{"id":"https://openalex.org/W2160818993","doi":"https://doi.org/10.1523/jneurosci.0519-06.2006","title":"\u03b1-Synuclein Overexpression Increases Cytosolic Catecholamine Concentration","display_name":"\u03b1-Synuclein Overexpression Increases Cytosolic Catecholamine Concentration","publication_year":2006,"publication_date":"2006-09-06","ids":{"openalex":"https://openalex.org/W2160818993","doi":"https://doi.org/10.1523/jneurosci.0519-06.2006","mag":"2160818993","pmid":"https://pubmed.ncbi.nlm.nih.gov/16957086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6674515"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0519-06.2006","doi":"https://doi.org/10.1523/jneurosci.0519-06.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0519-06.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/36/9304.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/26/36/9304.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004169353","display_name":"Eugene V. Mosharov","orcid":"https://orcid.org/0000-0002-0229-7114","observed_orcids":["https://orcid.org/0000-0002-0229-7114"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene V. Mosharov","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088451304","display_name":"Roland G. W. Staal","orcid":"https://orcid.org/0000-0002-2857-2241","observed_orcids":["https://orcid.org/0000-0002-2857-2241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland G. W. Staal","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017446072","display_name":"Jordi Bov\u00e9","orcid":"https://orcid.org/0000-0002-2529-205X","observed_orcids":["https://orcid.org/0000-0002-2529-205X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordi Bov\u00e9","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063200799","display_name":"Delphine Prou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delphine Prou","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078876314","display_name":"Anthonia Hananiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthonia Hananiya","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089614781","display_name":"Dmitriy A. Markov","orcid":"https://orcid.org/0009-0007-6574-0367","observed_orcids":["https://orcid.org/0009-0007-6574-0367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dmitriy Markov","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064202587","display_name":"Nathan W. Poulsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathan Poulsen","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kristin E. Larsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin E. Larsen","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042991604","display_name":"Candace Makeda Moore","orcid":"https://orcid.org/0000-0003-1672-7565","observed_orcids":["https://orcid.org/0000-0003-1672-7565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Candace M. H. Moore","raw_affiliation_strings":["Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","Departments of 1 Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Black Building , Room 308 , 650 West 168th Street , New York , NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"David Sulzer, Black Building, Room 308, 650 West 168th Street, New York, NY 10032","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041539369","display_name":"Matthew D. Troyer","orcid":"https://orcid.org/0000-0002-0821-7509","observed_orcids":["https://orcid.org/0000-0002-0821-7509"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Troyer","raw_affiliation_strings":["Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027616900","display_name":"Robert H. Edwards","orcid":"https://orcid.org/0000-0002-8650-3260","observed_orcids":["https://orcid.org/0000-0002-8650-3260"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Edwards","raw_affiliation_strings":["Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057571524","display_name":"Serge Przedborski","orcid":"https://orcid.org/0000-0002-7283-3883","observed_orcids":["https://orcid.org/0000-0002-7283-3883"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serge Przedborski","raw_affiliation_strings":["Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032,","Pathology and Cell Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Pathology and Cell Biology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026787858","display_name":"David Sulzer","orcid":"https://orcid.org/0000-0001-7632-0439","observed_orcids":["https://orcid.org/0000-0001-7632-0439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Sulzer","raw_affiliation_strings":["Department of Neuroscience, New York Psychiatric Institute, New York, New York 10032, and","Departments of 1 Neurology , Psychiatry , and","Psychiatry, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, New York Psychiatric Institute, New York, New York 10032, and","institution_ids":[]},{"raw_affiliation_string":"Departments of 1 Neurology , Psychiatry , and","institution_ids":[]},{"raw_affiliation_string":"Psychiatry, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.7363,"has_fulltext":true,"cited_by_count":167,"citation_normalized_percentile":{"value":0.98636972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"26","issue":"36","first_page":"9304","last_page":"9311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dopamine-homeostasis","display_name":"dopamine homeostasis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/catecholaminergic-neurons","display_name":"catecholaminergic neurons","score":0.8880000114440918},{"id":"https://openalex.org/keywords/a53t-alpha-synuclein","display_name":"A53T alpha-synuclein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/proton-leak","display_name":"proton leak","score":0.9380000233650208},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.8019999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5950000286102295},{"id":"https://openalex.org/keywords/alpha-synuclein-overexpression","display_name":"alpha-synuclein overexpression","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7190698981285095},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7052727937698364},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.6952357888221741},{"id":"https://openalex.org/C2776824294","wikidata":"https://www.wikidata.org/wiki/Q18344428","display_name":"Catecholaminergic","level":3,"score":0.6754124164581299},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.6305443048477173},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5331605672836304},{"id":"https://openalex.org/C43601244","wikidata":"https://www.wikidata.org/wiki/Q5051795","display_name":"Catecholaminergic cell groups","level":4,"score":0.5142723917961121},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5003747940063477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4908931851387024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47133660316467285},{"id":"https://openalex.org/C2780910648","wikidata":"https://www.wikidata.org/wiki/Q919689","display_name":"Chromaffin cell","level":4,"score":0.4573672413825989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4116191565990448},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40168529748916626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38980555534362793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3868643343448639},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2876329720020294},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.23599067330360413},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12177512049674988},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019439","descriptor_name":"Chromaffin Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.0519-06.2006","doi":"https://doi.org/10.1523/jneurosci.0519-06.