{"id":"https://openalex.org/W216201383","doi":null,"title":"Homeobox B13 protein expression in a randomized tamoxifen trial of premenopausal breast cancer","display_name":"Homeobox B13 protein expression in a randomized tamoxifen trial of premenopausal breast cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W216201383","mag":"216201383"},"language":"en","primary_location":{"id":"mag:216201383","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:416452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054814321","display_name":"Piiha-Lotta Jerevall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piiha-Lotta Jerevall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113738045","display_name":"Agneta Jansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agneta Jansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110041477","display_name":"Ann-Christine K\u00e4llstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann-Christine K\u00e4llstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046588878","display_name":"G\u00f6ran Landberg","orcid":"https://orcid.org/0000-0001-9004-9403","observed_orcids":["https://orcid.org/0000-0001-9004-9403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00f6ran Landberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9004-9403","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044494492","display_name":"M\u00e5rten Fern\u00f6","orcid":"https://orcid.org/0000-0003-2220-1236","observed_orcids":["https://orcid.org/0000-0003-2220-1236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00e5rten Fern\u00f6","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2220-1236","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044198521","display_name":"Olle St\u00e5l","orcid":"https://orcid.org/0000-0002-8290-0592","observed_orcids":["https://orcid.org/0000-0002-8290-0592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olle St\u00e5l","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8290-0592","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premenopausal-breast-cancer","display_name":"premenopausal breast cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9340000152587891},{"id":"https://openalex.org/keywords/breast-cancer-recurrence-risk","display_name":"breast cancer recurrence risk","score":0.5929999947547913},{"id":"https://openalex.org/keywords/breast-cancer-index","display_name":"Breast Cancer Index","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/postmenopausal-breast-cancer","display_name":"postmenopausal breast cancer","score":0.6980000138282776},{"id":"https://openalex.org/keywords/gene-expression-ratio","display_name":"gene expression ratio","score":0.5149999856948853},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5920000076293945},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.4860000014305115},{"id":"https://openalex.org/keywords/node-negative-breast-cancer","display_name":"node-negative breast cancer","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8311841487884521},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8242084980010986},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.7616559267044067},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7555476427078247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6670330762863159},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5237460136413574},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5115088224411011},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5023324489593506},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4420258104801178},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.436541348695755},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4171214699745178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05707836151123047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:216201383","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:416452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W579995768","https://openalex.org/W7097569203","https://openalex.org/W1987065631","https://openalex.org/W1993295117","https://openalex.org/W2054739409","https://openalex.org/W2472847620","https://openalex.org/W2082120145","https://openalex.org/W2084968309","https://openalex.org/W2107