{"id":"https://openalex.org/W2161279733","doi":"https://doi.org/10.1136/thx.2006.072041","title":"Airway hyperresponsiveness and bronchial mucosal inflammation in T cell peptide-induced asthmatic reactions in atopic subjects","display_name":"Airway hyperresponsiveness and bronchial mucosal inflammation in T cell peptide-induced asthmatic reactions in atopic subjects","publication_year":2007,"publication_date":"2007-03-28","ids":{"openalex":"https://openalex.org/W2161279733","doi":"https://doi.org/10.1136/thx.2006.072041","mag":"2161279733","pmid":"https://pubmed.ncbi.nlm.nih.gov/17389757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2117301"},"language":"en","primary_location":{"id":"doi:10.1136/thx.2006.072041","doi":"https://doi.org/10.1136/thx.2006.072041","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2006.072041","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/62/9/750.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/62/9/750.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054482911","display_name":"Faisal Ali","orcid":"https://orcid.org/0009-0008-1066-7446","observed_orcids":["https://orcid.org/0009-0008-1066-7446"]},"institutions":[{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F R. Ali","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, Imperial College, London, UK","Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK","institution_ids":["https://openalex.org/I4210141571","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114008642","display_name":"A.B. Kay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"A B. Kay","raw_affiliation_strings":["Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK","institution_ids":["https://openalex.org/I4210141571","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077280281","display_name":"Mark Larch\u00e9","orcid":"https://orcid.org/0000-0002-1439-7593","observed_orcids":["https://orcid.org/0000-0002-1439-7593"]},"institutions":[{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Larche","raw_affiliation_strings":["Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Allergy and Clinical Immunology and Leukocyte Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Imperial College, London, UK","institution_ids":["https://openalex.org/I4210141571","https://openalex.org/I47508984","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5114008642"],"corresponding_institution_ids":["https://openalex.org/I4210141571","https://openalex.org/I47508984","https://openalex.org/I90344618"],"apc_list":null,"apc_paid":null,"fwci":1.9005,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84787629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"9","first_page":"750","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9599999785423279},{"id":"https://openalex.org/keywords/late-asthmatic-reaction","display_name":"late asthmatic response","score":0.8859999775886536},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.703000009059906},{"id":"https://openalex.org/keywords/fel-d-1","display_name":"Fel d 1","score":0.972000002861023},{"id":"https://openalex.org/keywords/cat-allergen","display_name":"cat allergen","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ccl17","display_name":"CCL17","score":0.6589999794960022},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7210000157356262},{"id":"https://openalex.org/keywords/endobronchial-biopsy","display_name":"bronchial biopsy","score":0.6140000224113464},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9660000205039978},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8140279650688171},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7098644375801086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6988433003425598},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5874673128128052},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5667452812194824},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5590782165527344},{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.530014157295227},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5112869739532471},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5038229823112488},{"id":"https://openalex.org/C2776238763","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Bronchial hyperresponsiveness","level":4,"score":0.5023019313812256},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.44718703627586365},{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.4414900541305542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2743417024612427},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.18986952304840088},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.12248027324676514},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.07100120186805725}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1136/thx.2006.072041","doi":"https://doi.org/10.1136/thx.2006.072041","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2006.072041","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/62/9/750.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2117301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2117301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"pmid:17389757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17389757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.950.6746","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.950.6746","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thorax.bmj.com/content/62/9/750.