{"id":"https://openalex.org/W2161815207","doi":"https://doi.org/10.1158/0008-5472.can-05-1470","title":"\u03b3-Aminobutyric Acid Inhibits Cholangiocarcinoma Growth by Cyclic AMP\u2013Dependent Regulation of the Protein Kinase A/Extracellular Signal-Regulated Kinase 1/2 Pathway","display_name":"\u03b3-Aminobutyric Acid Inhibits Cholangiocarcinoma Growth by Cyclic AMP\u2013Dependent Regulation of the Protein Kinase A/Extracellular Signal-Regulated Kinase 1/2 Pathway","publication_year":2005,"publication_date":"2005-12-15","ids":{"openalex":"https://openalex.org/W2161815207","doi":"https://doi.org/10.1158/0008-5472.can-05-1470","mag":"2161815207","pmid":"https://pubmed.ncbi.nlm.nih.gov/16357152"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-1470","doi":"https://doi.org/10.1158/0008-5472.can-05-1470","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-1470","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000874500","display_name":"Giammarco Fava","orcid":"https://orcid.org/0000-0001-6757-1420","observed_orcids":["https://orcid.org/0000-0001-6757-1420"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giammarco Fava","raw_affiliation_strings":["3Medical Physiology;","5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","3Medical Physiology;; 5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Physiology;","institution_ids":[]},{"raw_affiliation_string":"5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]},{"raw_affiliation_string":"3Medical Physiology;; 5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046762353","display_name":"Luca Marucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Marucci","raw_affiliation_strings":["5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045220703","display_name":"Shannon S. Glaser","orcid":"https://orcid.org/0000-0002-0749-773X","observed_orcids":["https://orcid.org/0000-0002-0749-773X"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Glaser","raw_affiliation_strings":["4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030400303","display_name":"Heather Francis","orcid":"https://orcid.org/0000-0002-3466-3545","observed_orcids":["https://orcid.org/0000-0002-3466-3545","https://orcid.org/0000-0001-5428-641X"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Francis","raw_affiliation_strings":["4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006837430","display_name":"Sharon De Morrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon De Morrow","raw_affiliation_strings":["4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division R&E, Scott & White Hospital and The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas;","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017879870","display_name":"A. Benedetti","orcid":"https://orcid.org/0000-0003-0280-4574","observed_orcids":["https://orcid.org/0000-0003-0280-4574"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Benedetti","raw_affiliation_strings":["5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081350888","display_name":"Domenico Alvaro","orcid":"https://orcid.org/0000-0003-3771-9644","observed_orcids":["https://orcid.org/0000-0003-3771-9644"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Alvaro","raw_affiliation_strings":["6Division of Gastroenterology, La Sapienza University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Division of Gastroenterology, La Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091026103","display_name":"Julie K Venter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Venter","raw_affiliation_strings":["3Medical Physiology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Physiology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030903200","display_name":"Cynthia J. Meininger","orcid":"https://orcid.org/0000-0002-1314-5044","observed_orcids":["https://orcid.org/0000-0002-1314-5044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia Meininger","raw_affiliation_strings":["3Medical Physiology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Physiology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080886228","display_name":"Tushar C. Patel","orcid":"https://orcid.org/0000-0001-7021-9532","observed_orcids":["https://orcid.org/0000-0001-7021-9532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tushar Patel","raw_affiliation_strings":["2Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053409585","display_name":"Silvia Taffetani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Taffetani","raw_affiliation_strings":["2Medicine and","5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","2Medicine and; 5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine and","institution_ids":[]},{"raw_affiliation_string":"5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]},{"raw_affiliation_string":"2Medicine and; 5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046759342","display_name":"Marco