{"id":"https://openalex.org/W2162550348","doi":"https://doi.org/10.1177/0192623309335630","title":"\u03b3-Tocopherol Attenuates Ozone-induced Exacerbation of Allergic Rhinosinusitis in Rats","display_name":"\u03b3-Tocopherol Attenuates Ozone-induced Exacerbation of Allergic Rhinosinusitis in Rats","publication_year":2009,"publication_date":"2009-04-23","ids":{"openalex":"https://openalex.org/W2162550348","doi":"https://doi.org/10.1177/0192623309335630","mag":"2162550348","pmid":"https://pubmed.ncbi.nlm.nih.gov/19389874","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4465783"},"language":"en","primary_location":{"id":"doi:10.1177/0192623309335630","doi":"https://doi.org/10.1177/0192623309335630","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0192623309335630","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4465783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080137823","display_name":"James G. Wagner","orcid":"https://orcid.org/0000-0002-4216-0753","observed_orcids":["https://orcid.org/0000-0002-4216-0753"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Wagner","raw_affiliation_strings":["Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016212755","display_name":"Jack R. Harkema","orcid":"https://orcid.org/0000-0003-4682-0824","observed_orcids":["https://orcid.org/0000-0003-4682-0824"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack R. Harkema","raw_affiliation_strings":["Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101771662","display_name":"Qing Jiang","orcid":"https://orcid.org/0000-0002-0579-8280","observed_orcids":["https://orcid.org/0000-0002-0579-8280"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Jiang","raw_affiliation_strings":["Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091652058","display_name":"Beate Illek","orcid":"https://orcid.org/0000-0003-0076-3553","observed_orcids":["https://orcid.org/0000-0003-0076-3553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beate Illek","raw_affiliation_strings":["Children\u2019s Hospital of Oakland Research Institute, Oakland, CA 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Oakland Research Institute, Oakland, CA 94609, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110195895","display_name":"Bruce N. Ames","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce N. Ames","raw_affiliation_strings":["Children\u2019s Hospital of Oakland Research Institute, Oakland, CA 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Oakland Research Institute, Oakland, CA 94609, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010809550","display_name":"David B. Peden","orcid":"https://orcid.org/0000-0003-4526-4627","observed_orcids":["https://orcid.org/0000-0003-4526-4627","https://orcid.org/0000-0001-5668-2782"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Peden","raw_affiliation_strings":["Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.0509,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.78106021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"4","first_page":"481","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-tocopherol","display_name":"gamma-tocopherol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ozone-exposure","display_name":"ozone exposure","score":0.6399999856948853},{"id":"https://openalex.org/keywords/allergic-rhinosinusitis","display_name":"allergic rhinosinusitis","score":1.0},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":0.8730000257492065},{"id":"https://openalex.org/keywords/allergic-airway-disease","display_name":"allergic airway disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.5920000076293945},{"id":"https://openalex.org/keywords/maxillary-sinus","display_name":"maxillary sinus","score":0.7239999771118164},{"id":"https://openalex.org/keywords/health-effects-of-air-pollution","display_name":"air pollution health effects","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7126844525337219},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.6844558119773865},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.5874800086021423},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.5456663966178894},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5157168507575989},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5001225471496582},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.47762054204940796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4153788685798645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3238869905471802},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.20162323117256165},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12902051210403442}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024504","descriptor_name":"gamma-Tocopherol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024504","descriptor_name":"gamma-Tocopherol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055271","descriptor_name":"Mucin 5AC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055271","descriptor_name":"Mucin 5AC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1177/0192623309335630","doi":"https://doi.org/10.1177/0192623309335630","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0192623309335630","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:19389874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19389874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3429210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4465783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4465783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4465783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicol Pathol","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:mc87q0500","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/5v3m-0p87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicologic Pathology, 