{"id":"https://openalex.org/W2160556808","doi":"https://doi.org/10.7785/tcrt.2012.500278","title":"In vivo Photoacoustic Tomography of Total Blood Flow and Potential Imaging of Cancer Angiogenesis and Hypermetabolism","display_name":"In vivo Photoacoustic Tomography of Total Blood Flow and Potential Imaging of Cancer Angiogenesis and Hypermetabolism","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2160556808","doi":"https://doi.org/10.7785/tcrt.2012.500278","mag":"2160556808","pmid":"https://pubmed.ncbi.nlm.nih.gov/22417060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3376701"},"language":"en","primary_location":{"id":"doi:10.7785/tcrt.2012.500278","doi":"https://doi.org/10.7785/tcrt.2012.500278","is_oa":false,"landing_page_url":"https://doi.org/10.7785/tcrt.2012.500278","pdf_url":null,"source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research & Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3376701","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005956622","display_name":"Junjie Yao","orcid":"https://orcid.org/0000-0002-2381-706X","observed_orcids":["https://orcid.org/0000-0002-2381-706X","https://orcid.org/0000-0002-7278-9325"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjie Yao","raw_affiliation_strings":["Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027287669","display_name":"Konstantin Maslov","orcid":"https://orcid.org/0000-0003-3408-8840","observed_orcids":["https://orcid.org/0000-0003-3408-8840"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin I. Maslov","raw_affiliation_strings":["Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008233636","display_name":"Lihong V. Wang","orcid":"https://orcid.org/0000-0001-9783-4383","observed_orcids":["https://orcid.org/0000-0001-9783-4383"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lihong V. Wang","raw_affiliation_strings":["Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008233636"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":3.0966,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.91207037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"301","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoacoustic-tomography","display_name":"photoacoustic tomography","score":0.9169999957084656},{"id":"https://openalex.org/keywords/blood-flow-estimation","display_name":"blood flow estimation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/doppler-angle","display_name":"Doppler angle","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.7023444771766663},{"id":"https://openalex.org/C2777464067","wikidata":"https://www.wikidata.org/wiki/Q5958306","display_name":"Hypermetabolism","level":2,"score":0.6631753444671631},{"id":"https://openalex.org/C142757262","wikidata":"https://www.wikidata.org/wiki/Q76436","display_name":"Doppler effect","level":2,"score":0.5635170340538025},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5313886404037476},{"id":"https://openalex.org/C52305850","wikidata":"https://www.wikidata.org/wiki/Q1420475","display_name":"Laser Doppler velocimetry","level":3,"score":0.498882532119751},{"id":"https://openalex.org/C154954056","wikidata":"https://www.wikidata.org/wiki/Q1604164","display_name":"Transverse plane","level":2,"score":0.4891708195209503},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4121687412261963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3540048599243164},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3394646644592285},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3253440856933594},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2738523483276367},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.2612210512161255},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1871809959411621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10065564513206482},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004431","descriptor_name":"Ear, External","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7785/tcrt.2012.500278","doi":"https://doi.org/10.7785/tcrt.2012.500278","is_oa":false,"landing_page_url":"https://doi.org/10.7785/tcrt.2012.500278","pdf_url":null,"source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research & Treatment","raw_type":"journal-article"},{"id":"pmid:22417060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22417060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in cancer research & treatment","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3376701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3376701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Technol Cancer Res