{"id":"https://openalex.org/W2161893601","doi":"https://doi.org/10.1097/mib.0b013e3182802a4e","title":"Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10\u2212/\u2212 Mice","display_name":"Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10\u2212/\u2212 Mice","publication_year":2013,"publication_date":"2013-02-27","ids":{"openalex":"https://openalex.org/W2161893601","doi":"https://doi.org/10.1097/mib.0b013e3182802a4e","mag":"2161893601","pmid":"https://pubmed.ncbi.nlm.nih.gov/23446335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114389"},"language":"en","primary_location":{"id":"doi:10.1097/mib.0b013e3182802a4e","doi":"https://doi.org/10.1097/mib.0b013e3182802a4e","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mib.0b013e3182802a4e","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/19/4/712/23422793/ibd0712.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ibdjournal/article-pdf/19/4/712/23422793/ibd0712.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052244482","display_name":"Elizabeth M. Lennon","orcid":"https://orcid.org/0000-0002-9988-4365","observed_orcids":["https://orcid.org/0000-0002-9988-4365"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. M. Lennon","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27607, USA","Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27607, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079488262","display_name":"Nitsan Maharshak","orcid":"https://orcid.org/0000-0002-9324-0024","observed_orcids":["https://orcid.org/0000-0002-9324-0024"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Nitsan Maharshak","raw_affiliation_strings":["\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","\u2021 Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"\u2021 Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030848593","display_name":"Houda Zghal Elloumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Elloumi","raw_affiliation_strings":["\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077396148","display_name":"Luke B. Borst","orcid":"https://orcid.org/0000-0002-2736-1960","observed_orcids":["https://orcid.org/0000-0002-2736-1960"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Borst","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110881723","display_name":"Scott Eric Plevy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Plevy","raw_affiliation_strings":["\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Departments of Medicine, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090520820","display_name":"Adam James Moeser","orcid":"https://orcid.org/0000-0003-3068-627X","observed_orcids":["https://orcid.org/0000-0003-3068-627X"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam J. Moeser","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina","\u00a7 Center for Comparative Medicine and Translational Research (CCMTR), North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"\u00a7 Center for Comparative Medicine and Translational Research (CCMTR), North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052244482","https://openalex.org/A5090520820"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":4.6194,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.94780233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"4","first_page":"712","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-life-stress","display_name":"early life stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neonatal-maternal-separation","display_name":"neonatal maternal separation","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7308323979377747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5867214798927307},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4632912874221802},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4302574694156647},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4137198030948639},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3883017599582672},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33241748809814453},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20784959197044373}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008426","descriptor_name":"Maternal Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1097/mib.0b013e3182802a4e","doi":"https://doi.org/10.1097/mib.0b013e3182802a4e","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mib.0b013e3182802a4e","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/19/4/712/23422793/ibd0712.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:23446335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23446335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4114389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Inflamm Bowel Dis","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:tt44pt898","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/tdpy-t739","pdf_url":"https://cdr.lib.unc.edu/downloads/qn59qb463","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammatory Bowel Diseases, 19(4)","raw_type":"Article"},{"id":"doi:10.17615/tdpy-t739","doi":"https://doi.org/10.17615/tdpy-t739","is_oa":true,"landing_page_url":"https://doi.org/10.17615/tdpy-t739","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1097/mib.0b013e3182802a4e","doi":"https://doi.org/10.1097/mib.0b013e3182802a4e","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mib.0b013e3182802a4e","pdf_url":"https://academic.oup.com/ibdjournal/article-pdf/19/4/712/23422793/ibd0712.pdf","source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G125531235","display_name":"Enteric CRF Receptor Signaling in Stress-Induced Intestinal Barrier Dysfunction","funder_award_id":"K08DK084313","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5114779474","display_name":"Comparative Medicine and Translational Research Training