{"id":"https://openalex.org/W2161985291","doi":"https://doi.org/10.1152/japplphysiol.00499.2002","title":"Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats","display_name":"Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2161985291","doi":"https://doi.org/10.1152/japplphysiol.00499.2002","mag":"2161985291","pmid":"https://pubmed.ncbi.nlm.nih.gov/12486020"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00499.2002","doi":"https://doi.org/10.1152/japplphysiol.00499.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00499.2002","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102985448","display_name":"James A. Levine","orcid":"https://orcid.org/0000-0003-4321-5899","observed_orcids":["https://orcid.org/0000-0003-4321-5899","https://orcid.org/0000-0002-5441-0860"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Levine","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032457652","display_name":"Jonas Nygren","orcid":"https://orcid.org/0000-0001-8239-6376","observed_orcids":["https://orcid.org/0000-0001-8239-6376"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas Nygren","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069827652","display_name":"Kevin R. Short","orcid":"https://orcid.org/0000-0001-6704-9587","observed_orcids":["https://orcid.org/0000-0001-6704-9587"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin R. Short","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002287349","display_name":"K. Sreekumaran Nair","orcid":"https://orcid.org/0000-0002-0649-9469","observed_orcids":["https://orcid.org/0000-0002-0649-9469"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Sreekumaran Nair","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":3.2556,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.92480514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"94","issue":"1","first_page":"165","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/spontaneous-physical-activity","display_name":"spontaneous physical activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thyroid-hormone-excess","display_name":"thyroid hormone excess","score":0.9269999861717224},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.7822571992874146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7739294767379761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7589585781097412},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.7114794254302979},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.6528924703598022},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.6518690586090088},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5713109970092773},{"id":"https://openalex.org/C2780486670","wikidata":"https://www.wikidata.org/wiki/Q7318276","display_name":"Reverse triiodothyronine","level":4,"score":0.4750392735004425},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4489554166793823},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.4477001130580902},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44053059816360474},{"id":"https://openalex.org/C2779571634","wikidata":"https://www.wikidata.org/wiki/Q422106","display_name":"Thyroid hormones","level":3,"score":0.4317215383052826},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.429073303937912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42581647634506226},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.10366290807723999},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.06838619709014893}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.00499.2002","doi":"https://doi.org/10.1152/japplphysiol.00499.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00499.2002","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:12486020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12486020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2060051834","display_name":null,"funder_award_id":"DK 41973","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4069978706","display_name":null,"funder_award_id":"DK-07352","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G628048870","display_name":null,"funder_award_id":"DK-56650","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7592654877","display_name":"Non-exercise Activity Thermogenesis (NEAT)","funder_award_id":"R01DK056650","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000871886","display_name":"Diabetes and Metabolism","funder_award_id":"T32DK007352","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W160566051","https://openalex.org/W1594539479","https://openalex.org/W1635674943","https://openalex.org/W1907954152","https://openalex.org/W1999763722","https://openalex.org/W2032862544","https://openalex.org/W2038941183","https://openalex.org/W2041811148","https://openalex.org/W2058784350","https://openalex.org/W2080750216","https://openalex.org/W2112821460","https://openalex.org/W2126627580","https://openalex.org/W2144955458","https://openalex.org/W2148360020","https://openalex.org/W2162391320","https://openalex.org/W4245825595","https://openalex.org/W4248098588"],"related_works":["https://openalex.org/W2112104834","https://openalex.org/W7097291453","https://openalex.org/W1993180519","https://openalex.org/W2001530035","https://openalex.org/W2332445105","https://openalex.org/W1692384145","https://openalex.org/W2061669916","https://openalex.org/W7096260780","https://openalex.org/W2440778059","https://openalex.org/W15833294"],"abstract_inverted_index":{"Thyroid":[0],"hormone":[1],"excess":[2],"is":[3,35,184],"associated":[4,36,185],"with":[5,37,186],"increased":[6,38,106,147,187],"energy":[7],"expenditure.":[8],"The":[9],"contributions":[10],"of":[11,52],"increases":[12],"in":[13,70,88,107,129,148,168],"spontaneous":[14,39,103,188],"physical":[15,40,63,104,189],"activity":[16,19,41,64,105,119,190],"and":[17,42,58,65,87,191],"nonexercise":[18],"thermogenesis":[20],"(NEAT)":[21],"to":[22,115,156],"this":[23],"effect":[24],"have":[25],"not":[26,127,166,179],"been":[27],"defined.":[28],"To":[29],"address":[30],"the":[31,60,71,74,89,98,108,130,142,149,169],"hypothesis":[32],"that":[33],"hyperthyroidism":[34,183],"NEAT,":[43],"we":[44],"rendered":[45],"rats":[46,110,151],"hyperthyroid":[47,72,109,150],"by":[48],"using":[49],"continuous":[50],"infusion":[51],"high-dose":[53],"triiodothyronine":[54,78],"for":[55],"14":[56],"days":[57],"measured":[59],"effects":[61],"on":[62],"NEAT.":[66,192],"On":[67],"day":[68],"14,":[69],"group":[73,91],"mean":[75,102],"+/-":[76,82,93,113,117,133,137,154,158,172,176],"SD":[77],"concentration":[79],"was":[80],"755":[81],"137":[83],"(range":[84],"574-919)":[85],"ng/dl":[86],"control":[90],"59":[92],"0.5":[94],"(58-59)":[95],"ng/dl.":[96],"Over":[97],"14-day":[99,143],"treatment":[100],"period,":[101,144],"from":[111,152],"24":[112],"7":[114,134],"36":[116],"6":[118],"units":[120],"(AU)/min;":[121],"P":[122],"<":[123,162],"0.001":[124],"but":[125,164],"did":[126,165],"increase":[128,167],"controls":[131,170],"(23":[132],"vs.":[135],"22":[136],"4":[138],"AU/min).":[139],"Also,":[140],"over":[141],"daily":[145],"NEAT":[146],"8.1":[153],"2.8":[155],"19.7":[157],"5.0":[159],"kcal/day":[160],"(P":[161],"0.001)":[163],"(8.7":[171],"3.5":[173],"cf":[174],"9.4":[175],"1.7":[177],"kcal/day;":[178],"significant).":[180],"In":[181],"conclusion,":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}