{"id":"https://openalex.org/W2161539906","doi":"https://doi.org/10.1177/1470320312437893","title":"Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression","display_name":"Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression","publication_year":2012,"publication_date":"2012-03-13","ids":{"openalex":"https://openalex.org/W2161539906","doi":"https://doi.org/10.1177/1470320312437893","mag":"2161539906","pmid":"https://pubmed.ncbi.nlm.nih.gov/22415888"},"language":"en","primary_location":{"id":"doi:10.1177/1470320312437893","doi":"https://doi.org/10.1177/1470320312437893","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1470320312437893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1470320312437893","source":{"id":"https://openalex.org/S107472416","display_name":"Journal of the Renin-Angiotensin-Aldosterone System","issn_l":"1470-3203","issn":["1470-3203","1752-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1470320312437893","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015556779","display_name":"Orly Vardeny","orcid":"https://orcid.org/0000-0002-6387-1351","observed_orcids":["https://orcid.org/0000-0002-6387-1351"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orly Vardeny","raw_affiliation_strings":["University of Wisconsin School of Pharmacy, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Pharmacy, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016177618","display_name":"Anne\u2013Catherine Pouleur","orcid":"https://orcid.org/0000-0002-2395-1787","observed_orcids":["https://orcid.org/0000-0002-2395-1787"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne-Catherine Pouleur","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113800251","display_name":"Madoka Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madoka Takeuchi","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063645025","display_name":"Evan A. Appelbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Appelbaum","raw_affiliation_strings":["Beth Israel Deaconess Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Hospital, Boston, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034644073","display_name":"Anil Kumar Verma","orcid":"https://orcid.org/0000-0002-3105-4138","observed_orcids":["https://orcid.org/0000-0002-3105-4138"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Verma","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012641937","display_name":"MARGARET FORNEY PRESCOTT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Prescott","raw_affiliation_strings":["Novartis, East Hanover, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, East Hanover, USA","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105024498","display_name":"Beverly A. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly Smith","raw_affiliation_strings":["Novartis, East Hanover, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, East Hanover, USA","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034825133","display_name":"Bj\u00f6rn Dahl\u00f6f","orcid":"https://orcid.org/0000-0001-6050-388X","observed_orcids":["https://orcid.org/0000-0001-6050-388X"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bjorn Dahlof","raw_affiliation_strings":["Sahlgrenska University Hospital/\u00d6stra, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sahlgrenska University Hospital/\u00d6stra, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054830306","display_name":"Scott David Solomon","orcid":"https://orcid.org/0000-0003-3698-9597","observed_orcids":["https://orcid.org/0000-0003-3698-9597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D Solomon","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":null,"display_name":"(for the ALLAY Investigators)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"(for the ALLAY Investigators)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.821,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.79120124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"2","first_page":"265","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/left-ventricular-mass-regression","display_name":"left ventricular mass regression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/aliskiren","display_name":"aliskiren","score":0.9869999885559082},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":1.0},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8059999942779541},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.8980000019073486},{"id":"https://openalex.org/keywords/renin-activity","display_name":"renin activity","score":0.5139999985694885},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.9467540979385376},{"id":"https://openalex.org/C2779838083","wikidata":"https://www.wikidata.org/wiki/Q414904","display_name":"Aliskiren","level":4,"score":0.8909363150596619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.77765953540802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7689328193664551},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.7681889533996582},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6029557585716248},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5769267678260803},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5296654105186462},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5072314739227295},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.49271538853645325},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.48821285367012024},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.44012755155563354}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005650","descriptor_name":"Fumarates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005650","descriptor_name":"Fumarates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/1470320312437893","doi":"https://doi.org/10.1177/1470320312437893","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1470320312437893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1470320312437893","source":{"id":"https://openalex.org/S107472416","display_name":"Journal