{"id":"https://openalex.org/W2160911435","doi":null,"title":"Investigation into the ion channels and plasma membrane properties of white adipocytes","display_name":"Investigation into the ion channels and plasma membrane properties of white adipocytes","publication_year":2013,"publication_date":"2013-07-11","ids":{"openalex":"https://openalex.org/W2160911435","mag":"2160911435"},"language":"en","primary_location":{"id":"pmh:oai:eprints.nottingham.ac.uk:13004","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/13004/1/Donna_Bentley_PhD_2013.pdf","pdf_url":"https://eprints.nottingham.ac.uk/13004/1/Donna_Bentley_PhD_2013.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.nottingham.ac.uk/bitstreams/7c5c18b8-fe48-416f-b242-c4b5852a38bf/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074995844","display_name":"Donna Cynthia Bentley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donna Cynthia Bentley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074995844"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-adipocytes","display_name":"white adipocytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.640999972820282},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.515999972820282},{"id":"https://openalex.org/keywords/plasma-membrane-potential","display_name":"plasma membrane potential","score":0.828000009059906},{"id":"https://openalex.org/keywords/chloride-channels","display_name":"chloride channels","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.6819999814033508},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.3490000069141388},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6679999828338623},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.7120000123977661},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.671999990940094},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.3540000021457672},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.4309999942779541},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.5040000081062317},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6840384006500244},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6606995463371277},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6221793293952942},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5633514523506165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47641217708587646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.453127384185791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4479132890701294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3852226436138153},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.24522271752357483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11837217211723328}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:eprints.nottingham.ac.uk:13004","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/13004/1/Donna_Bentley_PhD_2013.pdf","pdf_url":"https://eprints.nottingham.ac.uk/13004/1/Donna_Bentley_PhD_2013.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:uilis.unsyiah.ac.id:9289","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/9289","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/35066","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/35066","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/7c5c18b8-fe48-416f-b242-c4b5852a38bf/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},{"id":"mag:2160911435","doi":null,"is_oa":false,"landing_page_url":"http://eprints.nottingham.ac.uk/13004/1/Donna_Bentley_PhD_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/35066","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/35066","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/7c5c18b8-fe48-416f-b242-c4b5852a38bf/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160911435.pdf","grobid_xml":"https://content.openalex.org/works/W2160911435.grobid-xml"},"referenced_works_count":298,"referenced_works":["https://openalex.org/W47946913","https://openalex.org/W56957918","https://openalex.org/W123622833","https://openalex.org/W164763019","https://openalex.org/W166158768","https://openalex.org/W370260827","https://openalex.org/W1484591950","https://openalex.org/W1497576400","https://openalex.org/W1507203601","https://openalex.org/W1519754933","https://openalex.org/W1520729429","https://openalex.org/W1525632749","https://openalex.org/W1534752717","https://openalex.org/W1545907911","https://openalex.org/W1546069399","https://openalex.org/W1548240598","https://openalex.org/W1563493452","https://openalex.org/W1570113205","https://openalex.org/W1574288427","https://openalex.org/W1576671418","https://openalex.org/W1592962814","https://openalex.org/W1675830194","https://openalex.org/W1686393656","https://openalex.org/W1786021994","https://openalex.org/W1819465909","https://openalex.org/W1824429632","https://openalex.org/W1890874737","https://openalex.org/W1892131812","https://openalex.org/W1899877571","https://openalex.org/W1958244357","https://openalex.org/W1963610951","https://openalex.org/W1964753346","https://openalex.org/W1964930341","https://openalex.org/W1970468800","https://openalex.org/W1971256871","https://openalex.org/W1972837195","https://openalex.org/W1973127639","https://openalex.org/W1973611043","https://openalex.org/W1974611207","https://openalex.org/W1975130654","https://openalex.org/W1975244785","https://openalex.org/W1977273311","https://openalex.org/W1977504592","https://openalex.org/W1977746407","https://openalex.org/W1979961108","https://openalex.org/W1981451392","https://openalex.org/W1982420826","https://openalex.org/W1982818212","https://openalex.org/W1983362094","https://openalex.org/W1984476260","https://openalex.org/W1986101977","https://openalex.org/W1986268203","https://openalex.org/W1986919040","https://openalex.org/W1987074136","https://openalex.org/W1987683730","https://openalex.org/W1988047960","https://openalex.org/W1988205894","https://openalex.org/W1989294105","https://openalex.org/W1989959217","https://openalex.org/W1996845076","https://openalex.org/W1997020689","https://openalex.org/W1997079696","https://openalex.org/W1997529256","https://openalex.org/W1998388042","https://openalex.org/W1999495254","https://openalex.org/W1999904792","https://openalex.org/W2000408293","https://openalex.org/W2000948750","https://openalex.org/W2001130359","https://openalex.org/W2004093709","https://openalex.org/W2004234324","https://openalex.org/W2004268761","https://openalex.org/W2004403903","https://openalex.org/W2005219438","https://openalex.org/W2006216368","https://openalex.org/W2007844778","https://openalex.org/W2008075340","https://openalex.org/W2008508150","https://openalex.org/W2009143060","https://openalex.org/W2009561055","https://openalex.org/W2009613933","https://openalex.org/W2009781552","https://openalex.org/W2009940405","https://openalex.org/W2010339131","https://openalex.org/W2011025084","https://openalex.org/W2012051487","https://openalex.org/W2012433024","https://openalex.org/W2012898950","https://openalex.org/W2013627907","https://openalex.org/W2015237552","https://openalex.org/W2016371603","https://openalex.org/W2016928499","https://openalex.org/W2017091114","https://openalex.org/W2018111790","https://openalex.org/W2018350483","https://openalex.org/W2019579712","https://openalex.org/W2019654282","https://openalex.org/W2021121638","https://openalex.org/W2021140520","https://openalex.org/W2021451578","https://openalex.org/W2022436579","https://openalex.org/W2022823501","https://openalex.org/W2024393097","https://openalex.org/W2024460873","https://openalex.org/W2025578932","https://openalex.org/W2026088200","https://openalex.org/W2027547456","https://openalex.org/W2027954222","https://openalex.org/W2028649508","https://openalex.org/W2028982633","https://openalex.org/W2029512914","https://openalex.org/W2031298570","https://openalex.org/W2034371514","https://openalex.org/W2034644036","https://openalex.org/W2035582618","https://openalex.org/W2038961236","https://openalex.org/W2039886039","https://openalex.org/W2040641918","https://openalex.org/W2041455826","https://openalex.org/W2041480360","https://openalex.org/W2042033504","https://openalex.org/W2042055122","https://openalex.org/W2042391144","https://openalex.org/W2042706232","https://openalex.org/W2045159219","https://openalex.org/W2045197162","https://openalex.org/W2049965571","https://openalex.org/W2050509217","https://openalex.org/W2051051060","https://openalex.org/W2052223108","https://openalex.org/W2052935441","https://openalex.org/W2054454072","https://openalex.org/W2054667743","https://openalex.org/W2054946491","https://openalex.org/W2055175897","https://openalex.org/W2056839311","https://openalex.org/W2058462966","https://openalex.org/W2059287499","https://openalex.org/W2059645143","https://openalex.org/W2059842910","https://openalex.org/W2060267166","https://openalex.org/W2060917353","https://openalex.org/W2061694403","https://openalex.org/W2063128928","https://openalex.org/W2063961981","https://openalex.org/W2065008766","https://openalex.org/W2065579335","https://openalex.org/W2067817632","https://openalex.org/W2068315659","https://openalex.org/W2069237083","https://openalex.org/W2069649414","https://openalex.org/W2070010954","https://openalex.org/W2070