{"id":"https://openalex.org/W2160683030","doi":null,"title":"Effects of all-trans retinoic acid and antireceptor antibodies on growth and programmed cell death of human myeloma cells.","display_name":"Effects of all-trans retinoic acid and antireceptor antibodies on growth and programmed cell death of human myeloma cells.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W2160683030","mag":"2160683030","pmid":"https://pubmed.ncbi.nlm.nih.gov/9816167"},"language":"en","primary_location":{"id":"pmid:9816167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065968376","display_name":"Raymond Taetle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Taetle","raw_affiliation_strings":["Departments of Medicine and Pathology, Arizona Health Sciences Center Tucson, Arizona 84724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Arizona Health Sciences Center Tucson, Arizona 84724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113534224","display_name":"B Dos Santos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Dos Santos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002169362","display_name":"Ken\u2010ichi Akamatsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Akamatsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031781312","display_name":"Yasuo Koishihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Koishihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111978914","display_name":"Y Ohsugi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ohsugi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1674,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76848742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"2","first_page":"253","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5669999718666077},{"id":"https://openalex.org/keywords/transferrin","display_name":"transferrin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.8489999771118164},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5320000052452087},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5502141714096069},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5334852933883667},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5289571285247803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5177856683731079},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5162642002105713},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.4863350987434387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46893954277038574},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4396131932735443},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4252520799636841},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36774933338165283},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2986164093017578},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2770649790763855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1587149202823639},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9816167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2160683030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1507469709","https://openalex.org/W1851299822","https://openalex.org/W1871569717","https://openalex.org/W1967928808","https://openalex.org/W1971427569","https://openalex.org/W1975579612","https://openalex.org/W1991865867","https://openalex.org/W1992045438","https://openalex.org/W2032243824","https://openalex.org/W2037401254","https://openalex.org/W2041431213","https://openalex.org/W2043869143","https://openalex.org/W2064508977","https://openalex.org/W2067347766","https://openalex.org/W2069637592","https://openalex.org/W2069871301","https://openalex.org/W2077423482","https://openalex.org/W2078003307","https://openalex.org/W2078297328","https://openalex.org/W2090578460","https://openalex.org/W2099510505","https://openalex.org/W2101511312","https://openalex.org/W2101525269","https://openalex.org/W2104949735","https://openalex.org/W2110031324","https://openalex.org/W2110439220","https://openalex.org/W2111876635","https://openalex.org/W2116304730","https://openalex.org/W2163773832","https://openalex.org/W2185703542","https://openalex.org/W2271048442","https://openalex.org/W2296225964","https://openalex.org/W2400313280","https://openalex.org/W2410099625","https://openalex.org/W2411260605","https://