{"id":"https://openalex.org/W2161743092","doi":"https://doi.org/10.1124/dmd.111.038661","title":"In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury","display_name":"In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury","publication_year":2011,"publication_date":"2011-04-22","ids":{"openalex":"https://openalex.org/W2161743092","doi":"https://doi.org/10.1124/dmd.111.038661","mag":"2161743092","pmid":"https://pubmed.ncbi.nlm.nih.gov/21511944"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.111.038661","doi":"https://doi.org/10.1124/dmd.111.038661","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.111.038661","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001819436","display_name":"Toru Usui","orcid":"https://orcid.org/0000-0002-9536-9868","observed_orcids":["https://orcid.org/0000-0002-9536-9868"]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Usui","raw_affiliation_strings":["Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98, Kasugade-naka, Konohana-ku, Osaka, 554-0022, Japan. toru-usui@ds-pharma.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98, Kasugade-naka, Konohana-ku, Osaka, 554-0022, Japan. toru-usui@ds-pharma.co.jp","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110326699","display_name":"Takanori Hashizume","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takanori Hashizume","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109099594","display_name":"Takashi Katsumata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Katsumata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089297113","display_name":"Tsuyoshi Yokoi","orcid":"https://orcid.org/0000-0002-3239-2817","observed_orcids":["https://orcid.org/0000-0002-3239-2817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuyoshi Yokoi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036087532","display_name":"Setsuko Komuro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Setsuko Komuro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.3041,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76456532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"7","first_page":"1303","last_page":"1310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.3197999894618988,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troglitazone","display_name":"troglitazone","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.875},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glutathione-s-transferase-m1","display_name":"glutathione S-transferase M1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glutathione-s-transferase-t1","display_name":"glutathione S-transferase T1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gstm1-null-genotype","display_name":"GSTM1 null genotype","score":0.8259999752044678},{"id":"https://openalex.org/keywords/gstt1-null-genotype","display_name":"GSTT1 null genotype","score":0.9959999918937683},{"id":"https://openalex.org/keywords/covalent-attachment","display_name":"covalent binding","score":0.7900000214576721},{"id":"https://openalex.org/keywords/reactive-metabolites","display_name":"reactive metabolites","score":0.8799999952316284},{"id":"https://openalex.org/keywords/glutathione-adducts","display_name":"glutathione adducts","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cyp2c8","display_name":"CYP2C8","score":1.0},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/idiosyncratic-hepatotoxicity","display_name":"idiosyncratic hepatotoxicity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2778150266","wikidata":"https://www.wikidata.org/wiki/Q7844989","display_name":"Troglitazone","level":4,"score":0.9718953371047974},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.685003399848938},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.613410472869873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5378998517990112},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5232476592063904},{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.43919479846954346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39200130105018616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38720008730888367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3714730143547058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3261069059371948},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.1995406448841095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18270576000213623},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1121143102645874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06647774577140808},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06298154592514038}],"mesh":[{"descriptor_ui":"D000077288","descriptor_name":"Troglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1124/dmd.111.038661","doi":"https://doi.org/10.1124/dmd.111.038661","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.111.038661","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:21511944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21511944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1002.69","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1002.69","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/early/2011/04/21/dmd.111.038661.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.990.8034","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.990.8034","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/39/7/1303.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2404824160","display_name":"MicroRNAs as biomarkers for drug-induced liver injury","funder_award_id":"21390174","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1752789387","https://openalex.org/W1976411764","https://openalex.org/W1987144475","https://openalex.org/W1997485867","https://openalex.org/W1999587831","https://openalex.org/W2003268732","https://openalex.org/W2011726280","https://openalex.org/W2015114639","https://openalex.org/W2022078658","https://openalex.org/W2022472126","https://openalex.org/W2031374844","https://openalex.org/W2031896095","https://openalex.org/W2032170189","https://openalex.org/W2034467767","https://openalex.org/W2037073171","https://openalex.org/W2037335942","https://openalex.org/W2047759690","https://openalex.org/W2055409375","https://openalex.org/W2061290402","https://openalex.org/W2062934575","https://openalex.org/W2064848476","https://openalex.org/W2068408135","https://openalex.org/W2068532562","https://openalex.org/W2073903529","https://openalex.org/W2078268792","https://openalex.org/W2101016189","https://openalex.org/W2112617703","https://openalex.org/W2118316875","https://openalex.org/W2119581293","https://openalex.org/W2134992319","https://openalex.org/W2140639850","https://openalex.org/W2142462614","https://openalex.org/W2168659368","https://openalex.org/W2302091022","https://openalex.org/W2570635802","https://openalex.org/W4238581030"],"related_works":["https://openalex.org/W7096400488","https://openalex.org/W7098796000","https://openalex.org/W2134992319","https://openalex.org/W2108204857","https://openalex.org/W1972867324","https://openalex.org/W2022472126","https://openalex.org/W2015114639","https://openalex.org/W4247150639","https://openalex.org/W1976451160","https://openalex.org/W3025713078"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}