{"id":"https://openalex.org/W2162362871","doi":"https://doi.org/10.1534/genetics.113.154914","title":"Pleiotropic Effects of a Mitochondrial\u2013Nuclear Incompatibility Depend upon the Accelerating Effect of Temperature in Drosophila","display_name":"Pleiotropic Effects of a Mitochondrial\u2013Nuclear Incompatibility Depend upon the Accelerating Effect of Temperature in Drosophila","publication_year":2013,"publication_date":"2013-09-12","ids":{"openalex":"https://openalex.org/W2162362871","doi":"https://doi.org/10.1534/genetics.113.154914","mag":"2162362871","pmid":"https://pubmed.ncbi.nlm.nih.gov/24026098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813842"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.113.154914","doi":"https://doi.org/10.1534/genetics.113.154914","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.154914","pdf_url":"https://www.genetics.org/content/genetics/195/3/1129.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.genetics.org/content/genetics/195/3/1129.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035325115","display_name":"Luke A. Hoekstra","orcid":"https://orcid.org/0000-0002-6122-8100","observed_orcids":["https://orcid.org/0000-0002-6122-8100"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke A Hoekstra","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046206086","display_name":"Mohammad A. Siddiq","orcid":"https://orcid.org/0000-0002-9186-1978","observed_orcids":["https://orcid.org/0000-0002-9186-1978"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad A Siddiq","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405","Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637","Indiana University, 1001 East Third St., Bloomington, IN 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Indiana University, 1001 East Third St., Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089550120","display_name":"Kristi L. Montooth","orcid":"https://orcid.org/0000-0001-9456-6694","observed_orcids":["https://orcid.org/0000-0001-9456-6694"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristi L Montooth","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089550120"],"corresponding_institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":5.7352,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.96561546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"195","issue":"3","first_page":"1129","last_page":"1139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.453900009393692,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.5199999809265137},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.871999979019165},{"id":"https://openalex.org/keywords/drosophila-simulans","display_name":"Drosophila simulans","score":0.996999979019165},{"id":"https://openalex.org/keywords/tyrosyl-trna-synthetase","display_name":"tyrosyl-tRNA synthetase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/trna-tyr","display_name":"tRNATyr","score":0.7839999794960022},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/metabolic-rate","display_name":"metabolic rate","score":0.6050000190734863},{"id":"https://openalex.org/keywords/development-time","display_name":"development time","score":0.6349999904632568},{"id":"https://openalex.org/keywords/larval-survival","display_name":"larval survival","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sterility","display_name":"sterility","score":0.8119999766349792},{"id":"https://openalex.org/keywords/metabolic-plasticity","display_name":"metabolic plasticity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ectotherms","display_name":"ectotherms","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hybrid-incompatibility","display_name":"hybrid incompatibility","score":0.4650000035762787},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8577864170074463},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.7485809922218323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6327463388442993},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.577409029006958},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5044540166854858},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4831816256046295},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.4106065034866333},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38306891918182373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2033708095550537}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012365","descriptor_name":"RNA, Transfer, Tyr","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012365","descriptor_name":"RNA, Transfer, Tyr","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012365","descriptor_name":"RNA, Transfer, Tyr","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1534/genetics.113.154914","doi":"https://doi.org/10.1534/genetics.113.154914","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.154914","pdf_url":"https://www.genetics.org/content/genetics/195/3/1129.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2804475","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3813842","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3813842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3813842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:24026098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24026098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1534/genetics.113.154914","doi":"https://doi.org/10.1534/genetics.113.154914","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.154914","pdf_url":"https://www.genetics.org/content/genetics/195/3/1129.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7772127251","display_name":"CAREER: The physiology and genetics of adaptation in a complex environment","funder_award_id":"1149178","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162362871.pdf","grobid_xml":"https://content.openalex.org/works/W2162362871.