{"id":"https://openalex.org/W2161404060","doi":"https://doi.org/10.1097/01.ju.0000153619.33446.60","title":"ULTRASENSITIVE SERUM PROSTATE SPECIFIC ANTIGEN NADIR ACCURATELY PREDICTS THE RISK OF EARLY RELAPSE AFTER RADICAL PROSTATECTOMY","display_name":"ULTRASENSITIVE SERUM PROSTATE SPECIFIC ANTIGEN NADIR ACCURATELY PREDICTS THE RISK OF EARLY RELAPSE AFTER RADICAL PROSTATECTOMY","publication_year":2005,"publication_date":"2005-02-11","ids":{"openalex":"https://openalex.org/W2161404060","doi":"https://doi.org/10.1097/01.ju.0000153619.33446.60","mag":"2161404060","pmid":"https://pubmed.ncbi.nlm.nih.gov/15711268"},"language":"en","primary_location":{"id":"doi:10.1097/01.ju.0000153619.33446.60","doi":"https://doi.org/10.1097/01.ju.0000153619.33446.60","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0000153619.33446.60","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057745568","display_name":"Samson Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SAMSON SHEN","raw_affiliation_strings":["From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011556876","display_name":"Herbert Lepor","orcid":"https://orcid.org/0000-0002-7839-835X","observed_orcids":["https://orcid.org/0000-0002-7839-835X"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HERBERT LEPOR","raw_affiliation_strings":["From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070102078","display_name":"Robert A. Yaffee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT YAFFEE","raw_affiliation_strings":["From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062397416","display_name":"Samir S. Taneja","orcid":"https://orcid.org/0000-0003-0887-8259","observed_orcids":["https://orcid.org/0000-0003-0887-8259"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SAMIR S. TANEJA","raw_affiliation_strings":["From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, New York University and Statistics and Social Sciences Group, New York University Academic Computing Services (RY), New York, New York","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.4377,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.92579153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"173","issue":"3","first_page":"777","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psa-nadir","display_name":"PSA nadir","score":0.9300000071525574},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.875},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.8240000009536743},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/early-relapse-prediction","display_name":"early relapse prediction","score":0.7279999852180481},{"id":"https://openalex.org/keywords/postoperative-follow-up","display_name":"postoperative follow-up","score":0.4819999933242798},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6359999775886536},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6449999809265137},{"id":"https://openalex.org/keywords/time-to-relapse","display_name":"time to relapse","score":0.6819999814033508},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.42800000309944153},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.5559999942779541},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4359999895095825},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.4740000069141388},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9397155046463013},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.8456641435623169},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.7659441828727722},{"id":"https://openalex.org/C88575799","wikidata":"https://www.wikidata.org/wiki/Q145825","display_name":"Nadir","level":3,"score":0.7559219598770142},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6539520025253296},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5150999426841736},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3439347743988037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.327123761177063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.058801740407943726},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C19269812","wikidata":"https://www.wikidata.org/wiki/Q26540","display_name":"Satellite","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/01.ju.0000153619.33446.60","doi":"https://