{"id":"https://openalex.org/W2162135019","doi":null,"title":"The effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats.","display_name":"The effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2162135019","mag":"2162135019","pmid":"https://pubmed.ncbi.nlm.nih.gov/24592306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3938885"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3938885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073377202","display_name":"Seyydeh Gohar Sharieh Hosseini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125694","display_name":"Islamic Azad University Kazeron","ror":"https://ror.org/02ytn4d59","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210125694"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyydeh Gohar Sharieh Hosseini","raw_affiliation_strings":["Islamic Azad University, Kazerun Branch, Department of Physiology, Kazerun, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic Azad University, Kazerun Branch, Department of Physiology, Kazerun, Iran","institution_ids":["https://openalex.org/I4210125694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016424780","display_name":"Saeed Khatamsaz","orcid":"https://orcid.org/0000-0001-7332-9657","observed_orcids":["https://orcid.org/0000-0001-7332-9657"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeed Khatamsaz","raw_affiliation_strings":["Islamic Azad University, Zarghan Branch, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic Azad University, Zarghan Branch, Iran","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103902834","display_name":"Mehrdad Shariati","orcid":"https://orcid.org/0000-0001-9441-8085","observed_orcids":["https://orcid.org/0000-0001-9441-8085"]},"institutions":[{"id":"https://openalex.org/I4210125694","display_name":"Islamic Azad University Kazeron","ror":"https://ror.org/02ytn4d59","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210125694"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Shariati","raw_affiliation_strings":["Islamic Azad University, Kazerun Branch, Department of Physiology, Kazerun, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic Azad University, Kazerun Branch, Department of Physiology, Kazerun, Iran","institution_ids":["https://openalex.org/I4210125694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6694,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.61241079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"41","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":1.0},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.753000020980835},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":1.0},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.8289999961853027},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8169999718666077},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.765999972820282},{"id":"https://openalex.org/keywords/serum-leptin-levels","display_name":"serum leptin","score":0.7459999918937683},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9599999785423279},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6240000128746033},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.8824536800384521},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8428596258163452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.800153911113739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7728126049041748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5777789950370789},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5257241129875183},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5003707408905029},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.49836230278015137},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4878559112548828},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.4817902445793152},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.3245968222618103},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.27268093824386597},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.20803102850914001},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1675075888633728}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3938885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2924922","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3938885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24592306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24592306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of basic medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.812.7716","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.812.7716","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/32/7a/ijbms-17-041.PMC3938885.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:95064205c87f45a4b43c7aa33749054b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95064205c87f45a4b43c7aa33749054b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Basic Medical Sciences, Vol 17, Iss 1, Pp 41-48 (2014)","raw_type":"article"},{"id":"mag:2162135019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24592306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3938885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3938885/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321389","display_name":"Islamic Azad University","ror":"https://ror.org/01kzn7k21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162135019.pdf","grobid_xml":"https://content.openalex.org/works/W2162135019.