{"id":"https://openalex.org/W2162105352","doi":"https://doi.org/10.1016/j.pain.2008.06.003","title":"The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPAR\u03b3 receptors and neurotrophic factors","display_name":"The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPAR\u03b3 receptors and neurotrophic factors","publication_year":2008,"publication_date":"2008-07-07","ids":{"openalex":"https://openalex.org/W2162105352","doi":"https://doi.org/10.1016/j.pain.2008.06.003","mag":"2162105352","pmid":"https://pubmed.ncbi.nlm.nih.gov/18602217"},"language":"en","primary_location":{"id":"doi:10.1016/j.pain.2008.06.003","doi":"https://doi.org/10.1016/j.pain.2008.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2008.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018577895","display_name":"Barbara Costa","orcid":"https://orcid.org/0000-0002-2910-6736","observed_orcids":["https://orcid.org/0000-0002-2910-6736"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Barbara Costa","raw_affiliation_strings":["Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy Department of Pharmacology, University of Milano, via Vanvitelli 32, 20129 Milano, Italy","Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy","fax: +39 02 64483450"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy Department of Pharmacology, University of Milano, via Vanvitelli 32, 20129 Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"fax: +39 02 64483450","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029559587","display_name":"Francesca Comelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Comelli","raw_affiliation_strings":["Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000781733","display_name":"Isabella Bettoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabella Bettoni","raw_affiliation_strings":["Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015592312","display_name":"Mariapia Colleoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariapia Colleoni","raw_affiliation_strings":["Department of Pharmacology, University of Milano, via Vanvitelli 32, 20129 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milano, via Vanvitelli 32, 20129 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017804093","display_name":"Gabriella Giagnoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Giagnoni","raw_affiliation_strings":["Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018577895"],"corresponding_institution_ids":["https://openalex.org/I66752286"],"apc_list":null,"apc_paid":null,"fwci":10.3683,"has_fulltext":false,"cited_by_count":296,"citation_normalized_percentile":{"value":0.99045865,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"139","issue":"3","first_page":"541","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palmitoylethanolamide","display_name":"palmitoylethanolamide","score":1.0},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.9120000004768372},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/trpv1-receptor","display_name":"TRPV1 receptor","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.781000018119812},{"id":"https://openalex.org/keywords/entourage-effect","display_name":"entourage effect","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/analgesic-mechanism","display_name":"analgesic mechanism","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2777767828","wikidata":"https://www.wikidata.org/wiki/Q2159860","display_name":"Palmitoylethanolamide","level":5,"score":0.956823468208313},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.7602866888046265},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.7488734722137451},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.6478173732757568},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6209529638290405},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.6121649742126465},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.582221269607544},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5416574478149414},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.47654658555984497},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.4612305462360382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4446570873260498},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.43029510974884033},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4076195955276489},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.2507375478744507},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.20291292667388916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19635608792304993},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.1492137908935547}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010169","descriptor_name":"Palmitic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010169","descriptor_name":"Palmitic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012585","descriptor_name":"Sciatica","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012585","descriptor_name":"Sciatica","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014110","descriptor_name":"Touch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pain.2008.06.003","doi":"https://doi.org/10.1016/j.pain.2008.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2008.