{"id":"https://openalex.org/W2160900058","doi":"https://doi.org/10.2217/nmt.14.36","title":"Aberrant Rna Homeostasis in Amyotrophic Lateral Sclerosis: Potential for New Therapeutic targets?","display_name":"Aberrant Rna Homeostasis in Amyotrophic Lateral Sclerosis: Potential for New Therapeutic targets?","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2160900058","doi":"https://doi.org/10.2217/nmt.14.36","mag":"2160900058","pmid":"https://pubmed.ncbi.nlm.nih.gov/25531686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308292"},"language":"en","primary_location":{"id":"doi:10.2217/nmt.14.36","doi":"https://doi.org/10.2217/nmt.14.36","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nmt.14.36","pdf_url":null,"source":{"id":"https://openalex.org/S2764766229","display_name":"Neurodegenerative Disease Management","issn_l":"1758-2024","issn":["1758-2024","1758-2032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Disease Management","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032094493","display_name":"Christopher J. Donnelly","orcid":"https://orcid.org/0000-0002-2383-9015","observed_orcids":["https://orcid.org/0000-0002-2383-9015"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Donnelly","raw_affiliation_strings":["Brain Science Institute Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","Department of Neurology Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Science Institute Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Neurology Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110761955","display_name":"Jonathan C. Grima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C Grima","raw_affiliation_strings":["The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083878416","display_name":"Rita Sattler","orcid":"https://orcid.org/0000-0002-7593-2908","observed_orcids":["https://orcid.org/0000-0002-7593-2908"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Sattler","raw_affiliation_strings":["Brain Science Institute Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","Department of Neurology Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Science Institute Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Neurology Johns Hopkins University School of Medicine\rBaltimore\rMD\r21205\rUSA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.869,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75322936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"6","first_page":"417","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/rna-homeostasis","display_name":"RNA homeostasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rna-toxicity","display_name":"RNA toxicity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.8399999737739563},{"id":"https://openalex.org/keywords/fus-tls","display_name":"FUS/TLS","score":0.9259999990463257},{"id":"https://openalex.org/keywords/c9orf72","display_name":"C9orf72","score":0.9900000095367432},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7310000061988831},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9664433002471924},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6330117583274841},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5586082339286804},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4759494960308075},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4568295478820801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35922276973724365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35885822772979736},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2754002809524536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1947520673274994},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17127469182014465},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1487419605255127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1447729468345642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08882066607475281}],"mesh":[{"descriptor_ui":"D000073885","descriptor_name":"C9orf72 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2217/nmt.14.36","doi":"https://doi.org/10.2217/nmt.14.36","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nmt.14.36","pdf_url":null,"source":{"id":"https://openalex.org/S2764766229","display_name":"Neurodegenerative Disease Management","issn_l":"1758-2024","issn":["1758-2024","1758-2032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Disease Management","raw_type":"journal-article"},{"id":"pmid:25531686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25531686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative disease management","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4308292","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neurodegener