{"id":"https://openalex.org/W2160639367","doi":"https://doi.org/10.1136/gut.30.1.90","title":"Beneficial effect of 8-ornithin vasopressin on renal dysfunction in decompensated cirrhosis.","display_name":"Beneficial effect of 8-ornithin vasopressin on renal dysfunction in decompensated cirrhosis.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2160639367","doi":"https://doi.org/10.1136/gut.30.1.90","mag":"2160639367","pmid":"https://pubmed.ncbi.nlm.nih.gov/2646181","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1378237"},"language":"en","primary_location":{"id":"doi:10.1136/gut.30.1.90","doi":"https://doi.org/10.1136/gut.30.1.90","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.30.1.90","pdf_url":"https://gut.bmj.com/content/gutjnl/30/1/90.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/30/1/90.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086432816","display_name":"Kurt Lenz","orcid":"https://orcid.org/0000-0002-2456-3188","observed_orcids":["https://orcid.org/0000-0002-2456-3188"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K Lenz","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020397427","display_name":"Heide H\u00f6rtnagl","orcid":"https://orcid.org/0000-0003-0608-0382","observed_orcids":["https://orcid.org/0000-0003-0608-0382"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H H\u00f6rtnagl","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108191642","display_name":"Wilfred Druml","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W Druml","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111413377","display_name":"Georg Grimm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G Grimm","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107379098","display_name":"Anton N. Laggner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A Laggner","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022428095","display_name":"B Schneeweisz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"B Schneeweisz","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011226069","display_name":"G. Kleinberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G Kleinberger","raw_affiliation_strings":["1st Department of Internal Medicine, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":4.8515,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.96400288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"1","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decompensated-cirrhosis","display_name":"decompensated cirrhosis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alcoholic-cirrhosis","display_name":"alcoholic cirrhosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.875},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.7289999723434448},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5199999809265137},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.5849999785423279},{"id":"https://openalex.org/keywords/hyperdynamic-circulation","display_name":"hyperdynamic circulation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.6570000052452087},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.8299999833106995},{"id":"https://openalex.org/keywords/vasoconstrictor-therapy","display_name":"vasoconstrictor therapy","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2779065481","wikidata":"https://www.wikidata.org/wiki/Q8578745","display_name":"Hyperdynamic circulation","level":4,"score":0.7996008396148682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7201856970787048},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6829389333724976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6825284957885742},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6627259254455566},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6583113074302673},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.6387366652488708},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5968361496925354},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5341511964797974},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5061697363853455},{"id":"https://openalex.org/C33893070","wikidata":"https://www.wikidata.org/wiki/Q5500348","display_name":"Free water clearance","level":3,"score":0.4676988124847412},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.4427230954170227},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.43377697467803955},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4047289192676544},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.3806719481945038},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.3627278208732605},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.22960638999938965}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009951","descriptor_name":"Ornipressin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/gut.30.1.90","doi":"https://doi.org/10.1136/gut.30.1.90","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.30.1.90","pdf_url":"https://gut.bmj.com/content/gutjnl/30/1/90.