{"id":"https://openalex.org/W2161069809","doi":"https://doi.org/10.1148/radiol.2461070057","title":"Assessment of Biologic Aggressiveness of Prostate Cancer: Correlation of MR Signal Intensity with Gleason Grade after Radical Prostatectomy","display_name":"Assessment of Biologic Aggressiveness of Prostate Cancer: Correlation of MR Signal Intensity with Gleason Grade after Radical Prostatectomy","publication_year":2007,"publication_date":"2007-11-17","ids":{"openalex":"https://openalex.org/W2161069809","doi":"https://doi.org/10.1148/radiol.2461070057","mag":"2161069809","pmid":"https://pubmed.ncbi.nlm.nih.gov/18024440"},"language":"en","primary_location":{"id":"doi:10.1148/radiol.2461070057","doi":"https://doi.org/10.1148/radiol.2461070057","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2461070057","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100754013","display_name":"Liang Wang","orcid":"https://orcid.org/0000-0003-2244-7535","observed_orcids":["https://orcid.org/0000-0003-2244-7535"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Wang","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021, USA. wang6@mskcc.org","1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021, USA. wang6@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032462026","display_name":"Yousef Mazaheri","orcid":"https://orcid.org/0000-0002-8493-1608","observed_orcids":["https://orcid.org/0000-0002-8493-1608"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yousef Mazaheri","raw_affiliation_strings":["1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022585880","display_name":"Jingbo Zhang","orcid":"https://orcid.org/0000-0002-8629-5676","observed_orcids":["https://orcid.org/0000-0002-8629-5676"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingbo Zhang","raw_affiliation_strings":["1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040809833","display_name":"Nicole M. Ishill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Ishill","raw_affiliation_strings":["Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017068775","display_name":"Kentaro Kuroiwa","orcid":"https://orcid.org/0000-0003-3656-4695","observed_orcids":["https://orcid.org/0000-0003-3656-4695"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kentaro Kuroiwa","raw_affiliation_strings":["Urology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021013894","display_name":"Hedvig Hricak","orcid":"https://orcid.org/0000-0003-2240-9694","observed_orcids":["https://orcid.org/0000-0003-2240-9694"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hedvig Hricak","raw_affiliation_strings":["1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1From the Departments of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10021. Received January 9, 2007","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":4.6599,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.94568037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"246","issue":"1","first_page":"168","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.8100000023841858},{"id":"https://openalex.org/keywords/t2-weighted-mri","display_name":"T2-weighted MRI","score":0.8080000281333923},{"id":"https://openalex.org/keywords/signal-intensity-ratio","display_name":"signal intensity ratio","score":0.8529999852180481},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.953825831413269},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7998826503753662},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6681824326515198},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5977500677108765},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5838432312011719},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5005578994750977},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.49498504400253296},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4035854637622833},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40109822154045105},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3564700782299042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12932002544403076}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1148/radiol.2461070057","doi":"https://doi.org/10.1148/radiol.2461070057","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2461070057","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},{"id":"pmid:18024440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18024440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3697567857","display_name":"Imaging in Risk Assessment of Prostate Cancer Patients","funder_award_id":"R01CA076423","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308932","display_name":"Radiological Society of North