{"id":"https://openalex.org/W2161285877","doi":"https://doi.org/10.1177/1076029613519849","title":"Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension","display_name":"Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension","publication_year":2014,"publication_date":"2014-01-22","ids":{"openalex":"https://openalex.org/W2161285877","doi":"https://doi.org/10.1177/1076029613519849","mag":"2161285877","pmid":"https://pubmed.ncbi.nlm.nih.gov/24459043"},"language":"en","primary_location":{"id":"doi:10.1177/1076029613519849","doi":"https://doi.org/10.1177/1076029613519849","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1076029613519849","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100725860","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0001-7706-2160","observed_orcids":["https://orcid.org/0000-0001-7706-2160"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037645443","display_name":"Xin Ping Xu","orcid":"https://orcid.org/0000-0002-6324-5211","observed_orcids":["https://orcid.org/0000-0002-6324-5211"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China","Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080427269","display_name":"Yong Huo","orcid":"https://orcid.org/0000-0002-5407-8773","observed_orcids":["https://orcid.org/0000-0002-5407-8773"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Huo","raw_affiliation_strings":["Department of Cardiology, Peking University First Hospital and Medical Department, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking University First Hospital and Medical Department, Beijing, P. R. China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101572178","display_name":"Dahai Liu","orcid":"https://orcid.org/0000-0001-6201-9776","observed_orcids":["https://orcid.org/0000-0001-6201-9776"]},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dahai Liu","raw_affiliation_strings":["Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, P. R. China","School of Life Sciences, Anhui University, Hefei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, P. R. China","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Life Sciences, Anhui University, Hefei, P. R. China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377723","display_name":"Yimin Cui","orcid":"https://orcid.org/0000-0002-4186-1005","observed_orcids":["https://orcid.org/0000-0002-4186-1005"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimin Cui","raw_affiliation_strings":["Department of Pharmacy, Peking University First Hospital and Medical Department, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Peking University First Hospital and Medical Department, Beijing, P. R. China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zeyuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyuan Liu","raw_affiliation_strings":["Department of Clinical Pharmacology, Affiliated Hospital, Academic of Military Medical Sciences, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Affiliated Hospital, Academic of Military Medical Sciences, Beijing, P. R. China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100706799","display_name":"Zhigang Zhao","orcid":"https://orcid.org/0000-0003-0281-2259","observed_orcids":["https://orcid.org/0000-0003-0281-2259"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Zhao","raw_affiliation_strings":["Department of pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105418284","display_name":"Xiping Xu","orcid":"https://orcid.org/0000-0002-3821-9257","observed_orcids":["https://orcid.org/0000-0002-3821-9257"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiping Xu","raw_affiliation_strings":["Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China","Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545259","display_name":"Lisheng Liu","orcid":"https://orcid.org/0000-0001-5025-3397","observed_orcids":["https://orcid.org/0000-0001-5025-3397"]},"institutions":[{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lisheng Liu","raw_affiliation_strings":["Beijing Fuwai Hospital, China Medical Academy, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Fuwai Hospital, China Medical Academy, Beijing, P. R. China","institution_ids":["https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394456","display_name":"Xiaoying Li","orcid":"https://orcid.org/0000-0002-7682-3789","observed_orcids":["https://orcid.org/0000-0002-7682-3789"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Li","raw_affiliation_strings":["Department of Geriatric Cardiology, PLA General Hospital, Beijing, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Cardiology, PLA General Hospital, Beijing, P. R. China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010844945","display_name":"Shanqun Jiang","orcid":"https://orcid.org/0000-0003-2602-3449","observed_orcids":["https://orcid.org/0000-0003-2602-3449"]},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shanqun Jiang","raw_affiliation_strings":["Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, P. R. China","Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China","School of Life Sciences, Anhui University, Hefei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, P. R. China","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institute of Biomedicine, Anhui Medical University, Hefei, P. R. China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"School of Life Sciences, Anhui University, Hefei, P. R. China","institution_ids":["https://openalex.org/I143868143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5010844945"],"corresponding_institution_ids":["https://openalex.org/I143868143","https://openalex.org/I197869895"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.7782,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.73413625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"7","first_page":"661","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.953000009059906},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6769999861717224},{"id":"https://openalex.org/keywords/screening-marker","display_name":"screening