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0519-06.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/36/9304.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6674515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6674515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:16957086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16957086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.670.8285","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.670.8285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sulzerlab.org/pdf_articles/Mosharov2006JNeurosciSyn.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0519-06.2006","doi":"https://doi.org/10.1523/jneurosci.0519-06.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0519-06.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/36/9304.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8946346975","display_name":"Pathways for the Inflammatory Damage of Biomolecules","funder_award_id":"R01AG021191","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306430","display_name":"National Parkinson Foundation","ror":"https://ror.org/005aa3k38"},{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332679","display_name":"Parkinsonfonden","ror":"https://ror.org/0300wre24"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160818993.pdf","grobid_xml":"https://content.openalex.org/works/W2160818993.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W936123105","https://openalex.org/W1485468448","https://openalex.org/W1550083773","https://openalex.org/W1599906730","https://openalex.org/W1603686013","https://openalex.org/W1637321639","https://openalex.org/W1683600212","https://openalex.org/W1923591030","https://openalex.org/W1966748491","https://openalex.org/W1970587959","https://openalex.org/W1972939055","https://openalex.org/W1986216002","https://openalex.org/W1986625112","https://openalex.org/W2009556855","https://openalex.org/W2011805483","https://openalex.org/W2023245921","https://openalex.org/W2024695579","https://openalex.org/W2025116212","https://openalex.org/W2026667182","https://openalex.org/W2029000167","https://openalex.org/W2033158324","https://openalex.org/W2033877544","https://openalex.org/W2040706104","https://openalex.org/W2045062740","https://openalex.org/W2046014998","https://openalex.org/W2052122668","https://openalex.org/W2068288454","https://openalex.org/W2073893553","https://openalex.org/W2074085543","https://openalex.org/W2078597038","https://openalex.org/W2079461108","https://openalex.org/W2079874861","https://openalex.org/W2087389265","https://openalex.org/W2091214947","https://openalex.org/W2104831013","https://openalex.org/W2104912043","https://openalex.org/W2105252647","https://openalex.org/W2111442935","https://openalex.org/W2111602670","https://openalex.org/W2115375118","https://openalex.org/W2129146981","https://openalex.org/W2130323165","https://openalex.org/W2132181394","https://openalex.org/W2133272695","https://openalex.org/W2149275773","https://openalex.org/W2414722770"],"related_works":["https://openalex.org/W7095974763","https://openalex.org/W2035879579","https://openalex.org/W1979944790","https://openalex.org/W2132181394","https://openalex.org/W1512509534","https://openalex.org/W2030748454","https://openalex.org/W2069632588","https://openalex.org/W2092528158","https://openalex.org/W2017049975","https://openalex.org/W2032746773"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,6,10,20,34,42,115,141,150,177,180,194,218],"dopamine":[2,53,122],"homeostasis":[3],"and":[4,52,83,157,185,234],"elevation":[5],"the":[7,11,18,35,80,113,159,168,192,216],"cytosolic":[8,68,121,195,219],"level":[9,123],"transmitter":[12],"have":[13],"been":[14],"suggested":[15],"to":[16,117,187],"underlie":[17],"vulnerability":[19],"catecholaminergic":[21,237],"neurons":[22],"in":[23,30,98,153,166,191,202],"Parkinson's":[24,43],"disease.":[25],"Because":[26],"several":[27],"known":[28],"mutations":[29],"alpha-synuclein":[31,50,64,146,181,229],"or":[32,104,144],"overexpression":[33,176],"wild-type":[36],"(WT)":[37],"protein":[38,82,161],"causes":[39],"familial":[40],"forms":[41],"disease,":[44],"we":[45,173],"investigated":[46],"possible":[47],"links":[48],"between":[49],"pathogenesis":[51],"homeostasis.":[54],"Chromaffin":[55],"cells":[56,78,101,116],"isolated":[57,154],"from":[58,85,91],"transgenic":[59],"mice":[60],"that":[61,136,158,175,200],"overexpress":[62],"A30P":[63,103],"displayed":[65],"significantly":[66,163],"increased":[67],"catecholamine":[69,220],"levels":[70,193],"as":[71],"measured":[72],"by":[73,130],"intracellular":[74],"patch":[75],"electrochemistry,":[76],"whereas":[77],"overexpressing":[79,102],"WT":[81,110,160],"those":[84,108],"knock-out":[86],"animals":[87],"were":[88,96],"not":[89],"different":[90,178],"controls.":[92],"Likewise,":[93],"catechol":[94,196],"concentrations":[95,140],"higher":[97],"L-DOPA-treated":[99],"PC12":[100],"A53T":[105,145],"compared":[106],"with":[107,138],"expressing":[109],"alpha-synuclein,":[111],"although":[112],"ability":[114],"maintain":[118],"a":[119,188],"low":[120],"after":[124],"L-DOPA":[125],"challenge":[126],"was":[127,162],"markedly":[128],"inhibited":[129,147],"either":[131],"protein.":[132],"We":[133],"also":[134],"found":[135],"incubation":[137],"low-micromolar":[139],"WT,":[142],"A30P,":[143],"ATP-dependent":[148],"maintenance":[149],"pH":[151,184],"gradients":[152],"chromaffin":[155],"vesicles":[156],"less":[164],"potent":[165],"inducing":[167],"proton":[169],"leakage.":[170],"In":[171],"summary,":[172],"demonstrate":[174],"types":[179],"disrupts":[182],"vesicular":[183],"leads":[186],"marked":[189],"increase":[190],"species,":[197],"an":[198],"effect":[199],"may":[201,212],"turn":[203],"trigger":[204],"cellular":[205],"oxyradical":[206],"damage.":[207],"Although":[208],"multiple":[209],"molecular":[210],"mechanisms":[211],"be":[213],"responsible":[214],"for":[215],"perturbation":[217],"homeostasis,":[221],"this":[222],"study":[223],"provides":[224],"critical":[225],"evidence":[226],"about":[227],"how":[228],"might":[230],"exert":[231],"its":[232],"cytotoxicity":[233],"selectively":[235],"damage":[236],"cells.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
