{"id":"https://openalex.org/W2162395048","doi":"https://doi.org/10.1093/hmg/dds532","title":"Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression","display_name":"Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression","publication_year":2012,"publication_date":"2012-12-18","ids":{"openalex":"https://openalex.org/W2162395048","doi":"https://doi.org/10.1093/hmg/dds532","mag":"2162395048","pmid":"https://pubmed.ncbi.nlm.nih.gov/23255163"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/dds532","doi":"https://doi.org/10.1093/hmg/dds532","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/dds532","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040653950","display_name":"Laurence Molina","orcid":"https://orcid.org/0000-0002-5332-3917","observed_orcids":["https://orcid.org/0000-0002-5332-3917"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Molina","raw_affiliation_strings":["SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, Cedex 4,Montpellier, France","SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, Cedex 4,Montpellier, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052066746","display_name":"Lydie Fasquelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"id":"https://openalex.org/I4210143740","display_name":"H\u00f4pital Saint Eloi","ror":"https://ror.org/04pwyfk22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210143740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lydie Fasquelle","raw_affiliation_strings":["Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","Universit\u00e9 de Montpellier, Montpellier 34091, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134790","https://openalex.org/I4210143740"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier 34091, France","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055498615","display_name":"R\u00e9gis Nouvian","orcid":"https://orcid.org/0000-0002-0901-4666","observed_orcids":["https://orcid.org/0000-0002-0901-4666"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"id":"https://openalex.org/I4210143740","display_name":"H\u00f4pital Saint Eloi","ror":"https://ror.org/04pwyfk22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210143740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9gis Nouvian","raw_affiliation_strings":["Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","Universit\u00e9 de Montpellier, Montpellier 34091, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134790","https://openalex.org/I4210143740"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier 34091, France","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036407103","display_name":"Nicolas Salvetat","orcid":"https://orcid.org/0000-0002-0759-5129","observed_orcids":["https://orcid.org/0000-0002-0759-5129"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Salvetat","raw_affiliation_strings":["SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038779121","display_name":"Hamish S. Scott","orcid":"https://orcid.org/0000-0002-5813-631X","observed_orcids":["https://orcid.org/0000-0002-5813-631X"]},"institutions":[{"id":"https://openalex.org/I107656453","display_name":"South Australia Pathology","ror":"https://ror.org/01kvtm035","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I107656453"]},{"id":"https://openalex.org/I4210140852","display_name":"Centre for Cancer Biology","ror":"https://ror.org/03yg7hz06","country_code":"AU","type":"facility","lineage":["https://openalex.org/I107656453","https://openalex.org/I4210140852","https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hamish S. Scott","raw_affiliation_strings":["Department of Molecular Pathology, The Centre for Cancer Biology, SA Pathology and Box 14 Rundle Mall Post Office, Adelaide, South Australia 5000, Australia","The Schools of Medicine and Molecular and Biomedical Science, The University of Adelaide, Adeliade, South Australia 5005, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, The Centre for Cancer Biology, SA Pathology and Box 14 Rundle Mall Post Office, Adelaide, South Australia 5000, Australia","institution_ids":["https://openalex.org/I107656453","https://openalex.org/I4210140852"]},{"raw_affiliation_string":"The Schools of Medicine and Molecular and Biomedical Science, The University of Adelaide, Adeliade, South Australia 5005, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026161707","display_name":"Michel Guipponi","orcid":"https://orcid.org/0009-0000-6149-2684","observed_orcids":["https://orcid.org/0009-0000-6149-2684"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michel Guipponi","raw_affiliation_strings":["Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 4 Geneva 1211, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 4 Geneva 1211, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070559991","display_name":"Franck Molina","orcid":"https://orcid.org/0000-0003-4181-0854","observed_orcids":["https://orcid.org/0000-0003-4181-0854"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Molina","raw_affiliation_strings":["SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SysDiag