{"id":"https://openalex.org/W2161286419","doi":"https://doi.org/10.1128/aac.03923-14","title":"The Novel Immunotherapeutic Oligodeoxynucleotide IMT504 Protects Neutropenic Animals from Fatal Pseudomonas aeruginosa Bacteremia and Sepsis","display_name":"The Novel Immunotherapeutic Oligodeoxynucleotide IMT504 Protects Neutropenic Animals from Fatal Pseudomonas aeruginosa Bacteremia and Sepsis","publication_year":2014,"publication_date":"2014-12-16","ids":{"openalex":"https://openalex.org/W2161286419","doi":"https://doi.org/10.1128/aac.03923-14","mag":"2161286419","pmid":"https://pubmed.ncbi.nlm.nih.gov/25512413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335857"},"language":"en","primary_location":{"id":"doi:10.1128/aac.03923-14","doi":"https://doi.org/10.1128/aac.03923-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.03923-14","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335857","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044576003","display_name":"Abdullah B. Chahin","orcid":"https://orcid.org/0000-0001-8209-4984","observed_orcids":["https://orcid.org/0000-0001-8209-4984"]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah Chahin","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025379878","display_name":"Steven M. Opal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Opal","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024194182","display_name":"Jorge Zorz\u00f3pulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Zorzopulos","raw_affiliation_strings":["Immunotech, SA, and Bioadvisory, SA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotech, SA, and Bioadvisory, SA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007077539","display_name":"David V. Jobes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David V. Jobes","raw_affiliation_strings":["Mid-Atlantic BioTherapeutics, Doylestown, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-Atlantic BioTherapeutics, Doylestown, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081952169","display_name":"Yazan Migdady","orcid":"https://orcid.org/0000-0001-8216-7709","observed_orcids":["https://orcid.org/0000-0001-8216-7709"]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yazan Migdady","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003087287","display_name":"Michelle Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Yamamoto","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057334371","display_name":"Nicholas A. Parejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Parejo","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192921","display_name":"John E. Palardy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Palardy","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of Rhode Island and Alpert Medical School, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I2801290373"]}]},{"author_position":"last","author":{"id":null,"display_name":"David L. Horn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Horn","raw_affiliation_strings":["David Horn LLC, Doylestown, Pennsylvania, USA","Mid-Atlantic BioTherapeutics, Doylestown, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Horn LLC, Doylestown, Pennsylvania, USA","institution_ids":[]},{"raw_affiliation_string":"Mid-Atlantic BioTherapeutics, Doylestown, Pennsylvania, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1641,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79433968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"2","first_page":"1225","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.11259999871253967,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.996999979019165},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cyclophosphamide-induced-neutropenia","display_name":"cyclophosphamide-induced neutropenia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.8187385201454163},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7730415463447571},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7404922246932983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7160789966583252},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6523703336715698},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6415736675262451},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5221519470214844},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.4572337567806244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4169299602508545},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37318605184555054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29541948437690735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.155195951461792},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.11715137958526611},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10206162929534912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.03923-14","doi":"https://doi.org/10.1128/aac.03923-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.03923-14","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4335857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:25512413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25512413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.968.7017","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.968.7017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/59/2/1225.