{"id":"https://openalex.org/W2162071928","doi":"https://doi.org/10.1109/iembs.1997.754508","title":"Propagation of action potentials in cardiac acute regional ischemia: a computer simulation study","display_name":"Propagation of action potentials in cardiac acute regional ischemia: a computer simulation study","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2162071928","doi":"https://doi.org/10.1109/iembs.1997.754508","mag":"2162071928"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.1997.754508","doi":"https://doi.org/10.1109/iembs.1997.754508","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.1997.754508","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070750789","display_name":"Jos\u00e9 Mar\u00eda Ferrero","orcid":"https://orcid.org/0000-0003-4200-9225","observed_orcids":["https://orcid.org/0000-0003-4200-9225"]},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose M. Ferrero","raw_affiliation_strings":["Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101768249","display_name":"V. Torres","orcid":"https://orcid.org/0000-0002-6829-7889","observed_orcids":["https://orcid.org/0000-0002-6829-7889"]},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Torres","raw_affiliation_strings":["Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063676325","display_name":"Javier S\u00e1iz","orcid":"https://orcid.org/0000-0002-9850-0825","observed_orcids":["https://orcid.org/0000-0002-9850-0825"]},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier F. Saiz","raw_affiliation_strings":["Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070750789","display_name":"Jos\u00e9 Mar\u00eda Ferrero","orcid":"https://orcid.org/0000-0003-4200-9225","observed_orcids":["https://orcid.org/0000-0003-4200-9225"]},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose M. Ferrero","raw_affiliation_strings":["Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088964967","display_name":"Nitish V. Thakor","orcid":"https://orcid.org/0000-0002-9981-9395","observed_orcids":["https://orcid.org/0000-0002-9981-9395"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitish V. Thakor","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10504202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"216","last_page":"219 vol.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-action-potential-propagation","display_name":"cardiac action potential propagation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ventricular-action-potential","display_name":"ventricular action potential","score":0.9449999928474426},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-current","display_name":"ATP-sensitive potassium current","score":0.9620000123977661},{"id":"https://openalex.org/keywords/extracellular-potassium","display_name":"extracellular potassium","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ischemic-border-zone","display_name":"ischemic border zone","score":0.8709999918937683},{"id":"https://openalex.org/keywords/calcium-current","display_name":"calcium current","score":0.8410000205039978},{"id":"https://openalex.org/keywords/upstroke-velocity","display_name":"upstroke velocity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2779096242","wikidata":"https://www.wikidata.org/wiki/Q218719","display_name":"Border zone","level":3,"score":0.8156710863113403},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7937009334564209},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.66829913854599},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5237779021263123},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5145418047904968},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.5070400238037109},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5041061639785767},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43158605694770813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4068419635295868},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37965574860572815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34336239099502563},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32691264152526855},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.322736918926239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26169633865356445},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.10120725631713867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iembs.1997.754508","doi":"https://doi.org/10.1109/iembs.1997.754508","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.1997.754508","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W583020534","https://openalex.org/W2044572054","https://openalex.org/W2070434571","https://openalex.org/W2074226713","https://openalex.org/W2121217634","https://openalex.org/W2130680932","https://openalex.org/W2132561989","https://openalex.org/W2150990549"],"related_works":["https://openalex.org/W2170779542","https://openalex.org/W3119152490","https://openalex.org/W2140330627","https://openalex.org/W2117311144","https://openalex.org/W2589792216","https://openalex.org/W2149710209","https://openalex.org/W2088923013","https://openalex.org/W2116905848","https://openalex.org/W1965599406","https://openalex.org/W4389314646"],"abstract_inverted_index":{"In":[0],"this":[1,30],"paper,":[2],"computer":[3],"simulations":[4],"have":[5,33],"been":[6,64],"carried":[7],"out":[8],"to":[9,66,91,121,135,186],"investigate":[10],"the":[11,23,44,50,53,89,93,122,126,136,140,150,189,196],"main":[12],"features":[13],"of":[14,25,38,43,52,74,103,116,125,139],"propagated":[15],"cardiac":[16],"action":[17,46,147,193],"potentials":[18,148,194],"in":[19,22,48,70,149,175,188,195],"myocardial":[20,75],"tissue":[21],"presence":[24],"regional":[26],"acute":[27],"ischemia.":[28],"For":[29],"purpose,":[31],"we":[32],"used":[34],"a":[35,71,112,130],"modified":[36,87],"version":[37],"Luo-Rudy":[39],"phase":[40],"II":[41],"model":[42,73],"ventricular":[45],"potential,":[47],"which":[49],"formulation":[51],"ATP-sensitive":[54],"K/sup":[55],"+/":[56],"current":[57,84,169],"proposed":[58],"by":[59],"Ferrero":[60],"et":[61],"al.":[62],"has":[63],"included,":[65],"simulate":[67,92],"electrical":[68,109],"activity":[69],"1-dimensional":[72],"tissue.":[76],"Both":[77],"extracellular":[78],"[K/sup":[79],"+/]":[80],"and":[81,98,129,177,204],"K/sub":[82],"ATP/":[83],"are":[85],"conveniently":[86],"along":[88],"strand":[90],"normal":[94,127,137,190],"zone,":[95,101,128],"electrophysiological":[96],"border-zone":[97],"central":[99,152,197],"ischemic":[100,141,151],"each":[102],"them":[104],"1":[105],"cm":[106],"long.":[107],"Control":[108],"stimuli":[110],"with":[111,166],"basic":[113],"cycle":[114],"length":[115],"500":[117],"milliseconds":[118],"were":[119],"applied":[120,134],"first":[123],"cell":[124],"premature":[131],"stimulus":[132],"was":[133],"side":[138],"border-zone.":[142],"The":[143],"results":[144],"show":[145,199],"that":[146],"zone":[153,198],"arising":[154],"from":[155,160,206],"control":[156],"stimulation,":[157],"(a)":[158],"result":[159,205],"Na/sup":[161],"+/-mediated":[162],"depressed":[163],"fast":[164],"responses,":[165],"Ca/sup":[167,208],"2+/":[168],"playing":[170],"also":[171],"an":[172],"important":[173],"role":[174],"depolarization,":[176],"(b)":[178],"their":[179],"duration":[180],"is":[181],"dramatically":[182],"reduced":[183],"when":[184],"compared":[185],"those":[187],"zone.":[191],"Premature":[192],"very":[200],"low":[201],"upstroke":[202],"velocities":[203],"slow":[207],"2+/-dependent":[209],"responses.":[210]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}