{"id":"https://openalex.org/W2160635731","doi":"https://doi.org/10.2337/diabetes.48.4.870","title":"Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial.","display_name":"Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2160635731","doi":"https://doi.org/10.2337/diabetes.48.4.870","mag":"2160635731","pmid":"https://pubmed.ncbi.nlm.nih.gov/10102706","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2862597"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.48.4.870","doi":"https://doi.org/10.2337/diabetes.48.4.870","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.48.4.870","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2862597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048439423","display_name":"Vincent M. Monnier","orcid":"https://orcid.org/0000-0002-4894-3142","observed_orcids":["https://orcid.org/0000-0002-4894-3142"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V M Monnier","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028064867","display_name":"O. Bautista","orcid":"https://orcid.org/0009-0003-4530-1923","observed_orcids":["https://orcid.org/0009-0003-4530-1923"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Bautista","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Kenny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Kenny","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029026718","display_name":"David R. Sell","orcid":"https://orcid.org/0000-0001-7510-5745","observed_orcids":["https://orcid.org/0000-0001-7510-5745"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Sell","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026664020","display_name":"Jane Fogarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Fogarty","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082639886","display_name":"William T. Dahms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Dahms","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108438937","display_name":"Patricia A. Cleary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Cleary","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035897807","display_name":"John M. Lachin","orcid":"https://orcid.org/0000-0001-9838-2841","observed_orcids":["https://orcid.org/0000-0001-9838-2841"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Lachin","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071915821","display_name":"SAUL M. GENUTH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Genuth","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. vmm3@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":6.7912,"has_fulltext":false,"cited_by_count":469,"citation_normalized_percentile":{"value":0.97483989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"48","issue":"4","first_page":"870","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/intensive-glycemic-control","display_name":"tight glycemic control","score":0.8220000267028809},{"id":"https://openalex.org/keywords/skin-collagen","display_name":"skin collagen","score":0.550000011920929},{"id":"https://openalex.org/keywords/collagen-glycation","display_name":"collagen glycation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glycoxidation","display_name":"glycoxidation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":0.9129999876022339},{"id":"https://openalex.org/keywords/furosine","display_name":"furosine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pentosidine","display_name":"pentosidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nepsilon-carboxymethyl-lysine","display_name":"carboxymethyllysine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9020000100135803},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.9179999828338623},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780758796","wikidata":"https://www.wikidata.org/wiki/Q7165277","display_name":"Pentosidine","level":4,"score":0.9031492471694946},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.8602320551872253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6725669503211975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6679555177688599},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6070354580879211},{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.5703920722007751},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5037264227867126},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.501354455947876},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4642333388328552},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4434855580329895},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.4299040138721466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18700039386749268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1531645655632019},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11254867911338806}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2337/diabetes.48.4.870","doi":"https://doi.org/10.2337/diabetes.48.4.870","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.48.4.870","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:10102706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10102706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2862597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2862597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/d67bc0b7-c0f0-4006-910b-b2ec796224e7","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/d67bc0b7-c0f0-4006-910b-b2ec796224e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Monnier, VM, Bautista, O, Kenny, D, Sell, DR, Fogarty, J, Dahms, W, Cleary, PA, Lachin, J, Genuth, S & DCCT Skin Collagen Ancillary Study Grp 1999, 'Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes - Relevance of glycated collagen products versus HbA(1c) as markers of diabetic complications', Diabetes, vol. 48, no. 4, pp. 870-880.