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1259546184","https://openalex.org/W1582423989","https://openalex.org/W1604789859","https://openalex.org/W1964050087","https://openalex.org/W1967061503","https://openalex.org/W1968293808","https://openalex.org/W1987248538","https://openalex.org/W1990681455","https://openalex.org/W1996840778","https://openalex.org/W1998052464","https://openalex.org/W2004198344","https://openalex.org/W2007725897","https://openalex.org/W2014093920","https://openalex.org/W2019752999","https://openalex.org/W2023359333","https://openalex.org/W2024590659","https://openalex.org/W2031040368","https://openalex.org/W2033997139","https://openalex.org/W2039377412","https://openalex.org/W2040895874","https://openalex.org/W2041872947","https://openalex.org/W2044380051","https://openalex.org/W2046806062","https://openalex.org/W2048079557","https://openalex.org/W2049511526","https://openalex.org/W2052321977","https://openalex.org/W2057528564","https://openalex.org/W2060853617","https://openalex.org/W2062644092","https://openalex.org/W2067487342","https://openalex.org/W2067830186","https://openalex.org/W2077842483","https://openalex.org/W2083278903","https://openalex.org/W2085722715","https://openalex.org/W2087277393","https://openalex.org/W2088396659","https://openalex.org/W2089264371","https://openalex.org/W2091643921","https://openalex.org/W2111732109","https://openalex.org/W2116215072","https://openalex.org/W2117630260","https://openalex.org/W2122035650","https://openalex.org/W2125510262","https://openalex.org/W2138018789","https://openalex.org/W2152788276","https://openalex.org/W2157734892","https://openalex.org/W2167369100","https://openalex.org/W2168344829","https://openalex.org/W2182271268","https://openalex.org/W2260580680","https://openalex.org/W2334337188","https://openalex.org/W2397387661","https://openalex.org/W2413426335"],"related_works":["https://openalex.org/W7100098538","https://openalex.org/W2388972994","https://openalex.org/W2100451931","https://openalex.org/W2587685997","https://openalex.org/W2357605311","https://openalex.org/W3030417493","https://openalex.org/W3094138177","https://openalex.org/W2059519099","https://openalex.org/W2870571707","https://openalex.org/W2353048508"],"abstract_inverted_index":{"OBJECTIVE(S):":[0],"Leptin":[1],"is":[2,10],"a":[3,194,206],"hormone":[4],"secreted":[5],"by":[6,92,240],"adipose":[7],"tissue":[8],"and":[9,19,49,70,88,118,121,124,149,154,187,201,216,242,254,257],"involved":[11],"not":[12],"only":[13],"in":[14,26,43,96,108,135,168,173,199,211,220,227],"the":[15,40,55,81,131,136,174,180,185,228,247],"regulation":[16],"of":[17,37,75,83,130,143,152,161,214,223],"feeding":[18],"energy":[20],"expenditure,":[21],"but":[22],"also":[23,192],"its":[24],"role":[25],"memory":[27,69,87,128],"enhancement":[28],"has":[29],"been":[30],"demonstrated":[31],"as":[32,65],"well.":[33],"The":[34,73,126],"partial":[35],"transfer":[36],"leptin":[38,47,51,89,153,215,237],"across":[39],"blood-brain":[41],"barrier":[42],"obese":[44,97],"individuals":[45],"causes":[46],"resistance":[48,90,238],"prevents":[50],"reaching":[52],"brain.":[53],"On":[54],"other":[56],"hand,":[57],"studies":[58],"have":[59],"shown":[60],"that":[61],"angiotensin":[62],"antagonists":[63],"such":[64],"losartan":[66,84,113,122],"can":[67,235],"improve":[68,236],"learning":[71,256],"abilities.":[72],"aim":[74],"this":[76],"study":[77],"was":[78,225],"to":[79],"evaluate":[80],"effects":[82],"on":[85],"improving":[86],"induced":[91,239],"high":[93,243],"fat":[94,244],"diet":[95,116,120],"rats.":[98],"MATERIALS":[99],"AND":[100],"METHODS:":[101],"40":[102],"Wistar":[103],"male":[104],"rats":[105,132],"were":[106,133,147,156,171],"divided":[107],"4":[109],"groups:":[110],"control":[111],"(C),":[112],"(LOS),":[114],"high-fat":[115,119,163],"(HFD)":[117],"(HFD":[123,175,188,229],"LOS).":[125],"spatial":[127],"performances":[129],"assessed":[134],"Morris":[137,181],"water":[138,182],"maze":[139,183],"after":[140],"2":[141],"months":[142],"treatment.":[144],"Then":[145],"they":[146],"weighed":[148],"serum":[150,212,221],"levels":[151,213,222],"triglyceride":[155,224],"measured.":[157],"RESULTS:":[158],"In":[159,179,204],"spite":[160],"receiving":[162],"diet,":[164],"no":[165,217],"significant":[166,195,207,218],"differences":[167],"body":[169,252],"weight":[170,253],"observed":[172,226],"&":[176,189,230],"LOS)":[177,190,231],"group.":[178,232],"trial,":[184],"(LOS)":[186],"groups":[191],"showed":[193],"reduction":[196],"(P":[197,209],"<0.05)":[198,210],"latency":[200],"path":[202],"length.":[203],"addition,":[205],"decrease":[208],"difference":[219],"CONCLUSION:":[233],"Losartan":[234],"obesity":[241],"diet.":[245],"At":[246],"same":[248],"time,":[249],"it":[250],"modulates":[251],"enhances":[255],"memory.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}