Program","funder_award_id":"T32RR024394","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7749418438","display_name":"Macrophage Gene Expression in Mucosal Inflammation","funder_award_id":"R01DK054452","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000166012","display_name":null,"funder_award_id":"DK 34987","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868127","display_name":"Center for Gastrointestinal Biology and Disease","funder_award_id":"P30DK034987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868721","display_name":"Comparative Medicine and Translational Research Training Program","funder_award_id":"T32OD011130","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320307160","display_name":"American Physicians Fellowship for Medicine in Israel","ror":"https://ror.org/04w2t4465"},{"id":"https://openalex.org/F4320310013","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161893601.pdf","grobid_xml":"https://content.openalex.org/works/W2161893601.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W199520757","https://openalex.org/W1515273152","https://openalex.org/W1977647049","https://openalex.org/W1980704757","https://openalex.org/W1983364350","https://openalex.org/W1987357375","https://openalex.org/W1996195725","https://openalex.org/W1998440529","https://openalex.org/W2006344901","https://openalex.org/W2018075167","https://openalex.org/W2019566299","https://openalex.org/W2022975557","https://openalex.org/W2028701448","https://openalex.org/W2028756447","https://openalex.org/W2029660423","https://openalex.org/W2030480886","https://openalex.org/W2030707095","https://openalex.org/W2035716309","https://openalex.org/W2037261229","https://openalex.org/W2042371226","https://openalex.org/W2049349880","https://openalex.org/W2051016124","https://openalex.org/W2061565958","https://openalex.org/W2062373903","https://openalex.org/W2063309155","https://openalex.org/W2065994153","https://openalex.org/W2072004231","https://openalex.org/W2077198680","https://openalex.org/W2079464767","https://openalex.org/W2080030919","https://openalex.org/W2084612577","https://openalex.org/W2091457240","https://openalex.org/W2100386143","https://openalex.org/W2101866959","https://openalex.org/W2112418861","https://openalex.org/W2117384610","https://openalex.org/W2118752824","https://openalex.org/W2129652475","https://openalex.org/W2137647558","https://openalex.org/W2141354880","https://openalex.org/W2142485152","https://openalex.org/W2144967252","https://openalex.org/W2146367607","https://openalex.org/W2146947417","https://openalex.org/W2148391152","https://openalex.org/W2152710382","https://openalex.org/W2154745198","https://openalex.org/W2158583133","https://openalex.org/W2169074329","https://openalex.org/W2286124080","https://openalex.org/W2411582783","https://openalex.org/W2415539806","https://openalex.org/W2418643478"],"related_works":["https://openalex.org/W4235941427","https://openalex.org/W4319434003","https://openalex.org/W4378649688","https://openalex.org/W2110434557","https://openalex.org/W4225388213","https://openalex.org/W3046183383","https://openalex.org/W2805096634","https://openalex.org/W2410371459","https://openalex.org/W2559662133","https://openalex.org/W2149489418"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1,20],"has":[2],"become":[3],"increasingly":[4],"evident":[5],"that":[6,23,184],"disease":[7,56,243],"flares":[8],"in":[9,29,74,170,186,202,211,244],"the":[10,49,131,228,236],"human":[11],"inflammatory":[12,54,241],"bowel":[13,55,242],"diseases":[14],"are":[15,39,206],"influenced":[16],"by":[17,138,192,230],"life":[18,24,69,233],"stress.":[19,194],"is":[21],"known":[22],"stress":[25,91,234],"can":[26,189],"trigger":[27],"disturbances":[28],"intestinal":[30,43,116,212],"barrier":[31,117,213],"function":[32,214],"and":[33,45,81,98,122,142,148,164,238],"activate":[34],"proinflammatory":[35,119,144],"signaling":[36],"pathways,":[37],"which":[38,231],"important":[40],"contributors":[41],"to":[42,59,86,96,105,174,226],"inflammation":[44],"clinical":[46],"disease;":[47],"however,":[48,153],"exact":[50],"mechanisms":[51,197,229],"of":[52,67,72,108,133,198,240],"stress-induced":[53,70],"exacerbations":[57],"remain":[58],"be":[60,190],"elucidated.":[61],"Here,":[62],"we":[63],"presented":[64],"a":[65,217,223],"model":[66,225],"early":[68,232],"exacerbation":[71],"colitis":[73,114,134,140,185,200],"interleukin":[75],"(IL)-10":[76],"mice.":[77],"METHODS:":[78],"C57Bl/6":[79],"wild-type":[80],"IL-10":[82,135,149,171,187],"mice":[83,136,172,188,205],"were":[84,126,168],"exposed":[85,173],"neonatal":[87],"maternal":[88],"separation":[89],"(NMS)":[90],"on":[92],"postnatal":[93],"days":[94],"1":[95],"18":[97],"reared":[99],"under":[100],"normal":[101],"conditions":[102],"until":[103],"10":[104],"12":[106],"weeks":[107],"age.":[109],"At":[110],"this":[111],"time,":[112],"histopathology,":[113],"scores,":[115],"function,":[118],"cytokine":[120,145],"expression,":[121],"mast":[123,161,177],"cell":[124,162,178],"activity":[125],"evaluated.":[127],"RESULTS:":[128],"NMS":[129,147,154,193,203,220],"increased":[130,150],"severity":[132,201],"indicated":[137],"greater":[139],"scores":[141],"colonic":[143,151,165],"concentrations.":[146],"permeability;":[152],"alone":[155],"did":[156],"not":[157],"induce":[158],"colitis.":[159],"Increased":[160],"activation":[163],"tryptase":[166],"release":[167],"observed":[169],"NMS,":[175],"indicating":[176],"activation.":[179],"CONCLUSIONS:":[180],"This":[181],"study":[182],"demonstrates":[183],"exacerbated":[191],"The":[195],"precise":[196],"enhanced":[199],"IL10":[204],"unclear":[207],"but":[208],"persistent":[209],"defects":[210],"likely":[215],"play":[216],"contributing":[218],"role.":[219],"serves":[221],"as":[222],"novel":[224],"investigate":[227],"influences":[235],"development":[237],"course":[239],"adulthood.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}