333022","https://openalex.org/W2123434562"],"abstract_inverted_index":{"A":[0],"major":[1],"issue":[2],"in":[3,73,94,162,176,304,387,415],"the":[4,57,60,82,126,131,147,171,193,234,243,343,367,388,396],"management":[5,389],"of":[6,35,59,87,121,144,165,174,192,205,221,230,250,256,287,294,331,345,350,380,390,398],"breast":[7,75,95,166,209,288,391],"cancer":[8,76,96,167,210,289,392],"is":[9,32],"to":[10,17,69,158,245,273,299,364,366,394],"identify":[11,246],"patients":[12,36,105,111,197,251,321,361,374,393,417],"who":[13,41],"are":[14],"less":[15,201,362],"likely":[16,363],"be":[18,44,300,355,385,404,419],"cured":[19],"after":[20,314],"primary":[21],"treatment":[22,108,140,277,351],"and":[23,84,146,182,208,215,279,353],"would":[24,43,48],"benefit":[25,117,327],"from":[26,118,328],"adjuvant":[27],"chemotherapy.":[28,399],"Of":[29],"great":[30],"importance":[31],"also":[33,80,297],"identification":[34],"with":[37,106,112,128,138,252,311,322,375],"only":[38,110],"local":[39],"disease":[40],"traditionally":[42],"given":[45],"chemotherapy":[46,282],"but":[47,412],"survive":[49],"without.":[50],"In":[51,317,370],"this":[52,185],"thesis":[53],"we":[54,213],"have":[55,79],"validated":[56,170],"utility":[58,86,173],"two-gene":[61],"ratio":[62],"HOXB13:IL17BR,":[63],"which":[64],"previously":[65],"has":[66,155,242],"been":[67,156],"demonstrated":[68],"predict":[70],"disease-free":[71],"survival":[72],"tamoxifen-treated":[74,194],"patients.":[77,290,306],"We":[78,98,169],"studied":[81],"prognostic":[83,153,172],"predictive":[85],"a":[88,92,113,177,200,217,253,284,301,318,348,376,407],"single":[89],"gene":[90],"as":[91,198,347,406],"biomarker":[93],"medicine.":[97],"could":[99],"confirm":[100],"that":[101,184,240,268,337],"HOXB13:IL17BR":[102,145],"may":[103,270,384,403],"classify":[104],"different":[107],"benefit;":[109],"low":[114,254,378],"value":[115],"showed":[116,326],"prolonged":[119],"duration":[120],"tamoxifen":[122,315,329,410],"therapy,":[123],"whereas":[124],"for":[125,228,283,409],"group":[127,286],"high":[129],"ratios,":[130],"long-term":[132],"recurrence":[133,207,231,257],"rate":[134],"did":[135],"not":[136],"improve":[137],"longer":[139],"duration.":[141],"The":[142,291],"combination":[143],"molecular":[148],"grade":[149],"index":[150],"(MGI),":[151],"another":[152],"marker,":[154],"shown":[157,298],"outperform":[159],"either":[160],"alone":[161],"predicting":[163],"risk":[164,186,204,219,232,255,263,379],"recurrence.":[168,382],"HOXB13:IL17BR+MGI":[175,222],"large":[178,285],"randomized":[179],"patient":[180],"cohort":[181],"found":[183],"classification":[187],"identified":[188],"more":[189,247,258],"than":[190,202,248,260],"50%":[191,249],"lymph":[195],"node-negative":[196],"having":[199],"3%":[203],"distant":[206,381],"death.":[211],"Furthermore,":[212],"developed":[214],"tested":[216],"continuous":[218],"model":[220],"called":[223],"Breast":[224],"Cancer":[225],"Index":[226],"(BCI),":[227],"estimation":[229],"at":[233],"individual":[235],"level.":[236],"Our":[237],"study":[238],"shows":[239],"BCI":[241,269,372],"ability":[244],"accurately":[259],"using":[261],"traditional":[262],"assessment.":[264],"These":[265],"results":[266],"suggest":[267],"help":[271],"clinicians":[272],"make":[274],"better":[275],"informed":[276],"decisions":[278],"spare":[280],"toxic":[281],"protein":[292,401],"expression":[293,308,402],"HOXB13":[295,332,346,400],"was":[296,309],"valuable":[302],"predictor":[303,349],"postmenopausal":[305],"High":[307],"associated":[310],"worse":[312],"outcome":[313],"therapy.":[316],"premenopausal":[319,416],"cohort,":[320],"hormone":[323],"receptor-positive":[324],"tumors":[325],"regardless":[330],"expression.":[333],"Further":[334],"analysis":[335],"indicated":[336],"estrogen":[338],"receptor":[339],"\u03b2":[340],"(ER\u03b2)":[341],"modified":[342,420],"performance":[344,414],"effect":[352],"should":[354],"taken":[356],"into":[357],"account":[358],"when":[359],"identifying":[360],"respond":[365],"therapy":[368],"given.":[369],"conclusion,":[371],"identifies":[373],"very":[377],"It":[383],"utilized":[386],"optimize":[395],"use":[397],"used":[405],"marker":[408],"benefit,":[411],"its":[413],"might":[418],"by":[421],"ER\u03b2.":[422]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