America","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W221956105","https://openalex.org/W1576553876","https://openalex.org/W1579010912","https://openalex.org/W1605096437","https://openalex.org/W1819910556","https://openalex.org/W1966431500","https://openalex.org/W1969369561","https://openalex.org/W1974809705","https://openalex.org/W1984829389","https://openalex.org/W1986627735","https://openalex.org/W1996011388","https://openalex.org/W2001710178","https://openalex.org/W2006115709","https://openalex.org/W2010483390","https://openalex.org/W2018628111","https://openalex.org/W2039373030","https://openalex.org/W2042389244","https://openalex.org/W2046993257","https://openalex.org/W2050303798","https://openalex.org/W2069630878","https://openalex.org/W2075654750","https://openalex.org/W2077506606","https://openalex.org/W2077591651","https://openalex.org/W2083043726","https://openalex.org/W2088071279","https://openalex.org/W2100120884","https://openalex.org/W2106942453","https://openalex.org/W2107807397","https://openalex.org/W2108659569","https://openalex.org/W2118625479","https://openalex.org/W2119530226","https://openalex.org/W2127160089","https://openalex.org/W2141374620","https://openalex.org/W2154787687","https://openalex.org/W2156307400","https://openalex.org/W2163791962","https://openalex.org/W2323868208","https://openalex.org/W2329106677","https://openalex.org/W4241688852"],"related_works":["https://openalex.org/W2518851757","https://openalex.org/W2591401381","https://openalex.org/W3119868302","https://openalex.org/W2118625479","https://openalex.org/W6911545358","https://openalex.org/W4313440643","https://openalex.org/W2529036742","https://openalex.org/W2324201585","https://openalex.org/W2471671733","https://openalex.org/W2902107553"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"retrospectively":[2],"investigate":[3],"whether":[4],"the":[5,20,186],"signal":[6],"intensity":[7],"(SI)":[8],"of":[9,43,50,93,111,124,130,141,185,302],"prostate":[10,142,303],"cancer":[11,304],"on":[12,119,153,232,288,294],"T2-weighted":[13,157,289,295],"magnetic":[14],"resonance":[15],"(MR)":[16],"images":[17,122,236,297],"correlates":[18],"with":[19,68,101,106,192,225,248,259,283],"Gleason":[21,95,102,162,188,199,203,209,221,244,261,279],"grade":[22,96,103,189,200,204,222],"at":[23,89,216],"whole-mount":[24,70],"step-section":[25,71],"pathologic":[26,72,217],"evaluation":[27,218,293],"after":[28],"radical":[29,66],"prostatectomy.":[30],"MATERIALS":[31],"AND":[32],"METHODS:":[33],"The":[34],"institutional":[35],"review":[36],"board":[37],"approved":[38],"and":[39,77,127,137,147,155,164,180,206,212,234,240],"issued":[40],"a":[41,107],"waiver":[42],"informed":[44],"consent":[45],"for":[46,229],"this":[47],"HIPAA-compliant":[48],"study":[49],"74":[51],"patients":[52],"(median":[53],"age,":[54],"57.5":[55],"years;":[56],"range,":[57],"32-72":[58],"years)":[59],"who":[60],"underwent":[61],"endorectal":[62],"MR":[63,121,138,158,290,296],"imaging":[64],"before":[65],"prostatectomy,":[67],"subsequent":[69],"evaluation,":[73],"between":[74,135,161],"January":[75],"2001":[76],"July":[78],"2004.":[79],"Inclusion":[80],"criteria":[81],"were":[82,167,190,219,246,266,281],"that":[83],"they":[84],"had:":[85],"no":[86,116],"prior":[87],"treatment;":[88],"least":[90],"one":[91],"lesion":[92],"uniform":[94],"3":[97],"or":[98,100,114],"4":[99,133,211],"5":[104,213],"components,":[105],"bidimensional":[108],"diameter":[109],"product":[110],"20":[112],"mm2":[113],"greater;":[115],"high":[117],"SI":[118,140,165,174,227,251,254,264,286,292],"T1-weighted":[120],"indicative":[123],"postbiopsy":[125],"changes;":[126],"an":[128,193],"interval":[129],"more":[131],"than":[132,270],"weeks":[134],"biopsy":[136],"imaging.":[139],"tumors,":[143],"nontumor":[144],"prostatic":[145],"tissue,":[146],"internal":[148],"obturator":[149],"muscles":[150],"was":[151],"measured":[152],"uncorrected":[154,235],"corrected":[156,233],"images.":[159,291],"Correlations":[160],"grades":[163,210,245,280],"ratios":[166,175,255,265,287],"assessed":[168],"by":[169],"using":[170],"generalized":[171],"estimating":[172],"equations.":[173],"in":[176,268,271],"peripheral":[177],"zone":[178,182],"(PZ)":[179],"transition":[181],"(TZ)":[183],"lesions":[184,214],"same":[187],"compared":[191],"unpaired":[194],"t":[195],"test.":[196],"RESULTS:":[197],"Seventy-nine":[198],"3,":[201],"eight":[202],"4,":[205],"four":[207],"mixed":[208],"identified":[215],"analyzed.":[220],"correlated":[223],"significantly":[224],"tumor-muscle":[226,250,285],"ratio":[228],"PZ":[230,272],"tumors":[231,273],"(P":[237,274],"=":[238],".006":[239],"<.001,":[241],"respectively).":[242],"Higher":[243,278],"associated":[247,282],"lower":[249,267,284],"ratios.":[252],"Nontumor-muscle":[253],"did":[256],"not":[257],"correlate":[258],"patients'":[260],"grades.":[262],"Tumor-muscle":[263],"TZ":[269],"<":[275],".001).":[276],"CONCLUSION:":[277],"may":[298],"facilitate":[299],"noninvasive":[300],"assessment":[301],"aggressiveness.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}