{"id":"https://openalex.org/W2162276354","doi":"https://doi.org/10.1007/s00223-011-9490-4","title":"Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism","display_name":"Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism","publication_year":2011,"publication_date":"2011-05-03","ids":{"openalex":"https://openalex.org/W2162276354","doi":"https://doi.org/10.1007/s00223-011-9490-4","mag":"2162276354","pmid":"https://pubmed.ncbi.nlm.nih.gov/21541686"},"language":"en","primary_location":{"id":"doi:10.1007/s00223-011-9490-4","doi":"https://doi.org/10.1007/s00223-011-9490-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00223-011-9490-4","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062703256","display_name":"Yasuo Imanishi","orcid":"https://orcid.org/0000-0002-9077-2631","observed_orcids":["https://orcid.org/0000-0002-9077-2631"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuo Imanishi","raw_affiliation_strings":["Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. imanishi@med.osaka-cu.ac.jp","Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. imanishi@med.osaka-cu.ac.jp","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027470042","display_name":"Takehisa Kawata","orcid":"https://orcid.org/0000-0002-1167-6925","observed_orcids":["https://orcid.org/0000-0002-1167-6925"]},"institutions":[{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]},{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehisa Kawata","raw_affiliation_strings":["Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan","Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028375775","display_name":"Takao Kenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Kenko","raw_affiliation_strings":["Osaka City University Medical School for Technical Assistance, Osaka City University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City University Medical School for Technical Assistance, Osaka City University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110250185","display_name":"Michihito Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michihito Wada","raw_affiliation_strings":["Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020972312","display_name":"Nobuo Nagano","orcid":"https://orcid.org/0000-0001-6527-3286","observed_orcids":["https://orcid.org/0000-0001-6527-3286"]},"institutions":[{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Nagano","raw_affiliation_strings":["Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Shizuoka, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102356736","display_name":"Takami Miki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takami Miki","raw_affiliation_strings":["Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049232174","display_name":"Andrew Arnold","orcid":"https://orcid.org/0000-0002-8821-8527","observed_orcids":["https://orcid.org/0000-0002-8821-8527"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Arnold","raw_affiliation_strings":["Center for Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108113496","display_name":"Masaaki Inaba","orcid":"https://orcid.org/0000-0002-9552-395X","observed_orcids":["https://orcid.org/0000-0002-9552-395X"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Inaba","raw_affiliation_strings":["Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Endocrinology and Molecular Medicine,  Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062703256"],"corresponding_institution_ids":["https://openalex.org/I317356780"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.4853,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83382054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"89","issue":"1","first_page":"29","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cinacalcet","display_name":"cinacalcet","score":0.9990000128746033},{"id":"https://openalex.org/keywords/calcimimetics","display_name":"calcimimetics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/primary-hyperparathyroidism","display_name":"primary hyperparathyroidism","score":0.996999979019165},{"id":"https://openalex.org/keywords/parathyroid-cell-proliferation","display_name":"parathyroid cell proliferation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/parathyroid-hormone-secretion","display_name":"parathyroid hormone secretion","score":0.8659999966621399},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.7450000047683716},{"id":"https://openalex.org/keywords/parathyroid-hyperplasia","display_name":"parathyroid hyperplasia","score":0.7870000004768372},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5040000081062317},{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C2780534505","wikidata":"https://www.wikidata.org/wiki/Q193978","display_name":"Cinacalcet","level":5,"score":0.9732921123504639},{"id":"https://openalex.org/C193699699","wikidata":"https://www.wikidata.org/wiki/Q3272785","display_name":"Parathyroid chief cell","level":4,"score":0.8366167545318604},{"id":"https://openalex.org/C2780280601","wikidata":"https://www.wikidata.org/wiki/Q5018775","display_name":"Calcimimetic","level":5,"score":0.7569449543952942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6856216192245483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6836053729057312},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6572153568267822},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.6297603845596313},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.6014042496681213},{"id":"https://openalex.org/C142590548","wikidata":"https://www.wikidata.org/wiki/Q417801","display_name":"Calcium-sensing receptor","level":4,"score":0.5907512903213501},{"id":"https://openalex.org/C2779053571","wikidata":"https://www.wikidata.org/wiki/Q2919083","display_name":"Primary hyperparathyroidism","level":2,"score":0.5181085467338562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38426637649536133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3525030016899109},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.12520527839660645}],"mesh":[{"descriptor_ui":"D000069449","descriptor_name":"Cinacalcet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010280","descriptor_name":"Parathyroid Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010280","descriptor_name":"Parathyroid Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049950","descriptor_name":"Hyperparathyroidism, Primary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D049950","descriptor_name":"Hyperparathyroidism, Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049950","descriptor_name":"Hyperparathyroidism, Primary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00223-011-9490-4","doi":"https://doi.org/10.1007/s00223-011-9490-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00223-011-9490-4","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},{"id":"pmid:21541686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified tissue international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322450","display_name":"Osaka Kidney Foundation","ror":"https://ror.org/0016t4p10"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1965945915","https://openalex.org/W1966772281","https://openalex.org/W1973835767","https://openalex.org/W1975367389","https://openalex.org/W1977864809","https://openalex.org/W1994082723","https://openalex.org/W1994494042","https://openalex.org/W1998271919","https://openalex.org/W2000125733","https://openalex.org/W2007275038","https://openalex.org/W2027695053","https://openalex.org/W2046698874","https://openalex.org/W2073679514","https://openalex.org/W2074542049","https://openalex.org/W2081227689","https://openalex.org/W2084039621","https://openalex.org/W2095233918","https://openalex.org/W2102120712","https://openalex.org/W2102583330","https://openalex.org/W2105314539","https://openalex.org/W2126830988","https://openalex.org/W2151794206","https://openalex.org/W2157212789"],"related_works":["https://openalex.org/W2105314539","https://openalex.org/W1965945915","https://openalex.org/W1966772281","https://openalex.org/W4406089314","https://openalex.org/W7129392785","https://openalex.org/W7096352186","https://openalex.org/W1997347485","https://openalex.org/W2139814523","https://openalex.org/W3001060079","https://openalex.org/W2138779981"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
