{"id":"https://openalex.org/W2160680368","doi":"https://doi.org/10.1016/j.canlet.2006.01.026","title":"The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage","display_name":"The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage","publication_year":2006,"publication_date":"2006-03-14","ids":{"openalex":"https://openalex.org/W2160680368","doi":"https://doi.org/10.1016/j.canlet.2006.01.026","mag":"2160680368","pmid":"https://pubmed.ncbi.nlm.nih.gov/16530324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658610"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2006.01.026","doi":"https://doi.org/10.1016/j.canlet.2006.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2006.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110364400","display_name":"Junqing Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junqing Zhou","raw_affiliation_strings":["Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113692574","display_name":"Chang U.K. Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang UK Lim","raw_affiliation_strings":["Cancer Center, Ordway Research Institute, 150 New Scotland Avenue Rm 4133, Albany, NY 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Ordway Research Institute, 150 New Scotland Avenue Rm 4133, Albany, NY 12208, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023118874","display_name":"Jian Jian Li","orcid":"https://orcid.org/0000-0003-3694-9675","observed_orcids":["https://orcid.org/0000-0003-3694-9675"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Jian Li","raw_affiliation_strings":["Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017873319","display_name":"Lu Cai","orcid":"https://orcid.org/0000-0003-3048-1135","observed_orcids":["https://orcid.org/0000-0003-3048-1135"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu Cai","raw_affiliation_strings":["Department of Medicine and Radiation Oncology, University of Louisville, School of Medicine, Louisville, KT 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Radiation Oncology, University of Louisville, School of Medicine, Louisville, KT 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051180946","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0003-3139-3524","observed_orcids":["https://orcid.org/0000-0003-3139-3524","https://orcid.org/0009-0001-0640-2356","https://orcid.org/0009-0008-8454-8618"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017873319","https://openalex.org/A5051180946"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I92446798"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":0.4494,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.37642077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"243","issue":"1","first_page":"9","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nbs1","display_name":"NBS1","score":1.0},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/atr-kinase","display_name":"ATR kinase","score":1.0},{"id":"https://openalex.org/keywords/pikk-family","display_name":"PIKK family","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mrn-complex","display_name":"MRN complex","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nijmegen-breakage-syndrome","display_name":"Nijmegen breakage syndrome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.656000018119812},{"id":"https://openalex.org/keywords/dna-damage-signaling","display_name":"DNA damage signaling","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2777136964","wikidata":"https://www.wikidata.org/wiki/Q1250362","display_name":"Nijmegen breakage syndrome","level":5,"score":0.915229082107544},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.818139910697937},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6674582362174988},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6143415570259094},{"id":"https://openalex.org/C2775984157","wikidata":"https://www.wikidata.org/wiki/Q18035037","display_name":"Rad50","level":5,"score":0.535230815410614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242578983306885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5170407891273499},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4929814338684082},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4351353347301483},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3835725486278534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37498825788497925},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2327686846256256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06915223598480225},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.canlet.2006.01.026","doi":"https://doi.org/10.1016/j.canlet.2006.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2006.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:16530324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16530324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2655714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3658610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2655714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7528504373","display_name":"Role of MnSOD in Acquired Resistance to Cancer Therapy","funder_award_id":"R01CA101990","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1533085584","https://openalex.org/W1541806623","https://openalex.org/W1794569271","https://openalex.org/W1818914725","https://openalex.org/W1968516742","https://openalex.org/W1968552183","https://openalex.org/W1972313386","https://openalex.org/W1974010399","https://openalex.org/W1977145510","https://openalex.org/W1987577420","https://openalex.org/W1988876917","https://openalex.org/W1988951520","https://openalex.org/W1989651108","https://openalex.org/W1990465427","https://openalex.org/W1996505651","https://openalex.org/W2001854404","https://openalex.org/W2003411878","https://openalex.org/W2008301561","https://openalex.org/W2010990642","https://openalex.org/W2011522975","https://openalex.org/W2012169363","https://openalex.org/W2015090136","https://openalex.org/W2020151423","https://openalex.org/W2022685241","https://openalex.org/W2024667285","https://openalex.org/W2031414445","https://openalex.org/W2032874501","https://openalex.org/W2034306661","https://openalex.org/W2043895957","https://openalex.org/W2045164156","https://openalex.org/W2045526190","https://openalex.org/W2049123604","https://openalex.org/W2052694602","https://openalex.org/W2053272124","https://openalex.org/W2058336786","https://openalex.org/W2061060103","https://openalex.org/W2061455523","https://openalex.org/W2063450668","https://openalex.org/W2074889730","https://openalex.org/W2077260273","https://openalex.org/W2082981258","https://openalex.org/W2084089807","https://openalex.org/W2086218293","https://openalex.org/W2089015411","https://openalex.org/W2091068450","https://openalex.org/W2093928080","https://openalex.org/W2096607093","https://openalex.org/W2099907467","https://openalex.org/W2120143131","https://openalex.org/W2130447102","https://openalex.org/W2130883309","https://openalex.org/W2131833681","https://openalex.org/W2150587707","https://openalex.org/W2152054208","https://openalex.org/W2152456839","https://openalex.org/W2157282246","https://openalex.org/W2158726042","https://openalex.org/W2162249357","https://openalex.org/W2163784659","https://openalex.org/W2169830490","https://openalex.org/W2188965955","https://openalex.org/W4285719527","https://openalex.org/W6687093578"],"related_works":["https://openalex.org/W1965364445","https://openalex.org/W4251660798","https://openalex.org/W2114616141","https://openalex.org/W1618806168","https://openalex.org/W2098951389","https://openalex.org/W2058075580","https://openalex.org/W2045526190","https://openalex.org/W2094566645","https://openalex.org/W2152456839","https://openalex.org/W1668554361"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}