{"id":"https://openalex.org/W2160722307","doi":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","title":"Action of dopamine on the exocrine pancreatic secretion of the intact dog","display_name":"Action of dopamine on the exocrine pancreatic secretion of the intact dog","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2160722307","doi":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","mag":"2160722307","pmid":"https://pubmed.ncbi.nlm.nih.gov/2871881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1917094"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1986.tb09486.x","doi":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1986.tb09486.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1986.tb09486.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110164198","display_name":"Richard Delcenserie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Delcenserie","raw_affiliation_strings":["Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111618259","display_name":"M.A. Devaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.A. Devaux","raw_affiliation_strings":["Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110396796","display_name":"HENRI SARLES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Sarles","raw_affiliation_strings":["Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de recherches de Pathologie Digestive, INSERM U 31, 46, Bd de la Gaye, 13009 Marseille, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.5963,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68739887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"88","issue":"1","first_page":"189","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-exocrine-secretion","display_name":"pancreatic exocrine secretion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/domperidone","display_name":"domperidone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dopamine-receptor-antagonists","display_name":"dopamine antagonists","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pancreatic-enzyme-secretion","display_name":"pancreatic enzyme secretion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pancreatic-protein-secretion","display_name":"pancreatic protein secretion","score":0.6290000081062317},{"id":"https://openalex.org/keywords/bicarbonate-secretion","display_name":"bicarbonate secretion","score":0.8479999899864197},{"id":"https://openalex.org/keywords/water-secretion","display_name":"water secretion","score":0.871999979019165},{"id":"https://openalex.org/keywords/secretin","display_name":"secretin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9129999876022339},{"id":"https://openalex.org/keywords/phenoxybenzamine","display_name":"phenoxybenzamine","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8547394275665283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8081133365631104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7890176773071289},{"id":"https://openalex.org/C2775995038","wikidata":"https://www.wikidata.org/wiki/Q424238","display_name":"Domperidone","level":3,"score":0.7642918825149536},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.5613143444061279},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5207424163818359},{"id":"https://openalex.org/C2780668150","wikidata":"https://www.wikidata.org/wiki/Q419824","display_name":"Phenoxybenzamine","level":3,"score":0.48618263006210327},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4662455916404724},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.42347294092178345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3505564332008362},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.22594395279884338},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.21589237451553345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19329175353050232}],"mesh":[{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004294","descriptor_name":"Domperidone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010189","descriptor_name":"Pancreatic Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1986.tb09486.x","doi":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1986.tb09486.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1917094","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1917094","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:2871881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1986.tb09486.x","doi":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1986.tb09486.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1986.tb09486.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160722307.pdf","grobid_xml":"https://content.openalex.org/works/W2160722307.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1973260047","https://openalex.org/W1998259247","https://openalex.org/W2010074242","https://openalex.org/W2010236462","https://openalex.org/W2010432059","https://openalex.org/W2012717573","https://openalex.org/W2026104679","https://openalex.org/W2030905853","https://openalex.org/W2048489653","https://openalex.org/W2048676180","https://openalex.org/W2050173489","https://openalex.org/W2062589931","https://openalex.org/W2064083616","https://openalex.org/W2064997097","https://openalex.org/W2120952829","https://openalex.org/W2123053214","https://openalex.org/W2137923910","https://openalex.org/W2270038839","https://openalex.org/W2417613936","https://openalex.org/W2428269418","https://openalex.org/W2614224079","https://openalex.org/W4323253275"],"related_works":["https://openalex.org/W2120952829","https://openalex.org/W2342175533","https://openalex.org/W1973260047","https://openalex.org/W1997738300","https://openalex.org/W1983559450","https://openalex.org/W214907179","https://openalex.org/W2010074242","https://openalex.org/W4233365629","https://openalex.org/W2043598853","https://openalex.org/W4323253275"],"abstract_inverted_index":{"The":[0,20,88,98,109,162,195],"effects":[1],"of":[2,16,22,57,85,90,112,148,176,183,199,221,248],"dopamine":[3,7,29,58,64,113,169,184,222,235,249],"and":[4,34,93,225,243],"domperidone,":[5,117,200],"a":[6,43,66,78,173,192,211],"antagonist,":[8],"have":[9],"been":[10,229],"studied":[11,54],"on":[12,31,122,185,223,240],"the":[13,17,86,123,140,144,157,181,207,216,219,245],"exocrine":[14],"secretion":[15,33,95,187,227,242,254],"dog":[18],"pancreas.":[19],"purpose":[21],"this":[23],"study":[24],"was":[25,38,72,75,82,96,101,114,152,165,170],"to":[26,143,160,191,210,252],"see":[27],"if":[28,35],"acted":[30],"enzyme":[32],"its":[36],"action":[37,111,239],"merely":[39],"'pharmacological'":[40],"or":[41,131],"had":[42,236],"physiological":[44,246],"role.":[45],"Conscious":[46],"Beagle":[47],"dogs,":[48],"fitted":[49],"with":[50,103,250],"Thomas":[51],"cannulae":[52],"were":[53],"following":[55],"infusions":[56],"125-1000":[59],"micrograms":[60,105,135,202],"kg-1":[61,106,136],"h-1.":[62],"During":[63],"infusion,":[65],"secretory":[67,141,158],"peak":[68],"lasting":[69],"10":[70,134,201],"min":[71],"observed.":[73],"This":[74,150,178],"followed":[76],"by":[77,116,129],"stable":[79],"plateau":[80],"which":[81],"approximately":[83],"1/3":[84],"peak.":[87],"pattern":[89],"water,":[91],"bicarbonate":[92,226],"protein":[94,163,186,241],"similar.":[97],"maximum":[99],"effect":[100,121,182,220],"obtained":[102],"500":[104],"h-1":[107],"dopamine.":[108,149,161],"stimulatory":[110],"blocked":[115],"without":[118],"any":[119],"detected":[120],"central":[124],"nervous":[125],"system,":[126],"but":[127],"not":[128,153,166,205],"propranolol":[130],"phenoxybenzamine.":[132],"Domperidone":[133],"almost":[137],"completely":[138],"suppressed":[139],"response":[142,159,164,209],"maximally":[145,196],"effective":[146,197],"dose":[147,198],"inhibition":[151],"competitive.":[154],"Atropine":[155],"decreased":[156],"observed":[167],"when":[168],"infused":[171],"against":[172],"background":[174],"infusion":[175],"secretin.":[177],"suggests":[179],"that":[180,234,244],"could":[188],"be":[189],"due":[190],"wash-out":[193],"phenomenon.":[194],"kg-1,":[203],"did":[204],"modify":[206],"pancreatic":[208,253],"solid":[212],"meal.":[213],"Thus,":[214],"in":[215],"non-anaesthetized":[217],"dog,":[218],"water":[224],"has":[228],"confirmed.":[230],"It":[231],"is":[232,255],"concluded":[233],"no":[237],"detectable":[238],"role":[247],"respect":[251],"still":[256],"questionable.":[257]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
