{"id":"https://openalex.org/W2160618567","doi":"https://doi.org/10.1016/j.cub.2004.12.031","title":"Loss of hPot1 Function Leads to Telomere Instability and a cut-like Phenotype","display_name":"Loss of hPot1 Function Leads to Telomere Instability and a cut-like Phenotype","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2160618567","doi":"https://doi.org/10.1016/j.cub.2004.12.031","mag":"2160618567","pmid":"https://pubmed.ncbi.nlm.nih.gov/15620654"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2004.12.031","doi":"https://doi.org/10.1016/j.cub.2004.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2004.12.031","pdf_url":"http://www.cell.com/article/S096098220400987X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S096098220400987X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113602987","display_name":"Timothy Veldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Veldman","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013970580","display_name":"Katherine T. Etheridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine T. Etheridge","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087099776","display_name":"Christopher M. Counter","orcid":"https://orcid.org/0000-0003-0748-3079","observed_orcids":["https://orcid.org/0000-0003-0748-3079"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Counter","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087099776"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":3.3158,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.92777604,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"24","first_page":"2264","last_page":"2270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pot1","display_name":"POT1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/telomere-instability","display_name":"telomere instability","score":0.8650000095367432},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/anaphase-bridges","display_name":"anaphase bridges","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chromatin-bridges","display_name":"chromatin bridges","score":0.8410000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9169999957084656},{"id":"https://openalex.org/keywords/telomere-length-regulation","display_name":"telomere length regulation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/telomeric-dna-binding","display_name":"telomeric DNA binding","score":0.5120000243186951},{"id":"https://openalex.org/keywords/tin2","display_name":"TIN2","score":0.7519999742507935},{"id":"https://openalex.org/keywords/trf1","display_name":"TRF1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/telomere-capping","display_name":"telomere capping","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8306711912155151},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.6943728923797607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6529242396354675},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.4553523361682892},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4212530255317688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36782383918762207},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2970113754272461},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2886766195297241},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10955476760864258},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10325312614440918},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09512051939964294},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.0756254494190216}],"mesh":[{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D035321","descriptor_name":"Telomeric Repeat Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048629","descriptor_name":"Micronuclei, Chromosome-Defective","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cub.2004.12.031","doi":"https://doi.org/10.1016/j.cub.2004.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2004.12.031","pdf_url":"http://www.cell.com/article/S096098220400987X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:15620654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15620654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2004.12.031","doi":"https://doi.org/10.1016/j.cub.2004.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2004.12.031","pdf_url":"http://www.cell.com/article/S096098220400987X/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8411539949","display_name":"The Molecular Basis of Telomerase Function & Regulation","funder_award_id":"R01CA082481","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2160618567.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1484414970","https://openalex.org/W1985910710","https://openalex.org/W1986108211","https://openalex.org/W1986659195","https://openalex.org/W2022013301","https://openalex.org/W2028320710","https://openalex.org/W2037728125","https://openalex.org/W2051990601","https://openalex.org/W2072744580","https://openalex.org/W2078651829","https://openalex.org/W2084960769","https://openalex.org/W2086992094","https://openalex.org/W2102839588","https://openalex.org/W2103735815","https://openalex.org/W2104908670","https://openalex.org/W2116282320","https://openalex.org/W2121389115","https://openalex.org/W2121444961","https://openalex.org/W2122658576","https://openalex.org/W2123105653","https://openalex.org/W2130525093","https://openalex.org/W2131028776","https://openalex.org/W2131549919","https://openalex.org/W2132899445","https://openalex.org/W2147161726","https://openalex.org/W2149471694","https://openalex.org/W2155983703","https://openalex.org/W2162736100","https://openalex.org/W2171757104"],"related_works":["https://openalex.org/W1985910710","https://openalex.org/W2120077024","https://openalex.org/W2138398263","https://openalex.org/W2125250665","https://openalex.org/W2341464315","https://openalex.org/W3093230859","https://openalex.org/W7095351701","https://openalex.org/W2141723290","https://openalex.org/W2554700777","https://openalex.org/W2125663907"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
