{"id":"https://openalex.org/W2161131941","doi":"https://doi.org/10.1128/jvi.00269-14","title":"Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection","display_name":"Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection","publication_year":2014,"publication_date":"2014-04-17","ids":{"openalex":"https://openalex.org/W2161131941","doi":"https://doi.org/10.1128/jvi.00269-14","mag":"2161131941","pmid":"https://pubmed.ncbi.nlm.nih.gov/24741080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4054457"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00269-14","doi":"https://doi.org/10.1128/jvi.00269-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00269-14","pdf_url":"https://jvi.asm.org/content/jvi/88/13/7221.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/88/13/7221.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082315352","display_name":"Nadia R. Roan","orcid":"https://orcid.org/0000-0002-5464-1976","observed_orcids":["https://orcid.org/0000-0002-5464-1976"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia R. Roan","raw_affiliation_strings":["Department of Urology, University of California, San Francisco, California, USA","Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041851178","display_name":"Haichuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haichuan Liu","raw_affiliation_strings":["Department of Obstetrics, Gynecology & Reproductive Sciences and Sandler-Moore Mass Spectrometry Core Facility, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology & Reproductive Sciences and Sandler-Moore Mass Spectrometry Core Facility, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043937923","display_name":"Shariq M. Usmani","orcid":"https://orcid.org/0000-0002-6462-1098","observed_orcids":["https://orcid.org/0000-0002-6462-1098"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shariq M. Usmani","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052639237","display_name":"Jason A. Neidleman","orcid":"https://orcid.org/0000-0003-3525-8047","observed_orcids":["https://orcid.org/0000-0003-3525-8047"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Neidleman","raw_affiliation_strings":["Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032280372","display_name":"Janis A. M\u00fcller","orcid":"https://orcid.org/0000-0002-0347-416X","observed_orcids":["https://orcid.org/0000-0002-0347-416X"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janis A. M\u00fcller","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011709644","display_name":"Aram Avila-Herrera","orcid":"https://orcid.org/0000-0003-2357-1757","observed_orcids":["https://orcid.org/0000-0003-2357-1757"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aram Avila-Herrera","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Diseases, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Diseases, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055782717","display_name":"Ali Gawanbacht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ali Gawanbacht","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037161335","display_name":"Onofrio Zirafi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Onofrio Zirafi","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simon Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Chu","raw_affiliation_strings":["Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642239","display_name":"Ming Dong","orcid":"https://orcid.org/0000-0002-9121-6020","observed_orcids":["https://orcid.org/0000-0002-9121-6020"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Dong","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112462194","display_name":"Senthil T. Kumar","orcid":"https://orcid.org/0000-0002-4322-3963","observed_orcids":["https://orcid.org/0000-0002-4322-3963"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Senthil T. Kumar","raw_affiliation_strings":["Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103129830","display_name":"James Foley Smith","orcid":"https://orcid.org/0000-0002-4221-9858","observed_orcids":["https://orcid.org/0000-0002-4221-9858"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Smith","raw_affiliation_strings":["Department of Urology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005062415","display_name":"Katherine S. Pollard","orcid":"https://orcid.org/0000-0002-9870-6196","observed_orcids":["https://orcid.org/0000-0002-9870-6196"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine S. Pollard","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, California, USA","Gladstone Institute of Cardiovascular Diseases, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Diseases, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033116224","display_name":"Marcus F\u00e4ndrich","orcid":"https://orcid.org/0000-0003-2123-6816","observed_orcids":["https://orcid.org/0000-0003-2123-6816"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus F\u00e4ndrich","raw_affiliation_strings":["Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072303851","display_name":"Jan M\u00fcnch","orcid":"https://orcid.org/0000-0001-7316-7141","observed_orcids":["https://orcid.org/0000-0001-7316-7141"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan M\u00fcnch","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110206821","display_name":"Halina Ewa Witkowska","orcid":"https://orcid.org/0000-0003-0175-0367","observed_orcids":["https://orcid.org/0000-0003-0175-0367"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ewa Witkowska","raw_affiliation_strings":["Department of Obstetrics, Gynecology & Reproductive Sciences and Sandler-Moore Mass Spectrometry Core Facility, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology & Reproductive Sciences and Sandler-Moore Mass Spectrometry Core