marker","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.609000027179718},{"id":"https://openalex.org/keywords/predictive-performance","display_name":"predictive performance","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9133391380310059},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7340772151947021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.731606662273407},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.7297738790512085},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7016064524650574},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6658019423484802},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6570602655410767},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6420772671699524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5224453806877136},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4984581470489502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19699448347091675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16355004906654358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059267282485961914}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/1076029613519849","doi":"https://doi.org/10.1177/1076029613519849","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1076029613519849","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},{"id":"pmid:24459043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24459043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321435","display_name":"Anhui University","ror":"https://ror.org/05th6yx34"},{"id":"https://openalex.org/F4320321603","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W90081202","https://openalex.org/W181791200","https://openalex.org/W1482397881","https://openalex.org/W1571571888","https://openalex.org/W1605661417","https://openalex.org/W1931181957","https://openalex.org/W1976205360","https://openalex.org/W1995908738","https://openalex.org/W1995931698","https://openalex.org/W2020623762","https://openalex.org/W2023855717","https://openalex.org/W2044986828","https://openalex.org/W2066688265","https://openalex.org/W2067148276","https://openalex.org/W2078420935","https://openalex.org/W2090897293","https://openalex.org/W2094555196","https://openalex.org/W2098297553","https://openalex.org/W2098587302","https://openalex.org/W2103393205","https://openalex.org/W2107959354","https://openalex.org/W2129606441","https://openalex.org/W2129939721","https://openalex.org/W2131205634","https://openalex.org/W2139514338","https://openalex.org/W2150153888","https://openalex.org/W2151899671","https://openalex.org/W2153735417","https://openalex.org/W2165715420","https://openalex.org/W2170739303","https://openalex.org/W2230430502","https://openalex.org/W2323783182","https://openalex.org/W2411983659"],"related_works":["https://openalex.org/W3094024543","https://openalex.org/W2176163062","https://openalex.org/W2084240548","https://openalex.org/W1997795016","https://openalex.org/W2098514192","https://openalex.org/W2334290796","https://openalex.org/W2351653615","https://openalex.org/W2102412171","https://openalex.org/W2770156437","https://openalex.org/W1972966863"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,53,69,73,88,110,124,138,142,162,166,194,232],"performance":[4,196],"of":[5,55,87,137,141,224],"methylenetetrahydrofolate":[6],"reductase":[7],"(MTHFR)":[8],"gene":[9],"C677T":[10,30,74,99,131,248],"polymorphism":[11,132],"in":[12,16,32,116,123,155],"predicting":[13,195,236],"hyperhomocysteinemia":[14],"(HHcy)":[15],"Chinese":[17,34],"patients":[18,35],"with":[19,36,105,113,151,198,201,215],"hypertension.":[20],"METHODS:":[21],"We":[22,42],"measured":[23],"plasma":[24],"total":[25,139],"homocysteine":[26],"tHcy":[27,108],"level":[28],"and":[29,46,58,80,127,180,188,214,226,244],"genotype":[31,75,101,148,168],"1058":[33],"hypertension":[37],"from":[38,68,119,204,219],"4":[39,111,125],"previous":[40],"studies.":[41],"used":[43],"10,":[44],"15,":[45],"20":[47],"\u03bcmol/L":[48],"as":[49,76,78,82,228],"cutoff":[50],"values":[51],"for":[52,64,159,165,185,206,211,235,255],"definition":[54],"mild,":[56,186],"modest,":[57,187],"severe":[59,189,212,256],"HHcy,":[60,190,213],"respectively.":[61,191],"Logistic":[62],"models":[63,89],"HHcy":[65,199,208],"were":[66,90],"built":[67],"study":[70],"sample":[71],"using":[72],"well":[77],"age":[79,227],"gender":[81,225],"predictors.":[83],"The":[84,130,146],"receiver-operating":[85],"characteristics":[86],"evaluated.":[91],"RESULTS:":[92],"Our":[93],"major":[94],"findings":[95],"are":[96,169],"that":[97],"(1)":[98],"TT":[100,147,167],"is":[102,149],"consistently":[103],"associated":[104,150],"a":[106,152,245,251],"higher":[107],"across":[109],"studies,":[112],"an":[114,241],"increase":[115,154],"size":[117],"ranging":[118],"38%":[120],"to":[121,209,221],"68%":[122],"studies":[126],"51%":[128],"overall.":[129],"independently":[133],"explained":[134],"about":[135],"14%":[136],"variance":[140],"normalized":[143],"tHcy.":[144],"(2)":[145],"large":[153],"odds":[156],"ratio":[157],"(OR)":[158],"HHcy.":[160,238,257],"Overall,":[161,193],"multivariate-adjusted":[163],"ORs":[164],"3.9":[170],"(95%":[171,177,182],"confidence":[172],"interval":[173],"[CI]:":[174],"2.4-6.4),":[175],"6.5":[176],"CI:":[178,183],"4.0-10.6),":[179],"17.9":[181],"8.4-38.1)":[184],"(3)":[192],"increased":[197],"severity,":[200],"sensitivity":[202,243],"improving":[203],"31.0%":[205],"mild":[207,237],"70.3%":[210],"specificity":[216],"slightly":[217],"decreasing":[218],"85.4%":[220],"80.3%.":[222],"Inclusion":[223],"predictors":[229],"significantly":[230],"improves":[231],"sensitivity,":[233],"especially":[234],"CONCLUSION:":[239],"With":[240],"excellent":[242],"modest":[246],"specificity,":[247],"could":[249],"be":[250],"useful":[252],"screening":[253],"marker":[254]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}