{"id":"https://openalex.org/W2161190692","doi":"https://doi.org/10.1002/rcm.3550","title":"Linkage position and residue identification of disaccharides by tandem mass spectrometry and linear discriminant analysis","display_name":"Linkage position and residue identification of disaccharides by tandem mass spectrometry and linear discriminant analysis","publication_year":2008,"publication_date":"2008-04-24","ids":{"openalex":"https://openalex.org/W2161190692","doi":"https://doi.org/10.1002/rcm.3550","mag":"2161190692","pmid":"https://pubmed.ncbi.nlm.nih.gov/18433086"},"language":"en","primary_location":{"id":"doi:10.1002/rcm.3550","doi":"https://doi.org/10.1002/rcm.3550","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.3550","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100323331","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-5793-8890","observed_orcids":["https://orcid.org/0000-0001-5793-8890"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I2802789608","display_name":"Ames National Laboratory","ror":"https://ror.org/041m9xr71","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I173911158","https://openalex.org/I2802789608","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I2802789608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023068897","display_name":"Steve M. Brokman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve M. Brokman","raw_affiliation_strings":["Department of Chemistry, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073307802","display_name":"Ning Fang","orcid":"https://orcid.org/0000-0003-4710-0984","observed_orcids":["https://orcid.org/0000-0003-4710-0984"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I2802789608","display_name":"Ames National Laboratory","ror":"https://ror.org/041m9xr71","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I173911158","https://openalex.org/I2802789608","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Fang","raw_affiliation_strings":["Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I2802789608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064222111","display_name":"Nicola L. B. Pohl","orcid":"https://orcid.org/0000-0001-7747-8983","observed_orcids":["https://orcid.org/0000-0001-7747-8983"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicola L. Pohl","raw_affiliation_strings":["Department of Chemistry, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061282830","display_name":"Edward S. Yeung","orcid":"https://orcid.org/0000-0003-0919-6700","observed_orcids":["https://orcid.org/0000-0003-0919-6700"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I2802789608","display_name":"Ames National Laboratory","ror":"https://ror.org/041m9xr71","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I173911158","https://openalex.org/I2802789608","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward S. Yeung","raw_affiliation_strings":["Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I2802789608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061282830"],"corresponding_institution_ids":["https://openalex.org/I173911158","https://openalex.org/I2802789608"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.9535,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.70430235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"10","first_page":"1579","last_page":"1586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disaccharides","display_name":"disaccharides","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.8889999985694885},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"linear discriminant analysis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/laser-desorption-ionization","display_name":"laser desorption ionization","score":0.6940000057220459},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7440000176429749},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":1.0},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":1.0}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.948318362236023},{"id":"https://openalex.org/C2777346074","wikidata":"https://www.wikidata.org/wiki/Q173600","display_name":"Disaccharide","level":2,"score":0.7472072839736938},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.6973416805267334},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.6450225114822388},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.574203372001648},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5238173604011536},{"id":"https://openalex.org/C2777814067","wikidata":"https://www.wikidata.org/wiki/Q1752317","display_name":"Tandem","level":2,"score":0.4974508583545685},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4839082658290863},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.45802339911460