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1378237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1378237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:2646181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2646181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/gut.30.1.90","doi":"https://doi.org/10.1136/gut.30.1.90","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.30.1.90","pdf_url":"https://gut.bmj.com/content/gutjnl/30/1/90.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160639367.pdf","grobid_xml":"https://content.openalex.org/works/W2160639367.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W55644921","https://openalex.org/W60311408","https://openalex.org/W87920584","https://openalex.org/W191428107","https://openalex.org/W1483437251","https://openalex.org/W1488357183","https://openalex.org/W1567509578","https://openalex.org/W1655942177","https://openalex.org/W1970444261","https://openalex.org/W1972965645","https://openalex.org/W1975622210","https://openalex.org/W1979573742","https://openalex.org/W1985232642","https://openalex.org/W1991109063","https://openalex.org/W1991653058","https://openalex.org/W1993812341","https://openalex.org/W2004875468","https://openalex.org/W2010438419","https://openalex.org/W2021039380","https://openalex.org/W2024109752","https://openalex.org/W2025800122","https://openalex.org/W2029995728","https://openalex.org/W2036206860","https://openalex.org/W2036487592","https://openalex.org/W2038747122","https://openalex.org/W2045979716","https://openalex.org/W2052198532","https://openalex.org/W2053466542","https://openalex.org/W2056069181","https://openalex.org/W2059004674","https://openalex.org/W2060338318","https://openalex.org/W2069236385","https://openalex.org/W2086698338","https://openalex.org/W2105920220","https://openalex.org/W2139205177","https://openalex.org/W2152488901","https://openalex.org/W2157019502","https://openalex.org/W2162888593","https://openalex.org/W2261008265","https://openalex.org/W2316727422","https://openalex.org/W2335725394","https://openalex.org/W2394896584","https://openalex.org/W2410286295","https://openalex.org/W2412592581","https://openalex.org/W2419616364","https://openalex.org/W2474570839","https://openalex.org/W2766509313","https://openalex.org/W3022340188","https://openalex.org/W4213088685","https://openalex.org/W4298354280","https://openalex.org/W6629368682"],"related_works":["https://openalex.org/W2071662737","https://openalex.org/W124747732","https://openalex.org/W1979573742","https://openalex.org/W2036869103","https://openalex.org/W188796256","https://openalex.org/W2038261793","https://openalex.org/W2090108706","https://openalex.org/W2078113157","https://openalex.org/W2072646675","https://openalex.org/W2029276570"],"abstract_inverted_index":{"In":[0],"nine":[1],"patients":[2],"with":[3],"decompensated":[4],"alcoholic":[5],"cirrhosis":[6],"of":[7,16,34,40,48,58,87,152,171,173,179,188],"the":[8,14,168,186],"liver":[9],"and":[10,23,75,96,125,141,161,176,183],"impaired":[11],"renal":[12,21,49,163,189],"function":[13,22,50,164],"effect":[15],"8-ornithin":[17],"vasopressin":[18],"(ornipressin)":[19],"on":[20],"haemodynamic":[24],"parameters":[25],"was":[26,29,51,106],"studied.":[27],"Ornipressin":[28],"infused":[30],"at":[31],"a":[32,38,109,153,158],"dose":[33],"6":[35],"IU/h":[36],"over":[37],"period":[39],"four":[41],"hours.":[42],"During":[43],"ornipressin":[44,115,135],"infusion":[45,136],"an":[46,56],"improvement":[47],"achieved":[52],"as":[53,90,99,101,197],"indicated":[54],"by":[55,92],"increase":[57],"creatinine":[59],"clearance":[60],"(76":[61],"(15)%;":[62],"p":[63,71,80],"less":[64,72,81,147],"than":[65,73,82,148],"0.01),":[66],"urine":[67],"volume":[68],"(108":[69],"(29)%;":[70],"0.05)":[74],"sodium":[76],"excretion":[77],"(168":[78],"(30)%;":[79],"0.05).":[83],"The":[84,117,150],"hyperdynamic":[85,159],"circulation":[86],"hepatic":[88,192],"failure,":[89],"characterised":[91],"increased":[93],"cardiac":[94],"index":[95],"heart":[97],"rate":[98],"well":[100],"decreased":[102],"systemic":[103],"vascular":[104],"resistance":[105],"reversed":[107],"to":[108,137],"nearly":[110],"normal":[111],"circulatory":[112],"state":[113,160],"during":[114,134],"infusion.":[116],"raised":[118],"noradrenaline":[119],"plasma":[120,126],"concentration":[121],"(1.74":[122],"(0.31)":[123],"ng/ml)":[124],"renin":[127],"activity":[128],"(13.5":[129],"(3.9)":[130],"ng/ml/h)":[131],"were":[132],"lowered":[133],"0.87":[138],"(0.21)":[139],"ng/ml":[140],"5.9":[142],"(2.1)":[143],"ng/ml/h,":[144],"respectively":[145],"(p":[146],"0.01).":[149],"efficacy":[151],"vasoconstrictor":[154],"agent":[155],"in":[156,185,191],"reverting":[157],"improving":[162],"provides":[165],"evidence":[166],"for":[167],"substantial":[169],"role":[170],"accumulation":[172],"vasodilator":[174],"substances":[175],"subsequent":[177],"activation":[178],"sympathetic":[180],"nervous":[181],"system":[182],"renin-angiotensin-axis":[184],"pathogenesis":[187],"dysfunction":[190],"failure.":[193],"Values":[194],"are":[195],"expressed":[196],"mean":[198],"(SE).":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}