"carcinomas":[4],"(BCCs)":[5],"in":[6,34,65,80,89,132,191,196,234,242,255],"skin":[7,35,81,104],"is":[8,27,37],"associated":[9],"with":[10],"uncontrolled":[11],"Sonic":[12],"hedgehog":[13],"(Shh)":[14],"signaling,":[15],"which":[16,159,217],"operates":[17],"primarily":[18],"through":[19],"the":[20,72,76,86,95,152,161,200,224,231,251],"Gli":[21,54],"family":[22],"transcription":[24,62],"factors.":[25],"Gli2":[26,66,77,123,225,239,252],"a":[28,47,101,246],"mediator":[29],"physiological":[31],"Shh":[32,156,164,188],"signaling":[33],"and":[36,113,145,193,238,244],"sufficient":[38],"to":[39,182,208,223],"produce":[40],"BCCs":[41],"when":[42,240],"overexpressed":[43,85,241],"by":[44,92],"use":[45,93],"Keratin":[48],"5":[49],"(K5)":[50],"promoter.":[51,97],"Analysis":[52],"protein":[55],"deletion":[56],"mutants":[57],"has":[58],"identified":[59],"an":[60,219],"NH(2)-terminal":[61,220],"repressor":[63,78,226],"domain":[64,79],"but":[67],"not":[68,168],"Gli1.":[69],"To":[70],"assess":[71],"potential":[73],"involvement":[74],"tumor":[82,257],"development,":[83],"we":[84],"Gli2DeltaN2":[87],"mutant":[88],"transgenic":[90,137],"mice":[91,99,120,138,204],"K5":[96,212],"K5-Gli2DeltaN2":[98,173,203],"developed":[100,124],"variety":[102],"tumors":[105,130],"resembling":[106],"human":[107,176],"trichoblastomas,":[108],"cylindromas,":[109],"basaloid":[110],"follicular":[111],"hamartomas,":[112],"rarely,":[114],"BCCs.":[115,126],"In":[116],"striking":[117],"contrast,":[118],"K5-Gli2":[119],"overexpressing":[121],"wild-type":[122],"only":[125],"Other":[127],"differences":[128],"between":[129],"arising":[131],"these":[133],"two":[134],"sets":[135],"included":[139],"their":[140],"gross":[141],"appearance,":[142],"growth":[143],"rate,":[144],"predilection":[146],"for":[147,250],"specific":[148],"body":[149],"sites.":[150],"However,":[151],"expression":[153],"levels":[154],"target":[157,189],"genes,":[158],"reflect":[160],"magnitude":[162],"pathway":[165],"activation,":[166],"were":[167,194],"dramatically":[169],"different.":[170],"Tumors":[171],"from":[172],"mice,":[174],"unlike":[175],"or":[177],"mouse":[178],"BCCs,":[179],"gave":[180],"rise":[181],"lines":[184],"that":[185,209],"constitutively":[186],"expressed":[187],"genes":[190],"vitro":[192],"tumorigenic":[195],"nude":[197],"mice.":[198],"Interestingly,":[199],"phenotype":[201],"was":[205],"strikingly":[206],"similar":[207],"reported":[210],"after":[211],"promoter-driven":[213],"overexpression":[214],"GLI1,":[216],"lacks":[218],"region":[221],"homologous":[222],"domain.":[227],"These":[228],"results":[229],"underscore":[230],"qualitative":[232],"difference":[233],"oncogenicity":[235],"GLI1":[237],"skin,":[243],"reveal":[245],"previously":[247],"unanticipated":[248],"role":[249],"NH(2)":[253],"terminus":[254],"defining":[256],"phenotype.":[258]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}