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:thoraxjnl:62/9/750","doi":null,"is_oa":false,"landing_page_url":"http://thorax.bmj.com/cgi/content/short/62/9/750","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:thoraxjnl:thx.2006.072041v1","doi":null,"is_oa":false,"landing_page_url":"http://thorax.bmj.com/cgi/content/short/thx.2006.072041v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/thx.2006.072041","doi":"https://doi.org/10.1136/thx.2006.072041","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2006.072041","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/62/9/750.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161279733.pdf","grobid_xml":"https://content.openalex.org/works/W2161279733.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1493122966","https://openalex.org/W1546400353","https://openalex.org/W1562876419","https://openalex.org/W1959487359","https://openalex.org/W1969132883","https://openalex.org/W1970336705","https://openalex.org/W1970648068","https://openalex.org/W1994362051","https://openalex.org/W2001728531","https://openalex.org/W2004421500","https://openalex.org/W2005786969","https://openalex.org/W2014943803","https://openalex.org/W2019099641","https://openalex.org/W2028293869","https://openalex.org/W2042140131","https://openalex.org/W2042604341","https://openalex.org/W2049239278","https://openalex.org/W2052940654","https://openalex.org/W2055680117","https://openalex.org/W2061808825","https://openalex.org/W2065496684","https://openalex.org/W2065719831","https://openalex.org/W2084399363","https://openalex.org/W2086782209","https://openalex.org/W2088407876","https://openalex.org/W2090739088","https://openalex.org/W2102153142","https://openalex.org/W2239962911","https://openalex.org/W2289688737","https://openalex.org/W7074022530"],"related_works":["https://openalex.org/W2167811062","https://openalex.org/W7096971836","https://openalex.org/W1970336705","https://openalex.org/W2015733532","https://openalex.org/W2067242130","https://openalex.org/W2042604341","https://openalex.org/W1994665473","https://openalex.org/W1493122966","https://openalex.org/W2039653120","https://openalex.org/W2033449334"],"abstract_inverted_index":{"BACKGROUND:":[0],"Subjects":[1],"with":[2,49,61,180,234,241],"allergic":[3],"asthma":[4,236],"develop":[5],"isolated":[6,101],"late":[7,102],"asthmatic":[8,103],"reactions":[9],"after":[10,66],"inhalation":[11,33,68,231],"of":[12,69,95,113,224],"allergen-derived":[13],"T":[14,41,227],"cell":[15,259],"peptides.":[16],"Animal":[17],"experiments":[18,266],"have":[19],"shown":[20],"that":[21,31],"airway":[22,226],"hyperresponsiveness":[23],"(AHR)":[24],"is":[25,29],"CD4+":[26,144,247,270],"cell-dependent.":[27],"It":[28],"hypothesised":[30],"peptide":[32,230],"produces":[34],"increases":[35,243],"in":[36,58,126,132,201,208,232,244,255],"non-specific":[37],"AHR":[38,133,240],"and":[39,52,84,91,137,148,150,168,246,249],"a":[40,106,181,197,269],"cell-dominant":[42],"bronchial":[43,50,138],"mucosal":[44,139],"inflammatory":[45],"response.":[46],"METHODS:":[47],"Bronchoscopy,":[48],"biopsies":[51],"bronchoalveolar":[53],"lavage":[54],"(BAL),":[55],"was":[56,175,196],"performed":[57],"24":[59,97],"subjects":[60,98],"cat":[62,80],"allergy":[63],"6":[64],"h":[65],"aerosol":[67],"short":[70],"overlapping":[71],"peptides":[72],"derived":[73],"from":[74],"Fel":[75],"d":[76],"1,":[77],"the":[78,96,127],"major":[79],"allergen.":[81],"Biopsy":[82],"specimens":[83],"BAL":[85,193],"fluid":[86,194],"were":[87],"studied":[88],"using":[89],"immunohistochemistry":[90],"ELISA.":[92],"RESULTS:":[93],"Twelve":[94],"developed":[99],"an":[100],"reaction":[104,111],"without":[105],"preceding":[107],"early":[108],"(mast":[109],"cell/histamine-dependent)":[110],"characteristic":[112],"whole":[114],"allergen":[115],"inhalation.":[116],"These":[117,261],"responders":[118],"had":[119],"significant":[120,198,253],"between-group":[121,171,199],"differences":[122],"(responders":[123],"vs":[124,130,186],"non-responders)":[125],"changes":[128,254],"(peptide":[129,185],"diluent)":[131],"(p":[134,141,145,154,203],"=":[135,142,146,155,177,190,204],"0.007)":[136],"CD3+":[140,245],"0.005),":[143],"0.006)":[147],"thymus-":[149],"activation-regulated":[151],"chemokine":[152],"(TARC)+":[153],"0.003)":[156],"but":[157,179,206,251],"not":[158,207],"CD8+":[159],"or":[160,163,213,219,257],"CD25+":[161],"cells":[162,167,228,248],"eosinophils,":[164],"basophils,":[165],"mast":[166],"macrophages.":[169],"The":[170],"difference":[172,200],"for":[173,272],"neutrophils":[174],"p":[176,189],"0.05":[178],"non-significant":[182],"within-group":[183],"value":[184],"diluent,":[187],"responders,":[188],"0.11).":[191],"In":[192],"there":[195],"TARC":[202,250],"0.02)":[205],"histamine,":[209],"tryptase,":[210],"basogranulin,":[211],"C3a":[212],"C5a,":[214],"leukotrienes":[215],"C(4)/D(4)/E(4),":[216],"prostaglandins":[217],"D(2)":[218],"F(2alpha).":[220],"CONCLUSIONS:":[221],"Direct":[222],"activation":[223],"allergen-specific":[225],"by":[229],"patients":[233],"atopic":[235],"leads":[237],"to":[238],"increased":[239],"local":[242],"no":[252],"eosinophils":[256],"basophil/mast":[258],"products.":[260],"findings":[262],"support":[263],"previous":[264],"animal":[265],"which":[267],"showed":[268],"dependence":[271],"AHR.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}