openalex.org/W2412072390","https://openalex.org/W2419299109","https://openalex.org/W2437658786"],"related_works":["https://openalex.org/W2153923717","https://openalex.org/W329959312","https://openalex.org/W2024551869","https://openalex.org/W2038731142","https://openalex.org/W2086770231","https://openalex.org/W2089914971","https://openalex.org/W2062735780","https://openalex.org/W2387419403","https://openalex.org/W302802154","https://openalex.org/W1987978372"],"abstract_inverted_index":{"In":[0],"contrast":[1],"to":[2,196],"cytotoxic":[3,102,195],"agents":[4,10,363],"inducing":[5],"rapid":[6],"cell":[7,28,32,115,143,214,221,316,344],"death,":[8],"biological":[9,362,374],"such":[11,351],"as":[12,335,352],"hormones,":[13],"vitamins":[14],"(e.g.,":[15],"retinoids),":[16],"cytokines,":[17],"and":[18,23,30,42,51,67,72,88,101,134,155,232,257,267,346,364],"antireceptor":[19],"antibodies":[20,46,186],"act":[21],"slowly":[22],"may":[24,79,365],"alter":[25],"ratios":[26],"between":[27],"growth":[29,50,62,226],"programmed":[31,220],"death":[33,53,222,317],"(apoptosis).":[34],"We":[35],"showed":[36,137,179,273,319],"previously":[37,212],"that":[38,180],"anti-interleukin":[39],"6":[40],"(IL-6)":[41],"antitransferrin":[43],"(Tf)":[44],"receptor":[45,70,112,126,175,185,236,284],"inhibited":[47,156],"in":[48,60,82,106,229,249,301,311,369],"vitro":[49,61,83,370],"induced":[52,148,223,277,360],"of":[54,63,86,104,141,151,164,183,239,252,265,294,372],"myeloma":[55,76,142,152,160,197,241,270],"cells.":[56,77,161,198],"Retinoids":[57,78,331],"also":[58,80,147,272],"inhibit":[59],"human":[64],"cancer":[65],"cells":[66,231,253,271,303],"decrease":[68],"IL-6":[69,153,157],"display":[71],"autosecretion":[73,158],"by":[74,159,168,224,233,278,361],"some":[75],"antagonize":[81],"growth-promoting":[84],"effects":[85,103,163,182],"iron":[87],"transferrin.":[89],"To":[90,199],"develop":[91],"a":[92,202],"novel":[93,373],"strategy":[94],"for":[95,275,341,347,368],"treating":[96,348],"myeloma,":[97],"we":[98],"examined":[99],"antiproliferative":[100,181],"retinoids":[105,120],"combination":[107],"with":[108,119,121,170,282],"anti-Tf":[109,171,184,268,283],"or":[110,122,326,338],"anti-IL-6":[111,174],"antibodies.":[113,128,176,285],"Myeloma":[114],"lines":[116],"were":[117,166,187,288,305],"cultured":[118],"without":[123],"anti-growth":[124,234],"factor":[125,227,235],"monoclonal":[127],"Both":[129],"all-trans":[130],"retinoic":[131],"acid":[132,136],"(ATRA)":[133],"13-cis-retinoic":[135],"variable,":[138],"dose-dependent":[139],"inhibition":[140],"line":[144,215],"growth.":[145],"ATRA":[146,165,193,266],"significant":[149],"down-regulation":[150],"receptors":[154],"Antiproliferative":[162],"increased":[167,258],"coculture":[169],"but":[172,190,280,304,318],"not":[173,281,306],"Colony-forming":[177],"assays":[178],"largely":[188],"reversible,":[189],"1":[191],"microM":[192],"was":[194,209],"assess":[200],"apoptosis,":[201],"flow":[203,217,324],"cytometry":[204,218,263,325,356],"assay":[205],"detecting":[206],"DNA":[207,260,296,321],"damage":[208,322],"used.":[210],"Using":[211],"studied":[213],"models,":[216],"detected":[219,307],"transforming":[225],"beta1":[228],"leukemia":[230],"antibody":[237],"treatment":[238],"IL-6-dependent":[240],"cells,":[242,313],"treatments":[243],"which":[244,314],"caused":[245],"only":[246],"modest":[247],"increases":[248],"the":[250],"percentage":[251],"undergoing":[254],"morphological":[255],"apoptosis":[256,276,359],"internucleosomal":[259,295],"degradation.":[261],"Flow":[262,355],"analysis":[264],"antibody-treated":[269],"evidence":[274],"ATRA,":[279],"These":[286],"changes":[287],"apparent":[289],"several":[290],"days":[291],"before":[292],"detection":[293],"degradation":[297,327],"on":[298,328],"agarose":[299,329],"gels":[300],"8226":[302],"at":[308],"any":[309],"time":[310],"U266":[312],"underwent":[315],"no":[320],"using":[323],"gels.":[330],"merit":[332],"further":[333],"study":[334],"possible":[336],"maintenance":[337],"chemoprevention":[339],"therapies":[340],"clonal":[342],"plasma":[343],"disorders":[345,350],"paraneoplastic":[349],"Castleman's":[353],"disease.":[354],"rapidly":[357],"detects":[358],"be":[366],"useful":[367],"screening":[371],"therapies.":[375]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