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/d67bc0b7-c0f0-4006-910b-b2ec796224e7","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/d67bc0b7-c0f0-4006-910b-b2ec796224e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, 48(4), 870 - 880. AMER DIABETES ASSOC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2862597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2862597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1357562839","display_name":null,"funder_award_id":"M01RR000080","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1650331929","display_name":null,"funder_award_id":"M01 RR000036","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2099331619","display_name":"General Clinical Research Center","funder_award_id":"M01RR000059","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2179012511","display_name":null,"funder_award_id":"N01 DK062204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2585761144","display_name":"GENERAL CLINICAL RESEARCH CENTER M01 RR12248","funder_award_id":"M01RR012248","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2600627088","display_name":null,"funder_award_id":"AG 05601","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4386737519","display_name":"PENTOSIDINE AS A BIOMARKER OF AGING","funder_award_id":"5r01ag011080-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G482954785","display_name":"EPIDEMIOLOGY OF DIABETES INTERVENTIONS &COMPLICATIONS","funder_award_id":"n01dk062204-003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G80055406","display_name":null,"funder_award_id":"AG 11080","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8205975590","display_name":"DIABETES CONTROL AND COMPLICATIONS TRIAL (DCCT)","funder_award_id":"3u01am030628-03s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8391543684","display_name":"BROWNING OF HUMAN COLLAGEN IN DIABETES AND AGING","funder_award_id":"5r01ag005601-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8878637015","display_name":"General Clinical Research Center","funder_award_id":"M01RR000827","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W150772031","https://openalex.org/W1529972356","https://openalex.org/W1964586920","https://openalex.org/W1965787101","https://openalex.org/W1975856506","https://openalex.org/W1976068063","https://openalex.org/W1979386588","https://openalex.org/W1993736540","https://openalex.org/W1996757319","https://openalex.org/W1997334144","https://openalex.org/W2017214714","https://openalex.org/W2028653335","https://openalex.org/W2034900477","https://openalex.org/W2059736408","https://openalex.org/W2067246958","https://openalex.org/W2077843346","https://openalex.org/W2082227293","https://openalex.org/W2091817515","https://openalex.org/W2108448809","https://openalex.org/W2144732441","https://openalex.org/W2337292567","https://openalex.org/W2769264260","https://openalex.org/W3024383408","https://openalex.org/W4232564846","https://openalex.org/W4234637623","https://openalex.org/W4245344909","https://openalex.org/W4248904215","https://openalex.org/W4248932937"],"related_works":["https://openalex.org/W1993736540","https://openalex.org/W2058786800","https://openalex.org/W2043294107","https://openalex.org/W4308922676","https://openalex.org/W2144732441","https://openalex.org/W2153605160","https://openalex.org/W7098506497","https://openalex.org/W7100313070","https://openalex.org/W1996757319","https://openalex.org/W2097899363"],"abstract_inverted_index":{"The":[0],"relationships":[1],"between":[2],"long-term":[3],"intensive":[4,58,197],"control":[5],"of":[6,10,43,57,82,91,101,112,153,173,179,237,261,265],"glycemia":[7],"and":[8,17,20,23,39,47,76,99,114,118,132,150,156,199,248,268],"indicators":[9],"skin":[11],"collagen":[12,120,145,174,188,225],"glycation":[13,243],"(furosine),":[14,254],"glycoxidation":[15],"(pentosidine":[16],"N(epsilon)-[carboxymethyl]-lysine":[18],"[CML]),":[19],"crosslinking":[21],"(acid":[22],"pepsin":[24],"solubility)":[25],"were":[26,85,122,166],"examined":[27],"in":[28,88,183,220,245],"216":[29],"patients":[30],"with":[31,52,62,109,125,133,142,169,195,204,232],"type":[32],"1":[33],"diabetes":[34],"from":[35,191,200],"the":[36,44,89,92,102,110,126,130,164,170,177,187,196,227,246,250,256,262],"primary":[37,93],"prevention":[38,94],"secondary":[40,103],"intervention":[41,104],"cohorts":[42],"Diabetes":[45],"Control":[46],"Complications":[48],"Trial.":[49],"By":[50],"comparison":[51],"conventional":[53,205],"treatment,":[54],"5":[55],"years":[56],"treatment":[59,198],"was":[60,226],"associated":[61,124,168,231],"30-32%":[63],"lower":[64,67,70],"furosine,":[65],"9%":[66],"pentosidine,":[68],"9-13%":[69],"CML,":[71],"24%":[72],"higher":[73,78],"acid-soluble":[74,115],"collagen,":[75],"50%":[77],"pepsin-soluble":[79],"collagen.":[80,116],"All":[81],"these":[83,238],"differences":[84],"statistically":[86],"significant":[87,211],"subjects":[90,239],"cohort":[95,105],"(P":[96,106],"<":[97,107],"0.006-0.001)":[98],"also":[100],"0.015-0.001)":[108],"exception":[111],"CML":[113],"Age-":[117],"duration-adjusted":[119],"variables":[121,149,161,189],"significantly":[123,167],"HbA1c":[127,136],"value":[128],"nearest":[129],"biopsy":[131],"cumulative":[134],"prior":[135],"values.":[137],"Multiple":[138],"logistic":[139],"regression":[140],"analyses":[141],"six":[143],"nonredundant":[144],"parameters":[146],"as":[147,159],"independent":[148],"various":[151],"expressions":[152],"retinopathy,":[154],"nephropathy,":[155],"neuropathy":[157],"outcomes":[158],"dependent":[160],"showed":[162],"that":[163],"complications":[165,184],"full":[171],"set":[172],"variables.":[175],"Surprisingly,":[176],"percentage":[178],"total":[180],"variance":[181],"(R2)":[182],"explained":[185],"by":[186],"ranged":[190],"19":[192],"to":[193,202,258],"36%":[194],"14":[201],"51%":[203],"treatment.":[206],"These":[207],"associations":[208],"generally":[209],"remained":[210],"even":[212,271],"after":[213],"adjustment":[214],"for":[215],"HbA1c,":[216],"and,":[217],"most":[218,229],"unexpectedly,":[219],"conventionally":[221],"treated":[222],"subjects,":[223],"glycated":[224,275],"parameter":[228],"consistently":[230],"diabetic":[233],"complications.":[234],"Continued":[235],"monitoring":[236],"may":[240],"determine":[241],"whether":[242],"products":[244],"skin,":[247],"especially":[249],"early":[251],"Amadori":[252],"product":[253],"have":[255],"potential":[257],"be":[259,270],"predictors":[260,273],"future":[263],"risk":[264],"developing":[266],"complications,":[267],"perhaps":[269],"better":[272],"than":[274],"hemoglobin":[276],"(HbA1c).":[277]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":22}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}