{"id":"https://openalex.org/W2162073766","doi":"https://doi.org/10.1074/jbc.m111.327809","title":"Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)","display_name":"Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)","publication_year":2012,"publication_date":"2012-01-21","ids":{"openalex":"https://openalex.org/W2162073766","doi":"https://doi.org/10.1074/jbc.m111.327809","mag":"2162073766","pmid":"https://pubmed.ncbi.nlm.nih.gov/22267737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3323040"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.327809","doi":"https://doi.org/10.1074/jbc.m111.327809","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.327809","pdf_url":"http://www.jbc.org/article/S0021925820654333/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820654333/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023525157","display_name":"Alexander E. Aleshin","orcid":"https://orcid.org/0000-0001-5079-6682","observed_orcids":["https://orcid.org/0000-0001-5079-6682"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander E. Aleshin","raw_affiliation_strings":["Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062097565","display_name":"Ingrid U. Schraufst\u00e4tter","orcid":"https://orcid.org/0000-0003-2084-9063","observed_orcids":["https://orcid.org/0000-0003-2084-9063"]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid U. Schraufstatter","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies, San Diego, California 92121","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084942532","display_name":"Boguslaw Stec","orcid":"https://orcid.org/0000-0002-8696-0349","observed_orcids":["https://orcid.org/0000-0002-8696-0349"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boguslaw Stec","raw_affiliation_strings":["Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021593173","display_name":"Laurie A. Bankston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie A. Bankston","raw_affiliation_strings":["Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919640","display_name":"Robert Liddington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert C. Liddington","raw_affiliation_strings":["Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and. Electronic address: rlidding@sanfordburnham.org","Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and. Electronic address: rlidding@sanfordburnham.org","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037 and","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110966862","display_name":"Richard G. DiScipio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. DiScipio","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies, San Diego, California 92121","institution_ids":["https://openalex.org/I40399489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007919640"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.4299,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.96588683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"287","issue":"13","first_page":"10210","last_page":"10222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c6","display_name":"complement C6","score":0.9890000224113464},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.9559999704360962},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8270000219345093},{"id":"https://openalex.org/keywords/auxiliary-domains","display_name":"auxiliary domains","score":0.699999988079071},{"id":"https://openalex.org/keywords/cholesterol-dependent-cytolysins","display_name":"cholesterol-dependent cytolysins","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.7645043134689331},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5318548083305359},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5035490393638611},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.4585104286670685},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4308927655220032},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.42782413959503174},{"id":"https://openalex.org/C44000306","wikidata":"https://www.wikidata.org/wiki/Q244330","display_name":"Hinge","level":2,"score":0.42608439922332764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4017634391784668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39064404368400574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3793853521347046},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3615228235721588},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23119783401489258},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17579716444015503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1447264552116394},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.09473016858100891},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003183","descriptor_name":"Complement C6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003183","descriptor_name":"Complement C6","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015938","descriptor_name":"Complement Membrane Attack Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.327809","doi":"https://doi.org/10.1074/jbc.m111.327809","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.327809","pdf_url":"http://www.jbc.org/article/S0021925820654333/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2601241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3323040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3323040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3323040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:22267737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22267737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.327809","doi":"https://doi.org/10.1074/jbc.m111.327809","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.327809","pdf_url":"http://www.jbc.org/article/S0021925820654333/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G168148697","display_name":"Role of C3a Receptors and C5a Receptors on Mesenchymal Stem Cells","funder_award_id":"R21HL094878","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332447","display_name":"U.S. Army","ror":"https://ror.org/00afsp483"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162073766.pdf","grobid_xml":"https://content.openalex.org/works/W2162073766.