{"id":"https://openalex.org/W2161558029","doi":"https://doi.org/10.1128/aac.00963-09","title":"Acinetobacter baumannii Increases Tolerance to Antibiotics in Response to Monovalent Cations","display_name":"Acinetobacter baumannii Increases Tolerance to Antibiotics in Response to Monovalent Cations","publication_year":2009,"publication_date":"2009-12-23","ids":{"openalex":"https://openalex.org/W2161558029","doi":"https://doi.org/10.1128/aac.00963-09","mag":"2161558029","pmid":"https://pubmed.ncbi.nlm.nih.gov/20028819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825970"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00963-09","doi":"https://doi.org/10.1128/aac.00963-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00963-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110187605","display_name":"Marguerite Indriati Hood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Indriati Hood","raw_affiliation_strings":["Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2363"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2363","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040927107","display_name":"Anna C. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna C. Jacobs","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042195176","display_name":"Khalid Sayood","orcid":"https://orcid.org/0000-0001-8010-5272","observed_orcids":["https://orcid.org/0000-0001-8010-5272"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalid Sayood","raw_affiliation_strings":["Department of Electrical Engineering, University of Nebraska, Lincoln, Nebraska 68588-0511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Nebraska, Lincoln, Nebraska 68588-0511","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056534291","display_name":"Paul M. Dunman","orcid":"https://orcid.org/0000-0001-5138-521X","observed_orcids":["https://orcid.org/0000-0001-5138-521X"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Dunman","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082616273","display_name":"Eric Patrick Skaar","orcid":"https://orcid.org/0000-0001-5094-8105","observed_orcids":["https://orcid.org/0000-0001-5094-8105","https://orcid.org/0000-0002-6533-2458"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric P. Skaar","raw_affiliation_strings":["Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2363"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2363","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082616273"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":2.1016,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.84951456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"54","issue":"3","first_page":"1029","last_page":"1041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/monovalent-cations","display_name":"monovalent cations","score":0.8820000290870667},{"id":"https://openalex.org/keywords/outer-membrane-porins","display_name":"outer membrane porins","score":0.6899999976158142},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8270000219345093},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/colistin-resistance","display_name":"colistin resistance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.9330000281333923},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/quinolone-resistance","display_name":"quinolone resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":0.8090000152587891},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/efflux-pump-inhibitors","display_name":"efflux pump inhibitors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.9730967283248901},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.8168497681617737},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.7978920936584473},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7458435297012329},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.7280997037887573},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5884032249450684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5476821660995483},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5263304114341736},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.4617837071418762},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.45896339416503906},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.44465166330337524},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.4272030293941498},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.2740122377872467},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.19780558347702026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17113080620765686}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002414","descriptor_name":"Cations, Monovalent","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040981","descriptor_name":"Acinetobacter baumannii","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D040981","descriptor_name":"Acinetobacter baumannii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040981","descriptor_name":"Acinetobacter baumannii","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D040981","descriptor_name":"Acinetobacter