{"id":"https://openalex.org/W2160885558","doi":null,"title":"Influence of asbestos on the uptake of benzo(a)pyrene and DNA alkylation in hamster tracheal epithelial cells.","display_name":"Influence of asbestos on the uptake of benzo(a)pyrene and DNA alkylation in hamster tracheal epithelial cells.","publication_year":1983,"publication_date":"1983-03-01","ids":{"openalex":"https://openalex.org/W2160885558","mag":"2160885558","pmid":"https://pubmed.ncbi.nlm.nih.gov/6297722"},"language":"en","primary_location":{"id":"pmid:6297722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016470161","display_name":"Alan R. Eastman","orcid":"https://orcid.org/0000-0002-8044-3092","observed_orcids":["https://orcid.org/0000-0002-8044-3092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Eastman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040898114","display_name":"Brooke T. Mossman","orcid":"https://orcid.org/0000-0002-5306-5153","observed_orcids":["https://orcid.org/0000-0002-5306-5153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B T Mossman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000727984","display_name":"Edward Bresnick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bresnick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.8,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.98256996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"3","first_page":"1251","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asbestos","display_name":"asbestos","score":0.9879999756813049},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9819999933242798},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cocarcinogenesis","display_name":"cocarcinogenesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dna-alkylation","display_name":"DNA alkylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.6119999885559082},{"id":"https://openalex.org/keywords/crocidolite","display_name":"crocidolite","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chrysotile","display_name":"chrysotile","score":0.9789999723434448},{"id":"https://openalex.org/keywords/asbestos-fibers","display_name":"asbestos fibers","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C111963520","wikidata":"https://www.wikidata.org/wiki/Q118781","display_name":"Chrysotile","level":3,"score":0.8667083978652954},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.7263935804367065},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.7181382775306702},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.7048129439353943},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6952537894248962},{"id":"https://openalex.org/C510490043","wikidata":"https://www.wikidata.org/wiki/Q104085","display_name":"Asbestos","level":2,"score":0.6898438930511475},{"id":"https://openalex.org/C2779229383","wikidata":"https://www.wikidata.org/wiki/Q1501961","display_name":"Benzopyrene","level":4,"score":0.6205690503120422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5607293248176575},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5404835939407349},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.5087643265724182},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4486869275569916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4127000570297241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29119086265563965},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10437020659446716},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000478","descriptor_name":"Alkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001194","descriptor_name":"Asbestos","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:6297722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2160885558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1533195630","https://openalex.org/W1777576568","https://openalex.org/W1963896234","https://openalex.org/W1998193589","https://openalex.org/W2007993189","https://openalex.org/W2012224376","https://openalex.org/W2073739277","https://openalex.org/W2083501504","https://openalex.org/W2099015663","https://openalex.org/W2167489016","https://openalex.org/W2179086184","https://openalex.org/W2268338303","https://openalex.org/W2392089762","https://openalex.org/W4298351295"],"related_works":["https://openalex.org/W1976867495","https://openalex.org/W7098542640","https://openalex.org/W2057674193","https://openalex.org/W2007998494","https://openalex.org/W2073739277","https://openalex.org/W2001886088","https://openalex.org/W827505446","https://openalex.org/W2018381012","https://openalex.org/W2129037164","https://openalex.org/W2047489505"],"abstract_inverted_index":{"The":[0,41,80,201],"objective":[1],"of":[2,10,12,36,47,55,78,93,130,140,144,177,185,199,204,210,216],"these":[3,186],"experiments":[4],"was":[5,20,59,83,104,125,133,152,159,188,192],"to":[6,34,69,102,111,164],"understand":[7],"the":[8,56,62,76,94,128,138,145,155,169,180,197],"mechanism":[9,215],"cocarcinogenicity":[11],"asbestos":[13,26,103,191],"and":[14,32,127,162,206],"polycyclic":[15],"aromatic":[16],"hydrocarbons.":[17],"Benzo(a)pyrene":[18],"[B(a)P]":[19],"coated":[21],"onto":[22],"crocidolite":[23],"or":[24,150],"chrysotile":[25],"fibers,":[27],"resuspended":[28],"in":[29,75,107,113],"serum-free":[30],"medium,":[31],"added":[33,193],"cultures":[35],"hamster":[37,121],"tracheal":[38,122],"epithelial":[39,123],"cells.":[40],"fibers":[42],"markedly":[43],"enhanced":[44,202],"cell":[45],"uptake":[46,203],"B(a)P.":[48,200],"Although":[49],"considerable":[50],"metabolism":[51],"occurred,":[52],"approximately":[53,91],"40%":[54],"applied":[57,99],"B(a)P":[58,74,95,117,131,149,158,205],"retained":[60,156],"by":[61,85],"cells":[63,108,114,124,146,172],"after":[64,71,142],"8-hr":[65],"incubation":[66,72],"as":[67,109],"opposed":[68],"5%":[70],"with":[73,116,147],"absence":[77],"asbestos.":[79],"hydrocarbon-containing":[81],"medium":[82],"replaced":[84],"fresh":[86],"medium.":[87],"Four":[88],"days":[89],"later,":[90],"3%":[92],"that":[96,168],"had":[97],"been":[98],"when":[100],"adsorbed":[101],"still":[105],"persistent":[106],"compared":[110],"0.5%":[112],"treated":[115,171],"alone.":[118],"DNA":[119,211],"from":[120],"purified,":[126],"amount":[129],"alkylation":[132,141,166,178,209],"assessed.":[134],"At":[135],"8":[136],"hr,":[137],"extent":[139],"treatment":[143],"either":[148],"B(a)P:asbestos":[151],"similar.":[153],"However,":[154],"unmetabolized":[157],"subsequently":[160],"metabolized":[161],"contributed":[163],"further":[165],"so":[167],"B(a)P-asbestos":[170],"demonstrated":[173],"considerably":[174],"higher":[175],"levels":[176],"throughout":[179],"4-day":[181],"posttreatment":[182],"period.":[183],"None":[184],"effects":[187],"observed":[189],"if":[190],"1":[194],"hr":[195],"before":[196],"addition":[198],"subsequent":[207],"additional":[208],"might":[212],"represent":[213],"a":[214],"asbestos-induced":[217],"cocarcinogenesis.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