Marzioni","orcid":"https://orcid.org/0000-0001-6014-6165","observed_orcids":["https://orcid.org/0000-0001-6014-6165"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Marzioni","raw_affiliation_strings":["5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; and","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103574484","display_name":"Ryun Summers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryun Summers","raw_affiliation_strings":["3Medical Physiology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Physiology;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089352196","display_name":"Ramona Reichenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116927","display_name":"Central Texas Veterans Health Care System","ror":"https://ror.org/02dcp1550","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116927","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramona Reichenbach","raw_affiliation_strings":["1Central Texas Veterans Health Care System, Research Service; Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Central Texas Veterans Health Care System, Research Service; Departments of","institution_ids":["https://openalex.org/I4210116927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029205234","display_name":"Gianfranco D. Alpini","orcid":"https://orcid.org/0000-0002-6658-3021","observed_orcids":["https://orcid.org/0000-0002-6658-3021"]},"institutions":[{"id":"https://openalex.org/I4210116927","display_name":"Central Texas Veterans Health Care System","ror":"https://ror.org/02dcp1550","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116927","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianfranco Alpini","raw_affiliation_strings":["1Central Texas Veterans Health Care System, Research Service; Departments of","2Medicine and","3Medical Physiology;","1Central Texas Veterans Health Care System, Research Service; Departments of; 2Medicine and; 3Medical Physiology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Central Texas Veterans Health Care System, Research Service; Departments of","institution_ids":["https://openalex.org/I4210116927"]},{"raw_affiliation_string":"2Medicine and","institution_ids":[]},{"raw_affiliation_string":"3Medical Physiology;","institution_ids":[]},{"raw_affiliation_string":"1Central Texas Veterans Health Care System, Research Service; Departments of; 2Medicine and; 3Medical Physiology;","institution_ids":["https://openalex.org/I4210116927"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.2605,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.97384228,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"65","issue":"24","first_page":"11437","last_page":"11446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.5989999771118164},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gaba-receptors","display_name":"GABA receptors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6420000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":1.0},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6489999890327454},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.4819999933242798},{"id":"https://openalex.org/keywords/biliary-tract-cancer","display_name":"biliary tract cancer","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5787944197654724},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47193047404289246},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.45406171679496765},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4495375156402588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4378493130207062},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43214717507362366},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4314482808113098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3879457414150238},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38539159297943115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36498332023620605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31199508905410767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2219609022140503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13823872804641724},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018682","descriptor_name":"GABA Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042582","descriptor_name":"Vascular Endothelial Growth Factor C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-05-1470","doi":"https://doi.org/10.1158/0008-5472.can-05-1470","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-1470","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16357152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16357152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.8622","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.8622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/65/24/11437.full.pdf","raw_type":"text"},{"id":"pmh:oai:iris.uniroma1.it:11573/114531","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/114531","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/51785","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/51785","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1761912709","display_name":"TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSIS","funder_award_id":"R01DK058411","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2450932047","display_name":"Regulation