Dis Manag","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4308292","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neurodegener Dis Manag","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2166982239","display_name":"ALS/FTD mutant C9orf72-induced genetic and nuclear pathology in iPS cell models","funder_award_id":"R01NS085207","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W61004016","https://openalex.org/W205602265","https://openalex.org/W1511534554","https://openalex.org/W1524308920","https://openalex.org/W1590729586","https://openalex.org/W1619082318","https://openalex.org/W1666530056","https://openalex.org/W1860915937","https://openalex.org/W1965850853","https://openalex.org/W1965975446","https://openalex.org/W1966180593","https://openalex.org/W1967932847","https://openalex.org/W1970397885","https://openalex.org/W1971529004","https://openalex.org/W1972453061","https://openalex.org/W1972989638","https://openalex.org/W1973771042","https://openalex.org/W1974032274","https://openalex.org/W1974448552","https://openalex.org/W1974961961","https://openalex.org/W1979837223","https://openalex.org/W1979937961","https://openalex.org/W1980894900","https://openalex.org/W1981530842","https://openalex.org/W1984538960","https://openalex.org/W1987533749","https://openalex.org/W1988134372","https://openalex.org/W1988283896","https://openalex.org/W1990422584","https://openalex.org/W1991208268","https://openalex.org/W1991570014","https://openalex.org/W1992002234","https://openalex.org/W1994794306","https://openalex.org/W1995148334","https://openalex.org/W1999522052","https://openalex.org/W2001653341","https://openalex.org/W2003618511","https://openalex.org/W2003982930","https://openalex.org/W2004327356","https://openalex.org/W2004850573","https://openalex.org/W2004901342","https://openalex.org/W2005352390","https://openalex.org/W2006167464","https://openalex.org/W2007239552","https://openalex.org/W2010201645","https://openalex.org/W2010383142","https://openalex.org/W2010659088","https://openalex.org/W2011184139","https://openalex.org/W2013215026","https://openalex.org/W2013488820","https://openalex.org/W2013846239","https://openalex.org/W2014140012","https://openalex.org/W2014599804","https://openalex.org/W2017916137","https://openalex.org/W2020159880","https://openalex.org/W2020266231","https://openalex.org/W2021542157","https://openalex.org/W2023556666","https://openalex.org/W2025621504","https://openalex.org/W2025912123","https://openalex.org/W2026931179","https://openalex.org/W2027420858","https://openalex.org/W2028580880","https://openalex.org/W2030893485","https://openalex.org/W2031964319","https://openalex.org/W2032719480","https://openalex.org/W2033842104","https://openalex.org/W2035943396","https://openalex.org/W2037230855","https://openalex.org/W2038354221","https://openalex.org/W2038438413","https://openalex.org/W2039247139","https://openalex.org/W2041665769","https://openalex.org/W2041676007","https://openalex.org/W2042744684","https://openalex.org/W2042930414","https://openalex.org/W2044033904","https://openalex.org/W2045245162","https://openalex.org/W2045962406","https://openalex.org/W2047569375","https://openalex.org/W2047670501","https://openalex.org/W2048097050","https://openalex.org/W2051072907","https://openalex.org/W2052069766","https://openalex.org/W2052134450","https://openalex.org/W2053362200","https://openalex.org/W2056401645","https://openalex.org/W2056470398","https://openalex.org/W2057260831","https://openalex.org/W2062238769","https://openalex.org/W2063061148","https://openalex.org/W2063996210","https://openalex.org/W2065219073","https://openalex.org/W2066952414","https://openalex.org/W2067015275","https://openalex.org/W2069171272","https://openalex.org/W2070038024","https://openalex.org/W2071471772","https://openalex.org/W2071505821","https://openalex.org/W2072297951","https://openalex.org/W2072552163","https://openalex.org/W2073073462","https://openalex.org/W2073190029","https://openalex.org/W2073419755","https://openalex.org/W2074726646","https://openalex.org/W2075186362","https://openalex.org/W2075929828","https://openalex.org/W2076363659","https://openalex.org/W2077332675","https://openalex.org/W2079470515","https://openalex.org/W2080696342","https://openalex.org/W2082210819","https://openalex.org/W2083204774","https://openalex.org/W2083734153","https://openalex.org/W2084091637","https://openalex.org/W2085165928","https://openalex.org/W2085793842","https://openalex.org/W2088201490","https://openalex.org/W2088461570","https://openalex.org/W2090088751","https://openalex.org/W2090804804","https://openalex