{"id":"https://openalex.org/W2160907987","doi":"https://doi.org/10.1083/jcb.92.2.249","title":"Role of proteoglycans in endochondral ossification: immunofluorescent localization of link protein and proteoglycan monomer in bovine fetal epiphyseal growth plate.","display_name":"Role of proteoglycans in endochondral ossification: immunofluorescent localization of link protein and proteoglycan monomer in bovine fetal epiphyseal growth plate.","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W2160907987","doi":"https://doi.org/10.1083/jcb.92.2.249","mag":"2160907987","pmid":"https://pubmed.ncbi.nlm.nih.gov/7037793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112085"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.92.2.249","doi":"https://doi.org/10.1083/jcb.92.2.249","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.92.2.249","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112085","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082113025","display_name":"A. Robin Poole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A R Poole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080666363","display_name":"Isabelle Pidoux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Pidoux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3169,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.94777713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"92","issue":"2","first_page":"249","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9869999885559082},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.8119999766349792},{"id":"https://openalex.org/keywords/link-protein","display_name":"link protein","score":0.9279999732971191},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.953000009059906},{"id":"https://openalex.org/keywords/calcified-cartilage","display_name":"calcified cartilage","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hypertrophic-chondrocytes","display_name":"hypertrophic chondrocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.7129999995231628},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.5920000076293945},{"id":"https://openalex.org/keywords/trabeculae","display_name":"trabeculae","score":0.8629999756813049},{"id":"https://openalex.org/keywords/immunofluorescence","display_name":"immunofluorescence","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.877145528793335},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7993346452713013},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.7429413199424744},{"id":"https://openalex.org/C25515809","wikidata":"https://www.wikidata.org/wiki/Q663949","display_name":"Perichondrium","level":3,"score":0.6265910863876343},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5935301184654236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5862910747528076},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.4849660396575928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48487457633018494},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.47844839096069336},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.45901644229888916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19180607795715332},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1844475269317627},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.08008930087089539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099249","descriptor_name":"Proteoglycan Link Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.92.2.249","doi":"https://doi.org/10.1083/jcb.92.2.249","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.92.2.249","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2112085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:7037793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7037793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2112085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W65863762","https://openalex.org/W79529656","https://openalex.org/W95449797","https://openalex.org/W124526046","https://openalex.org/W1486185605","https://openalex.org/W1486203466","https://openalex.org/W1497863747","https://openalex.org/W1506858910","https://openalex.org/W1523321921","https://openalex.org/W1527942330","https://openalex.org/W1544761069","https://openalex.org/W1598470014","https://openalex.org/W1606921260","https://openalex.org/W1608238415","https://openalex.org/W1608464