doi.org/10.1097/01.ju.0000153619.33446.60","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0000153619.33446.60","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:15711268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15711268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"},{"id":"pmid:16145486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16145486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W69788875","https://openalex.org/W155375076","https://openalex.org/W165132104","https://openalex.org/W1883868988","https://openalex.org/W1981110065","https://openalex.org/W2009576939","https://openalex.org/W2015274841","https://openalex.org/W2062576898","https://openalex.org/W2086878322","https://openalex.org/W2092624204","https://openalex.org/W2100531189","https://openalex.org/W2106493686","https://openalex.org/W4242531351","https://openalex.org/W4252605154","https://openalex.org/W4293658047","https://openalex.org/W4294715705","https://openalex.org/W4295773257"],"related_works":["https://openalex.org/W2794217698","https://openalex.org/W2021860137","https://openalex.org/W2009880745","https://openalex.org/W1883868988","https://openalex.org/W1990792205","https://openalex.org/W1988513079","https://openalex.org/W2137590869","https://openalex.org/W2744948834","https://openalex.org/W4233318803","https://openalex.org/W2047850607"],"abstract_inverted_index":{"PURPOSE:":[0],"Ultrasensitive":[1,255],"prostate":[2],"specific":[3],"antigen":[4],"(PSA)":[5],"assays":[6],"allow":[7],"a":[8,71,128,143,156,183,191,199,221,247,271,279],"lower":[9,193],"limit":[10],"of":[11,28,44,74,105,112,131,135,148,159,185,201,223,242,249,262,273,282],"detection":[12],"(less":[13],"than":[14,17,76,161,187,196,251,275],"0.01":[15,77,162,164,188,202,224,252,276],"ng/ml)":[16],"standard":[18],"PSA":[19,30,53,72,85,92,103,114,157,256],"assays.":[20],"In":[21],"this":[22],"study":[23],"we":[24],"examined":[25],"the":[26,65,260],"ability":[27,111],"ultrasensitive":[29,84,113],"nadir":[31,73,115,158,184,200,222,248,257,272,286],"to":[32,116,146,246],"predict":[33,117],"relapse":[34,95,118,141,147,194,244,265],"after":[35],"radical":[36],"prostatectomy":[37],"(RP).":[38],"MATERIALS":[39],"AND":[40],"METHODS:":[41],"A":[42],"total":[43],"906":[45,66],"men":[46,67,137,154,197],"treated":[47],"with":[48,52,70,142,155,182,198],"RP":[49],"were":[50,174],"followed":[51],"measurements":[54,86,104],"at":[55,80],"3,":[56],"6":[57],"and":[58,61,89,123,168,178,230],"12":[59],"months,":[60],"yearly":[62],"thereafter.":[63],"Of":[64],"545":[68,136],"(60%)":[69],"less":[75,160,186,250,274],"ng/ml":[78,107,172,189,212,234,277],"or":[79,108,170,208,210,232,294],"least":[81],"3":[82],"followup":[83,130],"underwent":[87],"analysis":[88,218],"stratification":[90],"by":[91,121],"nadir.":[93],"Biochemical":[94],"was":[96,119],"defined":[97],"as":[98],"2":[99],"consecutive":[100],"increasing":[101],"post-nadir":[102],"0.1":[106],"greater.":[109],"The":[110],"assessed":[120],"univariate":[122],"multivariate":[124],"analysis.":[125],"RESULTS:":[126],"At":[127],"mean":[129,144],"3.1":[132],"years":[133],"54":[134],"(9.9%)":[138],"experienced":[139],"biochemical":[140,243,264],"time":[145],"25.2":[149],"months.":[150],"Relapse":[151],"rates":[152],"in":[153],"(423),":[163],"(75),":[165],"0.02":[166,205,227],"(19)":[167],"0.04":[169,209,231],"greater":[171,211,233],"(28)":[173],"4%,":[175],"12%,":[176],"16%":[177],"89%,":[179],"respectively.":[180],"Men":[181,268],"had":[190],"significantly":[192],"rate":[195],"(p":[203,206,213,225,228,235],"<0.01),":[204],"<0.025)":[207],"<0.01).":[214],"Multivariate":[215],"logistic":[216],"regression":[217],"showed":[219],"that":[220],"<0.05),":[226],"<0.05)":[229],"<0.01)":[236],"independently":[237],"predicted":[238],"an":[239],"increased":[240],"risk":[241,261],"compared":[245],"ng/ml.":[253],"CONCLUSIONS:":[254],"accurately":[258],"predicts":[259],"early":[263,283,292],"following":[266],"RP.":[267],"who":[269],"achieve":[270],"have":[278],"low":[280],"likelihood":[281],"relapse.":[284],"Higher":[285],"points":[287],"may":[288],"identify":[289],"candidates":[290],"for":[291],"adjuvant":[293],"salvage":[295],"therapies.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}