{"id":"https://openalex.org/W2161915075","doi":"https://doi.org/10.2217/fvl.10.91","title":"Blocking Semen-Mediated Enhancement of HIV Infection by Amyloid-Binding Small Molecules","display_name":"Blocking Semen-Mediated Enhancement of HIV Infection by Amyloid-Binding Small Molecules","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2161915075","doi":"https://doi.org/10.2217/fvl.10.91","mag":"2161915075"},"language":"en","primary_location":{"id":"doi:10.2217/fvl.10.91","doi":"https://doi.org/10.2217/fvl.10.91","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fvl.10.91","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072303851","display_name":"Jan M\u00fcnch","orcid":"https://orcid.org/0000-0001-7316-7141","observed_orcids":["https://orcid.org/0000-0001-7316-7141"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan M\u00fcnch","raw_affiliation_strings":["Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210155144"],"apc_list":null,"apc_paid":null,"fwci":0.1185,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47583781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"2","first_page":"183","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-transmission","display_name":"HIV-1 transmission","score":0.9350000023841858},{"id":"https://openalex.org/keywords/semen","display_name":"semen","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sevi","display_name":"SEVI","score":0.8029999732971191},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microbicides","display_name":"microbicides","score":0.722000002861023},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cervical-cells","display_name":"cervical cells","score":0.6600000262260437},{"id":"https://openalex.org/keywords/sexual-transmission","display_name":"sexual transmission","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.8893855810165405},{"id":"https://openalex.org/C3019340110","wikidata":"https://www.wikidata.org/wiki/Q525512","display_name":"Sexual transmission","level":4,"score":0.6532315015792847},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5592921376228333},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5010905265808105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44604578614234924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4442325234413147},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.42411941289901733},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.41628050804138184},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4150206446647644},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.361696720123291},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.17008689045906067},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07249689102172852},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2217/fvl.10.91","doi":"https://doi.org/10.2217/fvl.10.91","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fvl.10.91","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1492050857","https://openalex.org/W1985884834","https://openalex.org/W2002574877","https://openalex.org/W2048904628","https://openalex.org/W2064647506","https://openalex.org/W2066754037","https://openalex.org/W2076027733","https://openalex.org/W2123004796","https://openalex.org/W2124471017","https://openalex.org/W2126265955","https://openalex.org/W2137024330","https://openalex.org/W2138686161","https://openalex.org/W2140065286","https://openalex.org/W2155414293","https://openalex.org/W2165032352","https://openalex.org/W2168527507","https://openalex.org/W2615187673","https://openalex.org/W6922072469"],"related_works":["https://openalex.org/W2076027733","https://openalex.org/W1973046776","https://openalex.org/W2168527507","https://openalex.org/W1499246489","https://openalex.org/W1922290585","https://openalex.org/W2099024023","https://openalex.org/W2323740357","https://openalex.org/W7098863270","https://openalex.org/W2170049497","https://openalex.org/W1974894479"],"abstract_inverted_index":{"Evaluation":[0],"of:":[1],"Olsen":[2,98],"JS,":[3],"Brown":[4],"C,":[5],"Capule":[6],"CC":[7],"et":[8],"al.:":[9],"Amyloid-binding":[10],"small":[11,160],"molecules":[12,162],"efficiently":[13],"block":[14,164],"SEVI":[15,113,121,131],"(semen-derived":[16],"enhancer":[17,77],"of":[18,24,42,78,94,106,120,130,145,167,180],"virus":[19,79,124],"infection)-":[20],"and":[21,46,85,99],"semen-mediated":[22,143,165],"enhancement":[23,144,166],"HIV-1":[25,53,64,95,146,168],"infection.":[26,65],"J.":[27],"Biol.":[28],"Chem.":[29],"285(46),":[30],"35488\u201335496":[31],"(2010).":[32],"Sexual":[33],"intercourse":[34],"is":[35,56],"the":[36,40,43,49,92,107,118,128,136,181],"major":[37],"route":[38],"for":[39,52,91,176],"spread":[41],"AIDS":[44],"pandemic":[45],"semen":[47,60,71],"represents":[48],"main":[50],"vector":[51],"transmission.":[54,96],"It":[55],"under":[57],"debate":[58],"whether":[59],"enhances":[61],"or":[62,151],"inhibits":[63,142],"However,":[66],"accumulating":[67],"evidence":[68],"suggests":[69],"that":[70,82,102,140,159,163],"contains":[72],"amyloid":[73],"aggregates":[74],"(termed":[75],"\u2018semen-derived":[76],"infection\u2019":[80],"[SEVI])":[81],"boost":[83],"infection":[84,125,147,169],"thus":[86],"represent":[87],"a":[88,104,171],"promising":[89],"target":[90,133],"prevention":[93],"Here,":[97],"colleagues":[100],"demonstrate":[101,139],"BTA-EG6,":[103],"derivative":[105],"amyloid-specific":[108],"dye":[109],"thioflavin":[110],"T,":[111],"binds":[112],"fibrils.":[114],"This":[115],"interaction":[116],"blocks":[117],"ability":[119],"to":[122,174],"enhance":[123],"by":[126],"preventing":[127,177],"association":[129],"with":[132],"cells.":[134,155],"Importantly,":[135],"authors":[137],"also":[138],"BTA-EG6":[141],"without":[148],"causing":[149],"inflammation":[150],"toxicity":[152],"in":[153],"cervical":[154],"These":[156],"results":[157],"suggest":[158],"amyloid-binding":[161],"are":[170],"useful":[172],"supplement":[173],"microbicides":[175],"sexual":[178],"transmission":[179],"virus.":[182]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