876},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.43730786442756653},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.339296817779541},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.30269718170166016},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1563655138015747},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.13621968030929565},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.060971856117248535},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004187","descriptor_name":"Disaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/rcm.3550","doi":"https://doi.org/10.1002/rcm.3550","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.3550","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:18433086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18433086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid communications in mass spectrometry : RCM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W84495269","https://openalex.org/W1578118950","https://openalex.org/W1973089359","https://openalex.org/W1975445339","https://openalex.org/W1976165460","https://openalex.org/W1979898046","https://openalex.org/W1980017824","https://openalex.org/W1989836820","https://openalex.org/W1990659485","https://openalex.org/W1992066825","https://openalex.org/W1996525310","https://openalex.org/W1998135327","https://openalex.org/W1998913794","https://openalex.org/W2004857756","https://openalex.org/W2011881552","https://openalex.org/W2014453006","https://openalex.org/W2029193900","https://openalex.org/W2029309140","https://openalex.org/W2029605325","https://openalex.org/W2036021342","https://openalex.org/W2036029928","https://openalex.org/W2037956398","https://openalex.org/W2040176812","https://openalex.org/W2046182332","https://openalex.org/W2057037040","https://openalex.org/W2070885380","https://openalex.org/W2075588454","https://openalex.org/W2077519420","https://openalex.org/W2078460983","https://openalex.org/W2084012987","https://openalex.org/W2092026083","https://openalex.org/W2092105992","https://openalex.org/W2093348573","https://openalex.org/W2100239119","https://openalex.org/W2127554246","https://openalex.org/W2143276151","https://openalex.org/W2155199877","https://openalex.org/W2839011212","https://openalex.org/W2949380205","https://openalex.org/W4241888211"],"related_works":["https://openalex.org/W2782948722","https://openalex.org/W7160115138","https://openalex.org/W3091841251","https://openalex.org/W4315767312","https://openalex.org/W2075887020","https://openalex.org/W4402488880","https://openalex.org/W1979160412","https://openalex.org/W4405484615","https://openalex.org/W4282570561","https://openalex.org/W2108797777"],"abstract_inverted_index":{"The":[0],"discrimination":[1],"of":[2,58,63,117,129],"isomeric":[3],"disaccharides":[4],"with":[5,24,76,91,107,113,160],"different":[6,10,92,96,115,139,162,165],"linkage":[7,93,110],"types":[8,94],"and":[9,16,29],"monosaccharide":[11,118,166],"residues--glucose":[12],"(Glc),":[13],"galactose":[14],"(Gal),":[15],"mannose":[17],"(Man)":[18],"at":[19],"the":[20,47,56,61,87,108,121,126,130,141,154],"non-reducing":[21],"end--was":[22],"investigated":[23],"tandem":[25,97,155],"mass":[26,49,98,156],"spectrometry":[27],"(MS/MS)":[28],"linear":[30],"discriminant":[31],"analysis":[32,62],"(LDA).":[33],"Conventional":[34],"matrix-assisted":[35],"laser":[36],"desorption/ionization":[37],"(MALDI)-MS":[38],"has":[39],"strong":[40],"interference":[41],"peaks":[42],"from":[43,101],"matrix":[44],"ions":[45],"in":[46,86],"low":[48],"region":[50],"(<500":[51],"Da).":[52],"This":[53],"greatly":[54],"limits":[55],"application":[57],"MALDI-MS":[59],"for":[60],"small":[64],"molecules":[65],"such":[66,149],"as":[67,150],"saccharides.":[68],"We":[69],"solved":[70],"this":[71],"problem":[72],"by":[73],"using":[74],"LDI":[75],"acidic":[77],"fullerene":[78],"matrix,":[79],"which":[80],"gives":[81],"a":[82],"very":[83],"clean":[84],"background":[85],"low-mass":[88],"region.":[89],"Disaccharides":[90,106],"give":[95],"spectral":[99],"profiles":[100],"various":[102],"cross-ring":[103],"fragmentation":[104,123],"pathways.":[105],"same":[109,122],"type":[111],"but":[112],"three":[114,142],"kinds":[116],"residues":[119,167],"bear":[120],"profiles.":[124],"However,":[125],"relative":[127],"ratios":[128],"fragment":[131],"ion":[132],"intensities":[133],"were":[134,168],"found":[135],"to":[136,152],"be":[137],"distinctly":[138],"among":[140],"disaccharide":[143,158],"isomers.":[144],"By":[145],"employing":[146],"statistical":[147],"tools":[148],"LDA":[151],"classify":[153],"spectra,":[157],"isomers":[159],"either":[161],"linkages":[163],"or":[164],"successfully":[169],"classified.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}