{"id":"https://openalex.org/W2162363796","doi":"https://doi.org/10.3109/02713683.2010.489182","title":"Genomic Profiling of miRNAs in Two Human Lens Cell Lines","display_name":"Genomic Profiling of miRNAs in Two Human Lens Cell Lines","publication_year":2010,"publication_date":"2010-08-26","ids":{"openalex":"https://openalex.org/W2162363796","doi":"https://doi.org/10.3109/02713683.2010.489182","mag":"2162363796","pmid":"https://pubmed.ncbi.nlm.nih.gov/20795863"},"language":"en","primary_location":{"id":"doi:10.3109/02713683.2010.489182","doi":"https://doi.org/10.3109/02713683.2010.489182","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713683.2010.489182","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010032346","display_name":"Lifeng Tian","orcid":"https://orcid.org/0009-0003-3797-3674","observed_orcids":["https://orcid.org/0009-0003-3797-3674"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lifeng Tian","raw_affiliation_strings":["FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. lifeng2@mail.med.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. lifeng2@mail.med.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108266086","display_name":"Kristen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Huang","raw_affiliation_strings":["FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075191661","display_name":"James B. DuHadaway","orcid":"https://orcid.org/0000-0001-8136-1999","observed_orcids":["https://orcid.org/0000-0001-8136-1999"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. DuHadaway","raw_affiliation_strings":["Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089381889","display_name":"George C. Prendergast","orcid":"https://orcid.org/0000-0002-1449-7332","observed_orcids":["https://orcid.org/0000-0002-1449-7332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George C. Prendergast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109815091","display_name":"Dwight E. Stambolian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight Stambolian","raw_affiliation_strings":["FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010032346"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.5033,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.67247583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"35","issue":"9","first_page":"812","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.906000018119812},{"id":"https://openalex.org/keywords/mir-184","display_name":"miR-184","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-31","display_name":"miR-31","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mir-222","display_name":"miR-222","score":1.0},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-line-selection","display_name":"cell line selection","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8727552890777588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7019351720809937},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6260696649551392},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6072540283203125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5448486804962158},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49240243434906006},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.4473945200443268},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4395878314971924},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4245093762874603},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.4142882525920868},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.367436945438385},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.35858970880508423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35474497079849243},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31529316306114197},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.30434346199035645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3005996346473694},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02713683.2010.489182","doi":"https://doi.org/10.3109/02713683.2010.489182","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713683.2010.489182","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},{"id":"pmid:20795863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20795863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6567110679","display_name":"RhoB Signaling in Cancer Suppression and Cell Suicide","funder_award_id":"R01CA100123","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W8128757","https://openalex.org/W1965948517","https://openalex.org/W1978337436","https://openalex.org/W1980018854","https://openalex.org/W2002832232","https://openalex.org/W2013444425","https://openalex.org/W2016112105","https://openalex.org/W2054499757","https://openalex.org/W2069053277","https://openalex.org/W2110403543","https://openalex.org/W2125167089","https://openalex.org/W2135106752","https://openalex.org/W2135920287","https://openalex.org/W2139791626","https://openalex.org/W2150393383","https://openalex.org/W4249588491"],"related_works":["https://openalex.org/W2135106752","https://openalex.org/W2765637267","https://openalex.org/W1998798740","https://openalex.org/W7098498945","https://openalex.org/W2038965779","https://openalex.org/W2738462671","https://openalex.org/W2077743833","https://openalex.org/W2041421154","https://openalex.org/W2061246072","https://openalex.org/W7099201162"],"abstract_inverted_index":{"PURPOSE:":[0],"Many":[1],"miRNAs":[2],"are":[3],"expressed":[4,122],"in":[5,18,38,144,208],"a":[6,19,102,211],"developmentally":[7],"regulated":[8],"and":[9,61,83,92,98,119,137],"tissue-specific":[10],"manner":[11],"making":[12],"them":[13,48],"crucial":[14],"for":[15,30,49,65,90,194],"tissue":[16,40],"development":[17],"structure":[20],"such":[21],"as":[22],"the":[23,31,99,124,148,191],"eye.":[24],"Since":[25],"miRNA":[26,50,72,164],"target":[27,105],"function":[28,100],"studies":[29],"eye":[32],"will":[33,177],"need":[34,178],"to":[35,46,133,163,179],"be":[36,180],"performed":[37,71],"ocular":[39],"culture":[41],"cells,":[42],"it":[43],"is":[44],"important":[45],"profile":[47],"expression.":[51,156],"Two":[52],"commonly":[53,76],"used":[54,77],"human":[55],"lens":[56,78,169,205,209],"epithelial":[57,79,170],"cell":[58,80,126,146,171,185],"lines,":[59,81,147],"HLE-B3":[60,82],"SRA01/04,":[62],"were":[63,94,173],"profiled":[64],"miRNA.":[66],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"We":[70,112,128],"profiling":[73],"of":[74,101,190],"two":[75,125,167],"SRA01/04.":[84],"The":[85,158],"differential":[86],"expression":[87,141,150,165,192,207],"levels":[88],"detected":[89],"miR-184":[91,104,131,155,202],"miR-31":[93],"confirmed":[95],"by":[96,210],"qRT-PCR":[97],"predicted":[103],"binding":[106],"site":[107],"was":[108,142,151],"validated":[109],"in-vitro.":[110],"RESULTS:":[111],"found":[113],"that":[114,130,201],"four":[115],"miRNAs-miR-31,":[116],"miR-124,":[117],"miR-184,":[118],"miR-222-were":[120],"differentially":[121],"between":[123,166],"lines.":[127],"show":[129],"binds":[132],"BIN3":[134,139,206],"3'":[135],"UTR":[136],"while":[138],"mRNA":[140],"equal":[143],"both":[145],"protein":[149],"inversely":[152],"correlated":[153],"with":[154,161],"CONCLUSION:":[157],"differences":[159,193],"observed":[160],"respect":[162],"different":[168],"lines":[172],"minimal.":[174],"Still,":[175],"caution":[176],"exercised":[181],"when":[182],"choosing":[183],"one":[184],"line":[186],"over":[187],"another":[188],"because":[189],"some":[195],"miRNAs.":[196],"Our":[197],"results":[198],"also":[199],"suggest":[200],"may":[203],"regulate":[204],"miRNA-mediated":[212],"translational":[213],"repression":[214],"mechanism.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
