{"id":"https://openalex.org/W2160611039","doi":"https://doi.org/10.1172/jci57761","title":"Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice","display_name":"Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice","publication_year":2011,"publication_date":"2011-08-15","ids":{"openalex":"https://openalex.org/W2160611039","doi":"https://doi.org/10.1172/jci57761","mag":"2160611039","pmid":"https://pubmed.ncbi.nlm.nih.gov/21841315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3163965"},"language":"en","primary_location":{"id":"doi:10.1172/jci57761","doi":"https://doi.org/10.1172/jci57761","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci57761","pdf_url":"http://www.jci.org/articles/view/57761/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/57761/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043411293","display_name":"Kimberly Michele Davis","orcid":"https://orcid.org/0000-0003-1870-3137","observed_orcids":["https://orcid.org/0000-0003-1870-3137"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly M. Davis","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA","Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006757027","display_name":"Shigeki Nakamura","orcid":"https://orcid.org/0000-0001-5272-8886","observed_orcids":["https://orcid.org/0000-0001-5272-8886"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shigeki Nakamura","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066405485","display_name":"Jeffrey N. Weiser","orcid":"https://orcid.org/0000-0001-7168-8090","observed_orcids":["https://orcid.org/0000-0001-7168-8090"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey N. Weiser","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066405485"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":7.8931,"has_fulltext":true,"cited_by_count":197,"citation_normalized_percentile":{"value":0.98270344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"121","issue":"9","first_page":"3666","last_page":"3676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nod2","display_name":"NOD2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9480000138282776},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pneumococcal-carriage","display_name":"pneumococcal carriage","score":0.8159999847412109},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.8999999761581421},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pneumolysin","display_name":"pneumolysin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/innate-immune-recognition","display_name":"innate immune recognition","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.7139999866485596},{"id":"https://openalex.org/keywords/intranasal-infection","display_name":"intranasal infection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/upper-respiratory-tract","display_name":"upper respiratory tract","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.8585828542709351},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7482775449752808},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6403135061264038},{"id":"https://openalex.org/C2776088486","wikidata":"https://www.wikidata.org/wiki/Q7205996","display_name":"Pneumolysin","level":4,"score":0.6395114064216614},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.600757360458374},{"id":"https://openalex.org/C7573103","wikidata":"https://www.wikidata.org/wiki/Q416481","display_name":"NOD2","level":4,"score":0.5905435085296631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5822758078575134},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5562557578086853},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5548065900802612},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5298696756362915},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.5252168774604797},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4460676908493042},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.4295586049556732},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.31343209743499756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3131815791130066},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.1714422106742859},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13622021675109863},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1109122633934021},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.09685271978378296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08992677927017212}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010457","descriptor_name":"Peptidoglycan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053473","descriptor_name":"Nod2 Signaling Adaptor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053473","descriptor_name":"Nod2 Signaling Adaptor Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci57761","doi":"https://doi.org/10.1172/jci57761","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci57761","pdf_url":"http://www.jci.org/articles/view/57761/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3163965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3163965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:21841315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21841315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci57761","doi":"https://doi.org/10.1172/jci57761","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci57761","pdf_url":"http://www.jci.org/articles/view/57761/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2112091386","display_name":"Mechanisms of pneumococcal persistence during carriage","funder_award_id":"R01AI038446","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3433971338","display_name":null,"funder_award_id":"AI 38446","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4042833792","display_name":"Bacterial phosphorycholine and pathogenesis","funder_award_id":"R21AI044231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6027503237","display_name":"Bacterial phosphorylcholine and pathogenesis","funder_award_id":"R01AI044231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7056866491","display_name":null,"funder_award_id":"AI44231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000866692","display_name":"Mechanisms of Pneumococcal Persistence During Carriage","funder_award_id":"R37AI038446","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000909123","display_name":"Center for Molecular Studies in Digestive and Liver Diseases","funder_award_id":"P30DK050306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160611039.pdf","grobid_xml":"https://content.openalex.org/works/W2160611039.