37(4)","raw_type":"Article"},{"id":"doi:10.17615/5v3m-0p87","doi":"https://doi.org/10.17615/5v3m-0p87","is_oa":true,"landing_page_url":"https://doi.org/10.17615/5v3m-0p87","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3429210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4465783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G224275916","display_name":"Translational Research Center for CAM Therapy of Asthma","funder_award_id":"P01AT002620","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W238974498","https://openalex.org/W1540026419","https://openalex.org/W1865284955","https://openalex.org/W1931909236","https://openalex.org/W1966734272","https://openalex.org/W1979661461","https://openalex.org/W1981457427","https://openalex.org/W1987928674","https://openalex.org/W1991596606","https://openalex.org/W1992357198","https://openalex.org/W1998033013","https://openalex.org/W2019013424","https://openalex.org/W2023635590","https://openalex.org/W2024993763","https://openalex.org/W2025172548","https://openalex.org/W2027394589","https://openalex.org/W2033528576","https://openalex.org/W2035816744","https://openalex.org/W2039382697","https://openalex.org/W2040180170","https://openalex.org/W2041854713","https://openalex.org/W2045744166","https://openalex.org/W2054197933","https://openalex.org/W2056249566","https://openalex.org/W2058798563","https://openalex.org/W2060644706","https://openalex.org/W2064981622","https://openalex.org/W2067298637","https://openalex.org/W2083900623","https://openalex.org/W2097481089","https://openalex.org/W2099750150","https://openalex.org/W2104928971","https://openalex.org/W2106564689","https://openalex.org/W2113564593","https://openalex.org/W2117497904","https://openalex.org/W2119218824","https://openalex.org/W2119449792","https://openalex.org/W2119811589","https://openalex.org/W2121487574","https://openalex.org/W2124968640","https://openalex.org/W2125688108","https://openalex.org/W2132251075","https://openalex.org/W2136271064","https://openalex.org/W2141979512","https://openalex.org/W2147538249","https://openalex.org/W2163894456","https://openalex.org/W2182486974"],"related_works":["https://openalex.org/W1991596606","https://openalex.org/W2056249566","https://openalex.org/W2119811589","https://openalex.org/W2378179599","https://openalex.org/W2329971703","https://openalex.org/W3123032844","https://openalex.org/W2186086142","https://openalex.org/W2586126679","https://openalex.org/W3091146440","https://openalex.org/W4386945714"],"abstract_inverted_index":{"Compared":[0],"to":[1,17,34,66,150,222,277],"healthy":[2],"subjects,":[3],"individuals":[4],"with":[5,51,226],"allergic":[6,11,27,172,220,265,282],"airway":[7,283],"disease":[8],"(e.g.,":[9],"asthma,":[10],"rhinitis)":[12],"have":[13],"enhanced":[14],"inflammatory":[15],"responses":[16,29],"inhaled":[18],"ozone.":[19],"We":[20],"created":[21],"a":[22,258,273],"rodent":[23],"model":[24,260],"of":[25,39,118,164,171,190,219,261,264,272,281],"ozone-enhanced":[26],"nasal":[28,108,159,241],"in":[30,89,154,177,201,211,234,239],"Brown":[31],"Norway":[32],"rats":[33,47,166,173],"test":[35],"the":[36,40,101,155,158,178,212,229,268],"therapeutic":[37,270],"effects":[38],"dietary":[41],"supplement":[42],"gamma-tocopherol":[43],"(gammaT).":[44],"Ovalbumin":[45],"(OVA)-sensitized":[46],"were":[48,80,110],"intranasally":[49],"challenged":[50],"0%":[52],"or":[53,68,84],"0.5%":[54],"OVA":[55,103,199,248],"(in":[56],"saline)":[57],"on":[58,74,92],"Days":[59,75],"1":[60,69],"and":[61,63,77,115,122,130,161,185,215,236,242,249,267],"2,":[62],"then":[64],"exposed":[65],"0":[67,83],"ppm":[70],"ozone":[71,210,262,279],"(eight":[72],"hours/day)":[73],"4":[76],"5.":[78],"Rats":[79],"also":[81,246],"given":[82],"100":[85],"mg/kg":[86],"gammaT":[87,227],"(p.o.,":[88],"corn":[90],"oil)":[91],"days":[93],"2":[94],"through":[95],"5,":[96],"beginning":[97],"twelve":[98],"hours":[99],"after":[100],"last":[102],"challenge.":[104],"On":[105],"Day":[106],"6,":[107],"tissues":[109],"collected":[111],"for":[112,139],"histological":[113],"evaluation":[114],"morphometric":[116],"analyses":[117],"intraepithelial":[119,191],"mucosubstances":[120,192],"(IM)":[121,193],"eosinophilic":[123],"inflammation.":[124],"Nasal":[125],"septal":[126],"tissue":[127],"was":[128,194,207],"microdissected":[129],"analyzed":[131],"by":[132,198,209],"reverse":[133],"transcriptase":[134],"polymerase":[135],"chain":[136],"reaction":[137],"(RT-PCR)":[138],"mucin":[140],"glycoprotein":[141],"5AC":[142],"(MUC5AC)":[143],"expression":[144],"levels.":[145],"Histological":[146],"analysis":[147],"revealed":[148],"mild":[149],"moderate":[151],"eosinophil":[152],"influx":[153],"mucosa":[156],"lining":[157],"airways":[160],"maxillary":[162,179,216],"sinus":[163,180,217],"OVA-challenged":[165],"(eosinophilic":[167],"rhinosinusitis).":[168],"Ozone":[169],"exposure":[170],"further":[174],"increased":[175,208],"eosinophils":[176,238],"(400%),":[181],"nasolacrimal":[182],"duct":[183],"(250%),":[184],"proximal":[186],"midseptum":[187],"(150%).":[188],"Storage":[189],"not":[195],"significantly":[196],"affected":[197],"challenge":[200],"filtered":[202],"air-exposed":[203],"rats,":[204],"but":[205],"it":[206],"septum":[213],"(45%)":[214],"(55%)":[218],"compared":[221],"control":[223],"rats.":[224],"Treatment":[225],"attenuated":[228],"ozone/":[230],"OVA-induced":[231],"synergistic":[232],"increases":[233],"IM":[235],"mucosal":[237],"both":[240],"paranasal":[243],"airways.":[244],"gamma-Tocopherol":[245],"blocked":[247],"ozone-induced":[250],"MUC5AC":[251],"gene":[252],"expression.":[253],"Together,":[254],"these":[255],"data":[256],"describe":[257],"unique":[259],"enhancement":[263],"rhinosinusitis":[266],"novel":[269],"efficacy":[271],"common":[274],"supplement,":[275],"gammaT,":[276],"inhibit":[278],"exacerbation":[280],"responses.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}