Facility, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075675860","display_name":"Warner C. Greene","orcid":"https://orcid.org/0000-0001-9896-8615","observed_orcids":["https://orcid.org/0000-0001-9896-8615"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warner C. Greene","raw_affiliation_strings":["Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, California, USA","Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9961,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92692241,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"88","issue":"13","first_page":"7221","last_page":"7234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semen-liquefaction","display_name":"semen liquefaction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/semenogelin","display_name":"semenogelin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.7630000114440918},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.7409999966621399},{"id":"https://openalex.org/keywords/great-apes","display_name":"great apes","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.3370000123977661},{"id":"https://openalex.org/keywords/hiv-1-core-protein","display_name":"HIV-1 core protein","score":0.3569999933242798},{"id":"https://openalex.org/keywords/hiv-1-accessory-proteins","display_name":"HIV-1 accessory proteins","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.789354681968689},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.6914342641830444},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5291735529899597},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5117156505584717},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4860099256038666},{"id":"https://openalex.org/C191859794","wikidata":"https://www.wikidata.org/wiki/Q180208","display_name":"Liquefaction","level":2,"score":0.41674426198005676},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3826243281364441},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36191341280937195},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3542506694793701},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12343186140060425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12337157130241394},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.108954519033432},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029607","descriptor_name":"Seminal Vesicle Secretory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00269-14","doi":"https://doi.org/10.1128/jvi.00269-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00269-14","pdf_url":"https://jvi.asm.org/content/jvi/88/13/7221.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4054457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4054457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:24741080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24741080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4h3862wk","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4h3862wk","pdf_url":"https://escholarship.org/content/qt4h3862wk/qt4h3862wk.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, vol 88, iss 13","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00269-14","doi":"https://doi.org/10.1128/jvi.00269-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00269-14","pdf_url":"https://jvi.asm.org/content/jvi/88/13/7221.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1843069816","display_name":null,"funder_award_id":"W81XWH-11-1-0562","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3181090803","display_name":null,"funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G3666278020","display_name":null,"funder_award_id":"K99/R00 1K99AI104262","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3780238105","display_name":null,"funder_award_id":"W81XWH-11-1-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G43984215","display_name":null,"funder_award_id":"K99\u2010R00","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4543819761","display_name":"UCSF KURe Career Development Program","funder_award_id":"K12DK083021","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5062866998","display_name":"BMI Bioinformatics Training Grant","funder_award_id":"T32GM067547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5265520087","display_name":"Host Factors Influencing HIV Viral Load and Infectivity in Semen","funder_award_id":"R01HD074511","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G550251769","display_name":null,"funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320310168","funder_display_name":"Gladstone Institutes"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5916384014","display_name":"Exploring HIV-Host Interactions in the Female Reproductive Tract","funder_award_id":"P01AI083050","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6252137478","display_name":"Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization","funder_award_id":"K99AI104262","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G670709873","display_name":"A NOVEL APPROACH FOR PREVENTING HIV INFECTION AND REDUCING RISK TO U.S. MILITARY PERSONNEL","funder_award_id":"W81XWH1110562","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G738160294","display_name":null,"funder_award_id":"K99-R00","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8780770865","display_name":"Integrative Program  in  Complex  Biological System (ipCBS)","funder_award_id":"T32EB009383","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8786279141","display_name":null,"funder_award_id":"FA 456/10","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000868711","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306202","display_name":"Gordon and Betty Moore Foundation","ror":"https://ror.org/006wxqw41"},{"id":"https://openalex.org/F4320310168","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161131941.pdf","grobid_xml":"https://content.openalex.org/works/W2161131941.