{"id":"https://openalex.org/W2162500611","doi":"https://doi.org/10.1016/s0014-2999(98)00927-3","title":"NG-Nitro-l-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol","display_name":"NG-Nitro-l-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2162500611","doi":"https://doi.org/10.1016/s0014-2999(98)00927-3","mag":"2162500611","pmid":"https://pubmed.ncbi.nlm.nih.gov/10082193"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(98)00927-3","doi":"https://doi.org/10.1016/s0014-2999(98)00927-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(98)00927-3","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078348855","display_name":"Stanis\u0142aw Jerzy Czuczwar","orcid":"https://orcid.org/0000-0003-2879-9945","observed_orcids":["https://orcid.org/0000-0003-2879-9945"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Stanis\u0142aw J Czuczwar","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Lublin Medical University School, Poland. czuczwar@galen.imw.lublin.pl","Department of Clinical Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland","Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Lublin Medical University School, Poland. czuczwar@galen.imw.lublin.pl","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Department of Clinical Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022761689","display_name":"Piotr Tutka","orcid":"https://orcid.org/0000-0001-5731-4295","observed_orcids":["https://orcid.org/0000-0001-5731-4295"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Tutka","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064424140","display_name":"Pawe\u0142 Klonowski","orcid":"https://orcid.org/0000-0002-5514-7988","observed_orcids":["https://orcid.org/0000-0002-5514-7988"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pawe\u0142 Klonowski","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113618589","display_name":"Zdzis\u0142aw Kleinrok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zdzis\u0142aw Kleinrok","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Lublin Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078348855"],"corresponding_institution_ids":["https://openalex.org/I121032520"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.667,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81868078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"366","issue":"2-3","first_page":"137","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ng-nitro-l-arginine","display_name":"L-NNA","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ethosuximide","display_name":"ethosuximide","score":0.906000018119812},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8679999709129333},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pentylenetetrazole-induced-seizures","display_name":"pentylenetetrazole-induced seizures","score":0.9710000157356262},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9860000014305115},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":1.0},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.796999990940094},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2779619453","wikidata":"https://www.wikidata.org/wiki/Q421567","display_name":"Ethosuximide","level":4,"score":0.9465043544769287},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.9371746778488159},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5938453078269958},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5841129422187805},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.513195812702179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4684070944786072},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.45254066586494446},{"id":"https://openalex.org/C2780639532","wikidata":"https://www.wikidata.org/wiki/Q7041427","display_name":"Nitro","level":3,"score":0.4397165775299072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37950414419174194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19277891516685486},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.18842005729675293},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06734496355056763},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.062297672033309937},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.055555492639541626},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003292","descriptor_name":"Convulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019335","descriptor_name":"Nitroarginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(98)00927-3","doi":"https://doi.org/10.1016/s0014-2999(98)00927-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(98)00927-3","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:10082193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10082193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W53981349","https://openalex.org/W263340198","https://openalex.org/W1440421401","https://openalex.org/W1929009802","https://openalex.org/W1965780422","https://openalex.org/W1968228025","https://openalex.org/W1969505170","https://openalex.org/W1971680727","https://openalex.org/W1975333295","https://openalex.org/W1976585673","https://openalex.org/W1980499815","https://openalex.org/W1985202739","https://openalex.org/W1987460794","https://openalex.org/W1987481833","https://openalex.org/W1997526564","https://openalex.org/W2009643798","https://openalex.org/W2009830428","https://openalex.org/W2012038403","https://openalex.org/W2012451275","https://openalex.org/W2019642046","https://openalex.org/W2021857511","https://openalex.org/W2023811880","https://openalex.org/W2025652380","https://openalex.org/W2030463612","https://openalex.org/W2031833127","https://openalex.org/W2035880314","https://openalex.org/W2037997999","https://openalex.org/W2039228321","https://openalex.org/W2055620557","https://openalex.org/W2060878473","https://openalex.org/W2062982587","https://openalex.org/W2073724878","https://openalex.org/W2085327871","https://openalex.org/W2085429609","https://openalex.org/W2091527142","https://openalex.org/W2401188729","https://openalex.org/W2412638650"],"related_works":["https://openalex.org/W2057479349","https://openalex.org/W2133403419","https://openalex.org/W2413107201","https://openalex.org/W2045883720","https://openalex.org/W2062982587","https://openalex.org/W1970160799","https://openalex.org/W2417543704","https://openalex.org/W3100237531","https://openalex.org/W2397847142","https://openalex.org/W7097959835"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}