{"id":"https://openalex.org/W2160835678","doi":null,"title":"Which antidepressant? A commentary from general practice on evidence-based medicine and health economics.","display_name":"Which antidepressant? A commentary from general practice on evidence-based medicine and health economics.","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2160835678","mag":"2160835678","pmid":"https://pubmed.ncbi.nlm.nih.gov/9101693","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1312914"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:257360","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1312914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1312914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015376704","display_name":"David P. Kernick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151371","display_name":"St. Thomas Medical Group","ror":"https://ror.org/04nhyzz08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D P Kernick","raw_affiliation_strings":["St Thomas Medical Group, Exeter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Thomas Medical Group, Exeter","institution_ids":["https://openalex.org/I4210151371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015376704"],"corresponding_institution_ids":["https://openalex.org/I4210151371"],"apc_list":null,"apc_paid":null,"fwci":2.9247,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90954403,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"47","issue":"415","first_page":"95","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antidepressant-selection","display_name":"antidepressant selection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9909999966621399},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":1.0},{"id":"https://openalex.org/keywords/general-practice","display_name":"general practice","score":0.7049999833106995},{"id":"https://openalex.org/keywords/evidence-based-medicine","display_name":"evidence-based medicine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/health-economics","display_name":"health economics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/value-for-money","display_name":"value for money","score":0.9710000157356262},{"id":"https://openalex.org/keywords/resource-allocation","display_name":"resource allocation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6670318245887756},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5714410543441772},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5411109328269958},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.5391334295272827},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5201663970947266},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.5022842884063721},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.48809564113616943},{"id":"https://openalex.org/C2781318095","wikidata":"https://www.wikidata.org/wiki/Q33127638","display_name":"General practice","level":2,"score":0.4857373833656311},{"id":"https://openalex.org/C524218345","wikidata":"https://www.wikidata.org/wiki/Q31218","display_name":"Health economics","level":3,"score":0.47526830434799194},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.4729178547859192},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4209877848625183},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36701035499572754},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3558182120323181},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.16516238451004028},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.1588033139705658},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.13043895363807678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1060299277305603},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.09560301899909973},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004739","descriptor_name":"England","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005194","descriptor_name":"Family Practice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:257360","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1312914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:9101693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9101693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of general practice : the journal of the Royal College of General Practitioners","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1312914","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1312914/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Gen Pract","raw_type":"Text"},{"id":"mag:2160835678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9101693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:257360","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1312914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W58955114","https://openalex.org/W59145449","https://openalex.org/W73558069","https://openalex.org/W124849650","https://openalex.org/W326363483","https://openalex.org/W1759860330","https://openalex.org/W1851723921","https://openalex.org/W1929168249","https://openalex.org/W1964494343","https://openalex.org/W1970130494","https://openalex.org/W1970278663","https://openalex.org/W1970387771","https://openalex.org/W1971782045","https://openalex.org/W1974946748","https://openalex.org/W1980132208","https://openalex.org/W1994801159","https://openalex.org/W2000750387","https://openalex.org/W2006140661","https://openalex.org/W2008911434","https://openalex.org/W2009386555","https://openalex.org/W2020571807","https://openalex.org/W2030269002","https://openalex.org/W2038036598","https://openalex.org/W2044053804","https://openalex.org/W2048361493","https://openalex.org/W2051949977","https://openalex.org/W2052223361","https://openalex.org/W2056676470","https://openalex.org/W2062064976","https://openalex.org/W2067570300","https://openalex.org/W2071104598","https://openalex.org/W2083630756","https://openalex.org/W2083991574","https://openalex.org/W2085349851","https://openalex.org/W2098454587","https://openalex.org/W2105063745","https://openalex.org/W2106075952","https://openalex.org/W2113816742","https://openalex.org/W2159011576","https://openalex.org/W2437038635","https://openalex.org/W2568455669","https://openalex.org/W2731812427","https://openalex.org/W2739418049"],"related_works":["https://openalex.org/W2025595549","https://openalex.org/W1969309814","https://openalex.org/W2048507500","https://openalex.org/W2030269239","https://openalex.org/W2006662382","https://openalex.org/W2092105799","https://openalex.org/W4416706816","https://openalex.org/W2397343939","https://openalex.org/W2781704429","https://openalex.org/W2313206494"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"increasing":[2],"demand":[3],"for":[4,105,119,141],"health":[5,11,61],"care,":[6],"evidence-based":[7,57,90,128],"medicine":[8,176],"combined":[9,59],"with":[10,31,60],"economics":[12,62],"offers":[13],"a":[14,28,66,71,159,171],"method":[15],"of":[16,19,41,55,83,99,144,175],"optimizing":[17],"allocation":[18],"limited":[20],"resources.":[21],"Depression":[22],"is":[23,43],"an":[24,56],"illness":[25],"that":[26,166],"has":[27],"high":[29],"prevalence":[30],"important":[32],"medical,":[33],"social":[34],"and":[35,45,103,117,162,169],"economic":[36],"implications.":[37],"More":[38],"than":[39,178],"90%":[40],"depression":[42,84,145],"diagnosed":[44],"treated":[46],"in":[47,63,80,85,146,158],"general":[48,86,147,153],"practice.":[49,87,148],"AIM:":[50],"To":[51],"review":[52],"the":[53,81,93,97,142],"effectiveness":[54,102,116],"approach":[58,129],"deciding":[64],"whether":[65,134],"tricyclic":[67],"antidepressant":[68],"(TCA)":[69],"or":[70,136],"selective":[72],"serotonin":[73],"reuptake":[74],"inhibitor":[75],"(SSRI)":[76],"should":[77,138,155,163],"be":[78,123,139,156],"used":[79,140],"treatment":[82,143],"METHOD:":[88],"An":[89,127],"strategy":[91],"tested":[92],"two":[94],"treatments":[95],"against":[96],"criteria":[98],"appropriateness,":[100],"efficacy,":[101],"value":[104,118],"money.":[106],"RESULTS:":[107],"Although":[108],"both":[109],"drugs":[110],"were":[111],"equally":[112],"efficacious,":[113],"their":[114],"relative":[115],"money":[120],"could":[121],"not":[122,131],"accurately":[124],"defined.":[125],"CONCLUSION:":[126],"does":[130],"make":[132],"clear":[133],"SSRIs":[135],"TCAs":[137],"Research":[149],"questions":[150],"arising":[151],"from":[152],"practice":[154],"addressed":[157],"relevant":[160],"setting":[161],"yield":[164],"answers":[165],"will":[167],"complement":[168],"support":[170],"more":[172],"pragmatic":[173],"system":[174],"rather":[177],"seek":[179],"to":[180],"direct":[181],"it.":[182]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}