of Bile Duct Growth in Bile Duct Ligated Rats","funder_award_id":"R01DK062975","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4228143868","display_name":"Aberrant kinase signaling in cholangiocarcinoma","funder_award_id":"R03DK060637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6509210190","display_name":"Mechanisms of survival signaling in biliary epithelia","funder_award_id":"R01DK069370","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W190352378","https://openalex.org/W912970237","https://openalex.org/W1506285409","https://openalex.org/W1642162311","https://openalex.org/W1825423094","https://openalex.org/W1855838686","https://openalex.org/W1915010695","https://openalex.org/W1922843138","https://openalex.org/W1964363319","https://openalex.org/W1964854188","https://openalex.org/W1967667628","https://openalex.org/W1970836813","https://openalex.org/W1974741720","https://openalex.org/W1974874748","https://openalex.org/W1974887744","https://openalex.org/W1976447190","https://openalex.org/W1976752775","https://openalex.org/W1988404173","https://openalex.org/W2009164637","https://openalex.org/W2009224840","https://openalex.org/W2020033147","https://openalex.org/W2023833232","https://openalex.org/W2026332484","https://openalex.org/W2032841846","https://openalex.org/W2037431673","https://openalex.org/W2043698030","https://openalex.org/W2044370664","https://openalex.org/W2048271629","https://openalex.org/W2053502586","https://openalex.org/W2062366983","https://openalex.org/W2065493935","https://openalex.org/W2066902251","https://openalex.org/W2073007713","https://openalex.org/W2074881736","https://openalex.org/W2076090601","https://openalex.org/W2085436522","https://openalex.org/W2088635282","https://openalex.org/W2094056353","https://openalex.org/W2097309438","https://openalex.org/W2106259279","https://openalex.org/W2117851005","https://openalex.org/W2133648805","https://openalex.org/W2138234756","https://openalex.org/W2158974754","https://openalex.org/W2162621296","https://openalex.org/W2169226263","https://openalex.org/W2286187793","https://openalex.org/W2397392406","https://openalex.org/W2398137194","https://openalex.org/W2415867315","https://openalex.org/W2416337448"],"related_works":["https://openalex.org/W7117996218","https://openalex.org/W2045295593","https://openalex.org/W991174953","https://openalex.org/W2047670144","https://openalex.org/W7096172906","https://openalex.org/W2588760044","https://openalex.org/W2386443964","https://openalex.org/W2052105501","https://openalex.org/W2162621296","https://openalex.org/W2522734760"],"abstract_inverted_index":{"We":[0,17],"studied":[1],"the":[2,5,12,19,26,29,39,66,80,181,198],"effect":[3,22,44],"of":[4,14,23,28,45,49,68,82,122,129,138,184,197],"inhibitory":[6],"neurotransmitter,":[7],"gamma-aminobutyric":[8],"acid":[9],"(GABA),":[10],"in":[11,20,62,100,104,147,167,171],"regulation":[13],"cholangiocarcinoma":[15,30,102,139],"growth.":[16],"determined":[18],"vitro":[21,101],"GABA":[24,46,69,98,136,141,174,186],"on":[25,47,70],"proliferation":[27,178],"cell":[31,74,144,154],"lines":[32],"(Mz-ChA-1,":[33],"HuH-28,":[34],"and":[35,37,65,79,88,107,116,132,156,179],"TFK-1)":[36],"evaluated":[38],"intracellular":[40],"pathways":[41],"involved.":[42],"The":[43],"migration":[48,145],"Mz-ChA-1":[50,57,143],"cells":[51,58],"was":[52,169],"also":[53],"evaluated.":[54],"In":[55],"vivo,":[56,148],"were":[59,93],"s.c.":[60],"injected":[61],"athymic":[63],"mice,":[64],"effects":[67],"tumor":[71,73,151,153],"size,":[72],"proliferation,":[75,155],"apoptosis,":[76],"collagen":[77,168],"quantity,":[78],"expression":[81,158],"vascular":[83],"endothelial":[84],"growth":[85,91,103],"factor-A":[86],"(VEGF-A)":[87],"VEGF-C":[89],"(cancer":[90],"regulators)":[92],"measured":[94],"after":[95],"82":[96],"days.":[97],"decreased":[99,150],"a":[105,189],"time-dependent":[106],"dose-dependent":[108],"manner,":[109],"by":[110,195],"both":[111],"cyclic":[112],"AMP/protein":[113],"kinase":[114,125],"A-":[115],"D-myo-inositol-1,4,5-thriphosphate/Ca(2+)-dependent":[117],"pathways,":[118],"leading":[119],"to":[120],"down-regulation":[121],"extracellular":[123],"signal-regulated":[124],"1/2":[126],"phosphorylation.":[127],"Blocking":[128],"GABA(A),":[130],"GABA(B),":[131],"GABA(C)":[133],"receptors":[134],"prevented":[135],"inhibition":[137],"proliferation.":[140],"inhibited":[142],"and,":[146],"significantly":[149],"volume,":[152],"VEGF-A/C":[157],"whereas":[159],"increasing":[160],"apoptosis":[161],"compared":[162],"with":[163],"controls.":[164],"An":[165],"increase":[166],"evident":[170],"GABA-treated":[172],"tumors.":[173],"decreases":[175],"biliary":[176,199],"cancer":[177],"reduces":[180],"metastatic":[182],"potential":[183],"cholangiocarcinoma.":[185],"may":[187],"represent":[188],"therapeutic":[190],"agent":[191],"for":[192],"patients":[193],"affected":[194],"malignancies":[196],"tract.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}