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W76517452","https://openalex.org/W123562126","https://openalex.org/W1544682453","https://openalex.org/W1550170046","https://openalex.org/W1558718790","https://openalex.org/W1559258852","https://openalex.org/W1563309475","https://openalex.org/W1604984248","https://openalex.org/W1799050010","https://openalex.org/W1848986953","https://openalex.org/W1855252201","https://openalex.org/W1908095301","https://openalex.org/W1922192141","https://openalex.org/W1953801165","https://openalex.org/W1964343732","https://openalex.org/W1964809391","https://openalex.org/W1965563492","https://openalex.org/W1966360257","https://openalex.org/W1967590676","https://openalex.org/W1967661812","https://openalex.org/W1968396466","https://openalex.org/W1969452055","https://openalex.org/W1974249394","https://openalex.org/W1975993137","https://openalex.org/W1979503875","https://openalex.org/W1981928735","https://openalex.org/W1982972392","https://openalex.org/W1986268380","https://openalex.org/W1991072105","https://openalex.org/W1995760984","https://openalex.org/W1999251354","https://openalex.org/W2003730362","https://openalex.org/W2005156953","https://openalex.org/W2006786379","https://openalex.org/W2008438855","https://openalex.org/W2009620498","https://openalex.org/W2013686034","https://openalex.org/W2014043714","https://openalex.org/W2014071424","https://openalex.org/W2014758663","https://openalex.org/W2023853020","https://openalex.org/W2028372309","https://openalex.org/W2042793210","https://openalex.org/W2043228196","https://openalex.org/W2056581871","https://openalex.org/W2057697250","https://openalex.org/W2062061362","https://openalex.org/W2063359097","https://openalex.org/W2067929169","https://openalex.org/W2070532728","https://openalex.org/W2073430553","https://openalex.org/W2076595891","https://openalex.org/W2077499935","https://openalex.org/W2079319076","https://openalex.org/W2080165174","https://openalex.org/W2080693688","https://openalex.org/W2081869206","https://openalex.org/W2090186265","https://openalex.org/W2093016244","https://openalex.org/W2093438701","https://openalex.org/W2093905196","https://openalex.org/W2094189284","https://openalex.org/W2096260958","https://openalex.org/W2098318347","https://openalex.org/W2103170242","https://openalex.org/W2103286699","https://openalex.org/W2103997560","https://openalex.org/W2109114598","https://openalex.org/W2110372454","https://openalex.org/W2111884469","https://openalex.org/W2113961839","https://openalex.org/W2121386743","https://openalex.org/W2125040660","https://openalex.org/W2128292906","https://openalex.org/W2128354723","https://openalex.org/W2130583792","https://openalex.org/W2130656799","https://openalex.org/W2131768903","https://openalex.org/W2133822760","https://openalex.org/W2136046510","https://openalex.org/W2142853164","https://openalex.org/W2149945475","https://openalex.org/W2151068319","https://openalex.org/W2151093048","https://openalex.org/W2152363514","https://openalex.org/W2154584207","https://openalex.org/W2157229031","https://openalex.org/W2157362632","https://openalex.org/W2158071560","https://openalex.org/W2158951611","https://openalex.org/W2161653752","https://openalex.org/W2162967657","https://openalex.org/W2163189051","https://openalex.org/W2165732320","https://openalex.org/W2168705761","https://openalex.org/W2170215004","https://openalex.org/W2176275556","https://openalex.org/W2281396668","https://openalex.org/W2291369360","https://openalex.org/W2318653984","https://openalex.org/W2324007724","https://openalex.org/W2582743722","https://openalex.org/W4246110703","https://openalex.org/W4254914422","https://openalex.org/W4299711483","https://openalex.org/W4388360685"],"related_works":["https://openalex.org/W7097985324","https://openalex.org/W2168705761","https://openalex.org/W2954828389","https://openalex.org/W2795631720","https://openalex.org/W4401441654","https://openalex.org/W7163180766","https://openalex.org/W2131768903","https://openalex.org/W6892183067","https://openalex.org/W2152363514","https://openalex.org/W6892013726"],"abstract_inverted_index":{"Interactions":[0],"between":[1,66],"mitochondrial":[2,74],"and":[3,78,98,117,233],"nuclear":[4],"gene":[5],"products":[6],"that":[7,54,152,176,194],"underlie":[8],"eukaryotic":[9],"energy":[10,154],"metabolism":[11,155],"can":[12],"cause":[13],"the":[14,28,33,43,58,72,84,150,165,184,195,207,222,236,246],"fitness":[15,197,241],"effects":[16,34,61,109,186,198,242],"of":[17,35,62,103,170,187,199,212,224,238],"mutations":[18,201],"in":[19,27,71,83,126,158,215,226,248],"one":[20],"genome":[21],"to":[22,40,123],"be":[23,204],"conditional":[24,205],"on":[25,206],"variation":[26],"other":[29],"genome.":[30],"In":[31],"ectotherms,":[32],"these":[36],"interactions":[37,214],"are":[38,110],"likely":[39],"depend":[41,244],"upon":[42,245],"thermal":[44,208],"environment,":[45],"because":[46],"increasing":[47],"temperature":[48,55],"accelerates":[49],"molecular":[50],"rates.":[51],"We":[52],"find":[53],"strongly":[56],"modifies":[57],"pleiotropic":[59],"phenotypic":[60],"an":[63],"incompatible":[64,89,132],"interaction":[65],"a":[67,79,135,142],"Drosophila":[68],"melanogaster":[69],"polymorphism":[70,82],"nuclear-encoded,":[73],"tyrosyl-transfer":[75],"(t)RNA":[76],"synthetase":[77],"D.":[80],"simulans":[81],"mitochondrially":[85],"encoded":[86],"tRNA(Tyr).":[87],"The":[88,131,210],"mitochondrial-nuclear":[90],"genotype":[91,133,160],"extends":[92,156],"development":[93,157,178],"time,":[94],"decreases":[95,167],"larval":[96],"survivorship,":[97],"reduces":[99],"pupation":[100],"height,":[101],"indicative":[102],"decreased":[104],"energetic":[105],"performance.":[106],"These":[107],"deleterious":[108,185,228],"ameliorated":[111],"when":[112],"larvae":[113,171],"develop":[114],"at":[115,119,129,139,146,161,173],"16\u00b0":[116,140],"exacerbated":[118],"warmer":[120,162],"temperatures,":[121],"leading":[122],"complete":[124],"sterility":[125],"both":[127],"sexes":[128],"28\u00b0.":[130],"has":[134],"normal":[136],"metabolic":[137,168,200],"rate":[138,145],"but":[141,218],"significantly":[143],"elevated":[144],"25\u00b0,":[147],"consistent":[148],"with":[149],"hypothesis":[151],"inefficient":[153],"this":[159,188],"temperatures.":[163],"Furthermore,":[164],"incompatibility":[166],"plasticity":[169],"developed":[172],"16\u00b0,":[174],"indicating":[175],"cooler":[177],"temperatures":[179],"do":[180],"not":[181,219],"completely":[182],"mitigate":[183],"genetic":[189],"interaction.":[190],"Our":[191],"results":[192],"suggest":[193],"epistatic":[196,213,229],"may":[202,234],"generally":[203],"environment.":[209],"expression":[211],"some":[216],"environments,":[217],"others,":[220],"weakens":[221],"efficacy":[223],"selection":[225],"removing":[227],"variants":[230],"from":[231],"populations":[232],"promote":[235],"accumulation":[237],"incompatibilities":[239],"whose":[240],"will":[243],"environment":[247],"which":[249],"hybrids":[250],"occur.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}