107","https://openalex.org/W1628236543","https://openalex.org/W1902549464","https://openalex.org/W1969359829","https://openalex.org/W1996712946","https://openalex.org/W2004069564","https://openalex.org/W2005511262","https://openalex.org/W2010391793","https://openalex.org/W2014564452","https://openalex.org/W2015778574","https://openalex.org/W2017689188","https://openalex.org/W2027834875","https://openalex.org/W2031420609","https://openalex.org/W2034807753","https://openalex.org/W2036331306","https://openalex.org/W2040126397","https://openalex.org/W2047366212","https://openalex.org/W2051048892","https://openalex.org/W2058675616","https://openalex.org/W2058844752","https://openalex.org/W2062930474","https://openalex.org/W2063180757","https://openalex.org/W2083439385","https://openalex.org/W2083544458","https://openalex.org/W2084473308","https://openalex.org/W2089687069","https://openalex.org/W2095627071","https://openalex.org/W2102753351","https://openalex.org/W2103749562","https://openalex.org/W2118008793","https://openalex.org/W2134683151","https://openalex.org/W2292439052","https://openalex.org/W2334632380","https://openalex.org/W2410222633","https://openalex.org/W2413301687"],"related_works":["https://openalex.org/W7097712400","https://openalex.org/W1988687046","https://openalex.org/W2084103637","https://openalex.org/W2055699737","https://openalex.org/W2044222496","https://openalex.org/W2157469235","https://openalex.org/W2217005512","https://openalex.org/W2079204122","https://openalex.org/W1550515208","https://openalex.org/W2009521757"],"abstract_inverted_index":{"The":[0,101],"hypothesis":[1,51],"is":[2,33,41,185,201,262],"widely":[3],"held":[4],"that,":[5],"in":[6,13,77,109,123,137,143,174,187,215,235],"growth":[7,86],"plate":[8],"during":[9,207],"endochondral":[10],"ossification,":[11],"proteoglycans":[12,206,212],"the":[14,18,34,54,68,78,82,115,126,134,144,162,166,170,175,179,188,193,211,216,236,241,246,259,265],"extracellular":[15,163],"matrix":[16,40,164],"of":[17,59,70,81,104,117,128,146,165,169,178,205,240],"lower":[19],"hypertrophic":[20,120,131,171],"zone":[21,172],"are":[22,156,228,249],"degraded":[23],"by":[24,36,52,73,256,264],"proteases":[25],"and":[26,30,57,64,67,97,111,119,122,130,133,153,173,209,226,254],"removed":[27,255],"before":[28],"mineralization,":[29],"that":[31,199,210],"this":[32,50],"mechanism":[35],"which":[37,219,224],"a":[38,44,221],"noncalcifiable":[39],"transformed":[42],"into":[43],"calcifiable":[45],"matrix.":[46],"We":[47],"have":[48],"evaluated":[49],"examining":[53],"immunofluorescent":[55,102],"localization":[56,103],"concentrations":[58,69],"proteoglycan":[60,93],"monomer":[61,94,150],"core":[62,95,151,239],"protein":[63,96,152,155],"link":[65,99,154],"protein,":[66],"glycosaminoglycans":[71],"demonstrated":[72],"safranin":[74],"0":[75],"staining,":[76],"different":[79],"zones":[80,116,127],"bovine":[83],"fetal":[84],"cartilage":[85,177,218,238],"plate.":[87],"Monospecific":[88],"antibodies":[89],"were":[90],"prepared":[91],"to":[92,98,192,232],"protein.":[100],"these":[105],"species":[106],"was":[107],"examined":[108],"decalcified":[110,136],"undecalcified":[112],"sections":[113,124],"containing":[114,125],"proliferating":[118,129],"chondrocytes":[121,132],"metaphysis,":[135],"0.5":[138],"M":[139],"EDTA,":[140],"pH":[141],"7.5,":[142],"presence":[145],"protease":[147],"inhibitors.":[148],"Proteoglycan":[149],"demonstrable":[157],"without":[158],"detectable":[159],"loss":[160,204],"throughout":[161],"longitudinal":[167],"septa":[168],"calcified":[176,217,237],"metaphysis.":[180],"In":[181],"fact,":[182],"increased":[183],"staining":[184],"observed":[186],"calcifying":[189],"cartilage.":[190],"Contrary":[191],"prevailing":[194],"hypothesis,":[195],"our":[196],"results":[197],"indicate":[198],"there":[200],"no":[202],"net":[203],"mineralization":[208],"become":[213],"entombed":[214],"provides":[220],"scaffolding":[222],"on":[223],"osteoid":[225],"bone":[227],"formed.":[229],"Proteoglycans":[230],"appear":[231],"persist":[233],"unaltered":[234],"trabeculae,":[242],"until":[243],"at":[244],"last":[245],"entire":[247],"trabeculae":[248],"eroded":[250],"from":[251],"their":[252],"surfaces":[253],"osteoclasts,":[257],"when":[258],"primary":[260],"spongiosa":[261],"replaced":[263],"secondary":[266],"spongiosa.":[267]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
