{"id":"https://openalex.org/W2160711953","doi":"https://doi.org/10.1215/15228517-2007-044","title":"Positron emission tomography-guided conformal fast neutron therapy for glioblastoma multiforme","display_name":"Positron emission tomography-guided conformal fast neutron therapy for glioblastoma multiforme","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2160711953","doi":"https://doi.org/10.1215/15228517-2007-044","mag":"2160711953","pmid":"https://pubmed.ncbi.nlm.nih.gov/18055860","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2600842"},"language":"en","primary_location":{"id":"doi:10.1215/15228517-2007-044","doi":"https://doi.org/10.1215/15228517-2007-044","is_oa":false,"landing_page_url":"https://doi.org/10.1215/15228517-2007-044","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2600842","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006946589","display_name":"Keith J. Stelzer","orcid":"https://orcid.org/0000-0001-9886-8382","observed_orcids":["https://orcid.org/0000-0001-9886-8382"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keith J. Stelzer","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center, Dalles, OR, USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center, Dalles, OR, USA","institution_ids":[]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113841777","display_name":"James G. Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Douglas","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072312981","display_name":"David A. Mankoff","orcid":"https://orcid.org/0000-0002-6971-5413","observed_orcids":["https://orcid.org/0000-0002-6971-5413"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Mankoff","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069068873","display_name":"Daniel L. Silbergeld","orcid":"https://orcid.org/0000-0001-8833-4221","observed_orcids":["https://orcid.org/0000-0001-8833-4221"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Silbergeld","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109093605","display_name":"Kenneth A. Krohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Krohn","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018914802","display_name":"George E. Laramore","orcid":"https://orcid.org/0000-0003-2595-2123","observed_orcids":["https://orcid.org/0000-0003-2595-2123"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George E. Laramore","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112106733","display_name":"Alexander M. Spence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. Spence","raw_affiliation_strings":["Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR; Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA; USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Celilo Radiation Therapy, Mid-Columbia Medical Center (K.J.S.), The Dalles, OR","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology (K.J.S., J.G.D., G.E.L.), Department of Nuclear Medicine (D.A.M., K.A.K.), Department of Neurological Surgery (J.G.D., D.L.S.), and Department of Neurology (A.M.S.), University of Washington Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006946589"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.3582,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.67792134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"88","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fast-neutron-therapy","display_name":"fast neutron therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.7919999957084656},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.7459999918937683},{"id":"https://openalex.org/keywords/3d-treatment-planning","display_name":"3D treatment planning","score":0.7829999923706055},{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-control-probability","display_name":"tumor control probability","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dose-response-modeling","display_name":"dose-response modeling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7110000252723694},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6781350374221802},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6689305305480957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5113388895988464},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5032257437705994},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.4237644672393799},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.25791528820991516},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1379600167274475}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017247","descriptor_name":"Neutron Capture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1215/15228517-2007-044","doi":"https://doi.org/10.1215/15228517-2007-044","is_oa":false,"landing_page_url":"https://doi.org/10.1215/15228517-2007-044","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2600842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2600842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},{"id":"pmid:18055860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18055860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2600842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2600842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1364894146","display_name":"Molecular Imaging of Cancer and Its Response to Therapy","funder_award_id":"P01CA042045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1583039384","https://openalex.org/W1993959306","https://openalex.org/W2001660159","https://openalex.org/W2020784028","https://openalex.org/W2021874670","https://openalex.org/W2033204120","https://openalex.org/W2036029019","https://openalex.org/W2046044146","https://openalex.org/W2059234310","https://openalex.org/W2066193527","https://openalex.org/W2068839377","https://openalex.org/W2085895801","https://openalex.org/W2171982115","https://openalex.org/W2260562219","https://openalex.org/W2424078637","https://openalex.org/W4234637425"],"related_works":["https://openalex.org/W1985188588","https://openalex.org/W4297792944","https://openalex.org/W2033204120","https://openalex.org/W2409927577","https://openalex.org/W2085105451","https://openalex.org/W2046044146","https://openalex.org/W2043836745","https://openalex.org/W2413460372","https://openalex.org/W1979419127","https://openalex.org/W2315663363"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"continues":[3],"to":[4,14,75,134,174,189,210,214],"be":[5,23],"a":[6,76,175,193,212,216],"difficult":[7],"therapeutic":[8,217],"challenge.":[9],"Our":[10],"study":[11],"was":[12,113,126,144,172,185],"conducted":[13],"determine":[15],"whether":[16],"improved":[17],"survival":[18,92,112],"and":[19,50,56,89,96,116,137,169,207],"tumor":[20,120,182,205],"control":[21,183,206],"could":[22],"achieved":[24],"with":[25,72,141,226],"modern":[26,165,227],"delivery":[27,171],"of":[28,45,63,79,132,153,178],"fast":[29,220],"neutron":[30,162,221],"radiation":[31,142,163,222],"using":[32,164],"three-dimensional":[33,65],"treatment":[34,66,167],"planning.":[35,67],"Ten":[36],"patients":[37,118],"were":[38,70,93],"enrolled.":[39],"Eligibility":[40],"criteria":[41],"included":[42],"pathologic":[43],"diagnosis":[44],"GBM,":[46,224],"age":[47],">or=18":[48],"years,":[49],"KPS":[51],">or=60.":[52],"Patients":[53],"underwent":[54],"MRI":[55],"(18)F-fluorodeoxyglucose":[57],"PET":[58],"(FDG":[59],"PET)":[60],"as":[61],"part":[62],"initial":[64],"Sequential":[68],"targets":[69],"treated":[71],"noncoplanar":[73],"fields":[74],"total":[77,176],"dose":[78,177],"18":[80,179],"Gy":[81],"in":[82,148,187,223],"16":[83,114],"fractions":[84],"over":[85],"4":[86],"weeks.":[87,124],"Median":[88,110],"1-year":[90],"overall":[91],"55":[94],"weeks":[95,107],"60%,":[97],"respectively.":[98],"One":[99],"patient":[100],"remains":[101],"alive":[102],"at":[103,146],"last":[104],"follow-up":[105],"255":[106],"after":[108],"diagnosis.":[109],"progression-free":[111],"weeks,":[115],"all":[117],"had":[119],"progression":[121],"by":[122],"39":[123],"Treatment":[125],"clinically":[127],"well":[128],"tolerated,":[129],"but":[130,181],"evidence":[131],"mild":[133],"moderate":[135],"gliosis":[136],"microvascular":[138],"sclerosis":[139],"consistent":[140],"injury":[143],"observed":[145],"autopsy":[147],"specimens":[149],"taken":[150],"from":[151,192],"regions":[152],"contralateral":[154],"brain":[155],"that":[156,190],"received":[157],"approximately":[158],"6-10":[159],"Gy.":[160],"Fast":[161],"imaging,":[166],"planning,":[168],"beam":[170],"feasible":[173],"Gy,":[180],"probability":[184],"poor":[186],"comparison":[188],"predicted":[191],"dose-response":[194,201],"model":[195],"based":[196],"on":[197],"older":[198],"studies.":[199],"Steep":[200],"curves":[202],"for":[203,219],"both":[204],"neurotoxicity":[208],"continue":[209],"present":[211],"challenge":[213],"establishing":[215],"window":[218],"even":[225],"techniques.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
