{"id":"https://openalex.org/W2162514293","doi":"https://doi.org/10.4269/ajtmh.2004.71.144","title":"ANALYSIS OF RECOMBINANT DENGUE VIRUS POLYPEPTIDES FOR DENGUE DIAGNOSIS AND EVALUATION OF THE HUMORAL IMMUNE RESPONSE","display_name":"ANALYSIS OF RECOMBINANT DENGUE VIRUS POLYPEPTIDES FOR DENGUE DIAGNOSIS AND EVALUATION OF THE HUMORAL IMMUNE RESPONSE","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W2162514293","doi":"https://doi.org/10.4269/ajtmh.2004.71.144","mag":"2162514293","pmid":"https://pubmed.ncbi.nlm.nih.gov/15306702"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.2004.71.144","doi":"https://doi.org/10.4269/ajtmh.2004.71.144","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2004.71.144","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016458360","display_name":"Fl\u00e1via Barreto dos Santos","orcid":"https://orcid.org/0000-0002-1309-5366","observed_orcids":["https://orcid.org/0000-0002-1309-5366"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"FLAVIA BARRETO DOS SANTOS","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017176773","display_name":"Marize Pereira Miagostovich","orcid":"https://orcid.org/0000-0003-3470-8093","observed_orcids":["https://orcid.org/0000-0003-3470-8093"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"MARIZE PEREIRA MIAGOSTOVICH","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111829566","display_name":"Rita Maria Ribeiro Nogueira","orcid":"https://orcid.org/0000-0002-8485-2432","observed_orcids":["https://orcid.org/0000-0002-8485-2432"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"RITA MARIA RIBEIRO NOGUEIRA","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111584272","display_name":"Hermann Gon\u00e7alves Schatzmayr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"HERMANN GONC\u0327ALVES SCHATZMAYR","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023155188","display_name":"Lee W. Riley","orcid":"https://orcid.org/0000-0001-9916-3894","observed_orcids":["https://orcid.org/0000-0001-9916-3894"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"LEE W. RILEY","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027442064","display_name":"Eva Harris","orcid":"https://orcid.org/0000-0002-7238-4037","observed_orcids":["https://orcid.org/0000-0002-7238-4037"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"EVA HARRIS","raw_affiliation_strings":["Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3584,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83033901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"71","issue":"2","first_page":"144","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue-virus-type-2","display_name":"dengue virus type 2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/recombinant-polypeptides","display_name":"recombinant peptide","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dengue-diagnosis","display_name":"dengue diagnosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9710000157356262},{"id":"https://openalex.org/keywords/envelope-protein","display_name":"envelope protein","score":0.753000020980835},{"id":"https://openalex.org/keywords/igg-elisa","display_name":"IgG ELISA","score":0.6039999723434448},{"id":"https://openalex.org/keywords/candidate-antigens","display_name":"candidate antigens","score":0.5799999833106995},{"id":"https://openalex.org/keywords/antibody-diversity","display_name":"antibody diversity","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8984513282775879},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8249046802520752},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.744026780128479},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.642815113067627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6379749178886414},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5784040093421936},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5605998635292053},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5589658617973328},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.496112197637558},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4498726725578308},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3841709494590759},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10348016023635864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4269/ajtmh.2004.71.144","doi":"https://doi.org/10.4269/ajtmh.2004.71.144","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2004.71.144","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},{"id":"pmid:15306702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15306702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W204328400","https://openalex.org/W1748018096","https://openalex.org/W1773048998","https://openalex.org/W1799888790","https://openalex.org/W1910154310","https://openalex.org/W1917851386","https://openalex.org/W1969185143","https://openalex.org/W1970455211","https://openalex.org/W1975258541","https://openalex.org/W1982219875","https://openalex.org/W1990086201","https://openalex.org/W1998628919","https://openalex.org/W2007449270","https://openalex.org/W2009760265","https://openalex.org/W2018750823","https://openalex.org/W2023274598","https://openalex.org/W2045211613","https://openalex.org/W2049280865","https://openalex.org/W2065175616","https://openalex.org/W2070603406","https://openalex.org/W2077295427","https://openalex.org/W2078375321","https://openalex.org/W2096137193","https://openalex.org/W2096935479","https://openalex.org/W2100837269","https://openalex.org/W2108240258","https://openalex.org/W2110565950","https://openalex.org/W2125546800","https://openalex.org/W2126971544","https://openalex.org/W2131112023","https://openalex.org/W2140415029","https://openalex.org/W2153028888","https://openalex.org/W2156003470","https://openalex.org/W2159368480","https://openalex.org/W2160508634","https://openalex.org/W2172226168","https://openalex.org/W2186717303","https://openalex.org/W2189481352","https://openalex.org/W2417941326"],"related_works":["https://openalex.org/W2189481352","https://openalex.org/W2096389486","https://openalex.org/W2981064624","https://openalex.org/W2380667432","https://openalex.org/W4300862022","https://openalex.org/W2385382256","https://openalex.org/W2149974027","https://openalex.org/W7099460497","https://openalex.org/W2161169857","https://openalex.org/W2049424635"],"abstract_inverted_index":{"Dengue":[0],"is":[1],"a":[2,24,100,136,147],"serious":[3],"cause":[4],"of":[5,23,43,74,80,102,142],"morbidity":[6],"and":[7,15,41,54,94,123,145],"mortality":[8],"in":[9,32,70,150,153],"tropical":[10],"areas":[11],"worldwide.":[12],"We":[13],"cloned":[14],"expressed":[16],"recombinant":[17],"polypeptides":[18],"spanning":[19],"the":[20,44,63,71,75,154],"entire":[21],"genome":[22],"Brazilian":[25],"dengue":[26,39],"virus":[27],"type":[28],"2":[29],"(DENV-2)":[30],"strain":[31],"contiguous":[33],"segments":[34],"to":[35,139,157],"generate":[36],"antigens":[37],"for":[38,119],"diagnosis":[40,141],"evaluation":[42],"human":[45,61],"humoral":[46],"immune":[47],"response.":[48],"When":[49],"analyzed":[50],"by":[51],"Western":[52],"blot":[53],"an":[55,81],"enzyme-linked":[56],"immunosorbent":[57],"assay":[58],"(ELISA)":[59],"using":[60,83],"sera,":[62,98],"most":[64],"reactive":[65],"polypeptide":[66],"(pD2-3(E))":[67],"was":[68,89],"located":[69],"N-terminal":[72],"portion":[73],"envelope":[76],"protein.":[77],"The":[78],"sensitivity":[79],"IgG-ELISA":[82],"pD2-3(E)":[84,113],"versus":[85],"mouse":[86],"brain":[87],"antigen":[88,138],"100%":[90],"with":[91,96,99,108],"convalescent":[92],"sera":[93,117],"79%":[95],"acute":[97],"specificity":[101],"100%.":[103],"Sera":[104],"from":[105],"patients":[106],"infected":[107],"other":[109],"DENV":[110,143,158],"serotypes":[111],"recognized":[112],"equally":[114],"well,":[115],"whereas":[116],"positive":[118],"yellow":[120],"fever,":[121],"rubella,":[122],"measles":[124],"showed":[125],"little":[126],"or":[127],"no":[128],"reactivity.":[129],"Using":[130],"this":[131],"novel":[132],"approach,":[133],"we":[134],"identified":[135],"candidate":[137],"facilitate":[140],"infections":[144],"observed":[146],"surprising":[148],"variability":[149],"antibody":[151],"patterns":[152],"clinical":[155],"response":[156],"infections.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}