{"id":"https://openalex.org/W2161686980","doi":null,"title":"Predominant role for DNA damage in etoposide-induced cytotoxicity and cell cycle perturbation in human SV40-transformed fibroblasts.","display_name":"Predominant role for DNA damage in etoposide-induced cytotoxicity and cell cycle perturbation in human SV40-transformed fibroblasts.","publication_year":1986,"publication_date":"1986-11-01","ids":{"openalex":"https://openalex.org/W2161686980","mag":"2161686980","pmid":"https://pubmed.ncbi.nlm.nih.gov/3019531"},"language":"en","primary_location":{"id":"pmid:3019531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101837563","display_name":"Paul J. Smith","orcid":"https://orcid.org/0000-0002-1012-1530","observed_orcids":["https://orcid.org/0000-0002-1012-1530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018625214","display_name":"Catherine O. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C O Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J V Watson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J V Watson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8379,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85422915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"46","issue":"11","first_page":"5641","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.9120000004768372},{"id":"https://openalex.org/keywords/g2-cell-cycle-arrest","display_name":"G2 cell cycle arrest","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cell-cycle-perturbation","display_name":"cell cycle disruption","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sv40-transformed-fibroblasts","display_name":"SV40-transformed fibroblasts","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6947888135910034},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6425279378890991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5857821106910706},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5753461718559265},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5425279140472412},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.539667010307312},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5228676795959473},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5220215916633606},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.4685650169849396},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4498080015182495},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4150199294090271},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4136779308319092},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3834913671016693},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.325605571269989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24629056453704834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21959397196769714},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3019531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2161686980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1514525963","https://openalex.org/W1540266015","https://openalex.org/W1605264162","https://openalex.org/W1613283346","https://openalex.org/W1952290204","https://openalex.org/W1971206358","https://openalex.org/W1997383476","https://openalex.org/W2029159424","https://openalex.org/W2030677118","https://openalex.org/W2047505314","https://openalex.org/W2054438892","https://openalex.org/W2073983482","https://openalex.org/W2075906592","https://openalex.org/W2076374835","https://openalex.org/W2078242581","https://openalex.org/W2085288390","https://openalex.org/W2093375792","https://openalex.org/W2094452942","https://openalex.org/W2097422864","https://openalex.org/W2101429114","https://openalex.org/W2132380666","https://openalex.org/W2142153650","https://openalex.org/W2144737712","https://openalex.org/W2145381472","https://openalex.org/W2151938785","https://openalex.org/W2155007470","https://openalex.org/W2165536622","https://openalex.org/W2212360188"],"related_works":["https://openalex.org/W2048553452","https://openalex.org/W1952290204","https://openalex.org/W1973803579","https://openalex.org/W2430222126","https://openalex.org/W1574800669","https://openalex.org/W1854896859","https://openalex.org/W1983868543","https://openalex.org/W2158373964","https://openalex.org/W1540266015","https://openalex.org/W324947715"],"abstract_inverted_index":{"The":[0,131],"cytotoxic":[1],"and":[2,99,137,153,170,180,199,213],"cell":[3,46,108,132,162],"kinetic":[4],"effects":[5],"of":[6,23,135,148,156,182,196,206,216,229],"the":[7,21,81,95,106,146,154,178,183,194,204,214,217,226],"epipodophyllotoxin":[8],"4,6-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyr":[9],"anoside)":[10],"(VP-16)":[11],"in":[12,37,73,158,161,193],"cultured":[13],"mammalian":[14],"cells":[15,39,124,139,157,172],"are":[16,190],"thought":[17],"to":[18,20,33,140,209],"relate":[19],"induction":[22],"DNA":[24,27,113,165,208,211],"damage,":[25],"specifically":[26],"strand":[28,85,166],"interruptions.":[29],"In":[30,187],"an":[31,49,57],"effort":[32],"explore":[34],"this":[35],"relationship":[36],"human":[38,45,231],"we":[40],"have":[41,126],"identified":[42],"a":[43,71,100],"VP-16-hypersensitive":[44],"system,":[47],"namely":[48],"SV40-transformed":[50],"fibroblast":[51],"line":[52,109],"(AT5BIVA)":[53],"originally":[54],"derived":[55,78],"from":[56],"ataxia":[58],"telangiectasia":[59],"(AT)":[60],"patient.":[61],"Evidence":[62],"is":[63,120],"presented":[64],"that":[65,105,122,203],"enhanced":[66],"VP-16":[67,117,141],"sensitivity":[68,83,205],"may":[69,125,220],"be":[70,175,221],"consistent":[72],"vitro":[74],"feature":[75],"at":[76],"AT":[77,107,123,138,171],"cells.":[79],"However,":[80],"intrinsic":[82],"(DNA":[84],"breaks":[86],"per":[87],"lethal":[88],"hit":[89],"quantitated":[90],"by":[91],"nucleoid":[92],"sedimentation)":[93],"was":[94],"same":[96],"for":[97,224],"AT5BIVA":[98],"corresponding":[101],"normal":[102,136,169],"control,":[103],"indicating":[104],"accumulated":[110],"more":[111],"drug-induced":[112],"damage":[114,212],"during":[115],"short-term":[116],"exposures.":[118],"It":[119],"suggested":[121],"abnormal":[127],"topoisomerase":[128],"II":[129],"activity.":[130],"cycle":[133],"responses":[134],"exposure":[142],"were":[143],"complex,":[144],"with":[145,177],"generation":[147],"parasynchronous":[149],"S":[150],"phase":[151],"populations":[152],"accumulation":[155],"G2.":[159],"Differences":[160],"killing":[163],"or":[164],"breakage":[167],"between":[168],"could":[173],"only":[174],"correlated":[176],"magnitude":[179],"kinetics":[181,215],"G2":[184,218],"retention":[185],"phenomenon.":[186],"short,":[188],"there":[189],"several":[191],"similarities":[192],"action":[195],"ionizing":[197],"radiation":[198],"VP-16.":[200],"We":[201],"suggest":[202],"cellular":[207],"VP-16-induced":[210],"delay":[219],"useful":[222],"parameters":[223],"predicting":[225],"survival":[227],"probability":[228],"drug-treated":[230],"tumor":[232],"populations.":[233]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}