{"id":"https://openalex.org/W2160720198","doi":"https://doi.org/10.1210/jc.2009-1140","title":"Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method","display_name":"Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2160720198","doi":"https://doi.org/10.1210/jc.2009-1140","mag":"2160720198","pmid":"https://pubmed.ncbi.nlm.nih.gov/19933393"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2009-1140","doi":"https://doi.org/10.1210/jc.2009-1140","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2009-1140","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075321838","display_name":"Fr\u00e9d\u00e9rique Courant","orcid":"https://orcid.org/0000-0003-2237-775X","observed_orcids":["https://orcid.org/0000-0003-2237-775X"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210092027","display_name":"Laboratoire D'\u00e9tude des R\u00e9sidus et Contaminants Dans les Aliments","ror":"https://ror.org/00kewvc41","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fre\u0301de\u0301rique Courant","raw_affiliation_strings":["Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075290042","display_name":"Lise Aksgl\u00e6de","orcid":"https://orcid.org/0000-0001-7885-7467","observed_orcids":["https://orcid.org/0000-0001-7885-7467"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lise Aksglaede","raw_affiliation_strings":["Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073561748","display_name":"Jean\u2010Philippe Antignac","orcid":"https://orcid.org/0000-0001-9512-9314","observed_orcids":["https://orcid.org/0000-0001-9512-9314"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210092027","display_name":"Laboratoire D'\u00e9tude des R\u00e9sidus et Contaminants Dans les Aliments","ror":"https://ror.org/00kewvc41","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Antignac","raw_affiliation_strings":["Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087478051","display_name":"Fabrice Monteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210092027","display_name":"Laboratoire D'\u00e9tude des R\u00e9sidus et Contaminants Dans les Aliments","ror":"https://ror.org/00kewvc41","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Monteau","raw_affiliation_strings":["Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112146803","display_name":"Kaspar S\u00f8rensen","orcid":"https://orcid.org/0009-0007-4119-5894","observed_orcids":["https://orcid.org/0009-0007-4119-5894"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kaspar Sorensen","raw_affiliation_strings":["Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022204794","display_name":"Anna\u2010Maria Andersson","orcid":"https://orcid.org/0000-0002-7300-1659","observed_orcids":["https://orcid.org/0000-0002-7300-1659"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anna-Maria Andersson","raw_affiliation_strings":["Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081123168","display_name":"Niels  Erik Skakkeb\u00e6k","orcid":"https://orcid.org/0000-0002-4282-8020","observed_orcids":["https://orcid.org/0000-0002-4282-8020"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Niels E. Skakkebaek","raw_affiliation_strings":["Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045917807","display_name":"Anders Juul","orcid":"https://orcid.org/0000-0002-0534-4350","observed_orcids":["https://orcid.org/0000-0002-0534-4350"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Juul","raw_affiliation_strings":["Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction (L.A., K.S., A.-M.A., N.E.S., A.J.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016121389","display_name":"Bruno Le Bizec","orcid":"https://orcid.org/0000-0002-0600-5895","observed_orcids":["https://orcid.org/0000-0002-0600-5895"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210092027","display_name":"Laboratoire D'\u00e9tude des R\u00e9sidus et Contaminants Dans les Aliments","ror":"https://ror.org/00kewvc41","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Le Bizec","raw_affiliation_strings":["Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Etude des Re\u0301sidus et Contaminants dans les Aliments (LABERCA) (F.C., J.-P.A., F.M., B.L.B.), Unite\u0301 Sous Contrat 2013 Institut National de la Recherche Agronomique, Ecole Nationale Ve\u0301te\u0301rinaire de Nantes, F-44307 Nantes, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4387154544"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075321838"],"corresponding_institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210092027","https://openalex.org/I4387154544"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":11.7688,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.98686237,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"95","issue":"1","first_page":"82","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.2304999977350235,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-steroids","display_name":"sex steroids","score":0.7400000095367432},{"id":"https://openalex.org/keywords/prepubertal-children","display_name":"prepubertal children","score":0.9710000157356262},{"id":"https://openalex.org/keywords/puberty-onset","display_name":"puberty onset","score":0.7739999890327454},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6980000138282776},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7590000033378601},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.7879999876022339},{"id":"https://openalex.org/keywords/androsterone","display_name":"androsterone","score":0.843999981880188},{"id":"https://openalex.org/keywords/etiocholanolone","display_name":"etiocholanolone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pubic-hair-development","display_name":"pubic hair development","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pubertal-timing","display_name":"pubertal timing","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5720021724700928},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.523573100566864},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4901450574398041},{"id":"https://openalex.org/C2909038973","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Gas Chromatography/Tandem Mass