{"id":"https://openalex.org/W2161963707","doi":"https://doi.org/10.2174/1874120701206010098","title":"Use of an Injectable Complex of \u03b2-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures","display_name":"Use of an Injectable Complex of \u03b2-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures","publication_year":2012,"publication_date":"2012-10-15","ids":{"openalex":"https://openalex.org/W2161963707","doi":"https://doi.org/10.2174/1874120701206010098","mag":"2161963707","pmid":"https://pubmed.ncbi.nlm.nih.gov/23115598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3480701"},"language":"en","primary_location":{"id":"doi:10.2174/1874120701206010098","doi":"https://doi.org/10.2174/1874120701206010098","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874120701206010098","pdf_url":"https://openbiomedicalengineeringjournal.com/VOLUME/6/PAGE/98/PDF/","source":{"id":"https://openalex.org/S18647887","display_name":"The Open Biomedical Engineering Journal","issn_l":"1874-1207","issn":["1874-1207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Biomedical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://openbiomedicalengineeringjournal.com/VOLUME/6/PAGE/98/PDF/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024331596","display_name":"Takaaki Tanaka","orcid":"https://orcid.org/0000-0003-0136-1708","observed_orcids":["https://orcid.org/0000-0003-0136-1708"]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T Tanaka","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060301288","display_name":"Seiichiro Kitasato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Kitasato","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081022855","display_name":"Masaaki Chazono","orcid":"https://orcid.org/0000-0002-0487-5715","observed_orcids":["https://orcid.org/0000-0002-0487-5715"]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Chazono","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082318691","display_name":"Yoshio Kumagae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kumagae","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Iida","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017271532","display_name":"Masatsugi Mitsuhashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Mitsuhashi","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111874805","display_name":"A. Kakuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Kakuta","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022993719","display_name":"Keishi Marumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285650","display_name":"National Hospital Organization Utsunomiya National Hospital","ror":"https://ror.org/05vq1f834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Marumo","raw_affiliation_strings":["Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan","institution_ids":["https://openalex.org/I4405285650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024331596"],"corresponding_institution_ids":["https://openalex.org/I4405285650"],"apc_list":null,"apc_paid":null,"fwci":1.6594,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8225868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"98","last_page":"103"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11509","display_name":"Hip and Femur Fractures","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11509","display_name":"Hip and Femur Fractures","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-tcp","display_name":"beta-tricalcium phosphate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/injectable-bone-substitute","display_name":"injectable bone substitute","score":0.7950000166893005},{"id":"https://openalex.org/keywords/unstable-intertrochanteric-fracture","display_name":"unstable intertrochanteric fracture","score":0.8880000114440918},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5960000157356262},{"id":"https://openalex.org/keywords/intramedullary-nailing","display_name":"intramedullary nailing","score":0.8059999942779541},{"id":"https://openalex.org/keywords/fracture-union","display_name":"fracture union","score":0.6700000166893005},{"id":"https://openalex.org/keywords/varus-deformity","display_name":"varus deformity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cortical-bone-defect","display_name":"cortical bone defect","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C92162645","wikidata":"https://www.wikidata.org/wiki/Q655955","display_name":"Intramedullary rod","level":2,"score":0.7874621152877808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5887182354927063},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.5053461194038391},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.46125683188438416},{"id":"https://openalex.org/C2779982284","wikidata":"https://www.wikidata.org/wiki/Q1182746","display_name":"Deformity","level":2,"score":0.4302270710468292},{"id":"https://openalex.org/C2778375840","wikidata":"https://www.wikidata.org/wiki/Q5600920","display_name":"Greater