baumannii","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.00963-09","doi":"https://doi.org/10.1128/aac.00963-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00963-09","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2825970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:20028819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20028819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2825970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3834006785","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007347","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W611976593","https://openalex.org/W1522929799","https://openalex.org/W1598844438","https://openalex.org/W1963893739","https://openalex.org/W1964799586","https://openalex.org/W1983888098","https://openalex.org/W1990273811","https://openalex.org/W2009373774","https://openalex.org/W2023178925","https://openalex.org/W2037248614","https://openalex.org/W2041752174","https://openalex.org/W2043185974","https://openalex.org/W2044746614","https://openalex.org/W2045110384","https://openalex.org/W2045605530","https://openalex.org/W2045792955","https://openalex.org/W2087184445","https://openalex.org/W2090084793","https://openalex.org/W2097700470","https://openalex.org/W2100141503","https://openalex.org/W2100837269","https://openalex.org/W2107250776","https://openalex.org/W2107347870","https://openalex.org/W2112903691","https://openalex.org/W2115486016","https://openalex.org/W2115806913","https://openalex.org/W2124486591","https://openalex.org/W2124804822","https://openalex.org/W2126480284","https://openalex.org/W2126504345","https://openalex.org/W2126984210","https://openalex.org/W2135923259","https://openalex.org/W2136700350","https://openalex.org/W2139321752","https://openalex.org/W2140381975","https://openalex.org/W2144010762","https://openalex.org/W2144038123","https://openalex.org/W2150295817","https://openalex.org/W2152683133","https://openalex.org/W2153969539","https://openalex.org/W2155031737","https://openalex.org/W2157226414","https://openalex.org/W2158146180","https://openalex.org/W2159435953","https://openalex.org/W2162191692","https://openalex.org/W2166899404","https://openalex.org/W2168052711","https://openalex.org/W2172046337","https://openalex.org/W2188533673","https://openalex.org/W2398098078"],"related_works":["https://openalex.org/W2404422304","https://openalex.org/W2331165028","https://openalex.org/W2553964711","https://openalex.org/W6926973974","https://openalex.org/W4390744413","https://openalex.org/W1872996651","https://openalex.org/W2468087508","https://openalex.org/W4381165150","https://openalex.org/W7099590609","https://openalex.org/W2156867488"],"abstract_inverted_index":{"Acinetobacter":[0],"baumannii":[1,37,93,103,194,235],"is":[2,130],"well":[3],"adapted":[4],"to":[5,47,82,123,148,170,182,245,253],"the":[6,32,52,60,89,107,142,145,175,180,190,222],"hospital":[7,53],"environment,":[8],"where":[9],"infections":[10],"caused":[11],"by":[12,34,152],"this":[13,67],"organism":[14],"are":[15,165],"associated":[16,131],"with":[17,132,173,195],"significant":[18,80],"morbidity":[19],"and":[20,86,120,184],"mortality.":[21],"Genetic":[22],"determinants":[23],"of":[24,63,91,101,109,177,192,202,205,215,218,225],"antimicrobial":[25],"resistance":[26,40,61,209],"have":[27,41,70],"been":[28,43],"described":[29],"extensively,":[30],"yet":[31],"mechanisms":[33],"which":[35],"A.":[36,64,92,102,193,219,234],"regulates":[38],"antibiotic":[39,133],"not":[42],"defined.":[44],"We":[45],"sought":[46],"identify":[48],"signals":[49],"encountered":[50],"within":[51],"setting":[54],"or":[55,128],"human":[56],"host":[57],"that":[58,78,164,233],"alter":[59],"phenotype":[62],"baumannii.":[65],"In":[66],"regard,":[68],"we":[69],"identified":[71],"NaCl":[72,97,138,149,178,206,247],"as":[73],"being":[74],"an":[75,196],"important":[76],"signal":[77],"induces":[79],"tolerance":[81,181,252],"aminoglycosides,":[83],"carbapenems,":[84],"quinolones,":[85],"colistin":[87,208],"upon":[88,189],"culturing":[90],"cells":[94],"in":[95,113,168,212,237,243,250],"physiological":[96,203,246],"concentrations.":[98],"Proteomic":[99],"analyses":[100,156],"culture":[104],"supernatants":[105],"revealed":[106],"release":[108],"outer":[110],"membrane":[111],"proteins":[112],"high":[114],"NaCl,":[115],"including":[116],"two":[117],"porins":[118],"(CarO":[119],"a":[121,213,239],"33-":[122],"36-kDa":[124],"protein)":[125],"whose":[126],"loss":[127],"inactivation":[129],"resistance.":[134],"To":[135],"determine":[136],"if":[137],"affected":[139],"expression":[140],"at":[141],"transcriptional":[143,146],"level,":[144],"response":[147,169,244],"was":[150,186,210],"determined":[151],"microarray":[153],"analyses.":[154],"These":[155],"highlighted":[157],"18":[158],"genes":[159],"encoding":[160],"putative":[161],"efflux":[162,197],"transporters":[163],"significantly":[166,187],"upregulated":[167],"NaCl.":[171],"Consistent":[172],"this,":[174],"effect":[176,201],"on":[179,207],"levofloxacin":[183],"amikacin":[185],"reduced":[188],"treatment":[191],"pump":[198],"inhibitor.":[199],"The":[200],"concentrations":[204],"conserved":[211],"panel":[214],"multidrug-resistant":[216],"isolates":[217],"baumannii,":[220],"underscoring":[221],"clinical":[223],"significance":[224],"these":[226,230],"observations.":[227],"Taken":[228],"together,":[229],"data":[231],"demonstrate":[232],"sets":[236],"motion":[238],"global":[240],"regulatory":[241],"cascade":[242],"concentrations,":[248],"resulting":[249],"broad-spectrum":[251],"antibiotics.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}