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:18602217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18602217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"},{"id":"pmh:oai:boa.unimib.it:10281/4650","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/4650","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1488329806","https://openalex.org/W1533115076","https://openalex.org/W1629776612","https://openalex.org/W1651476949","https://openalex.org/W1791356224","https://openalex.org/W1907919347","https://openalex.org/W1939978227","https://openalex.org/W1968917850","https://openalex.org/W1972207851","https://openalex.org/W1980524078","https://openalex.org/W1983747933","https://openalex.org/W1985937673","https://openalex.org/W1990177635","https://openalex.org/W1997879052","https://openalex.org/W2003706636","https://openalex.org/W2004071649","https://openalex.org/W2004832503","https://openalex.org/W2007715028","https://openalex.org/W2010233543","https://openalex.org/W2011987179","https://openalex.org/W2014007136","https://openalex.org/W2018439316","https://openalex.org/W2020939052","https://openalex.org/W2024009202","https://openalex.org/W2024554713","https://openalex.org/W2029227926","https://openalex.org/W2030266374","https://openalex.org/W2032823559","https://openalex.org/W2033235067","https://openalex.org/W2034949619","https://openalex.org/W2035976682","https://openalex.org/W2037436682","https://openalex.org/W2046872480","https://openalex.org/W2050346904","https://openalex.org/W2055321522","https://openalex.org/W2055945798","https://openalex.org/W2058020736","https://openalex.org/W2061169432","https://openalex.org/W2061301719","https://openalex.org/W2064701388","https://openalex.org/W2065648126","https://openalex.org/W2067212451","https://openalex.org/W2067523166","https://openalex.org/W2070506825","https://openalex.org/W2070876717","https://openalex.org/W2071595010","https://openalex.org/W2075072901","https://openalex.org/W2080222756","https://openalex.org/W2087437186","https://openalex.org/W2087454739","https://openalex.org/W2089573633","https://openalex.org/W2104663557","https://openalex.org/W2111276435","https://openalex.org/W2118725696","https://openalex.org/W2132886768","https://openalex.org/W2137979524","https://openalex.org/W2144748383","https://openalex.org/W2145373251","https://openalex.org/W2147780949","https://openalex.org/W2150530189","https://openalex.org/W2164688439","https://openalex.org/W2165127221","https://openalex.org/W2166997091","https://openalex.org/W2167845627","https://openalex.org/W2168374306","https://openalex.org/W2170556110","https://openalex.org/W4211004632","https://openalex.org/W6602511187","https://openalex.org/W6640418867","https://openalex.org/W6776488894"],"related_works":["https://openalex.org/W2746692301","https://openalex.org/W2182309689","https://openalex.org/W2064254036","https://openalex.org/W7042555630","https://openalex.org/W2074040841","https://openalex.org/W2514023866","https://openalex.org/W2145373054","https://openalex.org/W2004848791","https://openalex.org/W1978798118","https://openalex.org/W4306412410"],"abstract_inverted_index":{"Palmitoylethanolamide":[0],"(PEA)":[1],"is":[2,7,201],"an":[3,174],"endogenous":[4,13],"lipid":[5],"that":[6,133,146,171,189,207],"thought":[8],"to":[9,69,115,127,158,173,230],"be":[10,152],"involved":[11],"in":[12,37,54,104,113,228,237],"protective":[14],"mechanisms":[15],"activated":[16],"as":[17,62,217],"a":[18,57,80,95],"result":[19],"of":[20,22,27,33,52,75,97,120,162,176,196,213,235],"stimulation":[21],"inflammatory":[23],"response.":[24],"In":[25,185],"spite":[26],"the":[28,50,86,89,117,140,147,153,159,163,166,187,194,211,232],"well":[29],"demonstrated":[30],"anti-inflammatory":[31],"properties":[32],"PEA,":[34,144],"its":[35,177,182],"involvement":[36],"controlling":[38],"pain":[39],"pathways":[40],"still":[41],"remains":[42],"poorly":[43],"characterized.":[44],"On":[45],"this":[46],"basis,":[47],"we":[48],"tested":[49],"efficacy":[51],"PEA":[53,65,190,208,236],"vivo":[55],"against":[56],"peculiar":[58],"persistent":[59],"pain,":[60,239],"such":[61,216],"neuropathic":[63,105],"one.":[64],"was":[66],"administered":[67],"i.p.":[68],"mice":[70],"with":[71],"chronic":[72,238],"constriction":[73],"injury":[74],"sciatic":[76],"nerve":[77],"(CCI)":[78],"once":[79],"day":[81,87],"for":[82,244],"one":[83],"week":[84],"starting":[85],"after":[88],"lesion.":[90],"This":[91],"therapeutic":[92],"regimen":[93],"evoked":[94],"relief":[96],"both":[98],"thermal":[99],"hyperalgesia":[100],"and":[101,123,136,219],"mechanical":[102],"allodynia":[103],"mice.":[106],"Various":[107],"selective":[108],"receptor":[109,126],"antagonists":[110],"were":[111],"used":[112],"order":[114],"clarify":[116],"relative":[118],"contribution":[119],"cannabinoid,":[121],"vanilloid":[122],"peroxisome":[124],"proliferator-activated":[125],"PEA-induced":[128,160],"effects.":[129],"The":[130,224],"results":[131],"indicated":[132],"CB(1),":[134],"PPARgamma":[135],"TRPV1":[137],"receptors":[138],"mediated":[139],"antinociception":[141],"induced":[142],"by":[143,203],"suggesting":[145],"most":[148],"likely":[149],"mechanism":[150],"might":[151,191],"so-called":[154],"\"entourage":[155],"effect\"":[156],"due":[157],"inhibition":[161],"enzyme":[164],"catalyzing":[165],"endocannabinoid":[167],"anandamide":[168],"(AEA)":[169],"degradation":[170],"leads":[172],"enhancement":[175],"tissue":[178],"levels":[179],"thus":[180],"increasing":[181],"analgesic":[183,245],"action.":[184],"addition,":[186],"hypothesis":[188],"act":[192],"through":[193],"modulation":[195],"local":[197],"mast":[198],"cells":[199],"degranulation":[200],"sustained":[202],"our":[204],"findings":[205,225],"showing":[206],"significantly":[209],"reduced":[210],"production":[212],"many":[214],"mediators":[215],"TNFalpha":[218],"neurotrophic":[220],"factors,":[221],"like":[222],"NGF.":[223],"presented":[226],"here,":[227],"addition":[229],"prove":[231],"beneficial":[233],"effects":[234],"identify":[240],"new":[241],"potential":[242],"targets":[243],"medicine.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}