{"id":"https://openalex.org/W2160638726","doi":"https://doi.org/10.1093/genetics/143.3.1149","title":"RNA Polymerase III Defects Suppress a Conditional-Lethal Poly(A) Polymerase Mutation in Saccharomyces cerevisiae","display_name":"RNA Polymerase III Defects Suppress a Conditional-Lethal Poly(A) Polymerase Mutation in Saccharomyces cerevisiae","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2160638726","doi":"https://doi.org/10.1093/genetics/143.3.1149","mag":"2160638726","pmid":"https://pubmed.ncbi.nlm.nih.gov/8807289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1207386"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/143.3.1149","doi":"https://doi.org/10.1093/genetics/143.3.1149","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/143.3.1149","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1207386/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110111527","display_name":"Michael W. Briggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Briggs","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14624, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14624, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014087589","display_name":"J. Scott Butler","orcid":"https://orcid.org/0000-0001-7428-2897","observed_orcids":["https://orcid.org/0000-0001-7428-2897"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Scott Butler","raw_affiliation_strings":["Corresponding author: J. Scott Butler, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 575 Elmwood Ave., Box 672, Rochester, NY 14624","Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14624"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author: J. Scott Butler, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 575 Elmwood Ave., Box 672, Rochester, NY 14624","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14624","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014087589"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.6365,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61917094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"143","issue":"3","first_page":"1149","last_page":"1161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-iii","display_name":"RNA polymerase III","score":0.9290000200271606},{"id":"https://openalex.org/keywords/poly-a-polymerase","display_name":"poly(A) polymerase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/extragenic-suppressors","display_name":"extragenic suppressors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pds2","display_name":"PdS2","score":0.7699999809265137},{"id":"https://openalex.org/keywords/temperature-sensitive-mutation","display_name":"temperature-sensitive mutation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mrna-synthesis","display_name":"mRNA synthesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"polyadenylation","score":0.574999988079071},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8679999709129333},{"id":"https://openalex.org/keywords/conditional-lethality","display_name":"conditional lethality","score":0.5320000052452087},{"id":"https://openalex.org/keywords/functional-interactions","display_name":"functional interactions","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8625400066375732},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.7394313812255859},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6723472476005554},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6641828417778015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5851518511772156},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.5236672759056091},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5043157339096069},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5006558895111084},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.494790256023407},{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.41473403573036194},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4068461060523987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3113248348236084},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.21931806206703186}],"mesh":[{"descriptor_ui":"D000073718","descriptor_name":"Pancreatitis-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011062","descriptor_name":"Polynucleotide Adenylyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012320","descriptor_name":"RNA Polymerase III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/genetics/143.3.1149","doi":"https://doi.org/10.1093/genetics/143.3.1149","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/143.3.1149","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:8807289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8807289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1207386","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1207386/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1207386","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1207386/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7900852500","display_name":"INTERDEPARTMENTAL