683963","https://openalex.org/W2070806415","https://openalex.org/W2071102441","https://openalex.org/W2071782902","https://openalex.org/W2071786252","https://openalex.org/W2072214489","https://openalex.org/W2073666721","https://openalex.org/W2074382975","https://openalex.org/W2074574470","https://openalex.org/W2074784296","https://openalex.org/W2075179357","https://openalex.org/W2075606032","https://openalex.org/W2076963420","https://openalex.org/W2079075373","https://openalex.org/W2079428986","https://openalex.org/W2080307601","https://openalex.org/W2080962219","https://openalex.org/W2081477183","https://openalex.org/W2081941102","https://openalex.org/W2082438131","https://openalex.org/W2082855639","https://openalex.org/W2083493439","https://openalex.org/W2083493906","https://openalex.org/W2084508206","https://openalex.org/W2084870914","https://openalex.org/W2085267754","https://openalex.org/W2086258149","https://openalex.org/W2086273425","https://openalex.org/W2087133824","https://openalex.org/W2087243332","https://openalex.org/W2087327142","https://openalex.org/W2087510546","https://openalex.org/W2087902062","https://openalex.org/W2088940658","https://openalex.org/W2089017203","https://openalex.org/W2089607284","https://openalex.org/W2090132841","https://openalex.org/W2091349751","https://openalex.org/W2091759162","https://openalex.org/W2092789146","https://openalex.org/W2093061965","https://openalex.org/W2093820347","https://openalex.org/W2093908779","https://openalex.org/W2094626045","https://openalex.org/W2096020027","https://openalex.org/W2096252794","https://openalex.org/W2097170770","https://openalex.org/W2097893773","https://openalex.org/W2098251960","https://openalex.org/W2098481065","https://openalex.org/W2100411368","https://openalex.org/W2101072772","https://openalex.org/W2101521576","https://openalex.org/W2102204826","https://openalex.org/W2102893344","https://openalex.org/W2103142377","https://openalex.org/W2104177088","https://openalex.org/W2104287466","https://openalex.org/W2104316598","https://openalex.org/W2106259414","https://openalex.org/W2106336974","https://openalex.org/W2108764665","https://openalex.org/W2109279728","https://openalex.org/W2109391648","https://openalex.org/W2109646972","https://openalex.org/W2110668934","https://openalex.org/W2110700383","https://openalex.org/W2110764082","https://openalex.org/W2111680106","https://openalex.org/W2112286600","https://openalex.org/W2112543188","https://openalex.org/W2113159655","https://openalex.org/W2114392769","https://openalex.org/W2116826216","https://openalex.org/W2118602922","https://openalex.org/W2120688902","https://openalex.org/W2120738384","https://openalex.org/W2121582872","https://openalex.org/W2123652234","https://openalex.org/W2124241212","https://openalex.org/W2125155338","https://openalex.org/W2125821357","https://openalex.org/W2127738100","https://openalex.org/W2128409864","https://openalex.org/W2128801406","https://openalex.org/W2131085646","https://openalex.org/W2131458670","https://openalex.org/W2134904182","https://openalex.org/W2135426025","https://openalex.org/W2137258759","https://openalex.org/W2137911312","https://openalex.org/W2138885636","https://openalex.org/W2140205166","https://openalex.org/W2140552959","https://openalex.org/W2140907409","https://openalex.org/W2142040078","https://openalex.org/W2142118492","https://openalex.org/W2142313059","https://openalex.org/W2142394429","https://openalex.org/W2145265986","https://openalex.org/W2145736847","https://openalex.org/W2146609683","https://openalex.org/W2147821881","https://openalex.org/W2149605836","https://openalex.org/W2150530686","https://openalex.org/W2150781459","https://openalex.org/W2151022783","https://openalex.org/W2152065725","https://openalex.org/W2154149532","https://openalex.org/W2154540873","https://openalex.org/W2155795955","https://openalex.org/W2159121293","https://openalex.org/W2159216880","https://openalex.org/W2159926700","https://openalex.org/W2159998111","https://openalex.org/W2160732255","https://openalex.org/W2161324995","https://openalex.org/W2162073123","https://openalex.org/W2163435696","https://openalex.org/W2164438031","https://openalex.org/W2168509040","https://openalex.org/W2170530524","https://openalex.org/W2171614397","https://openalex.org/W2172146749","https://openalex.org/W2175831347","https://openalex.org/W2182150538","https://openalex.org/W2185964438","https://openalex.org/W2188376552","https://openalex.org/W2203909212","https://openalex.org/W2215518492","https://openalex.org/W2247141049","https://openalex.org/W2250052379","https://openalex.org/W2257082799","