trochanter","level":3,"score":0.42193278670310974},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.368818998336792}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2174/1874120701206010098","doi":"https://doi.org/10.2174/1874120701206010098","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874120701206010098","pdf_url":"https://openbiomedicalengineeringjournal.com/VOLUME/6/PAGE/98/PDF/","source":{"id":"https://openalex.org/S18647887","display_name":"The Open Biomedical Engineering Journal","issn_l":"1874-1207","issn":["1874-1207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Biomedical Engineering Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2477591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3480701","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23115598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23115598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The open biomedical engineering journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3480701","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3480701/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biomed Eng J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2174/1874120701206010098","doi":"https://doi.org/10.2174/1874120701206010098","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874120701206010098","pdf_url":"https://openbiomedicalengineeringjournal.com/VOLUME/6/PAGE/98/PDF/","source":{"id":"https://openalex.org/S18647887","display_name":"The Open Biomedical Engineering Journal","issn_l":"1874-1207","issn":["1874-1207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Biomedical Engineering Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161963707.pdf","grobid_xml":"https://content.openalex.org/works/W2161963707.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W568337824","https://openalex.org/W1507903039","https://openalex.org/W1534759688","https://openalex.org/W1966155452","https://openalex.org/W1979403186","https://openalex.org/W2010901408","https://openalex.org/W2011958934","https://openalex.org/W2022048615","https://openalex.org/W2029055538","https://openalex.org/W2035780771","https://openalex.org/W2063872833","https://openalex.org/W2069721408","https://openalex.org/W2074850931","https://openalex.org/W2081781420","https://openalex.org/W2086564192","https://openalex.org/W2089779401","https://openalex.org/W2090462065","https://openalex.org/W2092366187","https://openalex.org/W2132422721","https://openalex.org/W2145281964","https://openalex.org/W2225041880","https://openalex.org/W4244132297"],"related_works":["https://openalex.org/W7099934001","https://openalex.org/W1966155452","https://openalex.org/W2225041880","https://openalex.org/W2390450616","https://openalex.org/W2382438380","https://openalex.org/W2521242663","https://openalex.org/W2329216813","https://openalex.org/W2368968998","https://openalex.org/W4415603385","https://openalex.org/W4367026626"],"abstract_inverted_index":{"We":[0],"evaluated":[1],"effects":[2],"of":[3,7,22,43,56,69,88,106,153,158],"an":[4],"injectable":[5],"complex":[6,45,139],"\u03b2-tricalcium":[8],"phosphate":[9],"(\u03b2-TCP)":[10],"granules,":[11],"hyaluronate,":[12],"and":[13,52,59,66,77,86,116,149,163],"recombinant":[14],"human":[15],"fibroblast":[16],"growth":[17],"factor-2":[18],"(rhFGF-2)":[19],"on":[20],"repair":[21],"unstable":[23,160],"intertrochanteric":[24,57,161],"fractures":[25,36,58,162],"in":[26,83,98,127,156],"elderly":[27],"patients.":[28],"Twenty-five":[29],"patients":[30],"(range,":[31],"76-91":[32],"years)":[33],"having":[34],"31.A2":[35],"(AO":[37],"classification)":[38],"were":[39,73,111],"treated":[40,134],"with":[41,135,168],"injection":[42],"the":[44,64,70,89,94,122,136],"followed":[46],"by":[47,75,101,114],"intramedullary":[48],"nails.":[49],"Bone":[50],"regeneration":[51],"\u03b2-TCP":[53,109],"resorption,":[54],"unions":[55],"displaced":[60,90],"lesser":[61,91,123],"trochanters":[62],"to":[63,93,131,147],"shaft,":[65],"varus":[67],"deformity":[68],"femoral":[71],"neck":[72],"assessed":[74],"X-ray":[76],"CT":[78],"scans.":[79],"Fracture":[80],"union":[81,87],"occurred":[82],"all":[84,128],"cases":[85,100,129,132],"trochanter":[92,124],"shaft":[95],"was":[96,125],"obtained":[97],"24":[99],"12":[102],"weeks.":[103],"It":[104],"is":[105,140,145],"interest":[107],"that":[108,144],"granules":[110],"completely":[112],"replaced":[113],"bone":[115,119,166],"marked":[117],"new":[118],"formation":[120],"around":[121],"observed":[126],"compared":[130],"not":[133],"complex.":[137],"This":[138],"a":[141],"paste-like":[142],"material":[143],"easy":[146],"handle,":[148],"it":[150],"may":[151],"be":[152],"considerable":[154],"use":[155],"treatment":[157],"both":[159],"other":[164],"cortical":[165],"defects":[167],"minimal":[169],"surgical":[170],"invasion.":[171]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}