{"id":"https://openalex.org/W2162140549","doi":"https://doi.org/10.1242/jcs.21.2.391","title":"Ultrastructural and enzymic modulation of hela cells induced by sodium butyrate and the effects of cytochalasin b and colcemid","display_name":"Ultrastructural and enzymic modulation of hela cells induced by sodium butyrate and the effects of cytochalasin b and colcemid","publication_year":1976,"publication_date":"1976-07-01","ids":{"openalex":"https://openalex.org/W2162140549","doi":"https://doi.org/10.1242/jcs.21.2.391","mag":"2162140549","pmid":"https://pubmed.ncbi.nlm.nih.gov/972176"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.21.2.391","doi":"https://doi.org/10.1242/jcs.21.2.391","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.21.2.391","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047021203","display_name":"Stephen I. Deutsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. I. Deutsch","raw_affiliation_strings":["New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002153260","display_name":"David N. Silvers","orcid":"https://orcid.org/0009-0008-7499-7241","observed_orcids":["https://orcid.org/0009-0008-7499-7241"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. N. Silvers","raw_affiliation_strings":["New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111476094","display_name":"R. P. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. P. Cox","raw_affiliation_strings":["New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614860","display_name":"Martin J. Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Griffin","raw_affiliation_strings":["\u2020 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73116, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73116, U.S.A","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111202686","display_name":"N. K. Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. K. Ghosh","raw_affiliation_strings":["New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Medical Center * Division of Human Genetics and Departments of Medicine, Pharmacology and Dermatology , , New York, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9556,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.85721663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"2","first_page":"391","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.7570000290870667},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.871999979019165},{"id":"https://openalex.org/keywords/5-nucleotidase","display_name":"5'-nucleotidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9020000100135803},{"id":"https://openalex.org/keywords/colcemid","display_name":"colcemid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2776095844","wikidata":"https://www.wikidata.org/wiki/Q903666","display_name":"Colcemid","level":3,"score":0.9295812845230103},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.8251392841339111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8073252439498901},{"id":"https://openalex.org/C2776041460","wikidata":"https://www.wikidata.org/wiki/Q5201339","display_name":"Cytochalasin D","level":4,"score":0.7734522819519043},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.7087827920913696},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6888354420661926},{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.5951274633407593},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5316708087921143},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5132665634155273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5107071995735168},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.45892858505249023},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.45843347907066345},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3741741478443146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2993955612182617},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.29064080119132996},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2816693186759949},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2732987105846405},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003896","descriptor_name":"Desmosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009708","descriptor_name":"Nucleotidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/jcs.21.2.391","doi":"https://doi.org/10.1242/jcs.21.2.391","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.21.2.391","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:972176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/972176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:21/2/391","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/21/2/391","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W60541530","https://openalex.org/W229214304","https://openalex.org/W1021726471","https://openalex.org/W1775749144","https://openalex.org/W1971048984","https://openalex.org/W1980455626","https://openalex.org/W1998780157","https://openalex.org/W1999736404","https://openalex.org/W2004181810","https://openalex.org/W2010103468","https://openalex.org/W2022415916","https://openalex.org/W2028855091","https://openalex.org/W2035692772","https://openalex.org/W2049618391","https://openalex.org/W2050036623","https://openalex.org/W2051823729","https://openalex.org/W2056030570","https://openalex.org/W2067839546","https://openalex.org/W2071754365","https://openalex.org/W2075426052","https://openalex.org/W2088867375","https://openalex.org/W2092707511","https://openalex.org/W2094612201","https://openalex.org/W2155060964","https://openalex.org/W2330436374","https://openalex.org/W2333355649","https://openalex.org/W2343990802","https://openalex.org/W2395985139","https://openalex.org/W2499264031","https://openalex.org/W3216705818"],"related_works":["https://openalex.org/W7096252244","https://openalex.org/W2022726901","https://openalex.org/W2042233868","https://openalex.org/W2431990084","https://openalex.org/W2053895219","https://openalex.org/W2049618391","https://openalex.org/W2319807778","https://openalex.org/W159124330","https://openalex.org/W2130089260","https://openalex.org/W1525915127"],"abstract_inverted_index":{"Sodium":[0],"butyrate":[1],"causes":[2],"HeLa":[3,93],"cells":[4],"to":[5],"assume":[6],"an":[7,42],"elongated":[8],"and":[9,53,83,96],"jagged":[10],"shape.":[11],"Ultrastructurally":[12],"this":[13,129],"change":[14,91],"is":[15,65],"associated":[16],"with":[17,74],"the":[18,37,45,56,70,89,100],"formation":[19],"of":[20,22,47,58,69,102,111],"bundles":[21],"microfilaments.":[23],"Desmosomes":[24],"were":[25],"present":[26],"between":[27],"adjacent":[28],"cells.":[29,39,108],"No":[30],"increase":[31,43],"in":[32,36,44,92,106,124],"microtubules":[33],"was":[34],"observed":[35],"butyrate-treated":[38],"Butyrate":[40],"induces":[41],"activity":[46,57,105],"2":[48],"membrane-bound":[49],"enzymes,":[50],"alkaline":[51,103,115],"phosphatase":[52,104,116],"5'-nucleotidase;":[54],"however,":[55],"a":[59,122],"third":[60],"membrane":[61],"enzyme,":[62],"acetylcholine":[63],"esterase,":[64],"reduced.":[66],"The":[67,109],"activities":[68],"several":[71],"other":[72],"enzymes":[73],"different":[75],"subcellular":[76],"localizations":[77],"are":[78],"not":[79],"significantly":[80],"increased.":[81],"Colcemid":[82],"cytochalasin":[84,112],"B":[85,113],"prevent":[86],"or":[87],"reverse":[88],"butyrate-mediated":[90],"cell":[94],"morphology":[95],"also":[97],"partially":[98],"inhibit":[99],"induction":[101,117],"these":[107],"effect":[110],"on":[114],"may":[118],"be":[119],"caused":[120],"by":[121,128],"reduction":[123],"protein":[125],"synthesis":[126],"produced":[127],"fungal":[130],"metabolite.":[131]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