https://openalex.org/W2334906120","https://openalex.org/W2340062477","https://openalex.org/W2399186522","https://openalex.org/W2402039462","https://openalex.org/W2402097036","https://openalex.org/W2403247196","https://openalex.org/W2404507371","https://openalex.org/W2413265692","https://openalex.org/W2953213394","https://openalex.org/W3142779971","https://openalex.org/W3196492948","https://openalex.org/W4296928814","https://openalex.org/W4301907924"],"related_works":["https://openalex.org/W2084344935","https://openalex.org/W3096960308","https://openalex.org/W2990078688","https://openalex.org/W7217184475","https://openalex.org/W3211558517","https://openalex.org/W7172495398","https://openalex.org/W2168509040","https://openalex.org/W7135613165","https://openalex.org/W2808170112","https://openalex.org/W2912607252"],"abstract_inverted_index":{"Ca2+":[0,19,62,74,88,136,149,343],"is":[1,8,35,161,182,314],"a":[2,50,288],"ubiquitous":[3],"intracellular":[4],"signalling":[5],"molecule":[6],"that":[7,169],"involved":[9,191],"in":[10,23,37,45,53,79,101,114,155,192,197,292,311,346],"the":[11,38,41,54,59,70,85,94,108,166,188,193,243,275,299,317,328,342,349,354],"regulation":[12,194],"of":[13,40,56,61,72,93,97,110,128,195,218,231,245,248,252,261,277,290,309,316,319],"numerous":[14],"cellular":[15,148],"functions.":[16],"To":[17],"date":[18],"influx":[20,63,75,150,344],"pathways":[21,64,78,345],"present":[22],"white":[24],"fat":[25],"adipocytes":[26,48,102,222],"have":[27,49],"not":[28,134,340],"been":[29],"characterised.":[30],"Additionally":[31],"impaired":[32],"[Ca2+]i":[33,67,82,123],"management":[34,55],"implicated":[36],"induction":[39],"insulin":[42,204,296],"resistant":[43],"state":[44],"adipocytes.":[46,80,202,282],"As":[47,203],"prominent":[51],"role":[52,251,289,308],"energy":[57],"homeostasis,":[58],"presence":[60,71,92,318],"was":[65,103,112,214,257],"examined.\\n\\nInitial":[66],"measurements":[68,83],"confirmed":[69,104],"functional":[73,158],"and":[76,199,205,220,226,280,348],"efflux":[77],"Further":[81],"identified":[84],"Cav1.3":[86,98],"Voltage-gated":[87],"channel":[89,99],"(VGCC).":[90],"The":[91,138,250],"\u03b11":[95],"subunit":[96],"protein":[100],"by":[105,151,268,356],"Western":[106],"blotting,":[107],"expression":[109],"which":[111,357],"reduced":[113],"adipocyte":[115,180,208,255,293,306,312,332],"samples":[116],"sourced":[117],"from":[118,234,264],"Zucker":[119],"obese":[120],"rats.":[121],"\\n\\nInitial":[122],"imaging":[124],"experiments":[125],"utilising":[126],"conditions":[127],"elevated":[129],"extracellular":[130,232,262],"K+":[131,160,178,233],"(50mM)":[132],"did":[133],"stimulate":[135],"influx.":[137],"plasma":[139],"membrane":[140],"potential":[141],"(Vm)":[142],"regulates":[143,179],"many":[144,173],"physiological":[145],"processes,":[146],"including":[147],"VGCCs,":[152],"with":[153,271],"dysregulations":[154],"Vm":[156,171,181,196,213,217,244,256,276,313],"underlying":[157,331],"pathologies.":[159],"widely":[162],"believed":[163],"to":[164,236,266,326,338],"be":[165],"predominant":[167],"ion":[168],"controls":[170],"for":[172],"cell":[174],"types,":[175],"however,":[176],"whether":[177],"also":[183,215,286,353],"unknown,":[184],"prompting,":[185],"investigation":[186],"into":[187],"ionic":[189],"species":[190],"primary":[198,219,279],"differentiated":[200],"3T3-L1":[201,221,281],"\u03b2-adrenoceptors":[206],"regulate":[207],"function,":[209],"their":[210],"effect":[211,241],"on":[212,242,254],"explored.\\n\\nThe":[216],"were":[223],"-34.14mV":[224],"(n=68)":[225],"-28.5mV":[227],"(n=88)":[228],"respectively.":[229],"Elevation":[230],"5.6mM":[235],"50mM":[237],"had":[238],"no":[239],"significant":[240],"either":[246],"type":[247],"adipocyte.":[249],"Cl-":[253,263,310,320,329],"then":[258],"investigated.":[259],"Reduction":[260],"138":[265],"5mM,":[267],"equimolar":[269],"substitution":[270],"Gluconate":[272],"significantly":[273,304],"depolarised":[274],"both":[278],"Patch":[283],"clamp":[284],"investigations":[285,335],"revealed":[287],"Na+":[291],"Vm.":[294],"Neither":[295],"(100nM)":[297],"or":[298],"\u03b2-adrenocpetor":[300],"agonist":[301],"isoprenaline":[302],"(10\u00b5M)":[303],"changed":[305],"Vm.\\n\\nThe":[307],"indicative":[315],"channels,":[321],"however":[322],"electrophysiological":[323],"studies":[324],"failed":[325],"characterise":[327,339],"currents":[330],"Vm.\\n\\nOverall,":[333],"further":[334],"are":[336,359],"required":[337],"only":[341],"adipocytes,":[347],"roles":[350],"thereof,":[351],"but":[352],"means":[355],"they":[358],"regulated.":[360]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}