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W151550344","https://openalex.org/W1488927032","https://openalex.org/W1489594430","https://openalex.org/W1491611188","https://openalex.org/W1506059273","https://openalex.org/W1512543381","https://openalex.org/W1515924768","https://openalex.org/W1525465869","https://openalex.org/W1542411948","https://openalex.org/W1543417979","https://openalex.org/W1554825563","https://openalex.org/W1562626508","https://openalex.org/W1570780257","https://openalex.org/W1580112815","https://openalex.org/W1588600482","https://openalex.org/W1599286951","https://openalex.org/W1602141182","https://openalex.org/W1970026235","https://openalex.org/W1972222351","https://openalex.org/W1980273151","https://openalex.org/W1981898360","https://openalex.org/W1983628509","https://openalex.org/W1984302636","https://openalex.org/W1986191025","https://openalex.org/W1988296723","https://openalex.org/W1991111925","https://openalex.org/W1993998858","https://openalex.org/W1994342014","https://openalex.org/W1995017064","https://openalex.org/W1996616758","https://openalex.org/W1996725937","https://openalex.org/W1997103493","https://openalex.org/W1997720242","https://openalex.org/W2003852785","https://openalex.org/W2006089651","https://openalex.org/W2008380709","https://openalex.org/W2009010596","https://openalex.org/W2009035715","https://openalex.org/W2018299256","https://openalex.org/W2023140453","https://openalex.org/W2027249579","https://openalex.org/W2028475005","https://openalex.org/W2037816438","https://openalex.org/W2043680654","https://openalex.org/W2058509931","https://openalex.org/W2060619005","https://openalex.org/W2063420993","https://openalex.org/W2074481254","https://openalex.org/W2074857354","https://openalex.org/W2075095632","https://openalex.org/W2076406277","https://openalex.org/W2078046435","https://openalex.org/W2083568708","https://openalex.org/W2089934202","https://openalex.org/W2091035197","https://openalex.org/W2092369065","https://openalex.org/W2094197540","https://openalex.org/W2095345762","https://openalex.org/W2105148505","https://openalex.org/W2110893691","https://openalex.org/W2115099741","https://openalex.org/W2115563883","https://openalex.org/W2117129602","https://openalex.org/W2124026197","https://openalex.org/W2132629607","https://openalex.org/W2138150368","https://openalex.org/W2140813750","https://openalex.org/W2147545746","https://openalex.org/W2148417285","https://openalex.org/W2177078605","https://openalex.org/W2180229411","https://openalex.org/W2226184655","https://openalex.org/W2413647685","https://openalex.org/W2913186510","https://openalex.org/W6688830519"],"related_works":["https://openalex.org/W2090070005","https://openalex.org/W4211116394","https://openalex.org/W1997103493","https://openalex.org/W1992708993","https://openalex.org/W151738495","https://openalex.org/W2415123795","https://openalex.org/W2008171369","https://openalex.org/W1556867858","https://openalex.org/W1980273151","https://openalex.org/W2585554041"],"abstract_inverted_index":{"The":[0],"complement":[1],"membrane":[2],"attack":[3],"complex":[4],"(MAC)":[5],"is":[6,98,155,244],"formed":[7],"by":[8,50,73,123],"the":[9,57,62,67,77,80,87,101,131,140,152,161,183,187,194,197,205,208,211,222,228,234,240],"sequential":[10],"assembly":[11,195],"of":[12,23,31,60,66,79,90,145,151,160,164,182,196,207,210,214,233,239],"C5b":[13],"with":[14,76],"four":[15,135],"homologous":[16,116],"proteins":[17,69],"as":[18,218],"follows:":[19],"one":[20],"copy":[21],"each":[22,215],"C6,":[24,61,110,130],"C7,":[25],"and":[26,28,64,83,112,120,179,203,225],"C8":[27],"12-14":[29],"copies":[30],"C9.":[32],"Together":[33],"these":[34,171],"form":[35],"a":[36,46,93,175],"lytic":[37],"pore":[38,68,236],"in":[39,104,185,193,201,226],"bacterial":[40],"membranes.":[41],"C6":[42,91],"through":[43],"C9":[44],"comprise":[45],"MAC-perforin":[47],"domain":[48,89,213],"flanked":[49],"4-9":[51],"\"auxiliary\"":[52],"domains.":[53],"Here,":[54],"we":[55,173],"report":[56],"crystal":[58],"structure":[59],"first":[63],"longest":[65],"to":[70,157,221],"be":[71],"recruited":[72],"C5b.":[74],"Comparisons":[75],"structures":[78],"C8\u03b1\u03b2\u03b3":[81],"heterodimer":[82],"perforin":[84],"show":[85,108],"that":[86,97,109,138,247],"central":[88,162],"adopts":[92],"\"closed\"":[94],"(perforin-like)":[95],"state":[96],"distinct":[99,245],"from":[100,246],"\"open\"":[102],"conformations":[103],"C8.":[105],"We":[106],"further":[107],"C8\u03b1,":[111],"C8\u03b2":[113],"contain":[114],"three":[115],"subdomains":[117],"(\"upper,\"":[118],"\"lower,\"":[119],"\"regulatory\")":[121],"related":[122],"rotations":[124],"about":[125],"two":[126],"hinge":[127],"points.":[128],"In":[129,148],"regulatory":[132,153],"segment":[133,154],"includes":[134],"auxiliary":[136,188],"domains":[137,189],"stabilize":[139],"closed":[141],"conformation,":[142],"inhibiting":[143],"release":[144],"membrane-inserting":[146],"elements.":[147],"C8\u03b2,":[149],"rotation":[150],"linked":[156],"an":[158],"opening":[159,206],"\u03b2-sheet":[163,209],"its":[165],"clockwise":[166],"partner,":[167],"C8\u03b1.":[168],"Based":[169],"on":[170],"observations,":[172],"propose":[174],"model":[176,232],"for":[177,250],"initiation":[178,199],"unidirectional":[180],"propagation":[181],"MAC":[184],"which":[186],"play":[190],"key":[191],"roles:":[192],"C5b-8":[198],"complex;":[200],"driving":[202],"regulating":[204],"MAC-performin":[212],"new":[216],"recruit":[217],"it":[219],"adds":[220],"growing":[223],"pore;":[224],"stabilizing":[227],"final":[229],"pore.":[230],"Our":[231],"assembled":[235],"resembles":[237],"those":[238],"cholesterol-dependent":[241],"cytolysins":[242],"but":[243],"recently":[248],"proposed":[249],"perforin.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}