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1552745711","https://openalex.org/W1974894479","https://openalex.org/W1981797590","https://openalex.org/W1985884834","https://openalex.org/W1996543040","https://openalex.org/W2026057878","https://openalex.org/W2029379203","https://openalex.org/W2031383072","https://openalex.org/W2032050743","https://openalex.org/W2037754780","https://openalex.org/W2048904628","https://openalex.org/W2052175724","https://openalex.org/W2059903043","https://openalex.org/W2064511790","https://openalex.org/W2064647506","https://openalex.org/W2064928799","https://openalex.org/W2066556286","https://openalex.org/W2070199626","https://openalex.org/W2076027733","https://openalex.org/W2078155174","https://openalex.org/W2085019147","https://openalex.org/W2110521774","https://openalex.org/W2112112221","https://openalex.org/W2113979592","https://openalex.org/W2125495738","https://openalex.org/W2129507901","https://openalex.org/W2134634622","https://openalex.org/W2136618643","https://openalex.org/W2138686161","https://openalex.org/W2159465178","https://openalex.org/W2164766734","https://openalex.org/W2168527507","https://openalex.org/W2171545866","https://openalex.org/W2752892747"],"related_works":["https://openalex.org/W1974894479","https://openalex.org/W2168527507","https://openalex.org/W2343581721","https://openalex.org/W7098863270","https://openalex.org/W6999612978","https://openalex.org/W2099024023","https://openalex.org/W2064647506","https://openalex.org/W2188279409","https://openalex.org/W2772162179","https://openalex.org/W2161915075"],"abstract_inverted_index":{"UNLABELLED:":[0],"Semen":[1,276],"enhances":[2,260],"HIV":[3,104,179,258,261,374],"infection":[4,180,262],"in":[5,35,59,82,147,194,206,239,263,361,381],"vitro,":[6,264],"but":[7,152,265],"how":[8,266],"long":[9,267],"it":[10,268,284],"retains":[11,269],"this":[12,270],"activity":[13,50,61,163,271,326,350,384],"has":[14,272],"not":[15,273],"been":[16,274],"carefully":[17],"examined.":[18],"Immediately":[19],"postejaculation,":[20],"semen":[21,46,241,328,386],"exists":[22],"as":[23],"a":[24,31,36,83,137,234,287,291,339,395],"semisolid":[25],"coagulum,":[26,317],"which":[27],"then":[28],"converts":[29,285],"to":[30,102,109,132,135,161,177,232,290,372,393],"more":[32,292],"liquid":[33,293],"form":[34],"process":[37,149],"termed":[38,297],"liquefaction.":[39,91,355],"We":[40,125,321],"demonstrate":[41,322],"that":[42,51,79,143,323],"early":[43,146],"during":[44,157,387],"liquefaction,":[45,298,389],"exhibits":[47],"maximal":[48],"HIV-enhancing":[49,60,123,236,249,325,383],"gradually":[52,329],"declines":[53],"upon":[54,88],"further":[55],"incubation.":[56],"The":[57,209],"decline":[58],"parallels":[62],"the":[63,70,73,77,114,120,148,162,244,253,302,312,316,324,332,352,382],"degradation":[64],"of":[65,76,90,113,122,150,164,181,188,212,247,310,315,327,334,354,385,399],"peptide":[66,142],"fragments":[67,98,117],"derived":[68],"from":[69,96,128,286],"semenogelins":[71],"(SEMs),":[72],"major":[74,313],"components":[75,314],"coagulum":[78],"are":[80,175,218,358,370],"cleaved":[81],"site-specific":[84,306],"and":[85,174,198,214,242,307,337,363,369],"progressive":[86,308],"manner":[87],"initiation":[89],"Because":[92],"amyloid":[93,237],"fibrils":[94,366],"generated":[95,145,200],"SEM":[97,116,141],"were":[99],"recently":[100],"demonstrated":[101],"enhance":[103,178,373],"infection,":[105],"we":[106,390],"set":[107],"out":[108],"determine":[110],"whether":[111],"any":[112],"liquefaction-generated":[115],"associate":[118],"with":[119,191,348],"presence":[121],"activity.":[124,250],"identify":[126,230,338],"SEM1":[127],"amino":[129],"acids":[130],"86":[131],"107":[133],"[SEM1(86-107)]":[134],"be":[136,233,394],"short,":[138],"cationic,":[139],"amyloidogenic":[140,210],"is":[144,155,299],"liquefaction":[151,159,336],"that,":[153],"conversely,":[154],"lost":[156],"prolonged":[158],"due":[160],"serine":[165],"proteases.":[166,320],"Synthetic":[167],"SEM1(86-107)":[168,189,202,213,231,356,365,392],"amyloids":[169,205,357],"directly":[170],"bind":[171,367],"HIV-1":[172],"virions":[173,368],"sufficient":[176,371],"permissive":[182],"cells.":[183],"Furthermore,":[184],"endogenous":[185,204],"seminal":[186,319],"levels":[187,346],"correlate":[190,347],"donor-dependent":[192],"variations":[193],"viral":[195],"enhancement":[196],"activity,":[197],"antibodies":[199],"against":[201],"recognize":[203],"human":[207,240,400],"semen.":[208,401],"potential":[211],"its":[215],"virus-enhancing":[216,349,397],"properties":[217],"conserved":[219,226],"among":[220],"great":[221],"apes,":[222],"suggesting":[223],"an":[224],"evolutionarily":[225],"function.":[227],"These":[228],"studies":[229],"key,":[235],"species":[238],"underscore":[243],"dynamic":[245,379],"nature":[246],"semen's":[248],"IMPORTANCE:":[251],"Semen,":[252],"most":[254],"common":[255],"vehicle":[256],"for":[257],"transmission,":[259],"investigated.":[275],"naturally":[277,340,359],"undergoes":[278],"physiological":[279],"changes":[280,380],"over":[281,331,351],"time,":[282],"whereby":[283],"gel-like":[288],"consistency":[289],"form.":[294],"This":[295],"process,":[296],"characterized":[300],"at":[301],"molecular":[303],"level":[304],"by":[305,318,377],"cleavage":[309],"SEMs,":[311],"decreases":[330],"course":[333,353],"extended":[335,388],"occurring":[341],"semenogelin-derived":[342],"fragment,":[343],"SEM1(86-107),":[344],"whose":[345],"present":[360],"semen,":[362],"synthetic":[364],"infection.":[375],"Therefore,":[376],"characterizing":[378],"identified":[391],"key":[396],"component":[398]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}