{"id":"https://openalex.org/W2162000223","doi":"https://doi.org/10.5897/jmpr10.856","title":"Efficacy of Cryptolepis sanguinolenta root extract on slow-growing rifampicin resistant Mycobacterium tuberculosis","display_name":"Efficacy of Cryptolepis sanguinolenta root extract on slow-growing rifampicin resistant Mycobacterium tuberculosis","publication_year":2012,"publication_date":"2012-02-23","ids":{"openalex":"https://openalex.org/W2162000223","doi":"https://doi.org/10.5897/jmpr10.856","mag":"2162000223"},"language":"en","primary_location":{"id":"doi:10.5897/jmpr10.856","doi":"https://doi.org/10.5897/jmpr10.856","is_oa":true,"landing_page_url":"https://doi.org/10.5897/jmpr10.856","pdf_url":null,"source":{"id":"https://openalex.org/S157481311","display_name":"Journal of Medicinal Plants Research","issn_l":"1996-0875","issn":["1996-0875"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5897/jmpr10.856","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069264432","display_name":"Claude Kirimuhuzya","orcid":"https://orcid.org/0000-0001-5607-9860","observed_orcids":["https://orcid.org/0000-0001-5607-9860"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kirimuhuzya Claude","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069264432"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4397,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.63192683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.08190000057220459,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptolepis-sanguinolenta","display_name":"Cryptolepis sanguinolenta","score":1.0},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antitubercular-activity","display_name":"antitubercular activity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/root-extract","display_name":"root extract","score":0.7590000033378601},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8769999742507935},{"id":"https://openalex.org/keywords/minimum-bactericidal-concentration","display_name":"minimum bactericidal concentration","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mycobacterium-avium","display_name":"Mycobacterium avium","score":0.9330000281333923},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.8320000171661377},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.7166897654533386},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7045146226882935},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5452343821525574},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5301340818405151},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5030152201652527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4361531734466553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37818095088005066},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.367997944355011},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.22150394320487976},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.045716434717178345}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5897/jmpr10.856","doi":"https://doi.org/10.5897/jmpr10.856","is_oa":true,"landing_page_url":"https://doi.org/10.5897/jmpr10.856","pdf_url":null,"source":{"id":"https://openalex.org/S157481311","display_name":"Journal of Medicinal Plants Research","issn_l":"1996-0875","issn":["1996-0875"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Research","raw_type":"journal-article"},{"id":"pmh:oai:ir-library.ku.ac.ke:123456789/5825","doi":null,"is_oa":false,"landing_page_url":"http://ir-library.ku.ac.ke/handle/123456789/5825","pdf_url":null,"source":{"id":"https://openalex.org/S4306400122","display_name":"Kenyatta University Institutional Repository (Kenyatta University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153975220","host_organization_name":"Kenyatta University","host_organization_lineage":["https://openalex.org/I153975220"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.5897/jmpr10.856","doi":"https://doi.org/10.5897/jmpr10.856","is_oa":true,"landing_page_url":"https://doi.org/10.5897/jmpr10.856","pdf_url":null,"source":{"id":"https://openalex.org/S157481311","display_name":"Journal of Medicinal Plants Research","issn_l":"1996-0875","issn":["1996-0875"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Plants Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1771441866","https://openalex.org/W1984943870","https://openalex.org/W1990940396","https://openalex.org/W2061792625","https://openalex.org/W2069224657","https://openalex.org/W2108815635","https://openalex.org/W2109845978","https://openalex.org/W2146134790","https://openalex.org/W2146587649","https://openalex.org/W2949095798"],"related_works":["https://openalex.org/W6981339962","https://openalex.org/W2170127298","https://openalex.org/W1989991378","https://openalex.org/W2614780271","https://openalex.org/W2186594980","https://openalex.org/W1977741775","https://openalex.org/W4229442011","https://openalex.org/W4214942537","https://openalex.org/W2044244801","https://openalex.org/W4386427361"],"abstract_inverted_index":{"We":[0,97],"report":[1,98],"here,":[2],"the":[3,20,40,44,88,100,106,173,201,205],"results":[4],"from":[5,56],"total":[6,101],"crude":[7,102],"methanol":[8],"extract":[9,104],"as":[10,12],"well":[11],"serial":[13],"ether,":[14],"chloroform,":[15],"and":[16,47,80,111,121,151,162,167,210],"\\nmethanol":[17,103],"extracts":[18],"of":[19,22,33,51,116,123,125,195,207],"root":[21],"Cryptolepis":[23],"sanguinolenta":[24],"(Lindl)":[25],"Schltr":[26],"that":[27,99],"were":[28,85,146,160],"screened":[29],"against":[30,109,139],"\\nthree":[31],"strains":[32,37],"Mycobacterium":[34],"tuberculosis.":[35],"The":[36,60,142,156],"used":[38,65],"included":[39],"pan":[41],"sensitive":[42],"H37Rv,":[43],"\\nrifampicin-resistant":[45],"TMC-331":[46],"a":[48,57],"wild":[49],"strain":[50],"Mycobacetrium":[52],"avium":[53],"(MA)":[54],"isolated":[55],"Ugandan":[58],"\\npatient.":[59],"disc":[61],"diffusion":[62],"method":[63,91],"was":[64,176,183],"for":[66,149,154,158,165,171,179],"susceptibility":[67],"tests":[68],"on":[69,186],"solid":[70],"Middle":[71,93],"brook":[72,94],"7H10":[73],"while":[74,170,200],"\\nthe":[75],"minimum":[76,81],"inhibitory":[77],"concentration":[78,83,133],"(MIC)":[79],"bactericidal":[82],"(MBC)":[84],"\\ndetermined":[86],"by":[87],"microtitre":[89],"plate":[90],"using":[92],"7H9":[95],"broth.":[96],"showed":[105],"highest":[107],"activity":[108],"H37Rv":[110,150,166,180],"TM-331":[112],"with":[113],"complete":[114],"clearance":[115],"\\nquadrants":[117],"at":[118,130],"50":[119],"mg/ml":[120,132,148],"zones":[122],"inhibition":[124],"10.0":[126],"to":[127],"11":[128],"mm":[129],"25":[131],"although":[134],"it":[135,182],"\\nwas":[136],"not":[137,184],"effective":[138],"M.":[140],"avium.":[141],"corresponding":[143],"MIC":[144,174],"values":[145,157],"1.17":[147],"1.56":[152],"\\nmg/ml":[153],"TMC-331.":[155],"isoniazid":[159],"0.25":[161,177],"9.38":[163],"\u00b5g/ml":[164,178],"TMC-331,":[168],"\\nrespectively,":[169],"rifampicin":[172],"value":[175],"but":[181],"active":[185],"TMC-":[187],"\\n331.":[188],"Acute":[189],"toxicity":[190],"test":[191],"gave":[192],"an":[193],"LD50":[194],"758.5":[196],"mg/kg":[197],"body":[198],"weight":[199],"phytochemical":[202],"analysis":[203],"\\nshowed":[204],"presence":[206],"alkaloids,":[208],"tannins":[209],"flavonoids.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