Treat","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:68612","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/68612/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3376701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3376701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Technol Cancer Res Treat","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1964889935","display_name":"Diabetes Research & Training Center","funder_award_id":"5p60dk020579-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3209647093","display_name":"RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING","funder_award_id":"R01EB008085","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3341232771","display_name":null,"funder_award_id":"5P60DK02057933","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3538799493","display_name":"Confocal Photacoustic Microscopy: Technology Development","funder_award_id":"R01EB000712","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6427466625","display_name":"Photoacoustic endoscopy of Barretts esophagus","funder_award_id":"R01CA157277","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6941673650","display_name":"Photoacoustic / Optical / Ultrasonic Imaging of Sentinel Lymph Nodes and Metastas","funder_award_id":"U54CA136398","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7834233048","display_name":"Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic Tomograph","funder_award_id":"R01CA134539","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8684489041","display_name":"Development of Thermoacoustic Tomography Brain Imaging","funder_award_id":"R01EB010049","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G87705910","display_name":null,"funder_award_id":"P60-DK-020579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W598735987","https://openalex.org/W1668895383","https://openalex.org/W1917042571","https://openalex.org/W1970571345","https://openalex.org/W1974084336","https://openalex.org/W1982367678","https://openalex.org/W1985593321","https://openalex.org/W1987635435","https://openalex.org/W2018507306","https://openalex.org/W2020580212","https://openalex.org/W2024182101","https://openalex.org/W2024849456","https://openalex.org/W2027086893","https://openalex.org/W2032400359","https://openalex.org/W2050854738","https://openalex.org/W2056006661","https://openalex.org/W2068926508","https://openalex.org/W2071591340","https://openalex.org/W2074031205","https://openalex.org/W2091954406","https://openalex.org/W2096097264","https://openalex.org/W2108770540","https://openalex.org/W2111252483","https://openalex.org/W2117692326","https://openalex.org/W2128163907","https://openalex.org/W2131369545","https://openalex.org/W2140403349","https://openalex.org/W2142425748","https://openalex.org/W4249112794"],"related_works":["https://openalex.org/W2022625741","https://openalex.org/W3083344376","https://openalex.org/W2804751567","https://openalex.org/W2464819296","https://openalex.org/W2022602868","https://openalex.org/W2085080199","https://openalex.org/W2071686453","https://openalex.org/W1970011917","https://openalex.org/W1506964937","https://openalex.org/W1974084336"],"abstract_inverted_index":{"Blood":[0],"flow":[1,15,28,42,75,86,120],"is":[2,36],"a":[3,69,98,139],"key":[4],"parameter":[5],"in":[6,51,97,136],"studying":[7],"cancer":[8,155],"angiogenesis":[9,156],"and":[10,44,58,77,84,104,122,157],"hypermetabolism.":[11],"Current":[12],"photoacoustic":[13],"blood":[14,96],"estimation":[16],"methods":[17],"focus":[18],"on":[19,138],"either":[20],"the":[21,27,31,40,55,73,82,127,132,145,149],"axial":[22,57,83],"or":[23],"transverse":[24,85],"component":[25],"of":[26],"vector.":[29],"However,":[30],"Doppler":[32,78,105,128],"angle":[33,79],"(beam-to-flow":[34],"angle)":[35],"needed":[37],"to":[38,71,112,151],"calculate":[39],"total":[41,74,119],"speed,":[43,121],"it":[45],"cannot":[46],"always":[47],"be":[48,113,152],"estimated":[49],"accurately":[50],"practice,":[52],"especially":[53],"when":[54],"system's":[56],"lateral":[59],"resolutions":[60],"are":[61],"different.":[62],"To":[63],"overcome":[64],"this":[65],"problem,":[66],"we":[67],"propose":[68],"method":[70,89,133,147],"compute":[72],"speed":[76],"by":[80,93],"combining":[81],"measurements.":[87],"The":[88,107],"has":[90,148],"been":[91],"verified":[92],"flowing":[94],"bovine":[95],"plastic":[99],"tube":[100],"at":[101],"various":[102],"speeds":[103],"angles.":[106],"error":[108],"was":[109,134],"experimentally":[110],"determined":[111],"less":[114,123],"than":[115,124],"0.3":[116],"mm/s":[117],"for":[118,126,154],"158":[125],"angle.":[129],"In":[130],"addition,":[131],"tested":[135],"vivo":[137],"mouse":[140],"ear.":[141],"We":[142],"believe":[143],"that":[144],"proposed":[146],"potential":[150],"used":[153],"hypermetabolism":[158],"imaging.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}