UMR 3145 CNRS/Bio-Rad, Cap Delta/Parc Eurom\u00e9decine, 1682 rue de la Valsi\u00e8re, CS 61003, Cedex 4, Montpellier 34184, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008800869","display_name":"Jean\u2010Luc Puel","orcid":"https://orcid.org/0000-0002-3772-5190","observed_orcids":["https://orcid.org/0000-0002-3772-5190"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"id":"https://openalex.org/I4210143740","display_name":"H\u00f4pital Saint Eloi","ror":"https://ror.org/04pwyfk22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210143740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Luc Puel","raw_affiliation_strings":["Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","Universit\u00e9 de Montpellier, Montpellier 34091, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134790","https://openalex.org/I4210143740"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier 34091, France","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087401613","display_name":"Benjamin Delprat","orcid":"https://orcid.org/0000-0002-2457-6923","observed_orcids":["https://orcid.org/0000-0002-2457-6923"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]},{"id":"https://openalex.org/I4210143740","display_name":"H\u00f4pital Saint Eloi","ror":"https://ror.org/04pwyfk22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210143740"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Benjamin Delprat","raw_affiliation_strings":["Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","Universit\u00e9 de Montpellier, Montpellier 34091, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 1051, Institut des Neurosciences de Montpellier, H\u00f4pital Saint Eloi, Montpellier 34091, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134790","https://openalex.org/I4210143740"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier 34091, France","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5087401613"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790","https://openalex.org/I4210143740"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.9795,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.69617894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"7","first_page":"1289","last_page":"1299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss3","display_name":"TMPRSS3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kcnma1","display_name":"KCNMA1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inner-hair-cells","display_name":"inner hair cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cochlea","display_name":"cochlea","score":0.8330000042915344},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.8610000014305115},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.652999997138977},{"id":"https://openalex.org/keywords/hair-cell-maturation","display_name":"hair cell maturation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ion-channel-expression","display_name":"ion channel expression","score":0.5870000123977661},{"id":"https://openalex.org/keywords/proteomic-networks","display_name":"proteomic networks","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8106647729873657},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7661033868789673},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.7056794762611389},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5448662042617798},{"id":"https://openalex.org/C45516822","wikidata":"https://www.wikidata.org/wiki/Q6382011","display_name":"KcsA potassium channel","level":4,"score":0.4664109945297241},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4412325620651245},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.4188210964202881},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4179896116256714},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4169155955314636},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4121400713920593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34650570154190063},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25229138135910034},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.24762552976608276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19535169005393982},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06811392307281494}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006199","descriptor_name":"Hair Cells, Auditory, Inner","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051037","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channel alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051037","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channel alpha Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/hmg/dds532","doi":"https://doi.org/10.1093/hmg/dds532","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/dds532","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:23255163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23255163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doc.rero.ch:293365","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/293365/files/dds532.pdf","pdf_url":"http://doc.rero.ch/record/293365/files/dds532.