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W175241905","https://openalex.org/W1539099171","https://openalex.org/W1546783991","https://openalex.org/W1754166121","https://openalex.org/W1814700368","https://openalex.org/W1823644318","https://openalex.org/W1883296241","https://openalex.org/W1968718809","https://openalex.org/W1985188790","https://openalex.org/W1987596224","https://openalex.org/W1989286818","https://openalex.org/W2003634035","https://openalex.org/W2005820711","https://openalex.org/W2006595984","https://openalex.org/W2015141049","https://openalex.org/W2022135107","https://openalex.org/W2029361361","https://openalex.org/W2029565975","https://openalex.org/W2029948570","https://openalex.org/W2031269216","https://openalex.org/W2037450210","https://openalex.org/W2038143978","https://openalex.org/W2038444095","https://openalex.org/W2038701927","https://openalex.org/W2040853949","https://openalex.org/W2041170922","https://openalex.org/W2041928346","https://openalex.org/W2043667001","https://openalex.org/W2052127995","https://openalex.org/W2055402867","https://openalex.org/W2057239744","https://openalex.org/W2058127453","https://openalex.org/W2064358027","https://openalex.org/W2075583035","https://openalex.org/W2076893605","https://openalex.org/W2079866862","https://openalex.org/W2080013385","https://openalex.org/W2080475118","https://openalex.org/W2086607027","https://openalex.org/W2092940132","https://openalex.org/W2097035469","https://openalex.org/W2108360478","https://openalex.org/W2109056923","https://openalex.org/W2109357160","https://openalex.org/W2109381735","https://openalex.org/W2109491705","https://openalex.org/W2111253543","https://openalex.org/W2111374509","https://openalex.org/W2111900042","https://openalex.org/W2112580008","https://openalex.org/W2118283102","https://openalex.org/W2118878242","https://openalex.org/W2119236072","https://openalex.org/W2119740658","https://openalex.org/W2120124319","https://openalex.org/W2125841166","https://openalex.org/W2133449490","https://openalex.org/W2133454819","https://openalex.org/W2138177598","https://openalex.org/W2138424202","https://openalex.org/W2138651252","https://openalex.org/W2144576189","https://openalex.org/W2150532865","https://openalex.org/W2153114735","https://openalex.org/W2157262295","https://openalex.org/W2158737537","https://openalex.org/W2161320421","https://openalex.org/W2169167040","https://openalex.org/W2169356861","https://openalex.org/W2170605026","https://openalex.org/W2170629825","https://openalex.org/W2293885897","https://openalex.org/W2318151031","https://openalex.org/W2436860002"],"related_works":["https://openalex.org/W22934198","https://openalex.org/W2300976581","https://openalex.org/W1820351509","https://openalex.org/W7095577691","https://openalex.org/W1960478084","https://openalex.org/W2100439014","https://openalex.org/W1964447974","https://openalex.org/W2465100639","https://openalex.org/W2111374509","https://openalex.org/W2133454819"],"abstract_inverted_index":{"Streptococcus":[0],"pneumoniae":[1,45,196],"colonizes":[2],"the":[3,7,26,34,56,64,73,98,129,172,179,186,191],"mucosal":[4],"surface":[5],"of":[6,58,63,72,78,89,97,100,117,122,135,166,171,178,185,193],"human":[8],"upper":[9],"respiratory":[10],"tract.":[11],"A":[12],"colonization":[13,197],"event":[14],"is":[15,161],"gradually":[16],"cleared":[17],"through":[18],"phagocytosis":[19],"by":[20,91,102,113,119,125,142,158,163,175],"monocytes/macrophages":[21,59,188],"that":[22,39,55,155],"are":[23],"recruited":[24],"to":[25,32],"airway":[27],"lumen.":[28],"Here,":[29],"we":[30],"sought":[31],"define":[33],"bacterial":[35,49,110,156],"and":[36,43,68,80,94,115,149,182],"host":[37],"factors":[38],"promote":[40],"monocyte/macrophage":[41,81],"influx":[42],"S.":[44,167,195],"clearance":[46,192],"using":[47],"intranasal":[48],"challenge":[50],"in":[51,85],"mice.":[52],"We":[53],"found":[54],"recruitment":[57,82,184],"required":[60,128,189],"their":[61],"expression":[62,71],"chemokine":[65,180],"receptor":[66],"CCR2":[67,74],"correlated":[69],"with":[70],"ligand":[75],"CCL2.":[76],"Production":[77],"CCL2":[79,108],"were":[83],"deficient":[84],"mice":[86],"lacking":[87],"digestion":[88,101,112,165],"peptidoglycan":[90,118,124],"lysozyme":[92],"(LysM)":[93],"cytosolic":[95],"sensing":[96,116,170],"products":[99,174],"Nod2.":[103,120],"Ex":[104],"vivo":[105],"macrophages":[106],"produced":[107],"following":[109],"uptake,":[111],"LysM,":[114],"Sensing":[121],"digested":[123],"Nod2":[126],"also":[127,147],"pore-forming":[130],"toxin":[131],"pneumolysin.":[132],"The":[133],"generation":[134],"an":[136,194],"adaptive":[137],"immune":[138],"response,":[139],"as":[140],"measured":[141],"anti-pneumococcal":[143],"antibody":[144],"titers,":[145],"was":[146],"LysM-":[148],"Nod2-dependent.":[150],"Together,":[151],"our":[152],"data":[153],"suggest":[154],"uptake":[157],"professional":[159],"phagocytes":[160],"followed":[162],"LysM-mediated":[164],"pneumoniae-derived":[168],"peptidoglycan,":[169],"resulting":[173],"Nod2,":[176],"release":[177],"CCL2,":[181],"CCR2-dependent":[183],"additional":[187],"for":[190],"event.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
