{"id":"https://openalex.org/W2161269157","doi":null,"title":"Impairment of Moloney murine leukemia virus integration in a cell line underexpressing DNA topoisomerase II.","display_name":"Impairment of Moloney murine leukemia virus integration in a cell line underexpressing DNA topoisomerase II.","publication_year":1995,"publication_date":"1995-07-15","ids":{"openalex":"https://openalex.org/W2161269157","mag":"2161269157","pmid":"https://pubmed.ncbi.nlm.nih.gov/7606743"},"language":"en","primary_location":{"id":"pmid:7606743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7606743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016761287","display_name":"Pascale Bouill\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Bouill\u00e9","raw_affiliation_strings":["Laboratoire de Pharmacologie des Macromol\u00e9cules Biologiques, CNRS URA 0147, Institut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie des Macromol\u00e9cules Biologiques, CNRS URA 0147, Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025692362","display_name":"Fr\u00e9d\u00e9ric Subra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Subra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023634669","display_name":"H\u00e9l\u00e8ne Goulaouic","orcid":"https://orcid.org/0009-0003-4713-0216","observed_orcids":["https://orcid.org/0009-0003-4713-0216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Goulaouic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014631201","display_name":"Sandrine Carteau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Carteau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017477419","display_name":"Christian Auclair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Auclair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5296,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60928084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"55","issue":"14","first_page":"3211","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.3889000117778778,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.3889000117778778,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.22020000219345093,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moloney-murine-leukemia-virus","display_name":"Moloney murine leukemia virus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/retroviral-integration","display_name":"retroviral integration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.9750000238418579},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/viral-dna-replication","display_name":"viral DNA replication","score":0.6200000047683716},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chinese-hamster-cell-lines","display_name":"Chinese hamster cell lines","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8676745295524597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7568299770355225},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.5689325332641602},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5488366484642029},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5395429134368896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47137153148651123},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.46073079109191895},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45651718974113464},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.45086604356765747},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.42374375462532043},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4228888750076294},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3261869549751282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2995728552341461},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2756611108779907}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7606743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7606743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2161269157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7606743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1464706687","https://openalex.org/W1550262946","https://openalex.org/W1568345766","https://openalex.org/W1585435832","https://openalex.org/W1600900798","https://openalex.org/W1613470888","https://openalex.org/W1908207029","https://openalex.org/W1969656310","https://openalex.org/W1999966948","https://openalex.org/W2011870601","https://openalex.org/W2012949256","https://openalex.org/W2019508559","https://openalex.org/W2025260589","https://openalex.org/W2035270220","https://openalex.org/W2051527586","https://openalex.org/W2054760667","https://openalex.org/W2055686540","https://openalex.org/W2065979160","https://openalex.org/W2071351059","https://openalex.org/W2091987058","https://openalex.org/W2094657382","https://openalex.org/W2118944608","https://openalex.org/W2133140574","https://openalex.org/W2138204274","https://openalex.org/W2168697593","https://openalex.org/W2429392527"],"related_works":["https://openalex.org/W371680535","https://openalex.org/W2064601815","https://openalex.org/W2109664448","https://openalex.org/W2075862099","https://openalex.org/W2022750544","https://openalex.org/W2041471470","https://openalex.org/W2164479436","https://openalex.org/W2075519329","https://openalex.org/W1983717909","https://openalex.org/W2913271851"],"abstract_inverted_index":{"The":[0,187],"possible":[1],"intervention":[2],"of":[3,8,11,43,56,80,90,112,115,150,183,190,204,213,244,252],"nuclear":[4,25,219,262],"proteins":[5],"as":[6,221],"cofactors":[7],"integrase-catalyzed":[9],"integration":[10,49,191],"retroviral":[12,152],"DNA":[13,27,59,178,220,247,259],"into":[14],"the":[15,46,54,57,78,87,122,133,147,151,202,214,224,241,250,261],"host":[16],"cell":[17,104,124,238],"genome":[18,185,216],"is":[19,38,50,70,119,169,199],"not":[20],"fully":[21],"understood.":[22],"Among":[23],"various":[24],"proteins,":[26],"topoisomerase":[28,68,116,136,160],"II":[29,69,137,161],"appears":[30],"to":[31,76,196,240,249],"be":[32],"a":[33,41,91,129,173,211],"plausible":[34],"candidate.":[35],"This":[36,163],"hypothesis":[37],"supported":[39],"by":[40,53,171,201,223],"series":[42],"evidence,":[44],"including":[45],"fact":[47],"that":[48,146],"markedly":[51,155],"affected":[52],"topology":[55],"target":[58],"and":[60,107,127,142,168,180,210,248],"mainly":[61],"occurs":[62],"in":[63,66,99,157,176,192,217,231,236,260],"transcribed":[64],"regions":[65],"which":[67],"preferentially":[71],"located.":[72],"In":[73],"an":[74],"attempt":[75],"confirm":[77],"validity":[79],"this":[81],"hypothesis,":[82],"we":[83],"have":[84],"comparatively":[85],"investigated":[86],"early":[88,148],"stages":[89,149],"recombinant":[92],"Moloney":[93],"murine":[94],"leukemia":[95],"virus":[96],"(psi":[97],"neo)":[98],"two":[100,253],"related":[101],"Chinese":[102],"hamster":[103],"lines":[105],"(DC3F":[106],"R/DC3F)":[108],"expressing":[109],"different":[110],"levels":[111],"both":[113,237],"isoforms":[114],"II.":[117],"R/DC3F":[118,193],"derived":[120],"from":[121],"parental":[123],"line":[125],"DC3F":[126,197],"displays":[128],"resistant":[130],"phenotype":[131],"towards":[132],"usual":[134],"anticancer":[135],"inhibitors":[138],"(actinomycin":[139],"D,":[140],"doxorubicin,":[141],"taxol).":[143],"Results":[144],"show":[145],"cycle":[153],"are":[154,229],"impaired":[156],"cells":[158,194,198],"underexpressing":[159],"(R/DC3F).":[162],"alteration":[164],"mimics":[165],"Fv-1":[166],"restriction":[167],"characterized":[170],"about":[172],"6-fold":[174],"decrease":[175],"viral":[177,184,208,215,246],"synthesis":[179],"total":[181],"inhibition":[182],"integration.":[186],"specific":[188],"impairment":[189],"compared":[195],"assessed":[200],"absence":[203],"G418-resistant":[205],"colonies":[206],"upon":[207],"infection":[209],"lack":[212],"cellular":[218],"detected":[222],"PCR":[225],"procedure.":[226],"These":[227],"features":[228],"observed":[230],"relevant":[232],"infecting":[233],"conditions":[234],"leading,":[235],"lines,":[239],"same":[242],"amount":[243],"linear":[245],"occurrence":[251],"long":[254],"terminal":[255],"repeats":[256],"containing":[257],"circular":[258],"fractions.":[263]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}