.org/W2093933725","https://openalex.org/W2094920961","https://openalex.org/W2095013356","https://openalex.org/W2096386031","https://openalex.org/W2097233439","https://openalex.org/W2099694384","https://openalex.org/W2100715148","https://openalex.org/W2101042581","https://openalex.org/W2101627876","https://openalex.org/W2102099323","https://openalex.org/W2103964281","https://openalex.org/W2104160257","https://openalex.org/W2106430667","https://openalex.org/W2107508122","https://openalex.org/W2107768418","https://openalex.org/W2108169752","https://openalex.org/W2108621779","https://openalex.org/W2109299139","https://openalex.org/W2112538318","https://openalex.org/W2113525941","https://openalex.org/W2113670539","https://openalex.org/W2114872355","https://openalex.org/W2115670698","https://openalex.org/W2115940796","https://openalex.org/W2116086426","https://openalex.org/W2116660354","https://openalex.org/W2117428493","https://openalex.org/W2119558018","https://openalex.org/W2119679922","https://openalex.org/W2120402749","https://openalex.org/W2123193865","https://openalex.org/W2123779560","https://openalex.org/W2124654811","https://openalex.org/W2124727655","https://openalex.org/W2125073277","https://openalex.org/W2125093810","https://openalex.org/W2126810432","https://openalex.org/W2127122830","https://openalex.org/W2128739333","https://openalex.org/W2128744963","https://openalex.org/W2128768698","https://openalex.org/W2131198526","https://openalex.org/W2132166526","https://openalex.org/W2132573397","https://openalex.org/W2135607950","https://openalex.org/W2135718342","https://openalex.org/W2136949432","https://openalex.org/W2137039075","https://openalex.org/W2138207816","https://openalex.org/W2139264742","https://openalex.org/W2139267086","https://openalex.org/W2139919925","https://openalex.org/W2140043547","https://openalex.org/W2140679517","https://openalex.org/W2141136226","https://openalex.org/W2143355329","https://openalex.org/W2146627025","https://openalex.org/W2148253741","https://openalex.org/W2148437361","https://openalex.org/W2150523249","https://openalex.org/W2151187882","https://openalex.org/W2154417593","https://openalex.org/W2154923417","https://openalex.org/W2154945114","https://openalex.org/W2157580663","https://openalex.org/W2158949580","https://openalex.org/W2159280728","https://openalex.org/W2159354359","https://openalex.org/W2159855012","https://openalex.org/W2161239543","https://openalex.org/W2161693225","https://openalex.org/W2162932379","https://openalex.org/W2163203307","https://openalex.org/W2163731275","https://openalex.org/W2164245070","https://openalex.org/W2166483989","https://openalex.org/W2166499468","https://openalex.org/W2168137891","https://openalex.org/W2171300333","https://openalex.org/W2314689571","https://openalex.org/W2319303211","https://openalex.org/W2322093705","https://openalex.org/W2699220065","https://openalex.org/W2919268190","https://openalex.org/W4210582839"],"related_works":["https://openalex.org/W3186810214","https://openalex.org/W2913041247","https://openalex.org/W2136550982","https://openalex.org/W2065778101","https://openalex.org/W2784295908","https://openalex.org/W2059521403","https://openalex.org/W2027925622","https://openalex.org/W2998032431","https://openalex.org/W1983979798","https://openalex.org/W2011184139"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"is":[4,18],"a":[5,82],"fatal":[6],"neurodegenerative":[7,69],"disorder":[8],"characterized":[9],"by":[10],"progressive":[11],"motor":[12],"neuron":[13],"degeneration.":[14],"The":[15,50],"disease":[16,34,86],"pathogenesis":[17],"multifaceted":[19],"in":[20,55,71,99],"that":[21],"multiple":[22],"cellular":[23],"and":[24,73,101],"molecular":[25],"pathways":[26,98],"have":[27,40],"been":[28,41],"identified":[29],"as":[30,60,81],"contributors":[31],"to":[32,85],"the":[33,75,91],"progression.":[35],"Consequently,":[36],"numerous":[37],"therapeutic":[38,104],"targets":[39],"pursued":[42],"for":[43],"clinical":[44],"development,":[45],"unfortunately":[46],"with":[47],"little":[48],"success.":[49],"recent":[51],"discovery":[52],"of":[53,68,77],"mutations":[54],"RNA":[56,79,96],"modulating":[57],"genes":[58],"such":[59,95],"TARDBP/TDP-43,":[61],"FUS/TLS":[62],"or":[63],"C9ORF72":[64],"changed":[65],"our":[66],"understanding":[67],"mechanisms":[70],"ALS":[72,100],"introduced":[74],"role":[76],"dysfunctional":[78],"processing":[80],"significant":[83],"contributor":[84],"pathogenesis.":[87],"This":[88],"article":[89],"discusses":[90],"latest":[92],"findings":[93],"on":[94],"toxicity":[97],"potential":[102],"novel":[103],"approaches.":[105]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}