Spectrometry","level":4,"score":0.4799668788909912},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4362272620201111},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.43227800726890564},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.4125971794128418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4012015461921692},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31878662109375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30568966269493103},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10819759964942932}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/jc.2009-1140","doi":"https://doi.org/10.1210/jc.2009-1140","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2009-1140","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:19933393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19933393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:hal-01928619v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01928619","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Endocrinology and Metabolism, 2010, 95 (1), pp.82 - 92. &#x27E8;10.1210/jc.2009-1140&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0bbcb356-20d0-4148-819f-51ecc502a315","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/0bbcb356-20d0-4148-819f-51ecc502a315","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Courant, F, Aksgl\u00e6de, L, Antignac, J-P, Monteau, F, S\u00f8rensen, K, Andersson, A-M, Skakkeb\u00e6k, N E, Juul, A & Bizec, B L 2010, 'Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method', Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 1, pp. 82-92. https://doi.org/10.1210/jc.2009-1140","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W32521800","https://openalex.org/W197107379","https://openalex.org/W1561086246","https://openalex.org/W1749393079","https://openalex.org/W1969200869","https://openalex.org/W1970821796","https://openalex.org/W1975894774","https://openalex.org/W1979060893","https://openalex.org/W1979713715","https://openalex.org/W1981364565","https://openalex.org/W1982112050","https://openalex.org/W1985916667","https://openalex.org/W1994982991","https://openalex.org/W1997539143","https://openalex.org/W2005838348","https://openalex.org/W2022647398","https://openalex.org/W2035168282","https://openalex.org/W2041330989","https://openalex.org/W2046458096","https://openalex.org/W2051747123","https://openalex.org/W2057715430","https://openalex.org/W2060034722","https://openalex.org/W2060108903","https://openalex.org/W2071973137","https://openalex.org/W2072415550","https://openalex.org/W2080980386","https://openalex.org/W2084912719","https://openalex.org/W2097563817","https://openalex.org/W2097675120","https://openalex.org/W2102433335","https://openalex.org/W2114261552","https://openalex.org/W2146680184","https://openalex.org/W2151913401","https://openalex.org/W2152655978","https://openalex.org/W2153860757","https://openalex.org/W2155988875","https://openalex.org/W2156031360","https://openalex.org/W2161209070","https://openalex.org/W2417587222","https://openalex.org/W4244633382","https://openalex.org/W4249484275"],"related_works":["https://openalex.org/W2807187394","https://openalex.org/W3144704706","https://openalex.org/W1982112050","https://openalex.org/W2092436929","https://openalex.org/W3103171090","https://openalex.org/W2064559169","https://openalex.org/W2363754783","https://openalex.org/W2060034722","https://openalex.org/W2084788869","https://openalex.org/W2118356660"],"abstract_inverted_index":{"CONTEXT:":[0],"Estrogens":[1],"and":[2,10,62,76,99,196,216],"androgens":[3],"play":[4],"key":[5],"roles":[6,49],"for":[7],"pubertal":[8,128],"onset":[9,251],"sexual":[11],"maturation.":[12],"Most":[13],"currently":[14],"used":[15],"immunoassays":[16],"are":[17],"not":[18,41],"sensitive":[19,217],"enough":[20],"to":[21,77,248],"accurately":[22,55],"measure":[23],"the":[24,162],"low":[25,142],"circulating":[26],"levels":[27,57,90,134,148,223,243],"of":[28,36,58,67,74,91,123,224,252],"sex":[29,44,59,80,241],"steroids":[30,45],"in":[31,50,65,112,135,149,231,244],"children":[32,69,129,165],"without":[33,120],"any":[34,71,121],"signs":[35,73,122],"puberty.":[37,124],"However,":[38],"this":[39],"does":[40],"exclude":[42],"that":[43],"have":[46],"important":[47],"biological":[48],"prepubertal":[51,136,150,164,210,232,240],"children.":[52],"OBJECTIVES:":[53],"To":[54],"determine":[56],"steroid":[60,242],"hormones":[61],"their":[63,249],"metabolites":[64,230],"serum":[66,89],"healthy":[68,116],"before":[70],"physical":[72],"puberty":[75,253],"evaluate":[78],"possible":[79],"differences.":[81],"MAIN":[82],"OUTCOME":[83],"MEASURES:":[84],"Total":[85],"(unconjugated":[86],"plus":[87],"conjugated)":[88],"17beta-testosterone,":[92],"17alpha-testosterone,":[93],"5alpha-dihydrotestosterone,":[94],"5beta-dihydrotestosterone,":[95],"androsterone,":[96],"etiocholanolone,":[97],"estradiol,":[98],"estrone":[100],"measured":[101],"by":[102],"an":[103,214],"ultrasensitive":[104],"method":[105],"based":[106],"on":[107],"gas":[108],"chromatography-tandem":[109],"mass":[110],"spectrometry":[111],"samples":[113],"from":[114],"81":[115],"schoolchildren":[117],"(42":[118],"boys)":[119],"For":[125],"comparison,":[126],"48":[127],"were":[130,138,152],"studied.":[131],"RESULTS:":[132],"17beta-Estradiol":[133],"boys":[137],"undetectable":[139],"or":[140],"extremely":[141],"(median":[143,155],"<":[144,159,178,186,194,204],"3.7":[145],"pmol/liter),":[146],"whereas":[147],"girls":[151,168,233,245],"significantly":[153,170,221],"higher":[154,171,222,239],"9.6":[156],"pmol/liter,":[157],"P":[158,177,185,193,203],"0.001).":[160],"Among":[161],"older":[163],"(>8":[166],"yr),":[167],"had":[169],"androsterone":[172],"(4.07":[173],"vs.":[174,182,190,200],"1.45":[175],"nmol/liter,":[176,184,192,202],"0.05),":[179],"etiocholanolone":[180],"(5.45":[181],"1.95":[183],"0.0001),":[187],"5alpha-dihydrotestosterone":[188],"(0.11":[189],"<0.10":[191],"0.01),":[195],"17beta-testosterone":[197],"concentrations":[198],"(0.69":[199],"0.47":[201],"0.05)":[205],"compared":[206,234],"with":[207,235],"similarly":[208],"aged":[209],"boys.":[211,237],"CONCLUSION:":[212],"Using":[213],"accurate":[215],"method,":[218],"we":[219],"found":[220],"estrogens":[225],"as":[226,228],"well":[227],"androgen":[229],"age-matched":[236],"The":[238],"may":[246],"contribute":[247],"earlier":[250],"including":[254],"pubic":[255],"hair":[256],"development.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}