of the Renin-Angiotensin-Aldosterone System","issn_l":"1470-3203","issn":["1470-3203","1752-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System","raw_type":"journal-article"},{"id":"pmid:22415888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22415888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:122432","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/122432","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System, Vol. 13, no. 2, p. 265-272 (2012)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:427051bde93340a3961ea80a3fc34b66","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/427051bde93340a3961ea80a3fc34b66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System, Vol 13 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1470320312437893","doi":"https://doi.org/10.1177/1470320312437893","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1470320312437893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1470320312437893","source":{"id":"https://openalex.org/S107472416","display_name":"Journal of the Renin-Angiotensin-Aldosterone System","issn_l":"1470-3203","issn":["1470-3203","1752-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Renin-Angiotensin-Aldosterone System","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161539906.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W137431462","https://openalex.org/W180946569","https://openalex.org/W1968563590","https://openalex.org/W1977152294","https://openalex.org/W1977810373","https://openalex.org/W1985957699","https://openalex.org/W2003670762","https://openalex.org/W2008255759","https://openalex.org/W2008494063","https://openalex.org/W2008880079","https://openalex.org/W2012577336","https://openalex.org/W2029339674","https://openalex.org/W2031802566","https://openalex.org/W2039432504","https://openalex.org/W2039642014","https://openalex.org/W2064303441","https://openalex.org/W2066990527","https://openalex.org/W2093276210","https://openalex.org/W2106609827","https://openalex.org/W2114498807","https://openalex.org/W2115334126","https://openalex.org/W2118668550","https://openalex.org/W2118795360","https://openalex.org/W2122205824","https://openalex.org/W2125524254","https://openalex.org/W2127154429","https://openalex.org/W2128451215","https://openalex.org/W2129896045","https://openalex.org/W2131670561","https://openalex.org/W2133012200","https://openalex.org/W2137177722","https://openalex.org/W2139757550","https://openalex.org/W2145632481","https://openalex.org/W2145989856","https://openalex.org/W2155573254","https://openalex.org/W2156121263","https://openalex.org/W2163991033","https://openalex.org/W2166155176","https://openalex.org/W2170415924","https://openalex.org/W2334499091","https://openalex.org/W2337454357","https://openalex.org/W2615684303","https://openalex.org/W3021250193"],"related_works":["https://openalex.org/W2118795360","https://openalex.org/W2131178128","https://openalex.org/W2122205824","https://openalex.org/W6997952609","https://openalex.org/W2040951160","https://openalex.org/W7144688495","https://openalex.org/W104073616","https://openalex.org/W2116981106","https://openalex.org/W2057894304","https://openalex.org/W2088639601"],"abstract_inverted_index":{"UNLABELLED:":[0],"HYPOTHESIS/":[1],"INTRODUCTION:":[2],"We":[3],"investigated":[4],"whether":[5],"diabetes":[6,86],"modified":[7],"the":[8,25],"effectiveness":[9],"of":[10,81,162,197],"renin-angiotensin-aldosterone":[11],"system":[12],"(RAAS)":[13],"inhibition":[14,193],"on":[15],"left":[16],"ventricular":[17],"hypertrophy":[18],"(LVH)":[19],"regression":[20,61],"in":[21,24,27,78,140,147,173,215,222],"hypertensive":[22],"patients":[23,141,148,174],"Aliskiren":[26],"Left":[28],"Ventricular":[29],"Hypertrophy":[30],"(ALLAY)":[31],"trial.":[32],"MATERIALS":[33],"AND":[34],"METHODS:":[35],"Participants":[36],"(n=465)":[37],"with":[38,85,127,133,142,175,182,190,194,202,205],"LVH":[39,60,135,185,208],"and":[40,59,74,116,184,199],"a":[41,79,160,170,195],"BMI":[42,100],">":[43],"25":[44],"kg/m(2)":[45],"were":[46,76,91],"randomized":[47],"to":[48,169,207],"aliskiren":[49,128,198],"300mg,":[50],"losartan":[51,130,138,200,203],"100mg":[52],"or":[53],"both":[54],"daily":[55],"for":[56],"36":[57],"weeks,":[58],"was":[62,131,167],"assessed":[63,77],"by":[64],"cardiac":[65],"magnetic":[66],"resonance":[67],"imaging.":[68],"Renin":[69],"concentration,":[70],"plasma":[71,165],"renin":[72],"activity":[73],"aldosterone":[75,166],"subset":[80,161],"patients.":[82],"RESULTS:":[83],"Patients":[84,181],"mellitus":[87],"(DM)":[88],"(n=111,":[89],"24%)":[90],"older":[92],"(61\u00b19":[93],"vs.":[94,102,113,120],"58\u00b111":[95],"years,":[96],"p=0.03),":[97],"had":[98],"higher":[99,108],"(32.2\u00b14.2":[101],"30.7":[103],"\u00b1":[104],"4":[105],"kg/m(2),":[106],"p=0.004),":[107],"systolic":[109],"blood":[110],"pressure":[111],"(148\u00b114":[112],"145\u00b114mmHg,":[114],"p=0.03)":[115,122],"lower":[117],"eGFR":[118],"(79\u00b116":[119],"84\u00b116ml/min,":[121],"at":[123],"baseline.":[124],"Combination":[125],"therapy":[126],"plus":[129],"associated":[132],"greater":[134,171],"reduction":[136],"than":[137],"alone":[139,204],"DM":[143,150,176,183],"(p=0.01),":[144],"but":[145],"not":[146],"without":[149],"(p=0.91;":[151],"unadjusted":[152],"interaction":[153],"p=0.06;":[154],"adjusted":[155],"p":[156],"=":[157,178],"0.038).":[158],"In":[159],"138":[163],"participants,":[164],"reduced":[168],"extent":[172],"(p-interaction":[177],"0.004).":[179],"CONCLUSIONS:":[180],"may":[186],"derive":[187],"differential":[188],"benefit":[189],"dual":[191],"RAAS":[192],"combination":[196],"compared":[201],"respect":[206],"reduction.":[209],"Whether":[210],"these":[211],"findings":[212],"will":[213,218],"result":[214],"improved":[216],"outcomes":[217],"be":[219],"further":[220],"explored":[221],"larger":[223],"studies.":[224]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}