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4335857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1553307340","https://openalex.org/W1685574292","https://openalex.org/W1823321223","https://openalex.org/W1991180061","https://openalex.org/W2008112413","https://openalex.org/W2012799448","https://openalex.org/W2026170842","https://openalex.org/W2033221791","https://openalex.org/W2041461587","https://openalex.org/W2051613953","https://openalex.org/W2057854986","https://openalex.org/W2061061112","https://openalex.org/W2061729558","https://openalex.org/W2075057361","https://openalex.org/W2104415072","https://openalex.org/W2109417879","https://openalex.org/W2115505766","https://openalex.org/W2116140206","https://openalex.org/W2118011548","https://openalex.org/W2125045881","https://openalex.org/W2138763270","https://openalex.org/W2140353364","https://openalex.org/W2149054533","https://openalex.org/W2157758657","https://openalex.org/W2160810031","https://openalex.org/W2162428378","https://openalex.org/W2163518379","https://openalex.org/W2168168071","https://openalex.org/W2312633134","https://openalex.org/W2412277735","https://openalex.org/W2442246762","https://openalex.org/W2581605534","https://openalex.org/W3023757607"],"related_works":["https://openalex.org/W7097832189","https://openalex.org/W2318351701","https://openalex.org/W1972869781","https://openalex.org/W2070256101","https://openalex.org/W2171106090","https://openalex.org/W2148860016","https://openalex.org/W7100124754","https://openalex.org/W2469589034","https://openalex.org/W2259506816","https://openalex.org/W344063598"],"abstract_inverted_index":{"IMT504":[0,17,86,101,151,160,169,199,202],"is":[1],"a":[2,21,88,104,205,221],"novel":[3],"immunomodulatory":[4],"oligonucleotide":[5],"that":[6],"has":[7],"shown":[8],"immunotherapeutic":[9],"properties":[10],"in":[11,20,41,52,133,209,213,225],"early":[12,96],"preclinical":[13],"and":[14,29,81,92,97,131,138,144,211,216,236],"clinical":[15],"studies.":[16],"was":[18,50,124,153,171,193],"tested":[19],"neutropenic":[22,42,69,214],"rat":[23],"model":[24],"of":[25,36,55,72,90,129,136,142,190,198],"Pseudomonas":[26],"aeruginosa":[27,77],"bacteremia":[28,210],"sepsis.":[30,237],"This":[31],"animal":[32],"system":[33],"recapitulates":[34],"many":[35],"the":[37,53,109,115,122,127,134,140],"pathological":[38],"processes":[39],"found":[40],"patients":[43,226],"with":[44,75,114,118,159,195],"Gram-negative,":[45],"bacterial":[46,234],"infections.":[47],"The":[48,60],"research":[49,58],"conducted":[51],"setting":[54],"an":[56],"academic":[57],"laboratory.":[59],"test":[61],"subjects":[62],"were":[63,67],"Sprague-Dawley":[64],"rats.":[65],"Animals":[66],"rendered":[68],"by":[70,78],"administration":[71],"cyclophosphamide,":[73],"colonized":[74],"P.":[76],"oral":[79],"feeding,":[80],"then":[82],"randomized":[83],"to":[84],"receive":[85],"over":[87,108],"range":[89],"doses":[91],"treatment":[93,223],"regimens":[94],"representing":[95],"late":[98,149,167],"therapeutic":[99,191],"interventions.":[100],"immunotherapy":[102,203],"conferred":[103],"significant":[105],"survival":[106,207],"advantage":[107,208],"12-day":[110],"study":[111,219],"period":[112],"compared":[113],"results":[116],"seen":[117],"placebo-treated":[119],"animals":[120,215],"when":[121],"therapy":[123,161,176,197],"administered":[125],"at":[126,229],"onset":[128,141],"neutropenia":[130],"even":[132,148],"absence":[135],"antibiotics":[137],"after":[139],"fever":[143],"systemic":[145],"infection.":[146],"Notably,":[147],"salvage":[150,168],"monotherapy":[152,170],"highly":[154],"effective":[155,173],"(13/14":[156,177],"surviving":[157,178],"rats":[158,179],"versus":[162,180],"2/14":[163],"controls,":[164],"P=<0.001).":[165],"Moreover,":[166],"as":[172,174,220],"antibiotic":[175],"21/21":[181],"rats,":[182],"P=0.88).":[183],"In":[184],"addition,":[185],"no":[186],"antagonism":[187],"or":[188,228],"loss":[189],"efficacy":[192],"noted":[194],"combination":[196],"plus":[200],"antibiotics.":[201],"provides":[204],"remarkable":[206],"sepsis":[212],"deserves":[217],"further":[218],"new":[222],"option":[224],"with,":[227],"risk":[230],"for,":[231],"severe":[232],"Gram-negative":[233],"infections":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