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.971.2923","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.971.2923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hmg.oxfordjournals.org/content/early/2012/12/18/hmg.dds532.full.pdf","raw_type":"text"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/79653","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/79653","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1093/hmg/dds532","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1503465019","https://openalex.org/W1506027146","https://openalex.org/W1518401857","https://openalex.org/W1523716976","https://openalex.org/W1606945552","https://openalex.org/W1619024205","https://openalex.org/W1875790325","https://openalex.org/W1964512347","https://openalex.org/W1966389722","https://openalex.org/W1977630813","https://openalex.org/W1977632525","https://openalex.org/W1981555577","https://openalex.org/W1982505018","https://openalex.org/W1989712467","https://openalex.org/W1993938009","https://openalex.org/W1995405544","https://openalex.org/W2017614800","https://openalex.org/W2020725656","https://openalex.org/W2023130165","https://openalex.org/W2025255849","https://openalex.org/W2031813642","https://openalex.org/W2033817793","https://openalex.org/W2034555413","https://openalex.org/W2037232726","https://openalex.org/W2042707088","https://openalex.org/W2049352189","https://openalex.org/W2053068031","https://openalex.org/W2060956030","https://openalex.org/W2071029015","https://openalex.org/W2071969879","https://openalex.org/W2073672336","https://openalex.org/W2080885537","https://openalex.org/W2088939463","https://openalex.org/W2095766063","https://openalex.org/W2097966843","https://openalex.org/W2100164492","https://openalex.org/W2104784898","https://openalex.org/W2114220025","https://openalex.org/W2116211027","https://openalex.org/W2119397841","https://openalex.org/W2122563317","https://openalex.org/W2123931019","https://openalex.org/W2124099961","https://openalex.org/W2131439696","https://openalex.org/W2133812456","https://openalex.org/W2134478997","https://openalex.org/W2135178190","https://openalex.org/W2137531873","https://openalex.org/W2146950413","https://openalex.org/W2148291968","https://openalex.org/W2151914411","https://openalex.org/W2159557413","https://openalex.org/W2160697532","https://openalex.org/W2162263320","https://openalex.org/W2186261951","https://openalex.org/W4241872693"],"related_works":["https://openalex.org/W4414089875","https://openalex.org/W4318162642","https://openalex.org/W2951454612","https://openalex.org/W1977630813","https://openalex.org/W2097966843","https://openalex.org/W4412492675","https://openalex.org/W4416128040","https://openalex.org/W2793942079","https://openalex.org/W2158390212","https://openalex.org/W6997003992"],"abstract_inverted_index":{"Before":[0],"acquiring":[1],"their":[2,41,64],"mature":[3,59],"state,":[4],"cochlear":[5,135],"hair":[6,36,156],"cells":[7,157],"undergo":[8],"a":[9,29,111,134,173],"series":[10],"of":[11,15,47,53,58,97,110,154,169],"changes":[12],"in":[13,35,55,69,82,143,159,175,180],"expression":[14,179],"ion":[16],"channels.":[17,117],"How":[18],"this":[19,90],"complex":[20],"mechanism":[21,89],"is":[22,24,38],"achieved":[23],"not":[25],"fully":[26],"understood.":[27],"Tmprss3,":[28],"type":[30],"II":[31],"serine":[32],"protease":[33],"expressed":[34],"cells,":[37],"required":[39],"for":[40],"proper":[42],"functioning":[43],"at":[44,151],"the":[45,51,56,94,108,126,152],"onset":[46],"hearing.":[48],"To":[49,85],"unravel":[50],"role":[52],"Tmprss3":[54,170],"acquisition":[57],"K(+)":[60,78],"currents,":[61],"we":[62,92,140],"compared":[63,93],"function":[65],"by":[66,87,122],"patch-clamp":[67],"technique":[68],"wild-type":[70],"Tmprss3(WT)":[71,98],"and":[72,99],"Tmprss3(Y260X)-mutant":[73,83,100,160],"mice.":[74,84,161],"Interestingly,":[75],"only":[76],"outward":[77],"currents":[79],"were":[80,149],"altered":[81],"determine":[86],"which":[88],"occurred,":[91],"protein":[95,129],"network":[96],"mice":[101],"using":[102],"proteomic":[103],"analysis.":[104],"This":[105,118],"led":[106],"to":[107,114,145,172],"identification":[109],"pathway":[112,119],"related":[113],"potassium":[115,177],"Kcnma1":[116,147,176],"was":[120,131],"validated":[121],"immunohistochemistry,":[123],"focusing":[124],"on":[125],"most":[127],"downregulated":[128],"that":[130,167],"identified":[132],"as":[133],"Kcnma1-associated":[136],"protein,":[137],"APOA1.":[138],"Finally,":[139],"show":[141],"that,":[142],"contrast":[144],"Tmprss3(WT),":[146],"channels":[148,178],"absent":[150],"neck":[153],"inner":[155],"(IHCs)":[158],"In":[162],"conclusion,":[163],"our":[164],"data":[165],"suggest":[166],"lack":[168],"leads":[171],"decrease":[174],"(IHCs).":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