TRAINING IN GENETICS AND REGULATION","funder_award_id":"T32GM007102","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W27023215","https://openalex.org/W955649814","https://openalex.org/W1541626731","https://openalex.org/W1547269929","https://openalex.org/W1558106087","https://openalex.org/W1579500886","https://openalex.org/W1722376624","https://openalex.org/W1811297709","https://openalex.org/W1820518842","https://openalex.org/W1844843076","https://openalex.org/W1876905084","https://openalex.org/W1897053993","https://openalex.org/W1967274237","https://openalex.org/W1967390330","https://openalex.org/W1977186059","https://openalex.org/W1985001103","https://openalex.org/W1987200697","https://openalex.org/W2003676968","https://openalex.org/W2005764753","https://openalex.org/W2012288774","https://openalex.org/W2018333929","https://openalex.org/W2021302019","https://openalex.org/W2030230281","https://openalex.org/W2040386515","https://openalex.org/W2040472652","https://openalex.org/W2043382556","https://openalex.org/W2047049388","https://openalex.org/W2051194600","https://openalex.org/W2053180692","https://openalex.org/W2057677468","https://openalex.org/W2060397969","https://openalex.org/W2072180686","https://openalex.org/W2072363079","https://openalex.org/W2074314295","https://openalex.org/W2075988374","https://openalex.org/W2082658854","https://openalex.org/W2087646866","https://openalex.org/W2090173484","https://openalex.org/W2109684789","https://openalex.org/W2111358109","https://openalex.org/W2115580849","https://openalex.org/W2121776688","https://openalex.org/W2125855207","https://openalex.org/W2132094774","https://openalex.org/W2134088228","https://openalex.org/W2134910640","https://openalex.org/W2142574026","https://openalex.org/W2149799872","https://openalex.org/W2156102046","https://openalex.org/W2169512526","https://openalex.org/W2175025904"],"related_works":["https://openalex.org/W158539957","https://openalex.org/W1541626731","https://openalex.org/W2064257803","https://openalex.org/W1759109909","https://openalex.org/W2111358109","https://openalex.org/W1518824278","https://openalex.org/W2132903778","https://openalex.org/W1860455599","https://openalex.org/W1946529825","https://openalex.org/W7095398725"],"abstract_inverted_index":{"We":[0,121],"isolated":[1,154],"spontaneous":[2],"extragenic":[3],"suppressors":[4,29],"of":[5,23,27,32,61,83,93,117,132,159,166,179],"a":[6,48,156,177],"temperature-sensitive,":[7],"lethal":[8],"poly(A)":[9,66],"polymerase":[10,119,134,173],"mutation":[11,40],"(pap1-1)":[12],"in":[13,79,85,124,137,170],"Saccharomyces":[14],"cerevisiae":[15],"that":[16,90,149,162],"restore":[17],"growth":[18],"at":[19,70],"the":[20,33,58,80,86,91,114,126,129,150],"restrictive":[21],"temperature":[22],"30":[24,71],"degrees.":[25,72],"Three":[26],"five":[28],"represent":[30,155],"alleles":[31,143,152],"PDS2":[34,106],"complementation":[35],"group.":[36],"The":[37,52],"recessive":[38],"pds2-1":[39,138],"exerts":[41],"dominant":[42],"allele-specific":[43],"suppression":[44],"over":[45],"pap1-1,":[46,147],"suggesting":[47,89],"direct":[49],"functional":[50],"interaction.":[51],"suppressor":[53,87],"restores":[54],"to":[55,107,110],"near":[56],"normal":[57],"steady-state":[59,94,130],"concentrations":[60],"various":[62],"mRNAs":[63,84],"and":[64,128],"total":[65],"reduced":[67],"by":[68,168],"pap1-1":[69,167],"Transcriptional":[73],"chase":[74],"experiments":[75],"detect":[76],"no":[77],"reduction":[78],"decay":[81],"rates":[82],"strain,":[88],"restoration":[92],"message":[95],"levels":[96],"results":[97],"from":[98],"increased":[99],"stable":[100],"mRNA":[101],"synthesis.":[102],"Molecular":[103],"cloning":[104],"shows":[105],"be":[108],"allelic":[109],"RET1,":[111],"which":[112],"encodes":[113],"second-largest":[115],"subunit":[116,175],"RNA":[118,133,172],"III.":[120],"observe":[122],"alterations":[123],"both":[125],"length":[127],"amounts":[131],"III":[135,174],"transcripts":[136],"strains.":[139],"Previously":[140],"identified":[141],"ret1":[142],"do":[144],"not":[145],"suppress":[146,163],"indicating":[148],"pds2":[151],"we":[153],"specific":[157],"class":[158],"RET1":[160],"mutations":[161,169],"pap1-1.":[164],"Suppression":[165],"an":[171],"suggests":[176],"number":[178],"potentially":[180],"novel":[181],"interactions":[182],"between":[183],"these":[184],"enzymes.":[185]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}